Papers by Aman Kumar BASM, SPUP
Journal of Evolution of Medical and Dental Sciences, 2018
BACKGROUND Smoking is responsible for large number of premature deaths in India. Smokeless tobacc... more BACKGROUND Smoking is responsible for large number of premature deaths in India. Smokeless tobacco is also addictive and associated with development of risk of cancer of head and neck, oesophagus, stomach and pancreas besides many oral diseases. The objective of this study is to assess the pattern of tobacco use and association of tobacco use with BMI in adult population. MATERIALS AND METHODS A cross-sectional study was conducted among 150 adult population. Multistage random sampling technique was used for individual selection and data was collected using structured interview schedule. RESULTS Nearly eighty seven percent (86.7%) knew that tobacco use can cause cancer. It was found that 30.0% smokes only and 66.0% used smokeless form of tobacco. Among non-smokers, 3.3% used khaini, 12.0% used zarda, 8.0% used tobacco with betel leaf and 50.0% used tobacco in multiple forms. It was found that smokers had higher proportion of lower BMI (62.5%) compared to smokeless tobacco users (37.5%), but proportion of normal weight was higher among smokeless tobacco users (73.3%) compared to smokers (p= 0.007). CONCLUSION Smokeless form of tobacco use was quite high in spite of having good knowledge and awareness. We recommend further study involving more subjects including rural and urban population.
Metallurgical Research & Technology, 2019
The Iron and Steel Industry has undergone a radical change, and processes have been developed con... more The Iron and Steel Industry has undergone a radical change, and processes have been developed continually for the faster rate of production. The thermal characteristic of reaction depends on the thermal conductivity of coal charge by progressively developing the zone of coke. In general, higher the oven temperature, the more rapid is the initial rate of heating, plastic temperature range, plasticity and volatile evolution characteristics of the coal. The higher thermal conductivity of bricks will increase heat transfer rate and consequently, the output of the oven will increase the throughput. The heating rate is also associated with the pattern of heat supply during carbonization which influences the strength and fissuring of the coke. Results show that replacement of LC-65 castable with higher thermal conductivity castable SiC-30% reduces the coking time by 50% whereas LC-85 reduces the coking time by 20% even at same coke end temperature and coke CSR. The requirement of free spac...
mBio, 2018
The gut microbiota is usually regarded as providing colonization resistance against enteric patho... more The gut microbiota is usually regarded as providing colonization resistance against enteric pathogens. However, some pathogens evolved to thrive with the aid of certain members of the microbiota. Several Gram-negative bacteria employ type three secretion systems (T3SSs), which are molecular syringes that deliver effector proteins to host cells, hijacking host cell function. Here we show that the T3SS of enterohemorrhagic E. coli (EHEC) is cleaved by self and microbiota-derived proteases. Self-cleavage limits effector translocation, while cleavage by the microbiota member Bacteroides thetaiotamicron ( Bt ) exacerbates effector translocation and lesion formation on epithelial cells.
Indian journal of clinical biochemistry : IJCB, 2018
Renal cell carcinoma is the most common form of the kidney cancer accounting for more than 85% of... more Renal cell carcinoma is the most common form of the kidney cancer accounting for more than 85% of the cases of which clear cell renal cell carcinoma (ccRCC) is the major histological subtype. The central molecular signature for ccRCC pathogenesis is the biallelic inactivation of VHL gene due to the presence of mutations/hyper-methylation/complete gene loss, which results in the downstream HIF activation. These events lead to increased tyrosine kinase receptor signalling pathways (RAS/MEK/ERK pathway, PI3K/AKT/mTOR pathway and NF-κB pathway), which through their downstream effector proteins causes the cell to proliferate and migrate. Recent studies have shown that VHL inactivation alone is not sufficient to induce the tumor. Mutations in numerous other genes that codes for chromatin modifiers (PBRM1, SETD2 and BAP1) and signalling proteins (PTEN and mTOR) have been identified along with activation of alternate signalling pathways like STAT and Sonic Hedgehog (SHH) pathway. It has als...
