Papers by Channabasappa Kori
Indian Journal of Gynecologic Oncology, Sep 23, 2015
Malignant phylloides tumor (MPT) of the breast is a rare entity, comprising less than 25 % of phy... more Malignant phylloides tumor (MPT) of the breast is a rare entity, comprising less than 25 % of phylloides tumor. Histological hallmark is the presence of both stromal and epithelial elements. MPT’s usually spread by hematogenous route and are associated with 25 % incidence of distant metastasis, most common sites being lung (70–80 %), pleura (60–70 %), and bone (20–30 %). Risk of local and distant recurrence is determined by tumor biology. Very few cases (4) of successful resection of pulmonary metastasis of malignant phylloides tumor have been documented in the literature till date. To the best of our knowledge, we present a fifth case of successful resection of pulmonary metastatic of malignant phylloides tumor.
Fibromatosis also termed as desmoids is a rare benign but locally aggressive neoplasm characteriz... more Fibromatosis also termed as desmoids is a rare benign but locally aggressive neoplasm characterized by mass like or infiltrative growth of fibrous tissue. It usually arises from the abdominal wall or the extremities, rarely affects chest wall representing only 8-10% of all deep fibromatosis. Fibromatosis is locally aggressive but does not metastasize. Here, we present a rare case of fibromatosis of scapular region, treated successfully by wide local resection.
Chondrosarcomas are malignant mesenchymal neoplasm with cartilaginous differentiation of bone and... more Chondrosarcomas are malignant mesenchymal neoplasm with cartilaginous differentiation of bone and soft tissue. It is an uncommon primary malignant neoplasm of maxillofacial regions. Majority of chondrosarcomas of head and neck arise from maxilla, with very few cases arise from the mandible. The clinicopathological and radiographic features are usually characteristic; however, not decisive. CS is usually treated by wide surgical resection and is relatively chemoradioresistant. Radiotherapy is usually advised for high-grade lesions, and chemotherapy has a palliative role. Here we present a case high grade chondrosarcoma treated by surgery and adjuvant chemoradiotherapy.
Non Hodgkin lymphoma is a rare primary malignancy in the head and neck region. Head and neck is t... more Non Hodgkin lymphoma is a rare primary malignancy in the head and neck region. Head and neck is the second most common site for the extra-nodal lymphoma, next to gastrointestinal tract. Nasopharynx, tonsil, nose, paranasal sinuses, orbit and salivary glands are the other sites affected in head and neck region. Involvement of the oral cavity is uncommon. Among the jaw bones, maxilla is affected more commonly than the mandible. Primary NHL arising from mandible is extremely uncommon. To the best of our knowledge, very few cases of primary NHL arising from are reported in the literature.
Synovial sarcoma [SS] is a very rare soft tissue tumor accounting for 5.6 to 10% of all soft tiss... more Synovial sarcoma [SS] is a very rare soft tissue tumor accounting for 5.6 to 10% of all soft tissue sarcomas. Approximately 9% synovial sarcomas occur in head and neck region. SS is highly aggressive in nature and has tendency for distant metastasis. Most common site for head and neck synovial sarcoma is hypo pharynx, post pharyngeal region and parapharyngeal space. Very few cases of SS involving tongue, soft palate, mandible, buccal mucosa, and floor of the mouth have been described in the literature. Based on extensive literature review, very few cases of primary synovial sarcoma of mandible were noted in the literature .Here, we report a rare case of primary synovial sarcoma arising from mandible in a 40 year old lady and treated with definitive surgery.
Paratesticular rhabdomyosarcoma (RMS) is an extremely rare malignant neoplasm with aggressive beh... more Paratesticular rhabdomyosarcoma (RMS) is an extremely rare malignant neoplasm with aggressive behaviour. It accounts for only 7% of all RMS and usually presents as painless scrotal swelling. Multimodality treatment includes surgery, chemotherapy and radiotherapy have improved the disease outcome .we herein report a case of spindle cell variant of paratesticular RMS in a 20 year old gentleman being treated in our department.
Ewing sarcoma is malignant round cell tumour that primarily affects bones. Primary Extra osseous ... more Ewing sarcoma is malignant round cell tumour that primarily affects bones. Primary Extra osseous Ewing sarcoma (EES) is extremely rare. Clinical and radiologic features are non specific. Diagnosis is mainly based on immunohistochemistry. This article presents a rare case of Primary extrosseous soft tissue Ewing sarcoma of right antero-lateral abdomen wall in a 30 year old lady and was successfully treated with multi agent chemotherapy and local treatment in the form of aggressive surgery and radiation.
