Papers by Dimitra Koumoundourou
Heart echinococcus cyst as an incidental finding:
Monaldi Archives for Chest Disease
GATA3 is a transcription factor involved in embryogenesis of multiple human tissues and in mainta... more GATA3 is a transcription factor involved in embryogenesis of multiple human tissues and in maintaining cell differentiation and tissue homeostasis in the adult organism. GATA3 is also involved in carcinogenesis and regarded as a sensitive marker for urothelial and breast carcinomas, albeit expression in carcinomas of non-breast/urothelial origin has been frequently reported. We sought to examine the extent and intensity of GATA3 expression in various carcinomas, mainly lung, urothelial, and breast and various other primary sites. Patients with breast carcinoma (N=40), carcinoma of the urinary bladder/renal pelvis (N=40), lung carcinoma (N=110) and various other origins (N=45) were included in the study. One hundred and sixty-five patients had a primary tumor diagnosis, and 70 cases had a metastatic tumor diagnosis. Our results showed that GATA3 expression was significantly more common in carcinomas of the breast, urinary bladder and renal pelvis compared to all other origins. All pr...
Bangladesh Journal of Medical Science, 2016
Sarcoidosis is a chronic granulomatous disease of unknown etiology which principally affects the ... more Sarcoidosis is a chronic granulomatous disease of unknown etiology which principally affects the lower respiratory tract & lungs. Sarcoidosis in the head & neck region is infrequent. Isolated sino nasal sarcoidosis without pulmonary involvement is rare. Case: An 18 years old male patient presented with the complaints of nasal blockage, purulent nasal discharge which was occasionally blood stained for 6 months, deformity of nose, swelling of face & lips for 4 months & watering of eyes for same duration. Endoscopy of nose revealed intra nasal mucosal thickening which was friable & bleeds on touch. The diagnosis of sino nasal sarcoidosis was made by histopathological examination of nasal biopsy specimen.Conclusion: Sino nasal sarcoidosis is a disease of diagnostic challenge to the clinician as its mimicking clinical features may be misleading & cause delay in definitive diagnosis. In the current case report, we presented a case of sino nasal sarcoidosis presenting as chronic rhino sinusitis.
Healthcare
This study aimed to investigate the effects of cold-water immersion (CWI) and sports massage on d... more This study aimed to investigate the effects of cold-water immersion (CWI) and sports massage on delayed-onset muscle soreness (DOMS) in amateur athletes. Sixty male amateur athletes were randomised into four equal groups (n = 15) receiving either CWI, sports massage, their combination, or served as controls after applying plyometric training to their lower extremities. The main outcomes measures were pain, exertion, rectus femoris perimeter, knee flexion range of motion, knee extensors isometric strength and serum creatine phosphokinase (CPK) levels examined before the plyometric training, immediately after the treatment, and 24, 48 and 72 h post exercise. We observed no significant differences between study groups in the most tested variables. CWI improved pain compared to the combined application of CWI and sports massage, and the control group both on the second and third day post exercise. Sports massage combined with CWI also led to a significant reduction in pain sensation com...
Introduction: Transforming Growth Factor beta signaling pathway is thoroughly studied in a series... more Introduction: Transforming Growth Factor beta signaling pathway is thoroughly studied in a series of diseases and this molecule has been proved to act either as an oncogene or as a tumor suppressor molecule in human carcinogenesis. Recently, the Smad proteins' family has been identified as TGF-beta's intracellular substrates, which transfer the signal in the cell's nucleus. A lot of molecules have also been found to act as co-repressors or co-activators in this procedure. Ski protein is one of the most well-known Smad proteins' co-repressors. On the other hand, breast cancer is one of the most common cancers in women, and the discovery of new predictive factors, especially at early stages of the disease is very challenging. Objective: The purpose of the present study was the investigation of the expression of TGF-β receptor, as well as the expression of Smad2/3 and Ski protein in T1, T2, -node negative breast cancer specimens and the potent correlation of their expre...
Dermatologic Therapy, 2020
, KMP, CO have made substantial contributions to conception and design, acquisition of data, anal... more , KMP, CO have made substantial contributions to conception and design, acquisition of data, analysis and interpretation of data; KMP, DM, AS have been involved in drafting the manuscript and revising it critically for important intellectual content; and SG and TS have given final approval of the version to be published. Each author should have participated sufficiently in the work to take public responsibility for appropriate portions of the content.
