Papers by Carla Fabiana Toscano Macky
Journal of Cardiovascular Pharmacology, 2003
The present study reports the effects of apomorphine (APO) on blood pressure and the principal si... more The present study reports the effects of apomorphine (APO) on blood pressure and the principal site of action of this agonist in 4-week deoxycorticosterone-acetate (DOCA)-hypertensive conscious rats. In these preprations, intravenous (i.v.) administration of APO (0.50-1 mg/kg) induced short-lasting and dose-dependent decreases in mean arterial pressure. The hypotensive response to APO (0.3 mg/kg) was reversed into a significant pressor effect by i.v. hexamethonium (30 mg/kg), whereas it was enhanced by i.v. pretreatment with the vasopressor antagonist of arginine vasopressin (AVP) d(CH 2) 5 Tyr(Me)AVP (10 µg/kg) and/or prazosin (1 mg/kg). This depressor effect was suppressed by the central and peripheral dopamine D 2 receptor antagonist metoclopramide (5 mg/kg i.v.), unaffected by the selective dopamine D 1 receptor antagonist SCH 23390 (0.2 mg/kg i.v.), partly reduced by intrathecal domperidone (40 µg per rat at T9-T10 level), a dopamine D 2 receptor antagonist which does not cross the blood-brain barrier, and reversed into a significant pressor effect by i.v. domperidone (0.5 mg/kg). The latter pressor effect was fully abolished by combined i.v. pretreatment with the vasopressor antagonist of AVP and prazosin. These results show that, in conscious DOCA salt-hypertensive rats, APO induced a brief, initial depressor effect, which is opposed to a central pressor component. The depressor component is related to an inhibition of norepinephrine transmission through activation of dopamine D 2 receptors, some of which are located in the spinal cord and some of which are located in the peripheral circulation. The central pressor component, which became manifest after peripheral dopamine D 2 receptor blockade, appears to be related to an increase in vasopressin release and sympathetic tone through activation of brain dopamine D 2 receptors.
Brazilian Journal of Otorhinolaryngology, 2015
Introduction: Children with sensorineural hearing loss can present with instabilities in postural... more Introduction: Children with sensorineural hearing loss can present with instabilities in postural control, possibly as a consequence of hypoactivity of their vestibular system due to internal ear injury. Objective: To assess postural control stability in students with normal hearing (i.e., listeners) and with sensorineural hearing loss, and to compare data between groups, considering gender and age. Methods: This cross-sectional study evaluated the postural control of 96 students, 48 listeners and 48 with sensorineural hearing loss, aged between 7 and 18 years, of both genders, through the Balance Error Scoring Systems scale. This tool assesses postural control in two sensory conditions: stable surface and unstable surface. For statistical data analysis between groups, the Wilcoxon test for paired samples was used. Results: Students with hearing loss showed more instability in postural control than those with normal hearing, with significant differences between groups (stable surface, unstable surface) (p < 0.001).
Revista Paulista de Pediatria, 2012
OBJETIVO: Avaliar o equilíbrio corporal e a marcha de escolares surdos e ouvintes e comparar os d... more OBJETIVO: Avaliar o equilíbrio corporal e a marcha de escolares surdos e ouvintes e comparar os dados entre os grupos, considerando o sexo e a faixa etária da amostra. MÉTODOS: Estudo de corte transversal que avaliou 44 escolares surdos e 44 ouvintes, na faixa etária de sete a 17 anos. A avaliação do equilíbrio e das características da marcha foi realizada por meio da Escala de Equilíbrio e Mobilidade de Tinetti, e a velocidade da marcha, pelo teste Timed Up and Go. Para a análise dos dados foram utilizadas duas abordagens estatísticas: para o equilíbrio (teste t de Student) e para a marcha (teste do qui-quadrado ou exato de Fisher). RESULTADOS: A avaliação do equilíbrio não demonstrou diferenças significativas entre os grupos, os sexos e as faixas etárias, apesar de os escolares surdos apresentarem menor desempenho clínico nas categorias avaliadas. Na avaliação das características da marcha, os resultados apontaram diferenças significativas entre os grupos (p<0,001), os sexos (p...
Arquivos Internacionais de Otorrinolaringologia, 2011
Summary Introduction: Posture is determined by the performance of the visual, somatosensory and v... more Summary Introduction: Posture is determined by the performance of the visual, somatosensory and vestibular systems. Children with hearing loss can present problems in their posture or postural control, enabling postural deviations and alterations to appear in their vertebral column, possibly provoked by a hypoactivity of the vestibular system as a result of deafness. Objective: To evaluate the posture of the vertebral column in children and teenagers with hearing loss at school age, taking into consideration the sample gender and age. Method: A descriptive and prospective study was performed at both Duque de Caxias School and Rotary Rehabilitation and Special Education Center in Caruaru – Pernambuco. 44 students aged between 7-17 years old, out of whom 22 were female and 22 were male, with hearing loss were evaluated. The study was developed by way of a postural evaluation, using a symmetrograph, marking specific anatomical points with stickers placed over polystyrene balls and fixe...
Fisioterapia em Movimento, 2012
INTRODUÇÃO: A postura é determinada pela atuação dos sistemas visual, somatossensorial e vestibul... more INTRODUÇÃO: A postura é determinada pela atuação dos sistemas visual, somatossensorial e vestibular, situado na orelha interna. Crianças com perda auditiva sensório-neural podem apresentar problemas na regulação do controle postural, favorecendo o surgimento de desvios e alterações posturais na coluna vertebral, provocados, possivelmente, pela hipoatividade do sistema vestibular, em decorrência da lesão na orelha interna. OBJETIVOS: Identificar e comparar a distribuição de alterações posturais na coluna vertebral em escolares surdos e ouvintes na faixa etária entre 7 e 17 anos. MATERIAIS E MÉTODOS: Este estudo analítico, observacional, de corte transversal analisou a postura da coluna vertebral de 44 escolares com perda auditiva sensório-neural e 44 escolares ouvintes, de ambos os gêneros. O estudo foi desenvolvido por meio de uma avaliação postural, com o uso de um simetrógrafo, segundo os critérios propostos por Kendall et al. RESULTADOS: Observou-se uma maior ocorrência de altera...
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Papers by Carla Fabiana Toscano Macky