Choline is an essential nutrient critical to brain health. Our objective was to evaluate the asso... more Choline is an essential nutrient critical to brain health. Our objective was to evaluate the association of plasma choline (Cho) and Cho-related compounds with cognition and cerebrovascular patholo...
Lutein, a dietary carotenoid, is selectively taken up and accumulated in neural tissues. Macular ... more Lutein, a dietary carotenoid, is selectively taken up and accumulated in neural tissues. Macular pigment (MP) is considered a surrogate biomarker of lutein levels in the macula and brain. MP density and lutein brain concentrations have been related to better cognitive function, and lutein has also been associated with the reduction of atherosclerotic lesions. Lutein's antioxidant properties may be one of the mechanisms by which it is protective of neural tissue, vasculature, and cognition. Our objective was to evaluate the relationships among MP density, oxidative stress, and cognition in healthy older adults (50 - 84 y, n = 44). MP density was measured using heterochromatic flicker photometry. The resistance of LDL against oxidation (rLDLox), a biomarker of oxidative stress and vascular health, was assessed using lag time of Cu2+induced oxidation. A computerized assessment battery (CANTAB) was used for measures of cognition. Cognitive data were normalized to z-scores; subjects were designated as higher o...
Journal of Occupational & Environmental Medicine, 2021
Wildland firefighters (WLFFs) perform in adverse environments making rapid adjustments to dietary... more Wildland firefighters (WLFFs) perform in adverse environments making rapid adjustments to dietary needs. The National Mobile Food Services (NMFS) contract details WLFF dietary provisions on wildfire incidents. Objective: Determine the nutrient content of food and drink provided to and consumed by WLFFs under the NMFS contract. Methods: Individual (n = 122) dietary provisions and consumption was recorded during 1 workday. Nutritional analysis of items provided was compared with consumption and the recommended dietary allowance (RDA). Results: WLFFs consumed significantly (P < 0.05) fewer macronutrients than provided for calories, protein, and fat. Provided and consumed micronutrients were below the RDA for vitamins D and E, magnesium, and manganese. Conclusion: Most dietary recommendations were met by NMFS provisions. Next steps include WLFF nutrition education to improve consumption and contract revisions to meet micronutrient recommendations.
The authors used case study methods in 19 urban public schools: 120 interviews with program and s... more The authors used case study methods in 19 urban public schools: 120 interviews with program and school staff, 7 student focus groups, and 91 school observations. Measurable Outcome/Analysis: We coded data in Dedoose and met regularly to discuss emerging themes. Codes included the taxonomy of implementation outcomes (Proctor et al, 2010). This analysis draws from codes that focus on what program participants and staff see as the most successful and valuable parts of the program. We mapped our findings onto the Theory of Planned Behavior (Azjen, 1991), which posits that before behavior can change, 3 factors must shift (attitudes, perceived behavioral control, and subjective norms). Results: Participants indicated that the most important aspects of the program are "exposure" to new foods (attitude change), access to healthy foods (shift in perceived control), and school culture around health (change in subjective norms). Conclusions: We propose creating a new conceptual model for evaluating SNAP-Ed programming in a school, particularly for Policy, Systems, and Environmental (PSE) work, that aligns outcomes to participants' own understandings of program impacts. This model would capture changes in attitudes, perceived behavioral control, and subjective norms earlier in program implementation. These are vital to sustained behavior change but often overlooked when measuring nutrition interventions.
Objectives For many struggling with poverty, consuming a nutritious diet while managing an existi... more Objectives For many struggling with poverty, consuming a nutritious diet while managing an existing chronic condition can be extremely challenging. Often times food bank/pantries offer an emergency resource to help promote health to families in need, however, many of them lack healthy foods to improve nutrition, health and well-being. In Idaho's Kootenai County, over 35,000 people are food insecure, 13.1% of the population with over 6000 of them being children, 17.1% of the population. University Of Idaho Extension Eat Smart Idaho program, with funding from USDA's Supplemental Nutrition Assistance Program-Education and the Department of Health and Welfare, have created their Healthy Food Bank/Pantry Protocol and Healthy Food Drive Protocol to help mesh our food bank network with healthier food options and give access to healthier foods to our low income families. Methods Eat Smart Idaho's goal is to move as many pantries towards the “choice” model as well as “MyPlate” pa...
