Papers by Arlin Kiremitçi
Lasers in Medical Science, 2007
The purpose of this study was to evaluate the dentin bond strength to resin composite following e... more The purpose of this study was to evaluate the dentin bond strength to resin composite following erbium:yttrium-aluminum-garnet (Er:YAG) laser preparation using different adhesive systems. Seventy dentin specimens prepared from human molar teeth were randomly assigned to seven groups of ten. The first five groups were prepared with an Er:YAG laser 2940 nm at the manufacturer's recommended settings and (1) acid etched, and etch-and-rinse adhesive Excite was applied; (2) Excite was applied; (3) two-step self-etching adhesive AdheSE was applied; (4) laser etched (120 mJ/10 Hz), and Excite was applied; (5) laser etched, and AdheSE was applied. The last two groups were added as controls (prepared with a diamond bur): (6) acid etched, and Excite was applied; (7) AdheSE was applied. Nanohybrid composite cylinders 4 mm x 2 mm were bonded to the dentin surfaces. After the specimens had been stored in distilled water and had undergone thermocycling, the shear bond strength was tested and the data were analyzed statistically. The Duncan multiple comparison test showed that specimens prepared with a diamond bur and with acid and Excite applied showed the highest mean bond strength (13.01 +/- 2.09 MPa), followed by those prepared with Er:YAG and with AdheSE applied (11.5 +/- 3.59 MPa) and those prepared with a diamond bur and with AdheSE applied (10.75 +/- 1.95 MPa), but there were no significant differences among them (P > 0.05). Er:YAG-prepared specimens, with acid, Excite (3.28 +/- 0.95 MPa) and specimens that were laser etched and with AdheSE applied (3.37 +/- 0.63 MPa) showed the lowest mean values for bond strength (P < 0.05). The results suggested that dentin surfaces prepared with Er:YAG laser may provide comparable composite resin bond strengths depending on the adhesives used.
European Oral Research, 2022
The aim of this study is to compare the clinical outcomes of Mineral Trioxide Aggregate (MTA) and... more The aim of this study is to compare the clinical outcomes of Mineral Trioxide Aggregate (MTA) and calcium hydroxide pulp capping after complete caries removal. Materials and Methods In 73 regular patients (47 women, 26 men; age 20.65±3.02 years), having at least one deep carious lesion was recruited. Following complete caries removal, the pulp was indirectly capped with either MTA(n=51) or calcium hydroxide (n =49), randomly. Final restoration with a resin-based composite in a single session was performed. Clinical parameters including pulp vitality, sensitivity to cold or heat stimulants, percussion tests and discomfort during chewing and color were recorded after 6 months, 1 year, 2-year, 3-year and 4-year. Data were analysed statistically (p < 0.05). Results After 4-year, the survival rates were 86% (for MTA), and 82.9% (for calcium hydroxide). Totally, 8 teeth from calcium hydroxide group and 7 teeth from MTA group were endodontically treated. No significant difference was detected between the groups in terms of pulp vitality (p=0.613). Grey discoloration rate was 63% in MTA group. Conclusion Both pulp-capping materials, MTA and calcium hydroxide showed similar clinically successful performance in terms of pulp vitality in the treatment of deep dentin caries lesions after 4-year.
Hacettepe Dişhekimliği Fakültesi Derg.(. Clinical Dentistry and Research), 2008
The Anatomical Record, 1999
The Journal of the American Dental Association, 2006
Background. Long-term retention of pit and fissure sealants is essential for their success. The a... more Background. Long-term retention of pit and fissure sealants is essential for their success. The aim of this study was to compare the retention rates of sealants placed with acid-etching and air abrasion followed by acid etching. Methods. Sixteen subjects aged 16 and 17 years were included in the study. Using a half-mouth design, the authors performed fissure preparation with phosphoric acid gel on randomly assigned maxillary and mandibular permanent premolars and molars from one side of the mouth (Group I) and performed air abrasion followed by acid etching on the contralateral side of the mouth (Group II). The authors applied sealant material on 162 teeth, and they evaluated the sealants as complete retention, partial loss or total loss at six, 12 and 24 months. Results. While fissure sealant retention rates were not significantly different for the two techniques at six months (P = .97), the retention rates for the teeth in Group II were significantly higher at 12 (P = .025) and 24 months (P = .002). Molar retention rates were significantly less than those for premolars at each evaluation period (P < .05). Conclusion. The sealant retention rates at 12 and 24 months were higher in Group II (air abrasion followed by acid etching). Clinical Implications. As air abrasion followed by acid etching resulted in significantly higher sealant retention rates, this method could be a good choice for fissure preparation before sealant placement for long-term success.
