Papers by Colleen Mcmullen
The Journal of Neuroscience, Jan 7, 2004
The FASEB Journal, Mar 1, 2006
Hospital Topics, Aug 17, 2020
The FASEB Journal, Mar 1, 2006
Pflügers Archiv: European Journal of Physiology, Apr 27, 2004
Research Square (Research Square), Jan 27, 2023
Journal of Applied Physiology, Feb 1, 2006
PEC Innovation, Dec 1, 2023
Investigative Ophthalmology & Visual Science, May 14, 2008
Investigative Ophthalmology & Visual Science, May 1, 2005
Journal of Nervous and Mental Disease, Dec 1, 2020
Anxiety can contribute to poor prognosis in cardiac patients. Few studies have examined the role ... more Anxiety can contribute to poor prognosis in cardiac patients. Few studies have examined the role of optimism in anxiety after open heart surgery (OHS). This study investigated the influence of preoperative optimism on post-OHS anxiety, adjusting cardiac indices used by cardiac surgeons. Data were collected before and 1 month after OHS in 481 patients (58% men; age, 62.4 ± 11.94 years). Optimism was measured using the Life Orientation Test. Anxiety was measured using the Trait Anxiety Inventory. Medical and cardiac indices were retrieved from the Society of Thoracic Surgeon's national database. Multiple regression analyses showed that greater pre-OHS optimism was associated with lower levels of post-OHS anxiety (F[6, N = 306] = 50.18, p < 0.001, R = 0.502). No other factors showed similar protection. Pre-OHS anxiety, younger age, and minority status were associated with anxiety in the critical recovery month. The findings demonstrate the potential benefit of optimism against post-OHS anxiety, which may have clinical implications for improving disease management.
Laryngeal dysfunction in the elderly is a major cause of disability, from voice disorders to dysp... more Laryngeal dysfunction in the elderly is a major cause of disability, from voice disorders to dysphagia and loss of airway protective reflexes. Few, if any, therapies exist that target age-related laryngeal muscle dysfunction. Neurotrophins are involved in muscle innervation and differentiation of neuromuscular junctions (NMJs). It is thought that neurotrophins enhance neuromuscular transmission by increasing neurotransmitter release. The neuromuscular junctions (NMJs) become smaller and less abundant in aging rat laryngeal muscles, with evidence of functional denervation. We explored the effects of NTF4 for future clinical use as a therapeutic to improve function in aging human laryngeal muscles. Here, we provide the detailed protocol for systemic application and direct injection of NTF4 to investigate the ability of aging rat laryngeal muscle to remodel in response to NTF4 application. In this method, rats either received NTF4 either systemically via osmotic pump or by direct injec...
Signaling Pathways Project Datasets
Pacing and Clinical Electrophysiology, 2019
The Faseb Journal, Apr 1, 2007
The Faseb Journal, Apr 1, 2007
The Journal of Neuroscience, 2004
Previous studies have suggested that abnormal visual experience early in life induces ocular moto... more Previous studies have suggested that abnormal visual experience early in life induces ocular motor abnormalities. The purpose of this study was to determine how visual deprivation alters the function and gene expression profile of the ocular motor system in mice. We measured the effect of dark rearing on eye movements, gene expression in the oculomotor nucleus, and contractility of isolated extraocular muscles.In vivoeye movement recordings showed decreased gains for optokinetic and vestibulo-ocular reflexes, confirming an effect of dark rearing on overall ocular motor function. Saccade peak velocities were preserved, however, arguing that the quantitative changes in these reflexes were not secondary to limitations in force generation. Using microarrays and quantitative PCR, we found that dark rearing shifted the oculomotor nucleus transcriptome to a state of delayed/arrested development. The expression of 132 genes was altered by dark rearing; these genes fit in various functional ...
Pfl�gers Archiv - European Journal of Physiology, 2004
Uploads
Papers by Colleen Mcmullen