Papers by Jorge Bohórquez
Cochlear Implants International, May 1, 2011
Anatomical Record-advances in Integrative Anatomy and Evolutionary Biology, Mar 1, 2019
Mesenchymal stem cell (MSC) therapy is an emerging treatment modality for various human diseases.... more Mesenchymal stem cell (MSC) therapy is an emerging treatment modality for various human diseases. Although induced pluripotent stem cells have been explored for the restoration of hearing, the potential of MSCs as a therapeutic strategy for various cochlear insults is not precisely known. MSCs possess anti-inflammatory, anti-apoptotic and neuroprotective properties, making them an attractive target for the treatment of inner ear disorders such as hair cell damage in response to inflammation. Most of the previous studies have used immunosuppression or the complex surgical techniques to deliver stem cells into the cochlea. However, no information is available regarding the biocompatibility and safety of MSCs in the inner ear in immunocompetent cochlea. The aim of the present study was to determine the effect of nonsurgical administration of rodent bone marrow derived MSCs (BM-MSCs) through transtympanic delivery on the cochlear function and to assess any adverse effects on the auditory system employing a rat model without immunosuppression. We observed that the transtympanic administration of BM-MSCs has no significant effect on the hearing thresholds as determined by auditory brainstem response and distortion product otoacoustic emissions. Histopathological examination revealed no recruitment of inflammatory leukocytes and edema in the cochlea of BM-MSCs administrated rats. The results of this study suggest that transtympanic administration of BM-MSCs is safe and can be explored in providing otoprotection against cochlear insults.
Investigative Ophthalmology & Visual Science, 2015
Se presenta la metodologia de diseno de un sensor pasivo, inalambrico e implantable para la medic... more Se presenta la metodologia de diseno de un sensor pasivo, inalambrico e implantable para la medicion presion intraocular. El proceso de diseno garantizo su implementacion mediante procesos estandar de fabricacion de PCB de bajo costo. El sensor tiene un area efectiva maxima de 36 mm², sensibilidad minima de 1 mmHg y opera en presiones desde 0 mmHg hasta 40 mmHg. El sensor es pasivo e inalambrico con el fin de poder realizar durante varias semanas el monitoreo periodico del mismo, sin incurrir en procesos de mantenimiento o cambio de baterias. El sensor esta basado en un resonador RLC (serie), implementado a partir de dos bobinas en espiral concentricas ubicadas una encima de la otra y con conexion electrica entre ellas; con una de sus espiras unida una membrana de Polidimetilsiloxano (PDMS), la cual permite la compresion del sistema por una de sus caras, y por ende la variacion de la capacitancia existente entre las dos espirales. Tomando ventaja de la presencia de las bobinas que c...
Investigative Ophthalmology & Visual Science, 2015
Investigative Ophthalmology & Visual Science, 2010
Investigative Ophthalmology & Visual Science, 2011
Investigative Ophthalmology & Visual Science, 2012
Investigative Ophthalmology & Visual Science, 2016
Investigative Ophthalmology & Visual Science, 2013
Investigative Ophthalmology & Visual Science, 2015
2013 ASEE Annual Conference & Exposition Proceedings
Background: Modern industry requires engineers to function as effective team members, exhibiting ... more Background: Modern industry requires engineers to function as effective team members, exhibiting strong communication and problem solving skills [1]. Collaborative learning improves not only the academic achievement of students, but also their interpersonal skills. ABET requires engineering programs to incorporate collaboration in their curriculum and assess the student's collaborative skills. Despite all this evidence, engineering education typically remains more inclined towards individualistic or competitive learning. Design/Method: An existing laboratory course was overhauled and refocused to boost student's skills in design, crafting, self-efficacy, troubleshooting, and expertise in the field of Medical Electronics. The strategy was to use problem oriented methodology in a collaborative setup. Results: The main learning objectives were fulfilled and students reported a high level of satisfaction with the content and the methodology of the course.