Horizontal root fractures of the posterior teeth are rare and occur due to severe trauma. We repo... more Horizontal root fractures of the posterior teeth are rare and occur due to severe trauma. We report herein a case of horizontal root fracture in the middle third of a two-rooted maxillary left first premolar. Since the coronal part of tooth was non-vital, calcium hydroxide was used as an intracanal medication for 10 days. Later, root canal therapy was successfully performed with mineral trioxide aggregate (MTA) and gutta-percha cones. At 3-year follow-up, the tooth was asymptomatic, and clinical and radiographic examination revealed that healing patterns.
Quintessence international, 2004
OBJECTIVES This study investigated the effectiveness of three different dentin adhesive systems o... more OBJECTIVES This study investigated the effectiveness of three different dentin adhesive systems on the adhesion of resin composite to both dentin and enamel. METHOD AND MATERIALS The flat dentin and enamel surfaces of 60 extracted human molar teeth were exposed by wet grinding with 600-grit silicon carbide paper. One total-etch self-priming adhesive system (Prime & Bond NT), one two-step self-etching primer adhesive system (Clearfil SE Bond), and one "all-in-one" self-etching adhesive system (Prompt L-Pop) were evaluated. Each bonding system was applied according to the manufacturer's instructions and followed by composite (TPH Spectrum) application. Twenty-four hours after bonding, the teeth were subjected to shear testing. There were 10 replicates for each group. RESULTS Prompt L-Pop exhibited significantly higher bond strength values to enamel (27 +/- 4.2 MPa) than all other groups. There were no statistically significant differences for shear bond strength to denti...
Journal of Oral Science, 2018
The aim of this study was to evaluate the clinical root coverage results of subepithelial connect... more The aim of this study was to evaluate the clinical root coverage results of subepithelial connective tissue grafts (SCTG) performed on teeth with gingival recessions and non-carious cervical lesions (NCCLs) that were restored with cervical fillings and compare the results of two different filling materials: resin-modified glass ionomer (RMGIC) and nanoionomer cements (NIC). A total of 54 teeth with Miller Class I gingival recessions with or without NCCLs in 36 patients (28 females, 8 males) were treated with SCTGs. Cervical lesions were randomly treated with RMGIC or NIC restorations. Periodontal clinical parameters, height of gingival recession (HGR), width of gingival recession (WGR), height of keratinized tissue, and dentin sensitivity were measured at baseline and 3, 6, and 12 months postoperatively. HGR and WGR values were statistically significantly reduced at all time points when compared to baseline values in all groups. There were no statistically significant differences between the groups in any clinical periodontal parameter (P > 0.05). The percentage of root coverage at 12 months was 89.5%, 90.1%, and 96.2% in the RMGIC, NIC, and control groups, respectively. Successful root coverage with connective tissue grafts may be achieved on teeth restored with RMGIC or NIC cervical fillings.
Journal of Photochemistry and Photobiology B: Biology
Human dental pulp stem cells (hDPSCs) are able to differentiate into dopaminergic neurons and hel... more Human dental pulp stem cells (hDPSCs) are able to differentiate into dopaminergic neurons and help the maintenance of partially degenerated neurons, which makes them as an alternative cell source for treatment of Parkinsons' disease (PD) patients. Here, the effect of photobiomodulation with polychromatic light source in the near infrared (NIR) range (600-1200 nm) or low level 660 nm diode laser light on hDPSCs during dopaminergic induction was investigated. Real time RT-qPCR analysis indicated that expressions of brain derived neurotrophic factor (BDNF), glial cell line derived neurotropic factor (GNDF), matrix associated protein 2 (MAP2), nuclear receptor related 1 protein (NURR1) and dopamine transporter (DAT) were increased, especially in the first 7 days of dopaminergic induction when 660 nm laser light was applied with a total energy density of 1.6 J/cm2. The activity of polychromatic light on hDPSCs depended on the differentiation media and protein type. BDNF, GDNF, NURR-1 and MAP2 expressions were increased in the presence of pre-induction factors, and decreased when the post-induction factors were added into the culture medium. In contrast with all these promising results, the dopaminergically induced hDPSCs did not show any functional characteristics of dopaminergic neurons and died after they were transferred to a new laminin coated culture plates. In conclusion, the expression of dopaminergic neuron protective protein mRNAs in hDPSCs was increased by photobiomodulation in defined conditions. However, the cells were not able to differentiate into functional dopaminergic neurons either in control or in photobiomodulated groups that are prone to cell death and exhibit immature dopaminergic neuron characteristics.
