Papers by Marco Aurelio Andrade
A minha querida e amada esposa Patrícia, por sua constante renúncia, estímulo, ensino, compreensã... more A minha querida e amada esposa Patrícia, por sua constante renúncia, estímulo, ensino, compreensão e amor incondicional. Não teria conseguido percorrer e vencer tantos "mares calmos e revoltos" sem a sua presença ao meu lado. Aos meus amados filhos Marcela e Leonardo, pelo amor, carinho e apoio dispensados em todos os momentos da minha vida. Vocês são a razão do meu viver e o verdadeiro significado da palavra amor. Pelas suas vidas eu pude compreender o amor de Deus por cada um de nós. Aos meus queridos pais Renato e Ezilda, que sempre lutaram para me dar o maior dos tesouros, a educação. Isso foi tudo em minha vida. Aos meus queridos irmãos Paulo Renato e Jorge, pelos exemplos de dedicação e profissionalismo que sempre nortearam suas vidas. vi Ao meu orientador, Professor Doutor Marcio Ajudarte Lopes, pelo respeito, confiança, ensinamentos, convivência, profissionalismo, retidão, sinceridade, simplicidade e principalmente pela fraterna amizade. Muito lhe agradeço pelas inúmeras oportunidades de constante crescimento profissional a mim concedidas. vii AGRADECIMENTOS Agradeço ao Senhor Deus e Pai, Aquele que existia antes de todas as coisas, que com seu imenso amor e misericórdia susteve a mim e minha família durante todo esse período em Piracicaba;
Revista Naval de Odontologia, 2018
Este estudo observou a prevalência e a localização de patologias ósseas, correlacionando-as com o... more Este estudo observou a prevalência e a localização de patologias ósseas, correlacionando-as com o sexo e a idade, por meio de exames radiográficos de 155 pacientes, que procuraram o Serviço de Radiologia Odontológica e Imaginologia e a clínica de Estomatologia e Patologia bucal da Odontoclínica Central da Marinha. Foram avaliadas imagens panorâmicas, periapicais, tomografias computadorizadas de feixe cônico (TCFC) e multi-slices (TC) destes pacientes. Realizaramse testes estatísticos Qui-quadrado, razão de prevalência e ANOVA, com nível de significância de 5%. A amostra consistiu em 55,5% de mulheres e 45,5% de homens, com média de idade de 50 (±1,8) e 39,1 (±2,4) anos, respectivamente. O exame mais solicitado foi a radiografia panorâmica (97,4%), seguido das periapicais (44,5%), TCFC (26,5%) e TC (14,2%). As patologias mais detectadas foram as displasias ósseas (28,4%) posteriormente as escleroses ósseas (23,9%), tumores benignos (23,9%) e cistos (14,8%). A maioria das lesões foi observada na mandíbula (54,2%). Os molares foram os dentes mais associados às lesões (16,1%), seguido dos incisivos (11%) e pré-molares (7,1%). A razão de prevalência entre os gêneros revelou que os cistos foram aproximadamente 2,5 vezes mais comuns em homens e as displasias foram 2,7 vezes mais comuns em mulheres. Os pacientes que apresentaram tumores benignos (34,1 ± 2,6 anos) eram significativamente mais jovens que aqueles que apresentavam displasias ósseas (51,0 ± 2,3 anos, p<0,0001) ou escleroses ósseas (48,1 ± 3,2 anos, p=0,0006). Sendo assim, o sexo e a idade dos pacientes influenciaram ao tipo de lesão, mas não à sua localização.
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2015
Introduction: Sinonasal intestinaltype adenocarcinoma is a rare malignancy originating most commo... more Introduction: Sinonasal intestinaltype adenocarcinoma is a rare malignancy originating most commonly from the ethmoid sinuses. Morphologically, this cancer tends to resemble intestinal adenocarcinoma with immunohistologic staining mirroring what would be expected for a gastrointestinal malignancy. Definitive treatment involves surgical resection often followed by radiation. In the inoperable or metastatic setting, there is limited evidence for effective chemotherapeutic regimens. Case Report: A patient with unresectable sinonasal intestinaltype adenocarcinoma. Chemotherapy with 5FU and oxaliplatin (FOLFOX) was initiated based on the rationale of similar morphology and immunohistochemistry (IHC) of this patient's sinonasal intestinaltype adenocarcinoma and colon adenocarcinoma and the affirmed efficacy of FOLFOX regimens in the metastatic and adjuvant colon cancer settings. The patient had a dramatic partial radiologic response by response evaluation criteria in solid tumors (RECIST) criteria. Conclusion: Intestinaltype sinonasal adenocarcinoma presents a rare and challenging opportunity to select active chemotherapy for unresectable disease. We propose that further investigation of colorectal chemotherapy regimens including FOLFOX in intestinal-type sinonasal adenocarcinoma is warranted.