Gene, Jan 23, 2018
The regulation of histone 3 lysine 4 (H3K4) methylation codeis indispensable for the cell as any ... more The regulation of histone 3 lysine 4 (H3K4) methylation codeis indispensable for the cell as any disturbance in this has been associated with many pathologic conditions, like cancer. The SET domain-containing lysine methyltransferase 2 (KMT2) family of histone methyltransferases was the first to be identified as writers of H3K4 methylation. In mammals, seven members of the KMT2 family are responsible for carrying out the bulk of H3K4 methylation. Recent studies documented alterations in various histone methylases in human cancer, which were associated with therapeutic and prognostic potential. Notwithstanding, no report has documented the role of KMT2 family of histone methyltransferases in clear cell renal cell carcinoma (ccRCC). Therefore, we examined the expression profile of all the seven KMT2 family members of histone methyltransferases in ccRCC with the aim to establish their role as prognostic or therapeutic targets. Real-time PCR was employed to study the expression of KMT2 ...
Frontiers in nutrition, 2018
Biofortification is an upcoming, promising, cost-effective, and sustainable technique of deliveri... more Biofortification is an upcoming, promising, cost-effective, and sustainable technique of delivering micronutrients to a population that has limited access to diverse diets and other micronutrient interventions. Unfortunately, major food crops are poor sources of micronutrients required for normal human growth. The manuscript deals in all aspects of crop biofortification which includes-breeding, agronomy, and genetic modification. It tries to summarize all the biofortification research that has been conducted on different crops. Success stories of biofortification include lysine and tryptophan rich quality protein maize (World food prize 2000), Vitamin A rich orange sweet potato (World food prize 2016); generated by crop breeding, oleic acid, and stearidonic acid soybean enrichment; through genetic transformation and selenium, iodine, and zinc supplementation. The biofortified food crops, especially cereals, legumes, vegetables, and fruits, are providing sufficient levels of micronut...
Transboundary and emerging diseases, Jan 24, 2017
Bluetongue (BT) and peste-des-petits-ruminants (PPR) are major transboundary diseases of small ru... more Bluetongue (BT) and peste-des-petits-ruminants (PPR) are major transboundary diseases of small ruminant, which are endemic in India. Testing of bluetongue virus (BTV) and peste-des-petits-ruminants virus (PPRV) from recent outbreaks (2015-2016) in different regions of Haryana State of India revealed that 27.5% of the samples showed the presence of dual infection of BTV and PPRV. Analysis of Seg-2 of BTV (the serotype-determining protein) showed the presence of BTV-12w in several isolates. However, analysis of N gene fragment amplicons showed that viruses belong to lineage IV were most closely related to a pathogenic strain of PPRV from Delhi. This is the first report of co-circulation of PPRV lineage IV and bluetongue virus serotype 12 in the state.
Environmental Science and Pollution Research, 2016
An experiment was conducted under three levels of atmospheric CO2 [ambient (398 ± 10 μmol mol(-1)... more An experiment was conducted under three levels of atmospheric CO2 [ambient (398 ± 10 μmol mol(-1)), elevated (570 ± 10 μmol mol(-1)) and open condition], three levels of temperature (4, 25, and 40 °C) to study the degradation pattern of flubendiamide in soil and also carbon mineralization in soil. Results of this study revealed that flubendiamide was found to persist longer under outdoor condition (T1/2, 177.0 and 181.1 days) than ambient (T1/2, 168.4 and 172.3 days) and elevated condition (T1/2, 159.3 and 155.3 days) at 1 and 10 μg g(-1) fortification level, respectively. Results also revealed that flubendiamide dissipated faster at 40 °C (T1/2, 189.4 days) than 25 °C (T1/2, 225.3 days). Slower dissipation was recorded at 4 °C (T1/2, 326.3 days). Thus, increased CO2 levels and temperature following global warming might adversely affect flubendiamide degradation in soil. Laboratory study on microbial biomass carbon (MBC) and carbon mineralization (Cmin) in soil revealed that in des-iodo flubendiamide-treated soils, MBC significantly increased up to 45 days and then decreased. Flubendiamide-treated soil showed a non-significantly decreasing trend of soil MBC with time up to the 15th day of incubation and after 15 days significantly decreased up to 90 days of incubation. In des-iodo flubendiamide-treated soil, the evolution of CO2 decreased up to 45 days, which was increased after 45 days up to 90 days. In flubendiamide-treated soil, CO2 evolution decreased up to 30 days and after 45 days, it increased up to 90 days.