Plexiform neurofibroma is an extremely rare skin tumour. It constitutes less than 5% cases of neu... more Plexiform neurofibroma is an extremely rare skin tumour. It constitutes less than 5% cases of neurofibroma. Involvement of peripheral nerve is rare. Surgery is the best option for large or diffuse plexiform neurofibroma. Patients need regular follow up to rule out malignant change or recurrence.
International Journal of Health Sciences and Research, 2015
Mandibular metastasis due to thyroid carcinoma is extremely rare phenomena. Most of them were due... more Mandibular metastasis due to thyroid carcinoma is extremely rare phenomena. Most of them were due to follicular carcinoma of thyroid because of its haematogenous spread. Thyroid carcinoma with isolated mandible metastasis accounts for 3.85% of all jaw metastasis. To the best of our knowledge, very few cases are noted in the literature. Here, we are presenting two cases, in which metastatic lesion of mandible due to follicular variant of thyroid carcinoma was detected before or with diagnosis of primary neoplasm.
Introduction asal cell carcinoma is the most Bcommon skin malignancy. It usually appears as the c... more Introduction asal cell carcinoma is the most Bcommon skin malignancy. It usually appears as the classic "sore that does not heal". It usually occurs on the face, neck which are exposed to sunlight, relatively rare over leg, abdomen wall and scalp which are exposed little or not to sunlight. Basal cell carcinoma of scalp is less common and has a chronic and prolonged clinical course. Pigmented basal cell carcinoma of scalp has less favourable prognosis as compared to other sites. It has strong tendency to recur over scalp and can slowly penetrate galea, the periosteum, bone and eventually the brain. It has to be detected early and treated appropriately. We present a case of pigmented basal cell carcinoma over scalp in 62 years male patient who underwent wide excision with rotation flap to cover the defect. Patient has no recurrence and disease free on 1 year follow up.
Annals of Oncology, 2017
Background: The mainstay of treatment of nasopharyngeal carcinoma (NPC) is radiotherapy (RT) with... more Background: The mainstay of treatment of nasopharyngeal carcinoma (NPC) is radiotherapy (RT) with or without concurrent chemotherapy (CRT). The standard of care of NPC has undergone significant changes in HK since last decade: these included adopting the 7 th edition the AJCC/UICC staging system, employing MRI as standard radiological staging of loco-regional disease, adding concurrent cisplatin chemotherapy to radiation in patients with loco-regional advanced disease, and using IMRT as standard radiotherapy treatment. Methods: Eligible patients were identified from the Hong Kong Cancer Registry data base. All clinical data were retrieved throught the Electronic Patient Record System which is used in all public hospitals for clinical patient management. Data entry codes were pre-specified according to study protocol. Data was then retrieved by oncologist working in individual centers. The final electronic clinical data was then verified and analyzed by the principal investigator and the study statistican. Results: A total of 3328 patients were recruited. The median follow-up time was 80.2 months. The 8-year actuarial overall survival (OS), local failure-free survival (LFFS), regional failure-free survival (RFFS), distant failure-free survival (DFFS) and progression-free suruvial (PFS) for whole group was 68.5%, 85.8%, 91.5%, 81.5% and 62.6% respectively. Male gender, older age, advanced T and N stage were adverse prognostic factors for OS, DFFS and PFS, whereas use of chemotherapy in form of concurrent chemo-irradiation (CRT), neoadjuvant þ CRT, or CRT þ adjuvant chemotherapy were favorable prognostic factors for OS and PFS. The local control was adversely affected by advanced T stage. N stage remained as the single adverse prognostic factor for regional control. Seventy percent of the patients were free of symptomatic late complications. Distant metastasis was the commonest site of failure. Conclusions: IMRT is an effective treatment of NPC with excellent overall locoregional control. Distant metastasis is the major site of failure. Concurrent chemotherapy with cisplatin has an established role in NPC patients treated by IMRT. Serious symptomatic late complications related to IMRT are uncommon.