Der Orthopäde, 2005
Ori gi na li en A. Kai si dis 1 • P. Me gas 1 • D. Apo sto lo pou los 2 • T. Spi ri do ni dis 2 •... more Ori gi na li en A. Kai si dis 1 • P. Me gas 1 • D. Apo sto lo pou los 2 • T. Spi ri do ni dis 2 • D. Kou moun dou rou 3 P. Zou bou lis 1 • E. Lam bi ris 1 • P. Vas si la kos 2 1 Or tho pä di sche Kli nik, Uni ver si täts kli ni kum, Pa tras, Grie chen land 2 Ab tei lung für Nu kle ar me di zin, Uni ver si täts kli ni kum, Pa tras, Grie chen land 3 Ab tei lung für Pa tho lo gi sche Ana to mie, Uni ver si täts kli ni kum, Pa tras, Grie chen land Di ag no se sep ti scher Hüft pro the sen lo cke rung via Leu koS can SPECT-Scan mit 99m Tc-mar kier ten mo no klo na len An ti kör pern
International Journal of Gynecological Cancer, 2003
Coincidental detection of T-cell rich B-cell lymphoma in the paraaortic lymph nodes of a woman un... more Coincidental detection of T-cell rich B-cell lymphoma in the paraaortic lymph nodes of a woman undergoing lymph node dissection for cervical cancer.
American Journal of Case Reports, 2021
Objective: Rare disease Background: This article presents a rare case of 2 separate intraosseous ... more Objective: Rare disease Background: This article presents a rare case of 2 separate intraosseous ganglion cysts of the talus in a 51-year-old man, treated with a unique technique of precise lesion targeting to avoid extensive bone loss and minimize articular chondral injury of the talus. Case Report: Two separate intraosseous ganglion cysts of the talus were diagnosed in a 51-year-old man with chronic ankle pain. A single straight-line incision with an entry point through the talonavicular joint was created to spare the precarious blood supply of the talus network. The 2 distinct subchondral lesions were approached under fluoroscopic control for curettage and autologous bone grafting using the anterior cruciate ligament tibial guide in a pair-of-compasses fashion. In almost 5 years of follow-up the patient has been asymptomatic. Magnetic resonance imaging has revealed no signs of degenerative changes in the ankle or the talonavicular joint, and the intraosseous edema has almost disappeared. Conclusions: To the best of our knowledge, this case is the first report of 2 distinct intraosseous ganglion cysts of the talus. We recommend the precise targeting technique used in our case for treating intraosseous talar lesions with intact articular cartilage.
Dermatologic Therapy, 2021
Dear Editor Lobular capillary hemangioma (LCH), also known as pyogenic granuloma, is a benign vas... more Dear Editor Lobular capillary hemangioma (LCH), also known as pyogenic granuloma, is a benign vascular proliferative lesion of both, skin, and mucosa, which may occur in response to various stimuli, such as trauma or drugs. Azacitidine (AZA) is a cytidine analog, used as an interventional treatment of myelodysplastic syndromes (MDS). It exhibits antineoplastic action, either through incorporation into RNA and DNA or as an inhibitor of DNA-methyltransferases (DNMTs), which restores normal growth control and differentiation in hematopoietic cells. A 75-year-old Caucasian male was referred to the Dermatology Department with a history of hypertension, gout, and recent onset of high-risk MDS, namely, Refractory Anemia with Excess Blasts (EB) under AZA treatment. The patient reported a painless large red dome-shaped mass with hemorrhagic crust, sprouting at the right inner ankle, after receiving subcutaneously administered AZA (75 mg/ m) for 7 consecutive days of each month, for 4 cycles (Figure 1A. The emerging lesion was initially pink and bled profusely with little or no trauma, already by the end of the second cycle. During the next 2 cycles it grew rapidly, increasing in size to 30 mm, meantime, multiple similar new lesions (n = 5) appeared on the distal extremities. Cell culture swabs were negative for microorganisms and histopathological findings revealed LCH (Figure 1B. Halting AZA yielded a complete resolution of the lesions, according to the Common Terminology Criteria for Adverse Events CTCAEv5.0. The cutaneous adverse events induced by AZA in MDS patients have been recently reviewed, however, to the best of our knowledge, this is the first reported case of a high-risk MDS patient with no known mutational load (based on FISH and RT-qPCR analysis), developing LCH during AZA treatment. LCHs angiogenesis involves an imbalance between proangiogenic and antiangiogenic factors, whose gene expression may be affected by AZA, like endothelial nitric oxide synthase (eNOS) which stimulates nitric oxide (NO) biosynthesis and release, leading to overexpression of vascular endothelial growth factor (VEGF) which acts via VEGF receptor-2 (VEGFR2). Endothelial cells are in dynamic interplay with pericytes during new vessel