Objectives To investigate the relationships between self-reported dietary carotenoid intake and c... more Objectives To investigate the relationships between self-reported dietary carotenoid intake and cognitive outcomes in adolescents aged 11–14 years. Methods Thirty adolescents aged 11–14 years participated in the cross-sectional study. Dietary intake of lutein and zeaxanthin, lycopene, alpha- and beta-carotene, cryptoxanthin and total carotenoids were assessed from three days of 24-hour dietary recall data collected and analyzed using the Automated Self-Administered 24-hour (ASA24) Dietary Assessment Tool, developed by the National Cancer Institute. Assessments from the NIH Toolbox for Assessment of Neurological and Behavioral Function were administered to determine scores of executive function, episodic memory, working memory, attention, processing speed, and fluid cognition, all adjusted for age, gender, race, ethnicity, and parent education. Spearman correlations were used to evaluate relationships between variable pairs, using SAS software. Results A significant inverse relations...
and amount leftover for each meal component. The template tested asked about fruit, vegetable, an... more and amount leftover for each meal component. The template tested asked about fruit, vegetable, and milk components, as those were the focus of the interventions. Materials were also developed to train food service staff. Evaluation: FSS from 20 schools were trained on using the template and asked to complete for one week in the fall of 2017. Seventeen schools were able to fill in the template with no or minimal assistance and three were able to complete it with extensive assistance. The research team was able to calculate the number of servings of the targeted meal components from all schools, except for one school who did not report milk. Conclusions and Implications: Providing FSS with production record templates and requesting targeted information resulted in school FSS providing production data that can be used to evaluate intervention outcomes. To improve the quality of data collected, training should be provided to FSS who will complete the template. Funding: USDA Team Nutrition.
Consumer taste preference can be influenced by visual preference. To eliminate the influence of v... more Consumer taste preference can be influenced by visual preference. To eliminate the influence of visual preference in the sensory evaluation of whole grain wheat, a reproducible method to eliminate color differences between Whole Grain breads prepared from hard white wheat (HWW) and hard red wheat (HRW) was evaluated. Response surface methodology (RSM) was used to match the color of HWW to HRW with the addition of commercially available dye solutions: McCormick black (red #40, yellow #5, blue #1), red (red #40, red #3, yellow #6), and yellow (yellow #5). Bread color was assessed by L * , a * , and b * color parameters according to the CIELAB international system of color measurement. Four replicates of the control and dye treated breads were analyzed. Initial color values for HRW were L * = 56.8 ± 0.40; a * = 8.04 ± 0.44; b * = 21.34 ± 0.46. RSM was used to predict dye addition levels to match color between HWW and HRW. With the addition of black (0.457 µL/mL), red (0.574 µL/mL), and yellow (1.165 µL/mL) dye to HWW, breads could be produced with L * , a * , and b * values of no statistical difference to the HRW (P < 0.05). A timed storage trail demonstrated the need to standardize the time between bread production and feeding studies. Visual bias can hinder assessment of wheat varieties in sensory studies. A reproducible method of dying wheat was developed that can be used to reduce this bias in sensory studies.
with factor loadings less than 0.40 were eliminated, and a modified IJC survey was developed base... more with factor loadings less than 0.40 were eliminated, and a modified IJC survey was developed based on these findings. Next, the survey was re-piloted with youth participants in IJC, and data on survey completion time was collected. Researchers also conducted cognitive interviews with participants that investigated their understanding of the modified survey, and analyzed differences between the original and modified survey in regards to participants' preferences and ability to complete the survey. Conclusions and Implications: A modified IJC survey was developed that decreased participant burden in time and ease of administration which will result in the collection of higher quality data and survey completion rate from youth participants.
list users reported higher HEI (n¼62, mean 57.8AE 11.9 SD) relative to non-users (n¼20, mean 48.0... more list users reported higher HEI (n¼62, mean 57.8AE 11.9 SD) relative to non-users (n¼20, mean 48.0AE 11.1 SD, p¼0.002). No difference in mean BMI by use of grocery list was noted (p¼0.10). Covariate-adjusted regression model indicated total HEI was higher among participants who consistently used a grocery list by 7.9 points (p¼0.02), but use of a grocery list was not associated with BMI (p¼0.79). Conclusions and Implications: Consistent use of a grocery list was associated with a higher dietary quality, but not BMI. Adopting routine use of grocery lists appears to be a feasible, low-tech, no-cost approach to higher dietary quality.
