The Journal of Jewish Thought and Philosophy, 2018
In his writings, Rabbi Isaac Hutner integrated various insights from secular philosophy and parti... more In his writings, Rabbi Isaac Hutner integrated various insights from secular philosophy and particularly from existentialist thought. Concerns regarding temporality, authenticity, and death permeate his thought. This article deals with what we call “being-towards-eternity,” a modification of Martin Heidegger’s “being-towards-death,” through which Hutner seeks to reconcile genuine anxiety in the face of finitude with an unwavering belief in resurrection and life after death. Hutner’s appropriation and adaptation of this Heideggerian notion demonstrates how he adopted secular ideas while cautiously remaining within the boundaries of traditional Jewish concerns and vocabulary.
University of Minnesota M.S. thesis. May 2019. Major: Dentistry. Advisors: Larry Wolff, Massimo C... more University of Minnesota M.S. thesis. May 2019. Major: Dentistry. Advisors: Larry Wolff, Massimo Costalonga. 1 computer file (PDF); ix, 70 pages.
Many medical and biological protocols for analyzing individual biological cells involve morpholog... more Many medical and biological protocols for analyzing individual biological cells involve morphological evaluation based on cell staining, designed to enhance imaging contrast and enable clinicians and biologists to differentiate between various cell organelles. However, cell staining is not always allowed in certain medical procedures. In other cases, staining may be time consuming or expensive to implement. Here, we present a new deep-learning approach, called HoloStain, which converts images of isolated biological cells acquired without staining by holographic microscopy to their virtually stained images. We demonstrate this approach for human sperm cells, as there is a well-established protocol and global standardization for characterizing the morphology of stained human sperm cells for fertility evaluation, but, on the other hand, staining might be cytotoxic and thus is not allowed during human in vitro fertilization (IVF). We use deep convolutional Generative Adversarial Network...
Proceedings of the National Academy of Sciences, 2020
Significance We present a method for virtual staining for morphological analysis of individual bi... more Significance We present a method for virtual staining for morphological analysis of individual biological cells based on stain-free digital holography, allowing clinicians and biologists to visualize and analyze the cells as if they have been chemically stained. Our approach provides numerous advantages, as it 1) circumvents the possible toxicity of staining materials, 2) saves time and resources, 3) optimizes inter- and intralab variability, 4) allows concurrent staining of different types of cells with multiple virtual stains, and 5) provides ideal conditions for real-time analysis, such as rapid stain-free imaging flow cytometry. The proposed method is shown to be accurate, repeatable, and nonsubjective. Hence, it bears great potential to become a common tool in clinical settings and biological research.
GBR is a technique sensitive procedure that routinely involves placement of particulate bone with... more GBR is a technique sensitive procedure that routinely involves placement of particulate bone with or without fixation screws and either a resorbable or a non-resorbable membrane. Grafting of the buccal-crestal aspect of the implant site can be particularly challenging as external pressure from the flap or occlusal forces may displace the graft laterally and apically resulting in deficient bone in the desired region. A novel technique for stabilizing a resorbable membrane and underlying particulate graft allowing for predictable bone grafting across multiple edentulous sites. The use of both resorbable sutures and membrane eliminates the need for a retrieval surgery, thereby minimizing the associated risk and co-morbidities of this secondary surgery.
An endovascular system (10) includes an endovascular implant (20) and a delivery tool (30). The i... more An endovascular system (10) includes an endovascular implant (20) and a delivery tool (30). The implant (20) is configured to assume a radially-compressed delivery state, and a radially-expanded deployment state. The delivery tool (30) includes a proximal main delivery catheter (36), having a distal portion (46) in which the implant (20) is disposed while in the radially-compressed delivery state; and a distal restraining assembly (50), which includes a restraining-assembly tubular shaft (52) disposed distal to the proximal main delivery catheter (36).; The distal restraining assembly (50) is configured to assume an engaged state, in which the distal restraining assembly (50) prevents proximal displacement of the implant (20) relative to the distal restraining assembly (50), and a disengaged state, in which the distal restraining assembly (50) allows proximal displacement of the implant (20) relative to the distal restraining assembly (50). Other embodiments are also described.
