Circulation-arrhythmia and Electrophysiology, Sep 1, 2020
1Population Health Research Institute, Hamilton; 2Sunnybrook Health Sciences Centre, Toronto; 3Ca... more 1Population Health Research Institute, Hamilton; 2Sunnybrook Health Sciences Centre, Toronto; 3Cardiology Department, Health Sciences North, Sudbury, Ontario, Canada; 4Klinik für Innere Medizin Kardiologie, Diabetologie & Nephrologie, Evangelisches Klinikum Bethel, Bielefeld; 5Division Clinical Electrophysiology, Department of Cardiology, Johann Wolfgang Goethe University, Frankfurt, Germany; 6Department of Medicine, Medical University of South Carolina, Charleston, SC
Background: The goal of this study was to analyze the impact of dronedarone on the risk of myocar... more Background: The goal of this study was to analyze the impact of dronedarone on the risk of myocardial infarction and stroke in atrial fibrillation (AF) patients followed in general practices in Germany. Methods: This study included patients who had received a first prescription of dronedarone, amiodarone, flecainide, propafenone, or sotalol in 1258 general and 62 cardiology practices between January 2010 and March 2017 (index date). The main outcomes of this study were the percentages of patients with myocardial infarction and stroke in the dronedarone group and in the group of individuals who had received other antiarrhythmic drugs within six years of the index date. Cox proportional regression models were used to estimate the relationship between dronedarone and myocardial infarction and stroke. Results: This study included 3498 individuals who had received dronedarone and 17,724 individuals who had received other antiarrhythmic drugs. After six years of follow-up, 3.9% of patients who had received dronedarone and 5.2% of patients who had received other antiarrhythmic drugs had been diagnosed with myocardial infarction (log-rank p-value = 0.002). At the end of the follow-up period, 7.4% of individuals with dronedarone prescriptions and 8.3% of those who had been prescribed other antiarrhythmic drugs had been diagnosed with a stroke (log-rank p-value = 0.003). Dronedarone was associated with a significant decrease in the risk of developing myocardial infarction (HR = 0.78) and suffering a stroke (HR = 0.84) compared to other antiarrhythmics. Conclusions: In our study, dronedarone was associated with a lower risk of myocardial infarction and stroke in patients with AF compared to other antiarrhythmics.
Take-down policy If you believe that this document breaches copyright please contact us providing... more Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Herzschrittmachertherapie Und Elektrophysiologie, Mar 1, 2010
The storage of electrograms in pacemakers and ICDs represents an important step forward in the de... more The storage of electrograms in pacemakers and ICDs represents an important step forward in the detection of asymptomatic arrhythmias (e.g., paroxysmal atrial fibrillation) and the distinction between appropriate and inappropriate therapies. This review presents via clinical examples the information provided in stored electrograms in systems from Boston Scientific and tips how to interpret them.
Introduction: The World Stroke Organization (WSO) Brain & Heart Task Force developed the Brain & ... more Introduction: The World Stroke Organization (WSO) Brain & Heart Task Force developed the Brain & hEart globAl iniTiative (BEAT), a pilot feasibility implementation program to establish clinical collaborations between cardiologists and stroke physicians who work at large healthcare facilities. Methods: The WSO BEAT pilot project focused on atrial fibrillation (AF) and patent foramen ovale (PFO) detection and management, and poststroke cardiovascular complications known as the stroke-heart syndrome. The program included 10 sites from 8 countries: Brazil, China, Egypt, Germany, Japan, Mexico, Romania, and the USA The primary composite feasibility outcome was the achievement of the following 3 implementation metrics (1) developing site-specific clinical pathways for the diagnosis and management of AF, PFO, and the stroke-heart syndrome; (2) establishing regular Neurocardiology rounds (e.g., monthly); and (3) incorporating a cardiologist to the stroke team. The secondary objectives were ...
