Papers by Andrea Gerónimo torres
Preventive medicine, Oct 12, 2016
The Recreovia program provides free physical activity (PA) classes in public spaces in Bogota, Co... more The Recreovia program provides free physical activity (PA) classes in public spaces in Bogota, Colombia. The purpose of this study was to assess the effectiveness of the Recreovia program in increasing PA among users of nine parks in Bogota. This study was a natural experiment conducted between 2013 and 2015 in Bogota. Community members and park users living nearby three groups of parks were compared: Group 1 were parks implementing new Recreovias (n=3), Group 2 were control parks (n=3) without Recreovias, and Group 3 were parks with existing Recreovías. Individuals in the "intervention" group were exposed to newly implemented Recreovia programs in parks near their homes. Measurements were collected at baseline and 6-8months after the intervention started. A total of 1533 participants were enrolled in the study: 501 for the existing Recreovias (included in a cross-sectional assessment) and 1032 participants (from the new Recreovias and control parks) included in the cross-...
Journal of Physical Activity and Health, 2010
Background:The Ciclovía-Recreativa is a free, community-based program in which streets are closed... more Background:The Ciclovía-Recreativa is a free, community-based program in which streets are closed temporarily to motorized transport, allowing access to walkers, runners, rollerbladers, and cyclists only. We assessed existing information about the Ciclovía as a public health strategy and proposed next steps for research and public health practice.Methods:We conducted a systematic search of peer-reviewed and other literature, which was complemented by expert interviews and consultation.Results:We reviewed 38 Ciclovías from 11 countries. Most programs (84.2%) take place in urban settings. The programs range from 18−64 events per year (54 ± 24.6; 52 [mean ± standard deviation; median]) with events lasting from 2−12 hours (6 ± 2.4; 6). The length of the streets ranges from 1−121 km (14.6 ± 22.1; 7), and the estimated number of participants per event ranges from 60-1,000,000 persons (61,203 ± 186,668; 3810). Seventy-one percent of the programs include physical activity classes and in 89%...
Journal of Physical Activity and Health, 2010
Background:The Guide for Useful Interventions for Activity in Brazil and Latin America (GUIA), a ... more Background:The Guide for Useful Interventions for Activity in Brazil and Latin America (GUIA), a systematic review of community-based physical activity (PA) interventions in Latin American literature, selected the CuritibAtiva program for a comprehensive evaluation. We describe the process of developing logic models (LM) of PA community interventions from Curitiba, Brazil, and discuss influential factors.Methods:The year-long process included engaging stakeholders involved in the promotion of PA in Curitiba, working with stakeholders to describe the programs and their goals, and developing LMs for the 2 main secretaries promoting PA in the city.Results & Conclusions:As a result of stakeholder interviews and discussion and the development of the LMs, local officials are coordinating programming efforts and considering ways the programs can be more complementary. The process has prompted program managers to identify overlapping programs, refine program goals, and identify gaps in prog...
Revista Colombiana de Anestesiología, 2010
Virology, 2005
The mechanisms responsible for effective vs. ineffective viral containment are central to immunop... more The mechanisms responsible for effective vs. ineffective viral containment are central to immunoprevention and therapies of retroviral infections. Feline leukemia virus (FeLV) infection is unique as a naturally occurring, diametric example of effective vs. ineffective retroviral containment by the host. We developed a sensitive quantitative real-time DNA PCR assay specific for exogenous FeLV to further explore the FeLV-host relationship. By assaying p27 capsid antigen in blood and FeLV DNA in blood and tissues of successfully vaccinated, unsuccessfully vaccinated, and unvaccinated pathogen-free cats, we defined four statistically separable classes of FeLV infection, provisionally designated as abortive, regressive, latent, and progressive. These host-virus relationships were established by 8 weeks postchallenge and could be maintained for years. Real-time PCR methods offer promise in gaining deeper insight into the mechanisms of FeLV infection and immunity.
Veterinary Immunology and Immunopathology, 2010
A fraction of cats exposed to feline leukemia virus (FeLV) effectively contain virus and resist p... more A fraction of cats exposed to feline leukemia virus (FeLV) effectively contain virus and resist persistent antigenemia/viremia. Using real-time PCR (qPCR) to quantitate circulating viral DNA levels, previously we detected persistent FeLV DNA in blood cells of non-antigenemic cats considered to have resisted FeLV challenge. In addition, previously we used RNA qPCR to quantitate circulating viral RNA levels and determined that the vast majority of viral DNA is transcriptionally active, even in the absence of antigenemia. A single comparison of all USDA-licensed commercially available FeLV vaccines using these modern sensitive methods has not been reported. To determine whether FeLV vaccination would prevent nucleic acid persistence, we assayed circulating viral DNA, RNA, antigen, infectious virus, and virus neutralizing (VN) antibody in vaccinated and unvaccinated cats challenged with infectious FeLV. We identified challenged vaccinates with undetectable antigenemia and viremia concomitant with persistent FeLV DNA and/or RNA. Moreover, these studies demonstrated that two whole inactivated virus (WIV) adjuvanted FeLV vaccines (Fort Dodge Animal Health's Fel-O-Vax Lv-K® and Schering-Plough Animal Health's FEVAXYN FeLV®) provided effective protection against FeLV challenge. In nearly every recipient of these vaccines, neither viral DNA, RNA, antigen, nor infectious virus could be detected in blood after FeLV challenge. Interestingly, this effective viral containment occurred despite a weak to undetectable VN antibody response. The above findings reinforce the precept of FeLV infection as a unique model of effective retroviral immunity elicited by WIV vaccination, and as such holds valuable insights into retroviral immunoprevention and therapy.
