Papers by Anestis Zantidis
Cases Journal, 2009
Background We present the case of a patient who presented with anaplastic thyroid carcinoma with ... more Background We present the case of a patient who presented with anaplastic thyroid carcinoma with a solitary large liver metastasis. Hepatic metastases are extremely rare in anaplastic thyroid carcinoma. Case presentation We report the case of a 78-year old Greek man who presented with voice hoarseness, dyspnoea and a large mass on the anterior surface of the cervical region (neck), as well as constitutional symptoms such as anorexia, weight loss and malaise. On physical examination, the thyroid was hard and tender on palpation and a liver mass was palpable. Routine biochemistry yielded normal results except increased C-reactive protein, alkaline phosphatase and γ-glutaryl transferase. Other biochemical tests including tumor markers, thyroid hormones, antithyroid antibodies, hepatitis B and hepatitis C antibodies were negative. Imaging methods revealed enlargement of the left thyroid lobe extending to the anterior mediastinum and compressing the trachea, metastatic bilateral pulmonar...
Diabetes Research and Clinical Practice, Aug 1, 2011
Intensive care unit Hyperglycemia occurring during hospitalization is a common phenomenon among p... more Intensive care unit Hyperglycemia occurring during hospitalization is a common phenomenon among patients with or without a known history of diabetes mellitus. For several years, hyperglycemia in hospitalized patients had been considered as an accompanying characteristic of the acute disease that resulted in admission. That point of view changed over time mainly because of emerging indications from clinical studies showing that hyperglycemia during hospitalization could aggravate prognosis and increase mortality. Further studies engaged on how hyperglycemia should be treated, yielded results that highlighted the increasing risk of mortality due to hypoglycemia in such efforts and also questioned the initial relation between hyperglycemia during hospitalization and a poor prognosis. Based on the fact that there is still no common ground on what is the best approach on hyperglycemia of hospitalized patients, the best practice remains to follow a different regime with different glycemic goals for different patient groups. In this review, hospitalized patients are divided into three groups; intensive care unit patients (general and cardiac), nonintensive care unit patients (general and cardiac) and peri-operative patients.
Blood, 2006
Introduction: CA 15-3 is a glycoprotein expressed in several adenocarcinomas, especially of the b... more Introduction: CA 15-3 is a glycoprotein expressed in several adenocarcinomas, especially of the breast. It is used to detect recurrent or metastatic disease. Elevated levels can also be found in adenocarcinomas of the ovary, lung, pancreas, and colon, and are also related to benign breast or ovarian disease, endometriosis, hepatitis, pregnancy and lactation. To our knowledge with the exception of multiple myeloma, there are no references for the significance of the CA 15-3 in hematological malignancies. Aim of our study was to evaluate the levels of CA 15-3 in patients with various hematological malignancies. Material and Methods: 84 patients with hematological malignancies were tested: MDS 27 pts, non Hodgkin lymphoma 12 pts, Hodgkin’s lymphoma 3 pts, chronic lymphocytic leukemia 13 pts, acute leukemia: 7 pts, multiple myeloma 8 pts, chronic myeloid leukemia 3 pts and other chronic myeloproliferative disorders 11 pts. 55% of the patients were men with average age of 55 (17–87) and ...
World Journal of Gastroenterology, 2005
We present the fourth case of a primary pancreatic anaplastic large cell lymphoma (ALCL), ALK-. A... more We present the fourth case of a primary pancreatic anaplastic large cell lymphoma (ALCL), ALK-. An 80-year-old man was admitted to our clinic for further investigation of a fever of unknown origin. He noted anorexia, weight loss and fatigue. His laboratory tests showed anemia and a great elevation of ESR, LDH, and β 2 microglobulin. In CT and MRI scan, a soft tissue mass in the pancreas was observed. A repeated endoscopy after his admission revealed an ulcerated mass-like deformity of the duodenal bulb. Explorative laparotomy confirmed a diffuse spread of an unresectable malignant pancreatic mass extending to the adjacent organs. Duodenal and surgical biopsies identified an ALCL of T-cell lineage, ALK-. The patient died in the Intensive Care Unit due to hemodynamic instability. Our case is the first one indicating that primary pancreatic lymphoma should be suspected in a patient with pancreatic mass and elevated serum LDH and β 2 microglobulin.
Diabetes Research and Clinical Practice, 2011
Intensive care unit Hyperglycemia occurring during hospitalization is a common phenomenon among p... more Intensive care unit Hyperglycemia occurring during hospitalization is a common phenomenon among patients with or without a known history of diabetes mellitus. For several years, hyperglycemia in hospitalized patients had been considered as an accompanying characteristic of the acute disease that resulted in admission. That point of view changed over time mainly because of emerging indications from clinical studies showing that hyperglycemia during hospitalization could aggravate prognosis and increase mortality. Further studies engaged on how hyperglycemia should be treated, yielded results that highlighted the increasing risk of mortality due to hypoglycemia in such efforts and also questioned the initial relation between hyperglycemia during hospitalization and a poor prognosis. Based on the fact that there is still no common ground on what is the best approach on hyperglycemia of hospitalized patients, the best practice remains to follow a different regime with different glycemic goals for different patient groups. In this review, hospitalized patients are divided into three groups; intensive care unit patients (general and cardiac), nonintensive care unit patients (general and cardiac) and peri-operative patients.
Diabetes Care, 1983
The prevalence of carotid artery occlusive disease (CAOD) in a population of adults with diabetes... more The prevalence of carotid artery occlusive disease (CAOD) in a population of adults with diabetes mellitus was determined, and factors associated with its presence were identified. By oculoplethysmography and phonoangiography, 20% of the population studied had detectable CAOD. Univariate analyses revealed that patients with CAOD had a higher prevalence of retinopathy proteinuria, a slower mean conduction velocity in two of three nerves tested, and more atherosclerosis in the leg arteries. Furthermore, increased age, higher cholesterol, lower fasting insulin, higher systolic blood pressure, and less adiposity were associated with the presence of CAOD. Sex, race, type of diabetes (type I or II), duration of diabetes, and measures of glycemia were not related to CAOD. When 10 variables were analyzed by multivariate methods, higher systolic blood pressure, higher cholesterol, and reduced adiposity were found to be the combination most significantly related to CAOD.
Scandinavian Journal of Infectious Diseases, 2007
Primary infection by cytomegalovirus in immunocompetent patients is usually unapparent. We report... more Primary infection by cytomegalovirus in immunocompetent patients is usually unapparent. We report a case of severe acute cytomegalovirus infection in a young immunocompetent male with pulmonary and hepatic involvement and portal hypertension who recovered without specific antiviral therapy with complete resolution of sonographic signs of portal hypertension after 6 months.
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Papers by Anestis Zantidis