Papers by Christoph Al-Taie
Cardiovascular research, Apr 13, 2024
Scientific Reports, Oct 4, 2023
Cardiovascular Research
Aims The randomized Early Treatment of Atrial Fibrillation for Stroke Prevention Trial found that... more Aims The randomized Early Treatment of Atrial Fibrillation for Stroke Prevention Trial found that early rhythm control reduces cardiovascular events in patients with recently diagnosed atrial fibrillation (AF) compared with usual care. How genetic predisposition to AF and stroke interacts with early rhythm-control therapy is not known. Methods and results Array genotyping and imputation for common genetic variants were performed. Polygenic risk scores (PRS) were calculated for AF (PRS-AF) and ischaemic stroke risk (PRS-stroke). The effects of PRS-AF and PRS-stroke on the primary outcome (composite of cardiovascular death, stroke, and hospitalization for acute coronary syndrome or worsening heart failure), its components, and recurrent AF were determined. A total of 1567 of the 2789 trial patients were analysed [793 randomized to early rhythm control; 774 to usual care, median age 71 years (65–75), 704 (44%) women]. Baseline characteristics were similar between randomized groups. Ear...
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Papers by Christoph Al-Taie