The Journal of Jewish Thought and Philosophy, 2018
In his writings, Rabbi Isaac Hutner integrated various insights from secular philosophy and parti... more In his writings, Rabbi Isaac Hutner integrated various insights from secular philosophy and particularly from existentialist thought. Concerns regarding temporality, authenticity, and death permeate his thought. This article deals with what we call “being-towards-eternity,” a modification of Martin Heidegger’s “being-towards-death,” through which Hutner seeks to reconcile genuine anxiety in the face of finitude with an unwavering belief in resurrection and life after death. Hutner’s appropriation and adaptation of this Heideggerian notion demonstrates how he adopted secular ideas while cautiously remaining within the boundaries of traditional Jewish concerns and vocabulary.
University of Minnesota M.S. thesis. May 2019. Major: Dentistry. Advisors: Larry Wolff, Massimo C... more University of Minnesota M.S. thesis. May 2019. Major: Dentistry. Advisors: Larry Wolff, Massimo Costalonga. 1 computer file (PDF); ix, 70 pages.
Many medical and biological protocols for analyzing individual biological cells involve morpholog... more Many medical and biological protocols for analyzing individual biological cells involve morphological evaluation based on cell staining, designed to enhance imaging contrast and enable clinicians and biologists to differentiate between various cell organelles. However, cell staining is not always allowed in certain medical procedures. In other cases, staining may be time consuming or expensive to implement. Here, we present a new deep-learning approach, called HoloStain, which converts images of isolated biological cells acquired without staining by holographic microscopy to their virtually stained images. We demonstrate this approach for human sperm cells, as there is a well-established protocol and global standardization for characterizing the morphology of stained human sperm cells for fertility evaluation, but, on the other hand, staining might be cytotoxic and thus is not allowed during human in vitro fertilization (IVF). We use deep convolutional Generative Adversarial Network...
Proceedings of the National Academy of Sciences, 2020
Significance We present a method for virtual staining for morphological analysis of individual bi... more Significance We present a method for virtual staining for morphological analysis of individual biological cells based on stain-free digital holography, allowing clinicians and biologists to visualize and analyze the cells as if they have been chemically stained. Our approach provides numerous advantages, as it 1) circumvents the possible toxicity of staining materials, 2) saves time and resources, 3) optimizes inter- and intralab variability, 4) allows concurrent staining of different types of cells with multiple virtual stains, and 5) provides ideal conditions for real-time analysis, such as rapid stain-free imaging flow cytometry. The proposed method is shown to be accurate, repeatable, and nonsubjective. Hence, it bears great potential to become a common tool in clinical settings and biological research.
GBR is a technique sensitive procedure that routinely involves placement of particulate bone with... more GBR is a technique sensitive procedure that routinely involves placement of particulate bone with or without fixation screws and either a resorbable or a non-resorbable membrane. Grafting of the buccal-crestal aspect of the implant site can be particularly challenging as external pressure from the flap or occlusal forces may displace the graft laterally and apically resulting in deficient bone in the desired region. A novel technique for stabilizing a resorbable membrane and underlying particulate graft allowing for predictable bone grafting across multiple edentulous sites. The use of both resorbable sutures and membrane eliminates the need for a retrieval surgery, thereby minimizing the associated risk and co-morbidities of this secondary surgery.
An endovascular system (10) includes an endovascular implant (20) and a delivery tool (30). The i... more An endovascular system (10) includes an endovascular implant (20) and a delivery tool (30). The implant (20) is configured to assume a radially-compressed delivery state, and a radially-expanded deployment state. The delivery tool (30) includes a proximal main delivery catheter (36), having a distal portion (46) in which the implant (20) is disposed while in the radially-compressed delivery state; and a distal restraining assembly (50), which includes a restraining-assembly tubular shaft (52) disposed distal to the proximal main delivery catheter (36).; The distal restraining assembly (50) is configured to assume an engaged state, in which the distal restraining assembly (50) prevents proximal displacement of the implant (20) relative to the distal restraining assembly (50), and a disengaged state, in which the distal restraining assembly (50) allows proximal displacement of the implant (20) relative to the distal restraining assembly (50). Other embodiments are also described.
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