Journal of the Academy of Nutrition and Dietetics, 2016
Learning Outcome: Attendees will be able to describe a novel dietary assessment approach for asse... more Learning Outcome: Attendees will be able to describe a novel dietary assessment approach for assessing added sugar consumption, and understand the difference between d13C and d15N isotopes for use as dietary intake biomarkers. Introduction: The d13C value of blood is a novel validated biomarker of added sugar (AS) intake. Results are mixed if a dual-isotope model (d13C and d15N) demonstrates improved prediction of AS intake over a single-isotope model (d13C). Predication equations were previously developed in an adult population with high AS intake (reference group). Objective: To test the previously developed dual-and single-isotope prediction equations for AS intake in a different adult population (comparison group). Methods: The comparison group of adults completed 3 24-hour dietary recalls and provided blood samples (plasma or serum), which were analyzed for d13C and d15N values using NA-SIMS. The reference equations were established using fingerstick d13C (-19.1AE0.8&) and d15N (7.4AE0.5&) blood samples from a population (42AE15yrs) with high AS intake (89AE59g). Statistical analyses included t-tests and correlations. Results: The comparison group (53AE16yrs) had significantly lower (p<0.01) d13C (-19.5AE0.8&) and d15N (9.1AE0.3&) levels and consumed less AS (69AE43g;p¼0.017) than the reference group. Using the single-isotope equation, predicted AS intake was not significantly different from actual AS intake (difference¼-3.6AE40.9g;p¼0.51). Predicted and actual AS intake was correlated (R2¼0.12;p<0.01) and similar to the reference group (R2¼0.09;p<0.01). When testing the dual-isotope equation, predicted AS was different from actual AS intake (difference¼13AE41g;p¼0.02), and the correlation did not improve (R2¼0.09;p<0.01). Conclusion: d13C is able to successfully predict AS intake using a blood sample. Using a single-isotope prediction equation may be an alternative method to assessing AS intake.
Background: Use of repeated exposure in fostering development of food preferences has been examin... more Background: Use of repeated exposure in fostering development of food preferences has been examined; however, other techniques such as adult verbal communication have not. Child Centered Nutrition Phrases (CCNP) have been developed, but the efficacy of adults' use of these developmentally appropriate, nutritionally sound messages to improve children's intake and liking of lentils has not been evaluated. Objective: To determine whether repeated taste exposure (RE) and RE + CCNP would increase young children's liking and intake of lentils. Methods: Children (3-6 y; n=29) were offered lentils on 14 occasions (baseline, 12 exposures, and post). Taste preference and consumption were recorded and lentil consumption was measured to the nearest 0.1 g. A generalized linear model was used to assess the potential group (RE or RE + CCNP) by exposure interaction on the proportional intake (weight eaten divided by weight offered). A subsequent logistic regression analysis was carried out to estimate the change in the odds of children reporting liking in the RE + CCNP group compared to the RE group. Results: Children's consumption and liking of lentils increased with repeated exposure. Children exposed to CCNPs consumed a greater amount of lentils, although it was not statistically significant; however their reported liking at the beginning (p=0.04) and intermediate (p=0.02) time periods was more frequent than children who did not receive CCNP. Conclusions: Repeated taste exposure resulted in increased liking and intake of lentils in young children, and the use of CCNP may facilitate children's liking and intake of certain foods.
The American journal of clinical nutrition, Jun 29, 2017
Background: There is a potential role of choline in cardiovascular and cerebrovascular disease th... more Background: There is a potential role of choline in cardiovascular and cerebrovascular disease through its involvement in lipid and one-carbon metabolism.Objective: We evaluated the associations of plasma choline and choline-related compounds with cardiometabolic risk factors, history of cardiovascular disease, and cerebrovascular pathology.Design: A cross-sectional subset of the Nutrition, Aging, and Memory in Elders cohort who had undergone MRI of the brain (n = 296; mean ± SD age: 73 ± 8.1 y) was assessed. Plasma concentrations of free choline, betaine, and phosphatidylcholine were measured with the use of liquid-chromatography-stable-isotope dilution-multiple-reaction monitoring-mass spectrometry. A volumetric analysis of MRI was used to determine the cerebrovascular pathology (white-matter hyperintensities and small- and large-vessel infarcts). Multiple linear and logistic regression models were used to examine relations of plasma measures with cardiometabolic risk factors, his...
Emerging evidence indicates a direct link between age-associated changes in epigenetic mechanisms... more Emerging evidence indicates a direct link between age-associated changes in epigenetic mechanisms and onset of neurodegenerative diseases, and that these genomic modulations are directly affected b...
