A new approach to the synthesis of isoquinolone derivatives has been developed. It is based on th... more A new approach to the synthesis of isoquinolone derivatives has been developed. It is based on the protolytic recyclization of amides of 2-carboxybenzylfurans. It was shown that the reaction proceeds via formation of allylic alcohols of isoquinolone series, which under ...
... Alexander V. Butin* a , Artem S. Dmitriev a , Olga N. Kostyukova a , Vladimir T. Abaev b , Ig... more ... Alexander V. Butin* a , Artem S. Dmitriev a , Olga N. Kostyukova a , Vladimir T. Abaev b , Igor V. Trushkov c. a Research Institute of Heterocyclic Compounds Chemistry,Kuban State University of Technology, Moskovskaya St. ...
As part of our ongoing interest in the synthesis of benz-annelated heterocycles from O-substitute... more As part of our ongoing interest in the synthesis of benz-annelated heterocycles from O-substituted benzylfurans, recyclization of [ O-(hydroxymethyl)aryl]difurylmethanes was studied. It was shown that, under acidic conditions, the O-hydroxymethyl group in these compounds acts as a nucleophile and tetracyclic isochromene derivatives are formed via a recyclization-cyclization tandem sequence. Alternatively, these compounds can be synthesized by reduction of the corresponding isochromone derivatives with lithium aluminum hydride. The potent biologically active analogues of cannabinoids were also obtained by interaction of isochromone derivatives with excess of methylmagnesium iodide.
Pyridazine derivatives R 0500 Recyclization of Hydrazides of 2-Carboxyphenyldifurylmethanes: Synt... more Pyridazine derivatives R 0500 Recyclization of Hydrazides of 2-Carboxyphenyldifurylmethanes: Synthesis of Novel 4,10-Dihydro-3H-pyridazino[1,6-b]isoquinolin-10-one System.-Two synthetic protocols are developed to give the novel heterocyclic system (V) starting from ortho-carboxybenzylfurans.
... Vladimir T. Abaev [a], Artem S. Dmitriev [b], Andrey V. Gutnov [c], Sergey A. Podelyakin [b] ... more ... Vladimir T. Abaev [a], Artem S. Dmitriev [b], Andrey V. Gutnov [c], Sergey A. Podelyakin [b] andAlexander V. Butin* [b] [a] North-Ossetian State University, Vatutina 46, Vladikavkaz, 362025, Russia [b] Kuban State University of Technology, Moskovskaya 2, Krasnodar, 350072 ...
Benzopyran derivatives R 0350 Furan Ring Opening-Isochromene Ring Closure: A New Approach to Isoc... more Benzopyran derivatives R 0350 Furan Ring Opening-Isochromene Ring Closure: A New Approach to Isochromene Ring Synthesis.-A novel approach toward the synthesis of 1H-isochromenes (V) (7 examples) is based on the recyclization of the furan ring in hydroxymethylbenzyl bis-furan derivatives (IV).-(BUTIN*, A. V.
A new approach to the synthesis of isoquinolone derivatives has been developed. It is based on th... more A new approach to the synthesis of isoquinolone derivatives has been developed. It is based on the protolytic recyclization of amides of 2-carboxybenzylfurans. It was shown that the reaction proceeds via formation of allylic alcohols of isoquinolone series, which under ...
... Alexander V. Butin* a , Artem S. Dmitriev a , Olga N. Kostyukova a , Vladimir T. Abaev b , Ig... more ... Alexander V. Butin* a , Artem S. Dmitriev a , Olga N. Kostyukova a , Vladimir T. Abaev b , Igor V. Trushkov c. a Research Institute of Heterocyclic Compounds Chemistry,Kuban State University of Technology, Moskovskaya St. ...
As part of our ongoing interest in the synthesis of benz-annelated heterocycles from O-substitute... more As part of our ongoing interest in the synthesis of benz-annelated heterocycles from O-substituted benzylfurans, recyclization of [ O-(hydroxymethyl)aryl]difurylmethanes was studied. It was shown that, under acidic conditions, the O-hydroxymethyl group in these compounds acts as a nucleophile and tetracyclic isochromene derivatives are formed via a recyclization-cyclization tandem sequence. Alternatively, these compounds can be synthesized by reduction of the corresponding isochromone derivatives with lithium aluminum hydride. The potent biologically active analogues of cannabinoids were also obtained by interaction of isochromone derivatives with excess of methylmagnesium iodide.
Pyridazine derivatives R 0500 Recyclization of Hydrazides of 2-Carboxyphenyldifurylmethanes: Synt... more Pyridazine derivatives R 0500 Recyclization of Hydrazides of 2-Carboxyphenyldifurylmethanes: Synthesis of Novel 4,10-Dihydro-3H-pyridazino[1,6-b]isoquinolin-10-one System.-Two synthetic protocols are developed to give the novel heterocyclic system (V) starting from ortho-carboxybenzylfurans.
... Vladimir T. Abaev [a], Artem S. Dmitriev [b], Andrey V. Gutnov [c], Sergey A. Podelyakin [b] ... more ... Vladimir T. Abaev [a], Artem S. Dmitriev [b], Andrey V. Gutnov [c], Sergey A. Podelyakin [b] andAlexander V. Butin* [b] [a] North-Ossetian State University, Vatutina 46, Vladikavkaz, 362025, Russia [b] Kuban State University of Technology, Moskovskaya 2, Krasnodar, 350072 ...
Benzopyran derivatives R 0350 Furan Ring Opening-Isochromene Ring Closure: A New Approach to Isoc... more Benzopyran derivatives R 0350 Furan Ring Opening-Isochromene Ring Closure: A New Approach to Isochromene Ring Synthesis.-A novel approach toward the synthesis of 1H-isochromenes (V) (7 examples) is based on the recyclization of the furan ring in hydroxymethylbenzyl bis-furan derivatives (IV).-(BUTIN*, A. V.
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