Type 1 diabetes is an organ-specific autoimmune disease that is mediated by autoreactive T cells.... more Type 1 diabetes is an organ-specific autoimmune disease that is mediated by autoreactive T cells.We show here that administration of a soluble dimeric peptide-major histocompatibility complex (pMHC) class II chimera (DEF) to prediabetic double-transgenic mice prevents the onset of disease or, in animals that are already diabetic, restores normoglycemia.The antidiabetogenic effects of DEF rely on the induction of anergy in splenic autoreactive CD4 + T cells via alteration of early T cell receptor signaling and stimulation of interleukin 10-secreting T regulatory type 1 cells in the pancreas. Soluble dimeric pMHC class II may be useful in the development of immunospecific therapies for type 1 diabetes.
Type 1 diabetes is an organ-specific autoimmune disease that is mediated by autoreactive T cells.... more Type 1 diabetes is an organ-specific autoimmune disease that is mediated by autoreactive T cells.We show here that administration of a soluble dimeric peptide-major histocompatibility complex (pMHC) class II chimera (DEF) to prediabetic double-transgenic mice prevents the onset of disease or, in animals that are already diabetic, restores normoglycemia.The antidiabetogenic effects of DEF rely on the induction of anergy in splenic autoreactive CD4 + T cells via alteration of early T cell receptor signaling and stimulation of interleukin 10-secreting T regulatory type 1 cells in the pancreas. Soluble dimeric pMHC class II may be useful in the development of immunospecific therapies for type 1 diabetes.
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Papers by Alicia Hurtado