Choline is an essential nutrient critical to brain health. Our objective was to evaluate the asso... more Choline is an essential nutrient critical to brain health. Our objective was to evaluate the association of plasma choline (Cho) and Cho-related compounds with cognition and cerebrovascular patholo...
Lutein, a dietary carotenoid, is selectively taken up and accumulated in neural tissues. Macular ... more Lutein, a dietary carotenoid, is selectively taken up and accumulated in neural tissues. Macular pigment (MP) is considered a surrogate biomarker of lutein levels in the macula and brain. MP density and lutein brain concentrations have been related to better cognitive function, and lutein has also been associated with the reduction of atherosclerotic lesions. Lutein's antioxidant properties may be one of the mechanisms by which it is protective of neural tissue, vasculature, and cognition. Our objective was to evaluate the relationships among MP density, oxidative stress, and cognition in healthy older adults (50 - 84 y, n = 44). MP density was measured using heterochromatic flicker photometry. The resistance of LDL against oxidation (rLDLox), a biomarker of oxidative stress and vascular health, was assessed using lag time of Cu2+induced oxidation. A computerized assessment battery (CANTAB) was used for measures of cognition. Cognitive data were normalized to z-scores; subjects were designated as higher o...
Journal of Occupational & Environmental Medicine, 2021
Wildland firefighters (WLFFs) perform in adverse environments making rapid adjustments to dietary... more Wildland firefighters (WLFFs) perform in adverse environments making rapid adjustments to dietary needs. The National Mobile Food Services (NMFS) contract details WLFF dietary provisions on wildfire incidents. Objective: Determine the nutrient content of food and drink provided to and consumed by WLFFs under the NMFS contract. Methods: Individual (n = 122) dietary provisions and consumption was recorded during 1 workday. Nutritional analysis of items provided was compared with consumption and the recommended dietary allowance (RDA). Results: WLFFs consumed significantly (P < 0.05) fewer macronutrients than provided for calories, protein, and fat. Provided and consumed micronutrients were below the RDA for vitamins D and E, magnesium, and manganese. Conclusion: Most dietary recommendations were met by NMFS provisions. Next steps include WLFF nutrition education to improve consumption and contract revisions to meet micronutrient recommendations.
The authors used case study methods in 19 urban public schools: 120 interviews with program and s... more The authors used case study methods in 19 urban public schools: 120 interviews with program and school staff, 7 student focus groups, and 91 school observations. Measurable Outcome/Analysis: We coded data in Dedoose and met regularly to discuss emerging themes. Codes included the taxonomy of implementation outcomes (Proctor et al, 2010). This analysis draws from codes that focus on what program participants and staff see as the most successful and valuable parts of the program. We mapped our findings onto the Theory of Planned Behavior (Azjen, 1991), which posits that before behavior can change, 3 factors must shift (attitudes, perceived behavioral control, and subjective norms). Results: Participants indicated that the most important aspects of the program are "exposure" to new foods (attitude change), access to healthy foods (shift in perceived control), and school culture around health (change in subjective norms). Conclusions: We propose creating a new conceptual model for evaluating SNAP-Ed programming in a school, particularly for Policy, Systems, and Environmental (PSE) work, that aligns outcomes to participants' own understandings of program impacts. This model would capture changes in attitudes, perceived behavioral control, and subjective norms earlier in program implementation. These are vital to sustained behavior change but often overlooked when measuring nutrition interventions.
Objectives For many struggling with poverty, consuming a nutritious diet while managing an existi... more Objectives For many struggling with poverty, consuming a nutritious diet while managing an existing chronic condition can be extremely challenging. Often times food bank/pantries offer an emergency resource to help promote health to families in need, however, many of them lack healthy foods to improve nutrition, health and well-being. In Idaho's Kootenai County, over 35,000 people are food insecure, 13.1% of the population with over 6000 of them being children, 17.1% of the population. University Of Idaho Extension Eat Smart Idaho program, with funding from USDA's Supplemental Nutrition Assistance Program-Education and the Department of Health and Welfare, have created their Healthy Food Bank/Pantry Protocol and Healthy Food Drive Protocol to help mesh our food bank network with healthier food options and give access to healthier foods to our low income families. Methods Eat Smart Idaho's goal is to move as many pantries towards the “choice” model as well as “MyPlate” pa...
