Papers by DENISE SPINOLA PINHEIRO
Clinical neurophysiology, May 1, 2024
Journal of clinical neurophysiology, Feb 20, 2024
Clinical Neurophysiology, 2017
The study aimed to examine the effect of the stimulus phase of air-conducted sound on ocular vest... more The study aimed to examine the effect of the stimulus phase of air-conducted sound on ocular vestibular evoked myogenic potentials (oVEMPs). oVEMPs were recorded after air-conducted sounds (500Hz, 4ms duration), presented with initial condensation (positive), rarefaction (negative), and alternant polarities from 12 healthy subjects. Most responses showed a bifid n10 peak separated by ∼1.9ms. The most prominent sub-peak after condensation was shorter than the most prominent sub-peak after rarefaction; however, the first sub-peak was shorter after the rarefaction stimuli. When a third sub-peak appeared, it occurred before the most prominent sub-peak after condensation and after the most prominent sub-peak after rarefaction. The latency difference between this third sub-peak and the closest sub-peak was shorter than the difference among the others sub-peaks, in both cases; the oVEMPs after alternating stimuli was an amalgam of the responses to the different stimuli. The findings suggest that the negative to positive change of the stimulus was the main event responsible for the stimulation, and that when a third sub-peak appeared it was related to the initiation or the end of the stimulus. These findings suggested that the oVEMP response, obtained by air conducted sound, was secondary to stimulation of the same type of afferent vestibular unit, independent of the stimulus polarity.
Clinical Neurophysiology, 2016
European Neurology, 2013
Objective: Neuropathy is a well-recognized feature in spinocerebellar ataxia type 3 (SCA3) or Mac... more Objective: Neuropathy is a well-recognized feature in spinocerebellar ataxia type 3 (SCA3) or Machado-Joseph disease (MJD), but the pattern of neuropathy is still a matter of debate. This study aimed to evaluate peripheral nerve involvement in MJD patients. Neurophysiological and clinical data were analyzed to distinguish neuronopathy from length-dependent distal axonopathy. Methods: In the present study we evaluated 26 patients with clinical and molecular-proven MJD and investigated their peripheral nerve involvement. Neurophysiological and clinical data were compared and correlated aiming to distinguish neuronopathy from distal axonopathy. Results: The neurophysiological evaluation showed that 42.3% of the patients had polyneuropathy. Among these patients, 81.8% presented neuronopathy. Conclusion: We concluded that neuronopathy is the most common form of peripheral nerve involvement in MJD patients.
European Neurology, 2011
Objective: To evaluate a group of spinocerebellar ataxia type 3 (SCA3) or Machado-Joseph disease ... more Objective: To evaluate a group of spinocerebellar ataxia type 3 (SCA3) or Machado-Joseph disease (MJD) (SCA3/MJD) patients and assess whether there is an association between neuropathy and serum ferritin levels and restless legs syndrome (RLS). Methods: Twenty-six SCA3/MJD patients underwent electromyography studies to check for neuropathy. Their serum ferritin levels were measured as well. These findings were evaluated based on the presence or not of RLS and its severity. Results: The proportion of neuropathy in the RLS group was not significantly higher compared to the non-RLS group (23 vs. 15%, Fisher’s exact test, p = 1.000). Furthermore, no association was found between RLS and ferritin levels. Conclusion: We found no correlation between neuropathy or ferritin levels and RLS in SCA3/MJD patients.
Clinical Neurophysiology, 2004
Clinical Neurophysiology, 2008
Reproducibility testing of nerve conduction studies and F-wave latencies in a group of healthy vo... more Reproducibility testing of nerve conduction studies and F-wave latencies in a group of healthy volunteers. A total of 32 healthy volunteers underwent sensory and motor nerve conduction studies of the ulnar and tibial nerves, including F-waves, elicited by 32 stimuli, repeated in two different days by the same examiner. The F-wave latencies showed less variability than the other parameters of conduction studies, and, among them, the F-wave mean latency of the tibial nerve has been the one with the higher reproducibility. F-wave latencies were the parameters with best reproducibility, followed by conduction velocities and amplitudes. Our data showed that the F-wave mean latency is a parameter with a high reliability, considering the reproducibility, for sequential studies.
Archives of Pediatric Neurosurgery
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Papers by DENISE SPINOLA PINHEIRO