Dermatology Online Journal, 2019
Our Dermatology Online, 2020
Linear scleroderma is a variant of localized scleroderma characterized by longitudinal bands of d... more Linear scleroderma is a variant of localized scleroderma characterized by longitudinal bands of dense scleroatrophic skin sometimes causing deformities of the upper and lower extremities. Some case reports on small groups of patients suggest benefits of lasers in patients with localized scleroderma. We report a case of a twelve-year-old female with a two-year history of linear scleroderma on the right lower limb treated with 1064-nm long-pulsed Nd:YAG laser with successful results. Laser therapy may be a promising tool in the treatment of linear scleroderma.
Dermatologic Therapy, 2020
Dear Editor, Angiokeratomas are benign cutaneous vascular lesions characterized by ectasia of the... more Dear Editor, Angiokeratomas are benign cutaneous vascular lesions characterized by ectasia of the capillary network in the papillary dermis and hyperkeratosis of the epidermis. While their presence on the scrotum is common, vulvar involvement is relatively rare. The pathophysiology of angiokeratomas remains unknown, although many authors incriminate increased local venous pressure and consequent subepithelial vascular dilatation to be the causative factors. Although occasionally vulvar angiokeratomas may be accompanied by pain, intermittent pruritus, bleeding or dyspareunia, the majority of patients are asymptomatic. Nevertheless, the lesions are often reported to cause significant social embarrassment and anxiety which lead to poor quality of life, predominantly owing to their resemblance to other benign or malignant lesions. A 35-year-old, otherwise healthy, multiparous woman presented with a 10-year history of multiple asymptomatic unilateral vulvar lesions. Clinical examination revealed clustered dark red hyperkeratotic papules, each measuring 3 to 6 mm, located on the right labia majora and upper inner thigh (Figure 1). Dermoscopy revealed well-demarcated dusky-red and black lacunae intermingled with a whitish veil. A confirmatory punch biopsy was performed and histopathological examination revealed the presence of dilated, blood-filled vascular spaces in the papillary dermis, partially surrounded by the overlying acanthotic and hyperkeratotic epidermis
Dermatologic Therapy, 2020
There are many facets to the neurofibromatosis type 1 (NF1) syndrome, with cutaneous neurofibroma... more There are many facets to the neurofibromatosis type 1 (NF1) syndrome, with cutaneous neurofibromas (Cnf) being especially important. Cnfs are occasionally accompanied by severe and persisting pruritus which can be partly attributed to mast cell (MC) degranulation. Ketotifen, a relatively selective second-generation noncompetitive H1-antihistamine and mast cell stabilizer, has not yet been fully appreciated for its potential in NF1 treatment.
Journal of Physical Therapy Science, 2020
This study aimed to evaluate the posterior thigh's skin thermal responses to 448-kHz radiofrequen... more This study aimed to evaluate the posterior thigh's skin thermal responses to 448-kHz radiofrequency-based therapy applied either in the form of standard application (Indiba ® Activ) or combined soft tissue treatment (Indiba ® Fascia treatment). [Participants and Methods] Ten healthy males (22 ± 3 years of age, weight 75.2 ± 4.9 kg, height 178.5 ± 4.7) received four different treatments which included a) Indiba ® Activ (IA) radiofrequency treatment, b) Indiba ® Fascia (IF), c) Indiba ® Activ placebo (IAP) and d) Indiba ® Fascia Placebo (IFP) in the posterior thigh of their dominant lower limb, while the non-dominant served as the control. Skin temperature was recorded pre-and post-treatment and every minute until the surface temperature reached pre-treatment levels using a wireless infrared thermometer. [Results] Both radiofrequency-based therapy groups IA and IF led to a significant increase in skin temperature compared to placebo applications. The IF intervention led to an average retention of elevated temperature for 164.2 minutes compared to 54.8 minutes of IA, 23.17 of IFP and 17.6 minutes of IAP. [Conclusion] These findings indicate that radiofrequency treatment at 448 kHz can induce and sustain significant thermal skin adaptations reflecting an increased blood circulation and metabolism of underlying tissues.