Objectives To investigate the relationships between self-reported dietary carotenoid intake and c... more Objectives To investigate the relationships between self-reported dietary carotenoid intake and cognitive outcomes in adolescents aged 11–14 years. Methods Thirty adolescents aged 11–14 years participated in the cross-sectional study. Dietary intake of lutein and zeaxanthin, lycopene, alpha- and beta-carotene, cryptoxanthin and total carotenoids were assessed from three days of 24-hour dietary recall data collected and analyzed using the Automated Self-Administered 24-hour (ASA24) Dietary Assessment Tool, developed by the National Cancer Institute. Assessments from the NIH Toolbox for Assessment of Neurological and Behavioral Function were administered to determine scores of executive function, episodic memory, working memory, attention, processing speed, and fluid cognition, all adjusted for age, gender, race, ethnicity, and parent education. Spearman correlations were used to evaluate relationships between variable pairs, using SAS software. Results A significant inverse relations...
and amount leftover for each meal component. The template tested asked about fruit, vegetable, an... more and amount leftover for each meal component. The template tested asked about fruit, vegetable, and milk components, as those were the focus of the interventions. Materials were also developed to train food service staff. Evaluation: FSS from 20 schools were trained on using the template and asked to complete for one week in the fall of 2017. Seventeen schools were able to fill in the template with no or minimal assistance and three were able to complete it with extensive assistance. The research team was able to calculate the number of servings of the targeted meal components from all schools, except for one school who did not report milk. Conclusions and Implications: Providing FSS with production record templates and requesting targeted information resulted in school FSS providing production data that can be used to evaluate intervention outcomes. To improve the quality of data collected, training should be provided to FSS who will complete the template. Funding: USDA Team Nutrition.
Consumer taste preference can be influenced by visual preference. To eliminate the influence of v... more Consumer taste preference can be influenced by visual preference. To eliminate the influence of visual preference in the sensory evaluation of whole grain wheat, a reproducible method to eliminate color differences between Whole Grain breads prepared from hard white wheat (HWW) and hard red wheat (HRW) was evaluated. Response surface methodology (RSM) was used to match the color of HWW to HRW with the addition of commercially available dye solutions: McCormick black (red #40, yellow #5, blue #1), red (red #40, red #3, yellow #6), and yellow (yellow #5). Bread color was assessed by L * , a * , and b * color parameters according to the CIELAB international system of color measurement. Four replicates of the control and dye treated breads were analyzed. Initial color values for HRW were L * = 56.8 ± 0.40; a * = 8.04 ± 0.44; b * = 21.34 ± 0.46. RSM was used to predict dye addition levels to match color between HWW and HRW. With the addition of black (0.457 µL/mL), red (0.574 µL/mL), and yellow (1.165 µL/mL) dye to HWW, breads could be produced with L * , a * , and b * values of no statistical difference to the HRW (P < 0.05). A timed storage trail demonstrated the need to standardize the time between bread production and feeding studies. Visual bias can hinder assessment of wheat varieties in sensory studies. A reproducible method of dying wheat was developed that can be used to reduce this bias in sensory studies.
with factor loadings less than 0.40 were eliminated, and a modified IJC survey was developed base... more with factor loadings less than 0.40 were eliminated, and a modified IJC survey was developed based on these findings. Next, the survey was re-piloted with youth participants in IJC, and data on survey completion time was collected. Researchers also conducted cognitive interviews with participants that investigated their understanding of the modified survey, and analyzed differences between the original and modified survey in regards to participants' preferences and ability to complete the survey. Conclusions and Implications: A modified IJC survey was developed that decreased participant burden in time and ease of administration which will result in the collection of higher quality data and survey completion rate from youth participants.
list users reported higher HEI (n¼62, mean 57.8AE 11.9 SD) relative to non-users (n¼20, mean 48.0... more list users reported higher HEI (n¼62, mean 57.8AE 11.9 SD) relative to non-users (n¼20, mean 48.0AE 11.1 SD, p¼0.002). No difference in mean BMI by use of grocery list was noted (p¼0.10). Covariate-adjusted regression model indicated total HEI was higher among participants who consistently used a grocery list by 7.9 points (p¼0.02), but use of a grocery list was not associated with BMI (p¼0.79). Conclusions and Implications: Consistent use of a grocery list was associated with a higher dietary quality, but not BMI. Adopting routine use of grocery lists appears to be a feasible, low-tech, no-cost approach to higher dietary quality.