Journal of Nigeria Society of Physiotherapy, Jul 7, 2012
ABSTRACT Background & Objective: Decreased ability to maintain balance may be associated with... more ABSTRACT Background & Objective: Decreased ability to maintain balance may be associated with an increased risk of falling. In older adults, falls commonly leads to injury, loss of independence, associated illness and early death. Although some exercise interventions with balance and muscle strengthening components have been shown to reduce falls but it is not known which element or combination of elements, of exercise interventions are most effective for improving balance in older people. Age-related changes in the ability to adjust to alterations in sensory information contribute to impaired postural stability. The purpose of this randomized controlled trial was to investigate the effect of perceptual learning exercises on static balance in normal healthy geriatric population. Method: A total of 28 healthy elderly subjects (19 female & 9 male) participated in this randomized two-group parallel controlled trial. The whole population was divided into Control (group A) & Experimental (group B) by convenient sampling method. Static balance in terms of Postural sway of all subjects was measured with the help of trivially made Swaymeter before and after treatment protocol. Intervention: The experimental group received Perceptual Learning exercises i.e. hardness discrimination task using three different levels of hardness of a rubber sponge for 10 days whereas Control group received Conventional physiotherapy exercises for postural control such as maintenance of standing balance with forward & backward perturbations, shift of the weight loads to both side of the foot on the health meter and tandem walking. Results: Multivariable ‘t’ test (dependent and independent) showed that the group receiving hardness discrimination tasks showed remarkable decrease in postural sway, meaning statistical significant effect in improving static balance at most of the intervals.
Journal of Buffalo Science, 2015
The present study was aimed to isolate and characterize phenotypically as well as genotypically b... more The present study was aimed to isolate and characterize phenotypically as well as genotypically bacterial strain from tracheal froth of a Murrah buffalo on the Government livestock farm (GLF) located at Hisar, Haryana. The isolate showed the cultural, morphological and biochemical properties of Mannheimia haemolytica as per Bergey's manual of determinative bacteriology and as confirmed by GENIII microplate (biolog). However, the isolate was further confirmed as Mannheimia varigena by 16S rRNA sequencing.
Journal of Immunology and Immunopathology, 2012
Fowl typhoid caused by Salmonella enterica serovar Gallinarum remains to be a major problem for p... more Fowl typhoid caused by Salmonella enterica serovar Gallinarum remains to be a major problem for poultry health worldwide. The emergence of multidrug-resistant strains of Salmonella with increased virulence and survivability, leading to increased morbidity and mortality, has further complicated its management. Presently available vaccines against fowl typhoid have less-than-desired efficacy and unacceptable side effects, making it pertinent to search for new immunogens suitable for vaccine formulation. The outer membrane proteins (OMPs) of Salmonella have been considered as possible candidates for protection against typhoid. The present study was conducted to characterise the OMPs of Salmonella enterica serovar Gallinarum using immunodiffusion and western blot techniques. Presence of three precipitation lines against OMP preparation in immunodiffusion test indicated the presence of at least three immunogenic OMPs in S. Gallinarum. Further, western blot analysis revealed OMP 40 as one of the most immunopotent antigen. This study suggests that OMP 40 may be the suitable target for the development of vaccine formulation against fowl typhoid.
Lecture Notes in Computer Science, 2004
We describe how an ’in house’ classifier can enhance the performance of a commercial ’black box’ ... more We describe how an ’in house’ classifier can enhance the performance of a commercial ’black box’ classifier using the classic serial multiple classifier combination scheme. It is now acknowledged by the classifier combination community that parallel or hybrid decision fusion algorithms, in general, outperform serial combination schemes. However, classifier combination using techniques that use class labeling, ranking or probability estimators
SPIE Proceedings, 2006
This paper introduces a document clustering method within a commercial document repository, FileS... more This paper introduces a document clustering method within a commercial document repository, FileShare. FileShare is a commercial collaborative digital library offering facilities for sharing and accessing documents over a simple Internet browser (eg Microsoft Internet ...
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 2011
We report a case of sudden unilateral sensorineural hearing loss of sudden onset during an aeropl... more We report a case of sudden unilateral sensorineural hearing loss of sudden onset during an aeroplane flight, which completely resolved during a roller coaster ride at Alton Towers theme park. A review of the literature concerning sudden idiopathic sensorineural hearing loss and spontaneous resolution are discussed. Initially, pure-tone audiometry showed a profound sensorineural hearing loss in the right ear and mild sensorineural hearing loss in the left ear (of note, the hearing was normal prior to the episode). Following resolution of the patient's symptoms during a roller coaster ride, pure-tone audiometry showed normal hearing thresholds in both ears. Sudden sensorineural hearing loss is a symptom of cochlear injury and the mechanism of the patient's symptoms was attributed to a patent cochlear aqueduct.