… CACAP Joint Annual Meeting (October 18- …, 2011
... Saturday, October 22, 2011. Amalia Londono Tobon, BA, Department of Psychiatry, Stanford Univ... more ... Saturday, October 22, 2011. Amalia Londono Tobon, BA, Department of Psychiatry, Stanford University School of Medicine, Palo Alto, CA. ... Neil Risch, Ph.D., University of California, San Francisco, San Francisco, CA. Joachim Hallmayer, MD, Stanford University, Stanford, CA. See ...
Medicine & Science in Sports & Exercise, 2009
Journal of Psychiatric Research, 2014
This is a PDF file of an unedited manuscript that has been accepted for publication. As a service... more This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Contributors Wendy Froehlich-Santino Developed the hypotheses, designed the approach and analytic plan, conducted the literature search, conducted the statistical analyses, drafted the manuscript and oversaw all aspects of the development of this manuscript. Amalia Londono Tobon Contributed to the design of the approach and analytic plan, reviewed of data files, coded and compiled data, instrumental in analysis and drafting of the manuscript. Sue Cleveland Contributed to the data collection, diagnostic assessment, literature search, review of data files, and drafting of the manuscript. Andrea Torres Contributed to the data collection, literature search, review of data files, and drafting of the manuscript. Jennifer Phillips Contributed to the data collection, developed the protocol for the diagnostic assessments, review of data files, and drafting of the manuscript. Brianne Cohen Contributed to the data collection, literature search, review of data files, and drafting of the manuscript. Tiffany Torigoe Contributed to the data collection, literature search, review of data files, and drafting of the manuscript. Janet Miller Contributed to the data collection, literature search, review of data files, and drafting of the manuscript. Angie Fedele Contributed to the data collection, literature search, review of data files, and drafting of the manuscript. Jack Collins Contributed to the data collection, literature search, review of data files, and drafting of the manuscript. Karen Smith Contributed to the data collection, literature search, review of data files, and drafting of the manuscript. Linda Lotspeich Contributed to the data collection, development of the protocol, diagnostic criteria, review of data files, and drafting of the manuscript. Lisa A. Croen Contributed to the data collection, hypothesis development, development of the protocol, literature search, analytic approach, review of data files, and drafting of the manuscript. Sally Ozonoff Contributed to the data collection, hypothesis development, development of the protocol, literature search, analytic approach, review of data files, and drafting of the manuscript. Clara Lajonchere Contributed to the data collection, hypothesis development, development of the protocol, literature search, analytic approach, review of data files, and drafting of the manuscript. Judith K. Grether Contributed to the data collection, hypothesis development, development of the protocol, literature search, analytic approach, review of data files, and drafting of the manuscript. Ruth O'Hara Contributed to the hypothesis development, literature search, analytic approach, and drafting of the manuscript. Joachim Hallmayer Obtained funding for this study, developed the protocol, diagnostic criteria, analytic approach, and contributed to the hypothesis development, analysis of the data, literature search and drafting of the manuscript.
Journal of Pharmaceutical and Biomedical Analysis, 2011
In this work we describe the evaluation of the pharmacokinetics of a novel cardioactive compound ... more In this work we describe the evaluation of the pharmacokinetics of a novel cardioactive compound of the N-acylhydrazone class, LASSBio-294, using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) in dog plasma for the first time. Separation was achieved on a ZORBAX Rapid Resolution High Definition (RRHD) SB-C18 (50 mm × 2.1 mm, 1.8 m) reversed-phase column at 20 • C with methanol-10 mM ammonium acetate solution (65:35, v/v) at a flow rate of 1.0 mL/min. Detection was performed using an electrospray ionization (ESI) operating in positive ion multiple reaction monitoring (MRM) mode by monitoring the ion transitions from m/z 275.2 → 149.1 (LASSBio-294) and m/z 152.0 → 110.0 (acetaminophen, internal standard). The calibration curve of LASSBio-294 in plasma showed good linearity over the concentration range of 1.25-800 ng/mL. The validated method was successfully applied to a pre-clinical pharmacokinetic study of the cardioactive prototype LASSBio-294 in beagles after oral administration. The main pharmacokinetic parameters t 1/2 , C max and AUC 0-24 were (5.74 ± 0.55) h, (547.66 ± 35.12) ng/mL and (1621.77 ± 41.66) ng h/mL, respectively.