American Journal of Orthodontics and Dentofacial Orthopedics, 2014
Oral squamous cell carcinoma traditionally affects older men who smoke and drink. A change in thi... more Oral squamous cell carcinoma traditionally affects older men who smoke and drink. A change in this profile has been reported because of an increased incidence in young nonsmoking and nondrinking patients. The purpose of this article was to describe a series of young nonsmoking and nondrinking patients diagnosed with tongue squamous cell carcinoma who had recently received orthodontic treatment or evaluation. Details regarding diagnosis, treatment, follow-up, and disease evolution are presented, with a review of the pertinent literature. Orthodontists often treat young adults, who have frequent dental appointments and long-term follow-ups. Thus, practitioners should pay special attention to young patients during dental consultations, since the incidence of malignant oral lesions in this segment of the population seems to be increasing.
With the introduction of Combined Antiretroviral Therapy, individuals infected by the Human Immun... more With the introduction of Combined Antiretroviral Therapy, individuals infected by the Human Immunodeficiency Virus have a longer life expectancy and greater susceptibility to nondefining malignancies of Acquired Immunodeficiency Syndrome such as oral squamous cell carcinoma. In these individuals, oral squamous cell carcinoma is more common in men, over 50, smokers and alcoholics, and the vast majority present in an advanced stage with a worse prognosis. Human papillomavirus, immunosuppression and genetic alterations have also been implicated as responsible for oral squamous cell carcinoma in individuals infected by the Human Immunodeficiency Virus. A narrative review of the literature was performed and it was observed that individuals infected by the Human Immunodeficiency Virus who are smokers, alcoholics, carry oncogenic HPV and with a CD4 + T cell count < 200 cells/μL, are at higher risk of developing oral squamous cell carcinoma with worse prognosis than immunocompetent individuals.
International journal of odontostomatology, 2010
RESUMEN: El objetivo de esta revisión es presentar criterios de evaluación odontológica pre-radio... more RESUMEN: El objetivo de esta revisión es presentar criterios de evaluación odontológica pre-radioterapia y cuáles son las principales necesidades de tratamiento de estos pacientes después del tratamiento de radiación. Fueron revisados artículos en inglés, español y portugués entre 1995 y 2009 indexados en Pubmed y Scielo. Las palabras claves fueron: cáncer oral y radioterapia, complicaciones de la radioterapia en cabeza y cuello, evaluación oral pre-radioterapia.Los efectos colaterales de la radioterapia en la región de cabeza y cuello pueden ser temporales o tardíos. Aquellos que son tardíos, como la caries de radiación y la osteorradionecrosis pueden estar directamente relacionados con el hecho de no haber realizado una evaluación odontológica previa y pueden afectar severamente la calidad de vida del paciente.La participación del cirujano-dentista en el equipo multidisciplinario y la evaluación odontológica de los pacientes que serán sometidos a radioterapia en la región de cabeza y cuello son de vital importancia en mejorar la calidad de vida post-operatoria de estos pacientes. PALABRAS CLAVE: radioterapia, cáncer de cabeza y cuello, efectos colaterales, necesidades de tratamiento.
Supportive Care in Cancer, 2013
Side effects of head and neck radiotherapy are common and can interfere with treatment. However, ... more Side effects of head and neck radiotherapy are common and can interfere with treatment. However, scientific information on a patient&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s understanding of these complications is scarce and confusing. Therefore, the aim of this study was to assess the effect of an educational video on improving the understanding of head and neck cancer patients undergoing radiotherapy about treatment complications. A 6-min video about head and neck radiotherapy side effects was produced by a multidisciplinary oncology team. A controlled clinical study was performed with two groups: the control group (N = 19), which received verbal information, and the video group (N = 19), which received verbal information and watched the video. Two questionnaires were given to both groups, one before the beginning of radiotherapy and the other after finishing radiotherapy. Thirty-eight patients were included in the study (mean age of 59.7 years in the video group and 57.9 in the control group). Thirty-one patients had an education level less than high school education. All patients of the video group answered correctly why they were undergoing radiotherapy. On the other hand, three patients of the control group did not know the reason for the treatment. More patients of the video group demonstrated better knowledge about radiotherapy side effects than patients of the control group. Only one patient of the video group had doubts about the treatment, compared to seven of the control group. The present study showed that an educational video may improve patient understanding of head and neck radiotherapy and its side effects despite their education level.
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Papers by Marco Aurelio Andrade