ePoster, 2019
and 39 (10.9%) of the patients, respectively. ICG was used in 231 (64.7%) and blue dye in 126 (35... more and 39 (10.9%) of the patients, respectively. ICG was used in 231 (64.7%) and blue dye in 126 (35.3%) patients. Dyes were injected into the cervix in 355 (99.4%) patients. In 71 (19.9%) patients only SLN biopsy was done whereas 169 (47.3%) underwent pelvic and 117 (32.8%) underwent pelvic and paraaortic lymphadenectomy. The overall, unilateral and bilateral SLN detection rates were 91.9%, 20.7%, 71.1%, respectively. These rates were 91.2%, 17.4% and 73.8% by using ICG and 92.2%, 22.5% and 69.7% by using blue dye. There is no statistical significance (p=0.526). In 29 of 358 (8%) patients there was no lymph node in resected tissue labelled as SLN (empty packets). There were 40 (11%) patients with lymphatic metastasis. SLN was found metastatic in 32 of 40 patients and 14 of them also had metastasis in non-SLN(s). 4 of 40 cases were diagnosed by side specific lymphadenectomy. However, SLN algorithm were not able to detect 4 of 40 metastatic patients. NPV, sensitivity and false negative rates were 98.4%, 88.8% and 1.57%, respectively. Conclusion SLN biopsy has high accuracy in detecting lymphatic metastasis. However nearly half of the cases with metastatic SLN(s) also had non-SLN involvement and the effect of leaving these nodes in situ on survival should be evaluated. To avoid 'empty packet' on final pathology, intraoperative frozen section evaluation could be suggested. Disclosure Nothing to disclose.
ePoster, 2019
Introduction/Background ErbB receptors are trans-membrane glycoproteins with tyrosine kinase acti... more Introduction/Background ErbB receptors are trans-membrane glycoproteins with tyrosine kinase activity. Especially in cancer, they are implicated in cell proliferation, transformation, angiogenesis, migration and invasion. The expression of ErbB receptors, has not been studied well in endometrial cancer patients. The main aim of our study was to investigate ErbB receptors profile in selected patients with type II endometrial cancer. Methodology We evaluated retrospectively tissue specimens from 10 patients with type II endometrial cancer, that have been treated in the Division of Gynaecological Oncology of the University of Patras. For ErbB receptors immunostaining, we used: anti-EGFR polyclonal antibody sc-03 (Santa Cruz Biotechnology Inc., Santa Cruz, CA, USA) in a dilution 1:20, anti-ErbB-2 monoclonal antibody CB11 (BioGenex Laboratories Inc., San Ramon, CA, USA) in a dilution 1:100, anti-ErbB-3 polyclonal antibody sc-285 (Santa Cruz Biotechnology Inc., Santa Cruz, CA, USA) in a dilution 1:100 and anti-ErbB-4 polyclonal antibody sc-283 (Santa Cruz Biotechnology Inc., Santa Cruz, CA, USA) in a dilution 1:200. Results For EGFR receptor, 5 cases were positive (50%) and 5 cases were negative (50%), while for ErbB-2 receptor 9 cases were positive (90%) and 1 case was negative (10%). For ErbB-3 receptor all cases were positive (100%), while for ErbB-4 receptor 7 cases were positive (70%) and 3 cases were negative (30%). Overall, we observed high expression levels of all ErbB receptors in our study population and 5 patients were positive (50%) for all ErbB receptors. Conclusion The high expression levels of ErbB receptors in patients with type II endometrial cancer possibly indicates a future role of ErbB-targeted therapies in well-defined subgroups of type II endometrial cancer patients with EGFR and ErbB-2 overexpression. Disclosure Nothing to disclose.
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Papers by Dimitra Koumoundourou