Journal of Applied Pharmaceutical Sciences and Research, 2020
Introduction: The present study aims at evaluating anti oxidant activity and inhibition of topica... more Introduction: The present study aims at evaluating anti oxidant activity and inhibition of topical application of Terminalia chebula cream inultraviolet –B-induced psoriasis in rats.Materials and Methods: The seeds of Terminalia chebula were dried and powder was extracted with chloroform, ethyl acetate, ethanol,methanol, and deionized water by cold maceration method. Total phenolic content, total tannin content and total triterpenoid content wasdetermined by different methods. Anti oxidant activity was evaluated by DPPH method and reducing power assay. Cream formulation of theoptimized extract was prepared by hot fusion method. Psoriasis was induced by irradiatiating for 30 min at a vertical distance of 20 cm withUV light (385 nm) on the skin. Severity index, hydroxyproline content and epidermal thickness was determined.Results: Total Phenol (mg gallic acid/ g) content, Total Tannins (mg catechin/ g) content and Total triterpenoid (mg ursolic acid/ g) contentwas found to be signific...
Combinatorial Chemistry & High Throughput Screening, 2011
Powder layering technique was evaluated using laboratory scale centrifugal granulator instrument ... more Powder layering technique was evaluated using laboratory scale centrifugal granulator instrument to prepare extended release pellet dosage form of ketoprofen. Ethyl cellulose and shellac polymers were used for drug layering and extended release coating in the same apparatus. Inert sugar spheres were intermittently treated with drug powder and binding solution. Combination of ethyl cellulose (45cps) and shellac was evaluated as binders at different levels (1:3 ratio, at 6%, 12%, 16% and 21%w/w polymer) for drug loading and for extended release coating (1:3 ratio at 2%, 4% and 7% w/w polymer). Pellets were evaluated for drug release study using paddle apparatus in pH 6.8 Phosphate buffer, 900ml at 100 rpm. Ethyl cellulose and shellac when used as binder during drug layering did not extend the ketoprofen release beyond 4h. However, coating of drug loaded pellets using ethyl cellulose and shellac resulted in extended release profile of ketoprofen for about 10h. Ethyl cellulose coating alone at a level of 3% w/w resulted in extended release profile. Coated pellets were evaluated for sphericity, Hardness-Friability Index and scanning electron microscopy. Scanning electron micrographs of the pellets showed a uniform coating of polymer on the core pellets substantiating the use of centrifugal granulator for extended release coating. Release pattern from the optimized batch was best explained by Higuchi's model. The drug release pattern from the pellets was found to be Non-Fickian anomalous type, involving both diffusion and erosion mechanism. Accelerated stability study of the coated pellets filled in hard gelatin capsule was conducted for 3-month period and observed for the effect on drug release profile.
Nigerian Journal of Natural Products and Medicine, 2005
The petroleum ether (40-60 oC), chloroform, ethyl acetate, ethanol and aqueous extracts of Cassia... more The petroleum ether (40-60 oC), chloroform, ethyl acetate, ethanol and aqueous extracts of Cassia auriculata seeds, obtained by soxhlet extraction method were evaluated for antidiabetic activity using alloxan (60 mg/kg through tail vein) induced hypoglycemic rats on acute and prolonged treatment. The potency of extracts was compared with that of standard tolbutamide (250 mg/kg body weight, p.o.). Petroleum ether and ethyl acetate extracts showed highly significant (p Key words: Cassia auriculata seeds, Caesalpiniaceae, Blood glucose level, Tolbutamide and Petroleum ether extract. Nig. J. Nat. Prod. and Med. Vol.8 2004: 22-23
Diabetes mellitus is a disease in which homeostasis of carbohydrate, protein and lipid metabolism... more Diabetes mellitus is a disease in which homeostasis of carbohydrate, protein and lipid metabolism is improperly regulated by hormone insulin resulting in elevation of fasting and postprandial blood glucose levels1. The major chronic
Journal of Applied Pharmaceutical Sciences and Research
Introduction: The present study aims at evaluating anti oxidant activity and inhibition of topica... more Introduction: The present study aims at evaluating anti oxidant activity and inhibition of topical application of Terminalia chebula cream in ultraviolet –B-induced psoriasis in rats. Materials &Methods: The seeds of Terminalia chebula were dried and powder was extracted with chloroform, ethyl acetate, ethanol, methanol, and deionized water by cold maceration method. Total phenolic content, total tannin content and total triterpenoid content was determined by different methods. Anti oxidant activity was evaluated by DPPH method and reducing power assay. Cream formulation of the optimized extract was prepared by hot fusion method. Psoriasis was induced by irradiatiating for 30 min at a vertical distance of 20 cm with UV light (385 nm) on the skin. Severity index, hydroxyproline content and epidermal thickness was determined. Results and Discussion: Total Phenol (mg gallic acid/ g) content, Total Tannins (mg catechin/ g) content and Total triterpenoid (mg ursolic acid/ g) content was...
