Journal of Orthopaedics, Trauma and Rehabilitation, Apr 7, 2022
The degree of joint space narrowing measured on radiographs provide a reliable estimate of the ex... more The degree of joint space narrowing measured on radiographs provide a reliable estimate of the extent and severity of Osteoarthritis (OA) of the knee. While the standing antero-posterior (AP) view radiographs have been used traditionally, recent studies suggest that the Lyon-Schuss (LS) view is able to detect early OA changes better. The present study was, therefore, conducted to make an objective comparison between the two views with respect to their corelation with the patient's clinical and radiological scores. Forty patients (80 knees) were included in this cross-sectional study. Medial as well as lateral tibiofemoral joint space widths (JSW) were measured using vernier callipers on printed, calibrated radiographic images. Knee Society Score (Function) (KSS-F) was used as the clinical outcome measure while Ahlbäck grade was used for determining radiological severity. JSW was correlated with KSS-F and the Ahlbäck grade using Spearman's rho correlation coefficient. Reproducibility of the method was assessed using the intra-class correlation coefficient (ICC). Average age of the participants was 60 ± 7.65 (range 50–78) years, with 18 males and 22 females. ICC for intraobserver reliability was 0.97 and for inter-observer reliability, was 0.91 (AP view) and 0.92 (LS view), respectively. Medial JSW measurements taken on the AP view were found to have a significantly higher degree of correlation with both KSS-F and Ahlbäck grade ( p < 0.05) than those obtained from the LS view. Although the LS view may be more sensitive for detecting early OA changes in knee, particularly in the lateral tibiofemoral compartment, the present study shows that AP view correlates better with the patient's overall clinical and radiological profile.
Cervical cancer is the leading cause of death in women, mainly in developing countries, including... more Cervical cancer is the leading cause of death in women, mainly in developing countries, including India. Recent advancements in technologies could allow for more rapid, cost-effective, and sensitive screening and treatment measures for cervical cancer. To this end, deep learning-based methods have received importance for classifying cervical cancer patients into different risk groups. Furthermore, deep learning models are now available to study the progression and treatment of cancerous cervical conditions. Undoubtedly, deep learning methods can enhance our knowledge toward a better understanding of cervical cancer progression. However, it is essential to thoroughly validate the deep learning-based models before they can be implicated in everyday clinical practice. This work reviews recent development in deep learning approaches employed in cervical cancer diagnosis and prognosis. Further, we provide an overview of recent methods and databases leveraging these new approaches for cervical cancer risk prediction and patient outcomes. Finally, we conclude the state-of-the-art approaches for future research opportunities in this domain.
Mucormycosis, also known as Zygomycosis or Black Fungus, is an infection caused in humans via var... more Mucormycosis, also known as Zygomycosis or Black Fungus, is an infection caused in humans via various causative agents from the Zygomycetes class. Several countries including India is afflicted by the covid-19 virus, which has infected approximately 3.7 million people across the country. Some of the corona-positive patients suffer from another fatal infection, Mucormycosis, commonly known as Black Fungus. The strategy should be to administer an effective antifungal drug as soon as possible at the optimum dose. However, India being an epicenter of Diabetes with enormous 80 million diabetics, is of particular importance in the present scenario of the COVID pandemic. COVID therapy with Steroids and immune suppressants has increased the chances of infection in various individuals within the country with weaker immune system responses. The main purpose of this paper is to enlighten the community about the involvement of mucormycosis in covid-19 affected population and basic insights of i...
2018 4th International Conference for Convergence in Technology (I2CT), 2018
Today's computational genomics performs a very large scale database search of genomic data. T... more Today's computational genomics performs a very large scale database search of genomic data. The difficulty lies in extracting information from these databases to obtain optimum alignments. The alignment score is a critical parameter to find the similarities between two DNA sequences. The higher score implies high ratio of similarity. In the current paper global alignment based on Needleman-Wunsch Algorithm and local alignment based on Smith-Waterman Algorithm are implemented on PSOC4 with a core comprising of ARM Cortex-MO and the alignment score is calculated. The paper presents implementation and comparison of both algorithms based on different parameters like the execution time.
