John Butman

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Oleg Yu Vorobyev

Siberian Federal University

Roma Siugzdaite

Ghent University

Gustavo Ortiz Millán

Universidad Nacional Autónoma de México

Ignacio Aguaded

Huelva University

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University of Roma Tre

Jorge Iván Castillo-Quan

Harvard Medical School

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Pontificia Universidad Catolica de Chile

Graziella Mangone

Inserm

Gisele Silva

Universidade Federal de São Paulo (UNIFESP)

Jürgen Konczak

University of Minnesota

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1 Title : Time course and diagnostic utility of NfL , tau , GFAP , and UCH-L 1 in subacute and chronic TBI

Title: Time course and diagnostic utility of NfL, tau, GFAP, and UCH-L1 in subacute and chronic T... more Title: Time course and diagnostic utility of NfL, tau, GFAP, and UCH-L1 in subacute and chronic TBI Authors: Pashtun Shahim1,2,3,4,5, MD, PhD, Adam Politis1, MS, Andre van der Merwe2,3, BSc, Brian Moore2,3, PA-C, MPH, Vindhya Ekanayake2,3, MS, Sara Lippa6, PhD, Yi-Yu Chou1,2, MSs, Dzung L. Pham1,2, PhD, John Butman1,2, MD, PhD, Ramon Diaz-Arrastia7, MD, PhD, Henrik Zetterberg4,5,8,9, MD, PhD, Kaj Blennow4,5, MD, PhD, Jessica M. Gill1,2 , PhD, David L. Brody1,2,3,6, MD, PhD, Leighton Chan1,2, MD, MPH

Abstract P1-21-06: Phase I study of T-DM1 and metronomic temozolomide in secondary prevention of HER2+ breast cancer brain metastases following local radiation therapy

Cancer Research, 2022

Background: The incidence of breast cancer brain metastases is rising, and, these lesions in the ... more Background: The incidence of breast cancer brain metastases is rising, and, these lesions in the central nervous system (CNS) and their treatments cause physical and neurocognitive impairment. Only modest incremental advances in progression free survival have been achieved with drugs to treat CNS lesions, while nearly half of the patients who receive SRS will develop new brain metastases within 1 year. In murine models of breast cancer, we demonstrated that low doses of temozolomide (TMZ) administered in a prophylactic, metronomic fashion significantly prevented development of brain metastases. No effect, however, was seen in established brain metastases or systemic breast cancer metastases. We hypothesize that low dose, metronomic TMZ will prevent the outgrowth of brain lesions in HER2+ patients, when added to an active anti-HER2 treatment. We present here the results of the phase I trial combining T-DM1 to TMZ for the prevention of additional brain metastases after their first occ...

Atlas of impact-induced, in vivo human brain kinematics

Accelerations cause brain tissue to move, and this data summarizes MRI-based observations of 3D b... more Accelerations cause brain tissue to move, and this data summarizes MRI-based observations of 3D brain movement during an in vivo impact (brain-skull displacement and brain tissue deformation). The data is a group average, or atlas, of indivudial data from two groups of study participants: neck extension (n=10) and neck rotation (n=9).

Sulcus: A Method for Identifying the Central Sulcus in the Presence of Mass Effect and

Localization of the primary motor cortex is essential before brain tumor resection. Direct cortic... more Localization of the primary motor cortex is essential before brain tumor resection. Direct cortical stimulation remains the “gold standard ” but is an invasive technique that is associated with the expected risks of craniotomy and cortical electrode placement. Because the relationship of primary motor cortex to the central sulcus is well known, many noninvasive methods for identifying the central sulcus have been investigated. These include sulcal anatomy, functional MR imaging, positron-emission tomography, and magnetoencephalography. 1-5 Despite advances in technology, no single noninvasive method has proved to be 100 % accurate in identifying the central sulcus. Prior gross anatomic studies have demonstrated that the motor cortex (which lies in the anterior bank of the central sulcus) is approximately twice as thick as the sensory cortex (which lies in the posterior bank of the central sulcus). 6,7 This difference in thickness is readily demonstrable on high-resolution, T1-weight...

John Butman

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