Journal of Applied Pharmaceutical Sciences and Research, 2020
Introduction: The present study aims at evaluating anti oxidant activity and inhibition of topica... more Introduction: The present study aims at evaluating anti oxidant activity and inhibition of topical application of Terminalia chebula cream inultraviolet –B-induced psoriasis in rats.Materials and Methods: The seeds of Terminalia chebula were dried and powder was extracted with chloroform, ethyl acetate, ethanol,methanol, and deionized water by cold maceration method. Total phenolic content, total tannin content and total triterpenoid content wasdetermined by different methods. Anti oxidant activity was evaluated by DPPH method and reducing power assay. Cream formulation of theoptimized extract was prepared by hot fusion method. Psoriasis was induced by irradiatiating for 30 min at a vertical distance of 20 cm withUV light (385 nm) on the skin. Severity index, hydroxyproline content and epidermal thickness was determined.Results: Total Phenol (mg gallic acid/ g) content, Total Tannins (mg catechin/ g) content and Total triterpenoid (mg ursolic acid/ g) contentwas found to be signific...
Combinatorial Chemistry & High Throughput Screening, 2011
Powder layering technique was evaluated using laboratory scale centrifugal granulator instrument ... more Powder layering technique was evaluated using laboratory scale centrifugal granulator instrument to prepare extended release pellet dosage form of ketoprofen. Ethyl cellulose and shellac polymers were used for drug layering and extended release coating in the same apparatus. Inert sugar spheres were intermittently treated with drug powder and binding solution. Combination of ethyl cellulose (45cps) and shellac was evaluated as binders at different levels (1:3 ratio, at 6%, 12%, 16% and 21%w/w polymer) for drug loading and for extended release coating (1:3 ratio at 2%, 4% and 7% w/w polymer). Pellets were evaluated for drug release study using paddle apparatus in pH 6.8 Phosphate buffer, 900ml at 100 rpm. Ethyl cellulose and shellac when used as binder during drug layering did not extend the ketoprofen release beyond 4h. However, coating of drug loaded pellets using ethyl cellulose and shellac resulted in extended release profile of ketoprofen for about 10h. Ethyl cellulose coating alone at a level of 3% w/w resulted in extended release profile. Coated pellets were evaluated for sphericity, Hardness-Friability Index and scanning electron microscopy. Scanning electron micrographs of the pellets showed a uniform coating of polymer on the core pellets substantiating the use of centrifugal granulator for extended release coating. Release pattern from the optimized batch was best explained by Higuchi's model. The drug release pattern from the pellets was found to be Non-Fickian anomalous type, involving both diffusion and erosion mechanism. Accelerated stability study of the coated pellets filled in hard gelatin capsule was conducted for 3-month period and observed for the effect on drug release profile.
Nigerian Journal of Natural Products and Medicine, 2005
The petroleum ether (40-60 oC), chloroform, ethyl acetate, ethanol and aqueous extracts of Cassia... more The petroleum ether (40-60 oC), chloroform, ethyl acetate, ethanol and aqueous extracts of Cassia auriculata seeds, obtained by soxhlet extraction method were evaluated for antidiabetic activity using alloxan (60 mg/kg through tail vein) induced hypoglycemic rats on acute and prolonged treatment. The potency of extracts was compared with that of standard tolbutamide (250 mg/kg body weight, p.o.). Petroleum ether and ethyl acetate extracts showed highly significant (p Key words: Cassia auriculata seeds, Caesalpiniaceae, Blood glucose level, Tolbutamide and Petroleum ether extract. Nig. J. Nat. Prod. and Med. Vol.8 2004: 22-23
Diabetes mellitus is a disease in which homeostasis of carbohydrate, protein and lipid metabolism... more Diabetes mellitus is a disease in which homeostasis of carbohydrate, protein and lipid metabolism is improperly regulated by hormone insulin resulting in elevation of fasting and postprandial blood glucose levels1. The major chronic
Journal of Applied Pharmaceutical Sciences and Research
Introduction: The present study aims at evaluating anti oxidant activity and inhibition of topica... more Introduction: The present study aims at evaluating anti oxidant activity and inhibition of topical application of Terminalia chebula cream in ultraviolet –B-induced psoriasis in rats. Materials &Methods: The seeds of Terminalia chebula were dried and powder was extracted with chloroform, ethyl acetate, ethanol, methanol, and deionized water by cold maceration method. Total phenolic content, total tannin content and total triterpenoid content was determined by different methods. Anti oxidant activity was evaluated by DPPH method and reducing power assay. Cream formulation of the optimized extract was prepared by hot fusion method. Psoriasis was induced by irradiatiating for 30 min at a vertical distance of 20 cm with UV light (385 nm) on the skin. Severity index, hydroxyproline content and epidermal thickness was determined. Results and Discussion: Total Phenol (mg gallic acid/ g) content, Total Tannins (mg catechin/ g) content and Total triterpenoid (mg ursolic acid/ g) content was...
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