Journal of Ayub Medical College, Abbottabad : JAMC
Osteoporosis has emerged a major health hazard in postmenopausal women. The process of osteoporos... more Osteoporosis has emerged a major health hazard in postmenopausal women. The process of osteoporosis accelerates two year prior to menopause, reaching the peak level during first 3 years of menopause when women loss 3 (see symbol) 5% of their bone mass per year. This study tried to find out the role of phytoestrogne in improving the bone mineral density and bone related biochemical parameters in group of postmenopausal women. Fifty postmenopausal women with age range 50 (see symbol) 60 years were included in the study. Phytoestrogen with mineral supplement were given twice daily for 3 months. Biochemical parameters like serum calcium, magnesium, alkaline phosphatase, uric acid, total protein and oestrogen were determined before and after phytoestrogen therapy by autoanalyser and ELIZA (oestrogen assay). T-score before and after phytoestrogen were find out by densitometer DEXA. The level of serum calcium, magnesium, uric acid and oestrogen was increased in women after taking phytoestr...
Biochemical and Biophysical Research Communications, 2004
Calmodulin (CaM) is a highly conserved 17 kDa eukaryotic protein that can bind specifically to ov... more Calmodulin (CaM) is a highly conserved 17 kDa eukaryotic protein that can bind specifically to over 100 protein targets in response to a Ca 2þ signal. Present study was planned to mutate the crucial residues of N-terminal lobe, central helix, and C-terminal lobe that play important roles in activating and binding of enzymes. In all, 10 mutations were carried out in the predicted 3D structure of calmodulin using the computer program MODELLER 6v2. Mutations at specific residues in both the N-terminal and C-terminal regions resulted in the change in the interaction pattern of these amino acids. No significant change was however predicted by mutating amino acid residues in the central helix. The predicted alteration in the interaction of specific amino acids may either alter the binding affinity with calcium ions or decrease the ability of calmodulin to activate the specific enzymes.
It is a sad commentary on the much vaunted 'objectivity' of Western scholarship that a pr... more It is a sad commentary on the much vaunted 'objectivity' of Western scholarship that a prestigeous*publication like the New Encyclopaedia Britannica (1979 Edition) should fail to present a true picture of the Palestinian reality. This monumental work is divided into 10 volumes of Mircropaedias for "short, concise and factual entries" and 19 volumes of Macropaedias for "knowledge in depth", while the last volume contains an "Outline of Knowledge". It is quite shocking to discover that in Vol. 13 (N.P.) of Macropaedia, wherein one could find even the pedigree of the merest mongrel carefully recounted, the word 'Palestine' does not figure at all. One does find a brief note on Palestine in the Micropaedia (Vol. VII, pp. 693-94) but it is evident that its authors look upon the country only in the context of the present state of Israel.
Journal of Ayub Medical College, Abbottabad : JAMC
Osteoporosis has emerged a major health hazard in postmenopausal women. The process of osteoporos... more Osteoporosis has emerged a major health hazard in postmenopausal women. The process of osteoporosis accelerates two year prior to menopause, reaching the peak level during first 3 years of menopause when women loss 3 (see symbol) 5% of their bone mass per year. This study tried to find out the role of phytoestrogne in improving the bone mineral density and bone related biochemical parameters in group of postmenopausal women. Fifty postmenopausal women with age range 50 (see symbol) 60 years were included in the study. Phytoestrogen with mineral supplement were given twice daily for 3 months. Biochemical parameters like serum calcium, magnesium, alkaline phosphatase, uric acid, total protein and oestrogen were determined before and after phytoestrogen therapy by autoanalyser and ELIZA (oestrogen assay). T-score before and after phytoestrogen were find out by densitometer DEXA. The level of serum calcium, magnesium, uric acid and oestrogen was increased in women after taking phytoestr...
Biochemical and Biophysical Research Communications, 2004
Calmodulin (CaM) is a highly conserved 17 kDa eukaryotic protein that can bind specifically to ov... more Calmodulin (CaM) is a highly conserved 17 kDa eukaryotic protein that can bind specifically to over 100 protein targets in response to a Ca 2þ signal. Present study was planned to mutate the crucial residues of N-terminal lobe, central helix, and C-terminal lobe that play important roles in activating and binding of enzymes. In all, 10 mutations were carried out in the predicted 3D structure of calmodulin using the computer program MODELLER 6v2. Mutations at specific residues in both the N-terminal and C-terminal regions resulted in the change in the interaction pattern of these amino acids. No significant change was however predicted by mutating amino acid residues in the central helix. The predicted alteration in the interaction of specific amino acids may either alter the binding affinity with calcium ions or decrease the ability of calmodulin to activate the specific enzymes.
It is a sad commentary on the much vaunted 'objectivity' of Western scholarship that a pr... more It is a sad commentary on the much vaunted 'objectivity' of Western scholarship that a prestigeous*publication like the New Encyclopaedia Britannica (1979 Edition) should fail to present a true picture of the Palestinian reality. This monumental work is divided into 10 volumes of Mircropaedias for "short, concise and factual entries" and 19 volumes of Macropaedias for "knowledge in depth", while the last volume contains an "Outline of Knowledge". It is quite shocking to discover that in Vol. 13 (N.P.) of Macropaedia, wherein one could find even the pedigree of the merest mongrel carefully recounted, the word 'Palestine' does not figure at all. One does find a brief note on Palestine in the Micropaedia (Vol. VII, pp. 693-94) but it is evident that its authors look upon the country only in the context of the present state of Israel.
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