ZusammenfassungDie Versorgung mit einem implantierbaren Kardioverter-Defibrillator (ICD) bietet e... more ZusammenfassungDie Versorgung mit einem implantierbaren Kardioverter-Defibrillator (ICD) bietet einen effektiven Schutz vor lebensgefährlichen Herzrhythmusstörungen. Da es sich beim plötzlichen Herztod um ein unvorhersehbares Ereignis handelt, stellt die Selektion des Patientenguts, das von einer ICD-Implantation profitiert, jedoch nach wie vor eine große Herausforderung dar. Die Evidenz, auf der die aktuellen Leitlinienempfehlungen zur ICD-Implantation aufbauen, begründet sich zu einem relevanten Teil auf Studien, die bereits vor 20–30 Jahren durchgeführt wurden. Seitdem hat sich die medikamentöse und interventionelle Herzinsuffizienztherapie deutlich weiterentwickelt. Zudem stellen neuere Studien den prognostischen Nutzen einer primärprophylaktischen ICD-Implantation bei Patienten mit nicht ischämischer Kardiomyopathie infrage. Im Folgenden soll anhand der zugrunde liegenden Daten erörtert werden, welche Implikationen sich hieraus für den Alltag ergeben und welche Entwicklungen zu...
Dislodgement of a left atrial appendage occluder after liberation represents a nightmare in cardi... more Dislodgement of a left atrial appendage occluder after liberation represents a nightmare in cardiac interventions. We present a case with this complication and an easy step-by-step protocol that can help to retrieve and venously extract this foreign body with less stress. Particularly the do-it-yourself construction of a "home-made snare" facilitates trapping of large implants which are too large for conventional snares.
Heart Rhythm, Volume 2, Issue 5, Pages S53, May 2005, Authors:Gerian C. Grünefeld, MD; Karl-Heinz... more Heart Rhythm, Volume 2, Issue 5, Pages S53, May 2005, Authors:Gerian C. Grünefeld, MD; Karl-Heinz Kuck, MD; Pawel Ptaszynski, MD; Carsten W. Israel, MD; Stuart J. Connolly, MD; Robin S. Roberts, ScD; Paul Dorian, MD; Stefan H. Hohnloser, MD. ...
Atrial fibrillation is a common arrhythmia, difficult to treat pharmacologically and associated w... more Atrial fibrillation is a common arrhythmia, difficult to treat pharmacologically and associated with significant morbidity and mortality. Although traditionally prescribed when pharmacologic therapy is not effective, not tolerated, or contraindicated, electrical therapy
Circulation-arrhythmia and Electrophysiology, Sep 1, 2020
1Population Health Research Institute, Hamilton; 2Sunnybrook Health Sciences Centre, Toronto; 3Ca... more 1Population Health Research Institute, Hamilton; 2Sunnybrook Health Sciences Centre, Toronto; 3Cardiology Department, Health Sciences North, Sudbury, Ontario, Canada; 4Klinik für Innere Medizin Kardiologie, Diabetologie & Nephrologie, Evangelisches Klinikum Bethel, Bielefeld; 5Division Clinical Electrophysiology, Department of Cardiology, Johann Wolfgang Goethe University, Frankfurt, Germany; 6Department of Medicine, Medical University of South Carolina, Charleston, SC
Background: The goal of this study was to analyze the impact of dronedarone on the risk of myocar... more Background: The goal of this study was to analyze the impact of dronedarone on the risk of myocardial infarction and stroke in atrial fibrillation (AF) patients followed in general practices in Germany. Methods: This study included patients who had received a first prescription of dronedarone, amiodarone, flecainide, propafenone, or sotalol in 1258 general and 62 cardiology practices between January 2010 and March 2017 (index date). The main outcomes of this study were the percentages of patients with myocardial infarction and stroke in the dronedarone group and in the group of individuals who had received other antiarrhythmic drugs within six years of the index date. Cox proportional regression models were used to estimate the relationship between dronedarone and myocardial infarction and stroke. Results: This study included 3498 individuals who had received dronedarone and 17,724 individuals who had received other antiarrhythmic drugs. After six years of follow-up, 3.9% of patients who had received dronedarone and 5.2% of patients who had received other antiarrhythmic drugs had been diagnosed with myocardial infarction (log-rank p-value = 0.002). At the end of the follow-up period, 7.4% of individuals with dronedarone prescriptions and 8.3% of those who had been prescribed other antiarrhythmic drugs had been diagnosed with a stroke (log-rank p-value = 0.003). Dronedarone was associated with a significant decrease in the risk of developing myocardial infarction (HR = 0.78) and suffering a stroke (HR = 0.84) compared to other antiarrhythmics. Conclusions: In our study, dronedarone was associated with a lower risk of myocardial infarction and stroke in patients with AF compared to other antiarrhythmics.