Journal of Materials Science: Materials in Medicine
In the present study, a chitosan-based, multifunctional and double-faced barrier membrane was dev... more In the present study, a chitosan-based, multifunctional and double-faced barrier membrane was developed for the periodontitis therapy. The porous surface of the membrane was coated with bone-like hydroxyapatite (HA) produced by microwave-assisted biomimetic method and enriched with bone morphogenetic factor 6 (BMP-6) to enhance the bioactivity of chitosan. This surface of the membrane was designed to be in contact with the hard tissue that was damaged due to periodontitis. Otherwise the nonporous surface of membrane, which is in contact with the inflammatory soft tissue, was coated with electrospun polycaprolactone (PCL) fibers to prevent the migration of epithelial cells to the defect area. PrestoBlue, Scanning Electron Microscope (SEM) and real-time PCR results demonstrated that while porous surface of the membrane was enhancing the proliferation and differentiation of MC3T3-E1 preosteoblasts, nonporous surface of membrane did not allow migration of epithelial Madine Darby Bovine Kidney (MDBK) cells. The barrier membrane developed here is biodegradable and can be easily manipulated, has osteogenic activity and inactivity for epithelial cells. Thus, by implanting this membrane to the damaged periodontal tissue, bone regeneration will take place and integrity of periodontal tissues will be preserved.
Journal of prosthodontics : official journal of the American College of Prosthodontists, Jan 27, 2017
To investigate the etiologic factors, effect of age and gender on dental trauma, and to evaluate ... more To investigate the etiologic factors, effect of age and gender on dental trauma, and to evaluate the performance of composite resin on the fractured crown of permanent anterior teeth. Over a 2-year period, 73 permanent teeth from 51 patients with dental trauma were treated with direct composite resin restoration. Informed consent and standardized trauma forms were completed by the patient; teeth were restored with a submicron hybrid composite resin (Spectrum TPH) and respective adhesive system (Prime&Bond NT). Sixty-nine teeth were directly restored without fiber posts, while four were treated with fiber posts. Two experienced clinicians, besides the operator, evaluated each restoration at 6-, 12-, and 24-month follow-ups according to US Public Health Service (USPHS) criteria for the following characteristics: anatomical form, marginal adaptation, color match, marginal discoloration, surface roughness, and caries. Data were analyzed using the Wilcoxon Signed Rank, Kruskal-Wallis, Ma...
Journal of Clinical and Experimental Dentistry
Background: The aim of this study was to analyze the bond strength of aged resin based nanocompos... more Background: The aim of this study was to analyze the bond strength of aged resin based nanocomposites repaired with the same and bulk fill composites. Material and Methods: Seventy-two disc shaped resin composites consisted of three different nanocomposite resins (Filtek Ultimate/FU, Herculite XRV Ultra/HXRV, and Reflectys/R) were produced. After storing the samples for 8 weeks in distilled water, each material was combined with the same material or the bulk-fill composite resin system (Filtek Ultimate+Filtek Ultimate/Group-1; Filtek Ultimate+Tetric BF/Group-2; Herculite XRV+Herculite XRV/Group-3; Herculite XRV+Tetric BF/ Group-4; Reflectys+Reflectys/Group 5; Reflectys+Tetric BF/Group-6), for repair. Then specimens were subjected to shear bond strength testing(SBS), and the debonded surfaces were examined. Results: There was a significant difference among three materials(repaired with itself+bulk fill) for SBS testing values (p=0.001). FU and R were found to be similar, while HXRV was significantly different from them. A significant difference between group-1 and 2 (p=0.006) was detected, while there were no differences between group 3 and 4 (p= 0.142), and 5 and 6 (p=0.346). Among the six groups, repair SBS testing values with TBF were higher than repair with itself except for FU. Conclusions: The bulk-fill repaired materials showed higher bond strength except for FU, which showed the highest SBS value when repaired with itself. An increased incidence of adhesive fracture was observed at low strengths.