Journal of emerging technologies and innovative research, 2020
Nanoparticles is the emerging technique in current era and thus the following review paper presen... more Nanoparticles is the emerging technique in current era and thus the following review paper present the synthesis of silver nanoparticles and application towards its uses as antiviral activity. The silver nanoparticles have diverted the mass attention of the scientific community and medical professionals due to their wide range of application in the biomedical fields. It especially has effective use against the microbes and infectious agents. An antiviral Nano-coatings developed by Professor Ashwini Kumar Agrawal of Indian Institute of Technology, Delhi has been approved by the Department of Science and Technology (DST), India for producing anti-COVID-19 Triple Layer Medical masks. As Silver is known to have strong antimicrobial activity against bacteria, viruses, fungus, and so on it can be used for producing these triple layer masks. In this review paper the various techniques are explained for the preparation of silver nanoparticles. Along with its importance, applications in the ...
Background: The objective of this study was to compare the outcomes and complications of patients... more Background: The objective of this study was to compare the outcomes and complications of patients who underwent either the calcaneal skeletal traction (CST) or the elastic intramedullary nails (EIN) procedure. Methods: We retrospectively reviewed data of patients who underwent EIN or CST surgery for tibia shaft fracture at our center from 2013 to 2018. The patient demographics, fracture characteristics, radiographic information, length of hospital stay, and medical expenses were recorded. All patients were clinically followed-up until they started to walk or for at least 6 months. The treatment outcomes and postoperative complications of the two procedures were compared. Results: Overall, 186 patients who underwent EIN and CST were included in the study. The EIN patients had more low-energy mechanism of injury. In radiographic evaluation, significant differences were observed in distributions of fracture classification and location. Moreover, associated fibula fractures were higher in the EIN group than in the CST group. The CST procedure had faster surgical time, cast duration and lower expenses, and longer hospitalization time. Although they required more clinical visits, patients in the EIN group began exercising and endured weight-bearing earlier than those in the CST group. The average time for bone healing was 68.5 days in the EIN group, and 69.6 days in the CST group. However, the CST provided slight better results of coronal correction than EIN. Moreover, CST patients had less malalignment (> 5 °) in complications. None had delay union, nonunion, and shortening over 10 mm at final assessment. Conclusions: Both EIN and CST patients showed similar treatment outcomes. Hence, not only the characteristics of the patient and fracture, but also the individual's situation and expectation should be considered when choosing the best approach.
Eagle′s syndrome, also known as an elongated styloid process, is a condition that may be the sour... more Eagle′s syndrome, also known as an elongated styloid process, is a condition that may be the source of craniofacial and cervical pain. It is infrequently reported but is probably more common than generally considered. The symptoms related to Eagle′s syndrome can be confused with those attributed to a wide variety of facial neuralgias and/or oral, dental, and temporomandibular joint diseases. Surgical treatment is considered as the best option to remove the styloid process to its normal limit through extraoral or intraoral techniques. We are reporting a case and reviewed the recent literature of trans-oral extratonsillar approach without tonsillectomy and advantage such as simple, time-saving, and without any extra oral scar.
Objective: This paper analyzes the power of a digital clock with the help of Xilinx ISE V-14.2 an... more Objective: This paper analyzes the power of a digital clock with the help of Xilinx ISE V-14.2 and executing it on virtex-6 FPGA and Spartan 3E FPGA. Methods: On FPGA we use Verilog HDL to synthesize the clock where the targeted device is FPGA. Analysis of different IO Standard on Xilinx software depicts the least power consumption for 2 different frequencies. Findings: With the results portrayed in the paper we get a combination of perfect low power consuming IC design. Xilinx XPower analyzer has been used to analyze the power consumption of digital clock based on FPGA. Further power utilization using different IO standards at different frequency has been decreased effectively. The device when operating at 50 Mega Hertz and 100 Mega Hertz frequency the reduction of power is attained. Application: This low power consuming IC design will be useful wherever digital clock is used and energy efficiency is to be attained.