2011 ASEE Annual Conference & Exposition Proceedings
Dr. Bohrquez obtained his Bachelor degrees in electrical engineering and physics from Los Andes U... more Dr. Bohrquez obtained his Bachelor degrees in electrical engineering and physics from Los Andes University (Bogot, Colombia) in 1983 and 1984. After completing his Biomedical Engineering PhD studies in the National Institute of Applied Sciences (Lyon, France), he joined the faculty of the Electrical Engineering Department of Los Andes University in 1992. There, he actively participated in the development of the "Studio Design Approach" for undergraduate students and performed research in the Biomedical Engineering Research Group. In 2003 he moved to the Department of Biomedical Engineering of the University of Miami were directs the Biomedical Design and Instrumentation Laboratory and teaches Senior/Master Design Project, Biomedical Instrumentation, Microcomputer based medical instrumentation and Bio-signal processing. He mentors multidisciplinary teams of students, mainly interested in the design of novel bio-electric devices. In his teams he integrates students at different academic levels from undergraduate to PhD. In research he is affiliated with the Neurosensory Laboratory where he performs research in audiology, ophthalmology, anesthesia and neurology. Collaborating with researchers of the Miller School of Medicine, he develops and validates novel Electrophysiological diagnostic devices and methods.
Frontiers in Cellular Neuroscience, 2019
Otoprotection and Dexamethasone Eluting Electrode protection in implanted animals exposed to NT. ... more Otoprotection and Dexamethasone Eluting Electrode protection in implanted animals exposed to NT. The results of this study suggest that dexamethasone releasing electrode holds great potential in developing effective treatment modalities for NT in the implanted cochlea.
International journal of audiology, Jan 29, 2018
The effects of rate on auditory-evoked potentials (AEP) to short noise gaps (12 ms) recorded at h... more The effects of rate on auditory-evoked potentials (AEP) to short noise gaps (12 ms) recorded at high sampling rates using wide-band filters were investigated. Auditory brainstem (ABR), middle latency (MLR), late latency (LLR) and steady-state (ASSR) responses were simultaneously recorded in adult subjects at four gap rates (0.5, 1, 5 and 40 Hz). Major components (V, Na, Pa, Nb, Pb, N1 and P2) were identified at each rate and analysed for latency/amplitude characteristics. Gap responses at 40 Hz were recovered from Quasi-ASSRs (QASSR) using the CLAD deconvolution method. Fourteen right ears of young normal hearing subjects were tested. All major components were present in all subjects at 1 Hz. P1 (P50) appeared as a low-pass filtered component of Pa and Pb waves. At higher rates, N1 and P2 disappeared completely while major ABR-MLR components were identified. Peak latencies were mostly determined by noise onsets slightly delayed by offset responses. Major AEP components can be record...
International Journal of Pediatric Otorhinolaryngology, 2011
Aim: To examine the auditory function in a group of children with type 1 diabetes, and to study t... more Aim: To examine the auditory function in a group of children with type 1 diabetes, and to study the association between hearing impairment and duration of illness, metabolic control and diabetic complication. Material and Methods: Sixty-one diabetic patients below the age of 18 attending the ENT clinic were investigated together with 61 age and sex matched non-diabetic controls. Pure-tone audiometric tests were performed in a soundproof room. Both air and bone conduction were tested at frequencies between 250-8000 Hz and 250-4000 Hz respectively. Results: The hearing acuity was lower in the diabetic patients than in the control subjects in all tested frequencies. The hearing loss was symmetrical, generally mild, and affects both sexes equally. HbA1c concentration, and angiopathic complications showed positive correlation with the increased hearing thresholds. Conclusions: Hearing loss occurs early in diabetic children and strict glycemic control might prevent or delay this complication. A035 Relationship between the genetic background of hearing loss and cochlear implant electrophysiological parameterspreliminary results
Translational vision science & technology, 2017
To compare a new method for steady-state pattern electroretinogram (PERGx) with a validated metho... more To compare a new method for steady-state pattern electroretinogram (PERGx) with a validated method (PERGLA) in normal controls and in patients with optic neuropathy. PERGx and PERGLA were recorded in a mixed population (n = 33, 66 eyes) of younger controls (C1; n = 10, age 38 ± 8.3 years), older controls (C2; n = 11, 57.9 ± 8.09 years), patients with early manifest glaucoma (G; n = 7, 65.7 ±11.6 years), and patients with nonarteritic ischemic optic neuropathy (N; n = 5, mean age 59.4 ± 8.6 years). The PERGx stimulus was a black-white horizontal grating generated on a 14 × 14 cm LED display (1.6 cycles/deg, 15.63 reversals/s, 98% contrast, 800 cd/m(2) mean luminance, 25° field). PERGx signal and noise were averaged over 1024 epochs (∼2 minutes) and Fourier analyzed to retrieve amplitude and phase. Partial averages (16 successive samples of 64 epochs each) were also analyzed to quantify progressive changes over recording time (adaptation). PERGLA and PERGx amplitudes and latencies wer...
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Papers by Jorge Bohórquez