Selcuk Dental Journal
Bir oksalat hassasiyet gidericinin uzun donem baglanma dayanimi uzerine etkisi Amac: Bu in vitro ... more Bir oksalat hassasiyet gidericinin uzun donem baglanma dayanimi uzerine etkisi Amac: Bu in vitro calismanin amaci bir oksalat hassasiyet gidericinin, farkli adeziv prosedurlerle dentin dokusuna uygulanan bir rezin kompozitin uzun donem baglanma dayanimi (3 yil) uzerine etkisinin degerlendirilmesidir. Gerec ve Yontemler: Kirk adet cekilmis insan molar disi bukkal yuzeyleri acikta kalacak bicimde, akrilik bloklara yerlestirilmistir. Dislerin bukkal yuzeyleri, duzgun dentin yuzeyi elde edilene kadar asindirilmistir. Ornekler, rastgele dort gruba ayrilmistir (n=10). Grup 1: %32 fosforik asit (Uni-etch), Oksalat hassasiyet giderici (BisBlock), asitle ve yika adeziv (One Step Plus) uygulamasi. Grup 2: Oksalat hassasiyet giderici, kendinden asitli adeziv (Tyrian Spe+One Step Plus) uygulamasi. Grup 3: %32 fosforik asit, asitle ve yika adeziv uygulamasi. Grup 4: kendinden asitli adeziv uygulamasi. Yuzey hazirligi islemlerinin ardindan, dentin yuzeylerine yerlestirilmis teflon tupler (4x2 mm) hibrit rezin kompozit (TPH Spectrum) ile doldurulmustur. Distile suda 3 sene suren bekleme periyodunun ardindan orneklere, makaslama baglanma dayanim testi uygulanmistir. Veriler, Kruskall-Wallis testi ve Conover metodu ile istatistiksel olarak analiz edilmistir. Bulgular: Kendinden asitli adeziv oncesi uygulanan oksalat hassasiyet giderici (Grup 2) baglanma dayanimini istatistiksel olarak anlamli derecede dusurmustur (p<0,05). Grup 1, Grup 3 ve Grup 4 arasinda istatistiksel olarak anlamli bir farklilik gozlenmemistir. Sonuc: Oksalat hassasiyet giderici uygulamasi kendinden asitli adezivlerin dentin dokusuna uzun donem baglanma dayanimini negatif olarak etkileyebilir.
Lasers in Medical Science, 2016
Photobiomodulation (PBM) has been applied to manipulate cellular responses by using monochromatic... more Photobiomodulation (PBM) has been applied to manipulate cellular responses by using monochromatic light in different wavelengths from ultraviolet (UV) to infrared (IR) region. Until now, an effective wavelength has not been revealed to induce proliferation and/or differentiation of cells. Therefore, in the presented study, we decided to use a specially designed plasma arc light source providing wavelengths between 590 and 1500 nm in order to investigate its biomodulatory effects on chitosan scaffold-supported three-dimensional (3D) cell cultures. For comparison, two-dimensional (2D) cell cultures were also carried out in tissue-culture polystyrene dishes (TCPS). The results showed that light-induced temperature rise did not affect cells when the distance between the light source and the cells was 10 cm and the frequency of administration was daily. Moreover, light was applied for 5 and 10 min to the cells in TCPS and in chitosan scaffold groups, respectively. Cell culture studies under static conditions indicated that polychromatic light significantly stimulated bone nodule formation via the prolonged cell survival and stimulated differentiation of MC3T3-E1 preosteoblastic cells in both TCPS and chitosan scaffold groups. In conclusion, specially designed plasma arc light source used in this study induces formation of bone tissue and so, this light source is proposed as an appropriate system for in vitro bone tissue engineering applications. Statistical analyses were performed with one-way ANOVA by using GraphPad Instat software and standard deviations were calculated by using data of three parallel samples for each group.
Journal of Adhesion Science and Technology, 2016
This study evaluated monomer release and cytotoxicity of different adhesive restoration materials... more This study evaluated monomer release and cytotoxicity of different adhesive restoration materials used for dental restorations. The extracts (1, 2, and 7 days) of three types of adhesive dental restoration materials, [Quixfill (QF), Silorane Restorative (SR), and Ketac N 100 Restorative (KR)], and the adhesive resins, [XP Bond (XP), Silorane Primer (SP), Ketac N 100 Primer (KP), and Silorane Bond (SB)] were analyzed using high performance liquid chromatography/mass spectrometry (HPLC-MS). The cytotoxicity levels were determined at different time points (24, 48, and 72 h) of cell culture using 3-(4,5dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide (MTT) assay. All adhesive resin materials showed monomer release at varying amounts with the highest release after 7 days. The lowest amount of release was observed in QF and the highest with KP. Bis-Phenol A (BPA) was not detected in SP and KR that contain bisphenol-A diglycidyl ether dimethacrylate (bis-GMA). Decamethylpenthasiloxane (D5) was not eluted from SR. Except for SR and QF, all other adhesive restoration materials showed different degrees of toxicity along with different monomer release kinetics. The correlation between the monomer release and cytotoxicity of the materials indicated that the cytotoxicity of the materials increased with the monomer release (Spearman's rho correlation coefficient-r). The correlation after 48 h was statistically significant (r = −0.342, p = 0.017).