Journal of Autism and Developmental Disorders, 2009
In 1975, Herrmann et al. first described KBG syndrome. The letters "KBG" were derived from the su... more In 1975, Herrmann et al. first described KBG syndrome. The letters "KBG" were derived from the surnames of three unrelated families from which seven patients with the syndrome were identified. In the original report KBG was assumed to be an autosomal dominant condition characterized by short stature, skeletal abnormalities, mental retardation, dental abnormalities and distinct craniofacial anomalies. Since then an additional 51 patients have been reported. Monozygotic twins diagnosed with KBG syndrome were described as having autistic features in a recent article (Skjei et al. 2007). Here we report additional findings on the same twins. Through appropriate diagnostic testing, it was established that they did meet criteria for autism. We also reviewed the literature of previously published cases of KBG for reports of autism symptoms. Each boy was assessed at home at 12 years, 7 months of age by two separate assessors in order to eliminate bias. The assessments were videotaped and a child psychologist recoded the tests using the videotapes. In addition a thorough history was obtained by a child and adolescent psychiatrist. The following assessments were completed: Autism Diagnostic Interview-Revised (ADI-R) (Le Couteur et al. 1989; Rutter et al. 2003), Autism Diagnostic Observation Schedule-Generic (ADOS-G) (DiLavore et al. 1995) and the Stanford-Binet Intelligence Scales, Fifth Edition (SB5) (Roid 2003). Medical history of the twins: The twins were the 7th pregnancy for the mother. They have five older siblings and one younger sibling. Their mother had one early miscarriage at her 5th pregnancy at 6 weeks gestation when she was ill with the varicella virus. The twins' gestation was complicated by preterm labor treated with bed rest, morphine and terbutaline. At 34 weeks the twins were delivered via C-section due to transverse presentation of twin 2. At birth they had multiple problems including an inguinal hernia, jaundice and nursing difficulty. By 4 months of age, they were noticeably different, showing no interest in other people and not making eye contact while nursing. Physically they were weaker and had poor muscle tone and poor balance. Motor developmental milestones were delayed, sitting at 11-12 months1 old, walking at 15-16 months old, and running at 2½ years old. Toilet training was achieved at 5-6 years old. Language development was delayed. First words, "cup" and "that", were spoken at 4-5 years of age. First phrases, "go home" and a few echolalic responses to a movie were displayed at 7-8 years of age. Both developed partial complex and absence seizure disorder at 8-9 years old. Concomitantly, parents noticed a loss of
Journal of Autism and Developmental Disorders, 2013
To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorde... more To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorders (ASDs). Twin pairs with at least one twin with an ASD were assessed. HCs in affected and unaffected individuals were compared, as were HC correlations in monozygotic and dizygotic pairs. 404 subjects, ages 4-18, were included. 20 % of males and 27 % of females with an ASD had macrocephaly. Unaffected co-twins showed similar rates (15 % of males and 22 % of females). Statistical analysis revealed no significant difference in HCs between affected and unaffected twins. Twins with ASDs and unaffected co-twins have similar HCs and increased rates of macrocephaly. Correlations demonstrated partial inheritance of HCs. Thus, macrocephaly may represent an endophenotype in ASDs.
Global Health Promotion, 2010
This article focuses on results of the systematic review from the Guide for Useful Interventions ... more This article focuses on results of the systematic review from the Guide for Useful Interventions for Activity in Latin America project related to school-based physical education (PE) programs in Latin America. The aims of the article are to describe five school-based PE programs from Latin America, discuss implications for effective school-based PE recommendations, propose approaches for implementing these interventions, and identify gaps in the research literature related to physical activity promotion in Latin American youth. Following the US Community Guide systematic review process, five school-based PE intervention studies with sufficient quality of design, execution and detail of intervention and outcomes were selected for full abstraction. One study was conducted in Brazil, two studies were conducted in Chile and two studies were conducted on the US/Mexico border. While studies presented assorted outcomes, methods and duration of interventions, there were consistent positive ...
Skip to main content Digital Archive @ GSU. ... Public Health Theses. Title. The Bogota Ciclovia-... more Skip to main content Digital Archive @ GSU. ... Public Health Theses. Title. The Bogota Ciclovia-Recreativa and Cicloruta Programs: Promising Interventions to Promote Physical Activity, and Social Capital in the City of Bogota. Author. Andrea D. Torres. Date of Award. Fall 1-6-2012 ...
Bioorganic & Medicinal Chemistry Letters, 2010
Avian Diseases, 2013
Stemming from a recent freshwater invasives conference, Caffrey et al. (2014) identified 'the top... more Stemming from a recent freshwater invasives conference, Caffrey et al. (2014) identified 'the top 20 issues' that relate to invasive alien species (IAS) management in Europe. With a view to complement and balance the issues highlighted in their account, we offer six important additions that relate to the marine environment. These are: preventive measures, concerns of loss of taxonomic expertise and species identity, gaps in the knowledge of certain taxa and regions, inconsistencies of terminology, need for validation of data and the importance of concentrating on pathways, and their vectors, and levels of certainty associated with these routes.
Uploads
Papers by Andrea Gerónimo torres