Journal of Orthopaedics, Trauma and Rehabilitation, Apr 7, 2022
The degree of joint space narrowing measured on radiographs provide a reliable estimate of the ex... more The degree of joint space narrowing measured on radiographs provide a reliable estimate of the extent and severity of Osteoarthritis (OA) of the knee. While the standing antero-posterior (AP) view radiographs have been used traditionally, recent studies suggest that the Lyon-Schuss (LS) view is able to detect early OA changes better. The present study was, therefore, conducted to make an objective comparison between the two views with respect to their corelation with the patient's clinical and radiological scores. Forty patients (80 knees) were included in this cross-sectional study. Medial as well as lateral tibiofemoral joint space widths (JSW) were measured using vernier callipers on printed, calibrated radiographic images. Knee Society Score (Function) (KSS-F) was used as the clinical outcome measure while Ahlbäck grade was used for determining radiological severity. JSW was correlated with KSS-F and the Ahlbäck grade using Spearman's rho correlation coefficient. Reproducibility of the method was assessed using the intra-class correlation coefficient (ICC). Average age of the participants was 60 ± 7.65 (range 50–78) years, with 18 males and 22 females. ICC for intraobserver reliability was 0.97 and for inter-observer reliability, was 0.91 (AP view) and 0.92 (LS view), respectively. Medial JSW measurements taken on the AP view were found to have a significantly higher degree of correlation with both KSS-F and Ahlbäck grade ( p < 0.05) than those obtained from the LS view. Although the LS view may be more sensitive for detecting early OA changes in knee, particularly in the lateral tibiofemoral compartment, the present study shows that AP view correlates better with the patient's overall clinical and radiological profile.
Cervical cancer is the leading cause of death in women, mainly in developing countries, including... more Cervical cancer is the leading cause of death in women, mainly in developing countries, including India. Recent advancements in technologies could allow for more rapid, cost-effective, and sensitive screening and treatment measures for cervical cancer. To this end, deep learning-based methods have received importance for classifying cervical cancer patients into different risk groups. Furthermore, deep learning models are now available to study the progression and treatment of cancerous cervical conditions. Undoubtedly, deep learning methods can enhance our knowledge toward a better understanding of cervical cancer progression. However, it is essential to thoroughly validate the deep learning-based models before they can be implicated in everyday clinical practice. This work reviews recent development in deep learning approaches employed in cervical cancer diagnosis and prognosis. Further, we provide an overview of recent methods and databases leveraging these new approaches for cervical cancer risk prediction and patient outcomes. Finally, we conclude the state-of-the-art approaches for future research opportunities in this domain.
Mucormycosis, also known as Zygomycosis or Black Fungus, is an infection caused in humans via var... more Mucormycosis, also known as Zygomycosis or Black Fungus, is an infection caused in humans via various causative agents from the Zygomycetes class. Several countries including India is afflicted by the covid-19 virus, which has infected approximately 3.7 million people across the country. Some of the corona-positive patients suffer from another fatal infection, Mucormycosis, commonly known as Black Fungus. The strategy should be to administer an effective antifungal drug as soon as possible at the optimum dose. However, India being an epicenter of Diabetes with enormous 80 million diabetics, is of particular importance in the present scenario of the COVID pandemic. COVID therapy with Steroids and immune suppressants has increased the chances of infection in various individuals within the country with weaker immune system responses. The main purpose of this paper is to enlighten the community about the involvement of mucormycosis in covid-19 affected population and basic insights of i...
2018 4th International Conference for Convergence in Technology (I2CT), 2018
Today's computational genomics performs a very large scale database search of genomic data. T... more Today's computational genomics performs a very large scale database search of genomic data. The difficulty lies in extracting information from these databases to obtain optimum alignments. The alignment score is a critical parameter to find the similarities between two DNA sequences. The higher score implies high ratio of similarity. In the current paper global alignment based on Needleman-Wunsch Algorithm and local alignment based on Smith-Waterman Algorithm are implemented on PSOC4 with a core comprising of ARM Cortex-MO and the alignment score is calculated. The paper presents implementation and comparison of both algorithms based on different parameters like the execution time.