Nigerian Journal of Clinical Practice, 2016
Objective: This clinical study aimed to assess the effectiveness of mineral trioxide aggregate (M... more Objective: This clinical study aimed to assess the effectiveness of mineral trioxide aggregate (MTA) and calcium hydroxide (Ca[OH]2) in the treatment of deep carious lesions using the direct complete caries excavation technique. Subjects and Methods: Hundred permanent molars/premolars were capped either with Ca (OH)2 (n = 49) or MTA (n = 51) and restored with composite resin in 73 patients. Periapical radiographs were taken prior to the treatment, at 6 months and 12 months. Two calibrated examiners clinically and radiographically assessed the periapical pathology and pulpal symptoms. Inter-group comparisons of the observed values were analyzed using Fisher's exact test. Significance was predetermined at α = 0.05. Results: Recall rates were 100% at 6 and 12 months. Four teeth capped with Ca(OH)2 (two each at the end of 6 and 12 months) and one tooth capped with MTA (at the end of 12 months) received endodontic emergency treatment because of symptoms of irreversible pulpitis that were clinically and/or radiographically established. There was no significant difference between the protection of the tooth vitality and pulp capping agents at 6 and 12 months (P = 0.238, P = 0.606, respectively). Conclusion: Both materials were clinically applicable at the end of 12 months.
Journal (Canadian Dental Association)
The journal of contemporary dental practice, 2008
The aim of this report is to describe the management of a 16-year-old patient with oligodontia in... more The aim of this report is to describe the management of a 16-year-old patient with oligodontia including six permanent teeth. Oligodontia is agenesis of six teeth or more, excluding third molars. The etiology of congenital absence of teeth is believed to be involved in heredity or developmental anomalies. It can be isolated or as part of a syndrome. There are a number of options available to restore space generated by missing teeth. Dental treatment can vary depending on the severity of the disease and generally requires a multidisciplinary approach. Treatment options include orthodontic therapy, implants, adhesive techniques, and removable prostheses. A 16-year-old male patient with oligodontia affecting six permanent teeth received conservative care that met his and his parent's expectations. The existing primary teeth were restored to resemble permanent teeth in order to achieve a favorable esthetic result using direct composite resin. The restorative treatment was provided f...
Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2007
The aim of this study is to determine the effective concentrations of chlorhexidine on the releas... more The aim of this study is to determine the effective concentrations of chlorhexidine on the release for prolonged periods of time from a novel hydrogel system. A hydrogel that exhibits a volume phase transition in response to temperature was synthesized by radiation copolymerization of ethylene glycol vinyl ether and butyl vinyl ether in the presence of crosslinking agent, diethylene glycol divinyl ether. Hydrogel samples in the disc form (diameter, 10 mm and height, 1.5 mm) were utilized as a matrix for the release of an antimicrobial agent, chlorhexidine diacetate. Chlorhexidine loading into the hydrogel was performed by water sorption at 4 degrees C, which allows high swelling and thus high loading capacity, i.e., approximately 36 mg drug per gram of dry gel. Chlorhexidine release was examined as short-term (24 h) and long-term (27 days) by UV spectrophotometer. Microbial studies were carried out by micro-dilution method in order to determine the effectiveness of the drug release. Minimum inhibitory concentration values for the pathogens of Streptococcus mutans and Lactobacillus casei were determined. The long-term chlorhexidine release is initially very fast. After that, the drug release reaches a slow but a steady rate. Such a release pattern provides an effective drug release. The prolonged release of chlorhexidine is continued up to the 27th day. MIC values for the two pathogens have been shown that the release rate from disc is effective to inhibit the growth of pathogens. These in vitro drug release results suggested that the thermosensitive hydrogel system developed in this study can be evaluated as a delivery system for the release of chlorhexidine.
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Papers by Arlin Kiremitçi