Take-down policy If you believe that this document breaches copyright please contact us providing... more Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Herzschrittmachertherapie Und Elektrophysiologie, Mar 1, 2010
The storage of electrograms in pacemakers and ICDs represents an important step forward in the de... more The storage of electrograms in pacemakers and ICDs represents an important step forward in the detection of asymptomatic arrhythmias (e.g., paroxysmal atrial fibrillation) and the distinction between appropriate and inappropriate therapies. This review presents via clinical examples the information provided in stored electrograms in systems from Boston Scientific and tips how to interpret them.
Introduction: The World Stroke Organization (WSO) Brain & Heart Task Force developed the Brain & ... more Introduction: The World Stroke Organization (WSO) Brain & Heart Task Force developed the Brain & hEart globAl iniTiative (BEAT), a pilot feasibility implementation program to establish clinical collaborations between cardiologists and stroke physicians who work at large healthcare facilities. Methods: The WSO BEAT pilot project focused on atrial fibrillation (AF) and patent foramen ovale (PFO) detection and management, and poststroke cardiovascular complications known as the stroke-heart syndrome. The program included 10 sites from 8 countries: Brazil, China, Egypt, Germany, Japan, Mexico, Romania, and the USA The primary composite feasibility outcome was the achievement of the following 3 implementation metrics (1) developing site-specific clinical pathways for the diagnosis and management of AF, PFO, and the stroke-heart syndrome; (2) establishing regular Neurocardiology rounds (e.g., monthly); and (3) incorporating a cardiologist to the stroke team. The secondary objectives were ...
ZusammenfassungDie Versorgung mit einem implantierbaren Kardioverter-Defibrillator (ICD) bietet e... more ZusammenfassungDie Versorgung mit einem implantierbaren Kardioverter-Defibrillator (ICD) bietet einen effektiven Schutz vor lebensgefährlichen Herzrhythmusstörungen. Da es sich beim plötzlichen Herztod um ein unvorhersehbares Ereignis handelt, stellt die Selektion des Patientenguts, das von einer ICD-Implantation profitiert, jedoch nach wie vor eine große Herausforderung dar. Die Evidenz, auf der die aktuellen Leitlinienempfehlungen zur ICD-Implantation aufbauen, begründet sich zu einem relevanten Teil auf Studien, die bereits vor 20–30 Jahren durchgeführt wurden. Seitdem hat sich die medikamentöse und interventionelle Herzinsuffizienztherapie deutlich weiterentwickelt. Zudem stellen neuere Studien den prognostischen Nutzen einer primärprophylaktischen ICD-Implantation bei Patienten mit nicht ischämischer Kardiomyopathie infrage. Im Folgenden soll anhand der zugrunde liegenden Daten erörtert werden, welche Implikationen sich hieraus für den Alltag ergeben und welche Entwicklungen zu...
Dislodgement of a left atrial appendage occluder after liberation represents a nightmare in cardi... more Dislodgement of a left atrial appendage occluder after liberation represents a nightmare in cardiac interventions. We present a case with this complication and an easy step-by-step protocol that can help to retrieve and venously extract this foreign body with less stress. Particularly the do-it-yourself construction of a "home-made snare" facilitates trapping of large implants which are too large for conventional snares.
Heart Rhythm, Volume 2, Issue 5, Pages S53, May 2005, Authors:Gerian C. Grünefeld, MD; Karl-Heinz... more Heart Rhythm, Volume 2, Issue 5, Pages S53, May 2005, Authors:Gerian C. Grünefeld, MD; Karl-Heinz Kuck, MD; Pawel Ptaszynski, MD; Carsten W. Israel, MD; Stuart J. Connolly, MD; Robin S. Roberts, ScD; Paul Dorian, MD; Stefan H. Hohnloser, MD. ...
Atrial fibrillation is a common arrhythmia, difficult to treat pharmacologically and associated w... more Atrial fibrillation is a common arrhythmia, difficult to treat pharmacologically and associated with significant morbidity and mortality. Although traditionally prescribed when pharmacologic therapy is not effective, not tolerated, or contraindicated, electrical therapy
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