National Journal of Maxillofacial Surgery, 2015
Malignant melanoma of oral cavity is an infrequent neoplasm originating from malignant transforma... more Malignant melanoma of oral cavity is an infrequent neoplasm originating from malignant transformation of melanocytes found in the basal layer of oral mucosal membrane. Melanocytes are neural crest-derived cells
European Journal of Cancer, 2015
Material and Methods: The population reviewed for this retrospective study was composed of a seri... more Material and Methods: The population reviewed for this retrospective study was composed of a series of 102 postoperatively irradiated patients with either unilateral or bilateral cN0. Patients were treated at our hospital from 1997 to 2012. The majority of patients (92%) were men. The median age was 62 y. The analysis was carried out for each neck separately. All 102 patients (204 hemi-necks) underwent surgery of the primary tumor. 123 hemi-necks (cN0) were treated with elective nodal irradiation. 137 heminecks had undergone surgery (elective or therapeutic) and were pN+ 60 hemi-necks (43,8%). Results: The risk of recurrence in a cN0 irradiated hemi-neck was 2% versus 14% in a cN+ irradiated hemi-neck. Prophylactic cN0-hemineck irradiation did not reduce the risk of in-field recurrence (3/123 after irradiation vs. 0/30 after no-irradiation). The risk of recurrence in 77 pN0 hemi-necks was 0% while in 55 pN+ hemi-necks (53 received RT) the recurrence risk was 18,2%. Analysis of prognostic factors for recurrence could not be accomplished due to the low number of events. Conclusions: cN0/pN0 neck irradiation in the postoperative setting is debatable. Multicentric studies with high number of patients are needed in order to define adverse prognostic factors for recurrence. No conflict of interest.
Clinics and Practice, 2011
Retroperitoneal liposarcoma presenting as an inguinal hernia is a rare entity. We present the fir... more Retroperitoneal liposarcoma presenting as an inguinal hernia is a rare entity. We present the first case of Giant recurrent liposarcoma presenting as a recurrent inguinal hernia in a 40-year-old male. Physical examination showed an irreducible lump in the right inguinal region and a scar in the right lumbar and right inguinal region. Computed tomography (CT) scan of abdomen revealed it to be a retro peritoneal mass extending into the right inguinal region along and involving the cord structures. Wide local excision of the tumour with right orchidectomy and inguinal hernioplasty was performed. Histo-pathology confirmed it to be a liposarcoma. Patient received postoperative radio therapy. Follow up of two years has shown him to be disease free. Retroperitoneal liposarcoma can grow along cord structures into the inguinal canal and mimic an irreducible indirect inguinal hernia.
Clinics and Practice, 2012
Ameloblastoma is a benign odontogenic tumor. These are usually asymptomatic until a large size is... more Ameloblastoma is a benign odontogenic tumor. These are usually asymptomatic until a large size is attained. Ameloblastoma has tendency to spread locally and has a high recurrence rate. Majority of ameloblastomas (80%) arise from the mandible. Ameloblastoma arising from anterior mandibular region (symphysis- menti) is rare. Very few cases of midline anterior ameloblastomas are reported in the literature. They often require wide local excision. Reconstruction of mandible in these cases is challenging. We present a case of mandibular ameloblastoma arising from symphysis- menti. Patient underwent wide surgical excision of the tumor followed by immediate reconstruction using free fibular vascular flap, stabilized with titanium reconstructive plates. A brief case report ands review of literature is presented.
Journal of Clinical Oncology, 2015
e15158 Background: North India reports one of the highest incidences of gallbladder cancer (GBC) ... more e15158 Background: North India reports one of the highest incidences of gallbladder cancer (GBC) in the world. There are very few studies evaluating biomolecular expression profile in GBC and study...
International Journal of Anatomy Radiology and Surgery, 2014
Primary neuroendocrine carcinoma of the gall bladder (GB) is an extremely rare condition and is u... more Primary neuroendocrine carcinoma of the gall bladder (GB) is an extremely rare condition and is usually an incidental diagnosis. Here, we describe a rare case of primary gall bladder neuroendocrine carcinoma in a 30 year old lady who presented with upper abdominal pain and palpable lump in the right hypochondrium. Computed tomography of the abdomen showed an ill-defined heterogeneous soft tissue mass involving gall bladder and adjacent liver parenchyma with no obvious regional adenopathy. Metastatic work-up was normal and the patient underwent radical cholecystectomy. Histopathology and immunohistochemistry (IHC) study revealed high grade neuroendocrine carcinoma of the gall bladder involving the adjacent hepatic parenchyma. However, there was no evidence of clinical endocrinopathy. Patient received adjuvant chemotherapy and is disease free at 14 months of follow up. The present case emphasizes the need for better detection, evaluation and analysis of such rare entities, to identify...
European Journal of Cancer, 2015
Paragangliomas (PGs) are very rare extra adrenal tumors derived from neuroendocrine cells of auto... more Paragangliomas (PGs) are very rare extra adrenal tumors derived from neuroendocrine cells of autonomic nervous system which rarely present as retroperitoneal mass. The Extra-adrenal paragangliomas are reported to account for only 10-15% of all paragangliomas. They may present incidentally as a mass. Histological findings are used for definitive diagnosis and surgery is the treatment of choice. We report a case of a non functional retroperitoneal PG with extensive skeletal metastasis in a 22-year-old gentleman treated with palliative chemotherapy.
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Papers by Channabasappa Kori