Lecture Notes in Computer Science
This paper introduces a toolkit that allows programmers with no linguistic knowledge to rapidly d... more This paper introduces a toolkit that allows programmers with no linguistic knowledge to rapidly develop a Spoken Language User Interface (SLUI) for various applications. The applications may vary from web-based e-commerce to the control of domestic appliances. Using the SLUI Toolkit, a programmer is able to create a system that incorporates Natural Language Processing (NLP), complex syntactic parsing, and semantic understanding. The system has been tested using ten human evaluators in a specific domain of a web based e-commerce application. The evaluators have overwhelmingly endorsed the ease of use and applicability of the tool kit in rapid development of speech and natural language processing interfaces for this domain.
Proceedings of the 19th international conference on Computational linguistics -, 2002
With the rapid growth of real application domains for NLP systems, there is a genuine demand for ... more With the rapid growth of real application domains for NLP systems, there is a genuine demand for a general toolkit from which programmers with no linguistic knowledge can build specific NLP systems. Such a toolkit should provide an interface to accept sample sentences and convert them into semantic representations so as to allow programmers to map them to domain actions. In order to reduce the workload of managing a large number of semantic forms individually, the toolkit will perform what we call semantic grouping to organize the forms into meaningful groups. In this paper, we present three semantic grouping methods: similaritybased, verb-based and category-based grouping, and their implementation in the SLUI toolkit. We also discuss the pros and cons of each method and how they can be utilized according to the different domain needs.
Veterinary World, 2013
Bluetongue (BT) is a noncontagious, vector-borne disease of domestic and wild ruminants. The caus... more Bluetongue (BT) is a noncontagious, vector-borne disease of domestic and wild ruminants. The causative agent bluetongue virus (BTV) is a double stranded RNA virus belonging to genus Orbivirus within family Reoviridae. Eradication of BTV from endemic regions like India is not an easy task due to the widely distributed Culicoides spp. midge vectors, the ubiquitous distribution of vertebrate hosts and existence of a large number of serotypes of the virus (at least 26 till date). The complete genomes (19,193 base-pairs) of several strains of bluetongue virus serotype 16 (BTV-16) originated from Australia, China, Indian subcontinent, Mediterranean basin, Middle East, Africa (Nigeria) and Europe, were compared. These analysis showed that all ten genome segments of a Nigerian strain are derived from a western lineage, showing only 77%-84% nt identity with the eastern topotype reference strain 'RSArrrr/16' (and its derivative 'RSAvvvv/16', a vaccine strain) that was originally isolated in Pakistan, 76.4%-83% with eastern BTV-16 strain from Australia (DPP96) and 77%-89% with a reassortant strain from India. These detailed comparisons involving global strains showed that there is a very high degree of variation (up to 24%) between BTV-16 strains from eastern and western geographical regions. These data confirm the value of whole genome sequencing for characterization of novel BTV isolates and has helped to identify representative suitable 'reference-strain' of eastern topotype (BTV-16e), western topotype (BTV-16w), as well as 'cross-topotype' reassortant strain (BTV-16r) that are generated in the field for further serological, phylogenetic and molecular epidemiology studies.
Proceedings of the 19th international conference on Computational linguistics -, 2002
With the rapid growth of real world applications for NLP systems, there is a genuine demand for a... more With the rapid growth of real world applications for NLP systems, there is a genuine demand for a general toolkit from which programmers with no linguistic knowledge can build specific NLP systems. Such a toolkit should have a parser that is general enough to be used across domains, and yet accurate enough for each specific application. In this paper, we describe a parser that extends a broad-coverage parser, Minipar (Lin, 2001), with an adaptable shallow parser so as to achieve both generality and accuracy in handling domain specific NL problems. We test this parser on our corpus and the results show that the accuracy is significantly higher than a system that uses Minipar alone.
International Conference on Artificial Intelligence, 2008
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Papers by Aman Kumar BASM, SPUP