Journal of the Academy of Nutrition and Dietetics, 2016
Learning Outcome: Attendees will be able to describe a novel dietary assessment approach for asse... more Learning Outcome: Attendees will be able to describe a novel dietary assessment approach for assessing added sugar consumption, and understand the difference between d13C and d15N isotopes for use as dietary intake biomarkers. Introduction: The d13C value of blood is a novel validated biomarker of added sugar (AS) intake. Results are mixed if a dual-isotope model (d13C and d15N) demonstrates improved prediction of AS intake over a single-isotope model (d13C). Predication equations were previously developed in an adult population with high AS intake (reference group). Objective: To test the previously developed dual-and single-isotope prediction equations for AS intake in a different adult population (comparison group). Methods: The comparison group of adults completed 3 24-hour dietary recalls and provided blood samples (plasma or serum), which were analyzed for d13C and d15N values using NA-SIMS. The reference equations were established using fingerstick d13C (-19.1AE0.8&) and d15N (7.4AE0.5&) blood samples from a population (42AE15yrs) with high AS intake (89AE59g). Statistical analyses included t-tests and correlations. Results: The comparison group (53AE16yrs) had significantly lower (p<0.01) d13C (-19.5AE0.8&) and d15N (9.1AE0.3&) levels and consumed less AS (69AE43g;p¼0.017) than the reference group. Using the single-isotope equation, predicted AS intake was not significantly different from actual AS intake (difference¼-3.6AE40.9g;p¼0.51). Predicted and actual AS intake was correlated (R2¼0.12;p<0.01) and similar to the reference group (R2¼0.09;p<0.01). When testing the dual-isotope equation, predicted AS was different from actual AS intake (difference¼13AE41g;p¼0.02), and the correlation did not improve (R2¼0.09;p<0.01). Conclusion: d13C is able to successfully predict AS intake using a blood sample. Using a single-isotope prediction equation may be an alternative method to assessing AS intake.
Background: Use of repeated exposure in fostering development of food preferences has been examin... more Background: Use of repeated exposure in fostering development of food preferences has been examined; however, other techniques such as adult verbal communication have not. Child Centered Nutrition Phrases (CCNP) have been developed, but the efficacy of adults' use of these developmentally appropriate, nutritionally sound messages to improve children's intake and liking of lentils has not been evaluated. Objective: To determine whether repeated taste exposure (RE) and RE + CCNP would increase young children's liking and intake of lentils. Methods: Children (3-6 y; n=29) were offered lentils on 14 occasions (baseline, 12 exposures, and post). Taste preference and consumption were recorded and lentil consumption was measured to the nearest 0.1 g. A generalized linear model was used to assess the potential group (RE or RE + CCNP) by exposure interaction on the proportional intake (weight eaten divided by weight offered). A subsequent logistic regression analysis was carried out to estimate the change in the odds of children reporting liking in the RE + CCNP group compared to the RE group. Results: Children's consumption and liking of lentils increased with repeated exposure. Children exposed to CCNPs consumed a greater amount of lentils, although it was not statistically significant; however their reported liking at the beginning (p=0.04) and intermediate (p=0.02) time periods was more frequent than children who did not receive CCNP. Conclusions: Repeated taste exposure resulted in increased liking and intake of lentils in young children, and the use of CCNP may facilitate children's liking and intake of certain foods.
The American journal of clinical nutrition, Jun 29, 2017
Background: There is a potential role of choline in cardiovascular and cerebrovascular disease th... more Background: There is a potential role of choline in cardiovascular and cerebrovascular disease through its involvement in lipid and one-carbon metabolism.Objective: We evaluated the associations of plasma choline and choline-related compounds with cardiometabolic risk factors, history of cardiovascular disease, and cerebrovascular pathology.Design: A cross-sectional subset of the Nutrition, Aging, and Memory in Elders cohort who had undergone MRI of the brain (n = 296; mean ± SD age: 73 ± 8.1 y) was assessed. Plasma concentrations of free choline, betaine, and phosphatidylcholine were measured with the use of liquid-chromatography-stable-isotope dilution-multiple-reaction monitoring-mass spectrometry. A volumetric analysis of MRI was used to determine the cerebrovascular pathology (white-matter hyperintensities and small- and large-vessel infarcts). Multiple linear and logistic regression models were used to examine relations of plasma measures with cardiometabolic risk factors, his...
Emerging evidence indicates a direct link between age-associated changes in epigenetic mechanisms... more Emerging evidence indicates a direct link between age-associated changes in epigenetic mechanisms and onset of neurodegenerative diseases, and that these genomic modulations are directly affected b...
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Papers by Annie Roe