Journal of emerging technologies and innovative research, 2020
Nanoparticles is the emerging technique in current era and thus the following review paper presen... more Nanoparticles is the emerging technique in current era and thus the following review paper present the synthesis of silver nanoparticles and application towards its uses as antiviral activity. The silver nanoparticles have diverted the mass attention of the scientific community and medical professionals due to their wide range of application in the biomedical fields. It especially has effective use against the microbes and infectious agents. An antiviral Nano-coatings developed by Professor Ashwini Kumar Agrawal of Indian Institute of Technology, Delhi has been approved by the Department of Science and Technology (DST), India for producing anti-COVID-19 Triple Layer Medical masks. As Silver is known to have strong antimicrobial activity against bacteria, viruses, fungus, and so on it can be used for producing these triple layer masks. In this review paper the various techniques are explained for the preparation of silver nanoparticles. Along with its importance, applications in the ...
Background: The objective of this study was to compare the outcomes and complications of patients... more Background: The objective of this study was to compare the outcomes and complications of patients who underwent either the calcaneal skeletal traction (CST) or the elastic intramedullary nails (EIN) procedure. Methods: We retrospectively reviewed data of patients who underwent EIN or CST surgery for tibia shaft fracture at our center from 2013 to 2018. The patient demographics, fracture characteristics, radiographic information, length of hospital stay, and medical expenses were recorded. All patients were clinically followed-up until they started to walk or for at least 6 months. The treatment outcomes and postoperative complications of the two procedures were compared. Results: Overall, 186 patients who underwent EIN and CST were included in the study. The EIN patients had more low-energy mechanism of injury. In radiographic evaluation, significant differences were observed in distributions of fracture classification and location. Moreover, associated fibula fractures were higher in the EIN group than in the CST group. The CST procedure had faster surgical time, cast duration and lower expenses, and longer hospitalization time. Although they required more clinical visits, patients in the EIN group began exercising and endured weight-bearing earlier than those in the CST group. The average time for bone healing was 68.5 days in the EIN group, and 69.6 days in the CST group. However, the CST provided slight better results of coronal correction than EIN. Moreover, CST patients had less malalignment (> 5 °) in complications. None had delay union, nonunion, and shortening over 10 mm at final assessment. Conclusions: Both EIN and CST patients showed similar treatment outcomes. Hence, not only the characteristics of the patient and fracture, but also the individual's situation and expectation should be considered when choosing the best approach.
Eagle′s syndrome, also known as an elongated styloid process, is a condition that may be the sour... more Eagle′s syndrome, also known as an elongated styloid process, is a condition that may be the source of craniofacial and cervical pain. It is infrequently reported but is probably more common than generally considered. The symptoms related to Eagle′s syndrome can be confused with those attributed to a wide variety of facial neuralgias and/or oral, dental, and temporomandibular joint diseases. Surgical treatment is considered as the best option to remove the styloid process to its normal limit through extraoral or intraoral techniques. We are reporting a case and reviewed the recent literature of trans-oral extratonsillar approach without tonsillectomy and advantage such as simple, time-saving, and without any extra oral scar.
Objective: This paper analyzes the power of a digital clock with the help of Xilinx ISE V-14.2 an... more Objective: This paper analyzes the power of a digital clock with the help of Xilinx ISE V-14.2 and executing it on virtex-6 FPGA and Spartan 3E FPGA. Methods: On FPGA we use Verilog HDL to synthesize the clock where the targeted device is FPGA. Analysis of different IO Standard on Xilinx software depicts the least power consumption for 2 different frequencies. Findings: With the results portrayed in the paper we get a combination of perfect low power consuming IC design. Xilinx XPower analyzer has been used to analyze the power consumption of digital clock based on FPGA. Further power utilization using different IO standards at different frequency has been decreased effectively. The device when operating at 50 Mega Hertz and 100 Mega Hertz frequency the reduction of power is attained. Application: This low power consuming IC design will be useful wherever digital clock is used and energy efficiency is to be attained.
Uploads
Papers by Akshat Gupta