Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat, 2004
Maraş powder (MP) is a kind of smokeless tobacco prepared by a mixture of ash and the powder obta... more Maraş powder (MP) is a kind of smokeless tobacco prepared by a mixture of ash and the powder obtained from the leaves of a tobacco plant called "deli tütün" in the region. In this study, we investigated the physical changes occurring in the oral cavity of MP users. A total of 92 subjects (5 females, 87 males; mean age 46.6+/-14.3 years; range 21 to 88) who had been using MP were included in the study. Subjects with a history of MP usage of less than one year duration and those who smoked cigarettes were excluded from the study. Of the patients, 86 applied the MP between the lower labial mucosa and gingiva. All the patients had dental discoloration in varying degrees. There were total dental prosthesis in 12 subjects, partial dental prosthesis in two, absence of incisors in four, and dental decay of varying degrees in 30 cases. Forty-six cases had mild, 15 cases had marked, and 12 cases had severe gingival recession. In 22 cases, there were lesions in the labial mucosa wher...
Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat, 2005
Pilomatrixomas are benign neoplasms of the hair follicle, presenting as a mass in the head and ne... more Pilomatrixomas are benign neoplasms of the hair follicle, presenting as a mass in the head and neck region. Those arising from the parotid region may pose a diagnostic challenge. We present six patients (age range 6 to 68 years) with pilomatrixoma in the head and neck region. The lesions were located in the preauricular region in two cases, and in the periorbital region, the forehead, the neck, and in the dorsum of the nose in the other patients, respectively. The main complaint was a hard, slow-growing mass in all the cases. All the patients were treated surgically. Histopathologic diagnosis was pilomatrixoma. No recurrences or surgery-associated complications were observed in the follow-up period.
The aim of the present study is to investigate the effect of N-acetylcysteine (NAC) given 30 minu... more The aim of the present study is to investigate the effect of N-acetylcysteine (NAC) given 30 minutes before carboplatin administration on carboplatininduced ototoxicity and nitric oxide (NO) levels in a rat model. Study Design: Animal study. Methods: Eighteen Sprague-Dawley rats were divided into three groups that each contained six animals. Intraperitoneal injection of physiologic saline was performed in group 1 twice with an interval of 30 minutes. Group 2 was treated with a single bolus administration of carboplatin at a dose of 256 mg/kg 30 minutes after the intraperitoneal injection of physiologic saline. Group 3 was treated with a single bolus administration of carboplatin at a dose of 256 mg/kg 30 minutes after the intraperitoneal injection of NAC at a dose of 400 mg/kg. Pretreatment and posttreatment distortion product otoacoustic emissions (DPOAE) were performed in rats from all groups. Then, the animals were sacrificed on the fourth day, and cochlear tissue NO and glutathione peroxidase (GSH-Px) levels were measured. Results: The comparison of pre-and posttreatment DPOAE responses did not demonstrate any significant changes for groups 1 and 3. Results of group 2 showed a decrease of the DPOAE amplitude. Cochlear NO levels were significantly higher in rats treated with carboplatin than in controls and in those treated with carboplatin plus NAC (P Ͻ .05). Cochlear GSH-Px levels were higher in rats treated with carboplatin plus NAC than in those treated with carboplatin, but the difference did not reach statistical significance (P ϭ .079). Conclusions: The present study showed that carboplatin at higher doses induced hearing loss and increased NO levels in the cochlea of rats. NAC appears to have a protective effect against carboplatin-induced ototoxicity, which may be related to its inhibitory effect on NO production.
OBJECTIVES: Although there are many reports on adenosine deaminase (ADA) activities in different ... more OBJECTIVES: Although there are many reports on adenosine deaminase (ADA) activities in different tissues, no information is available about the enzyme activity in nasal mucosa and polyp tissues. Whereas ADA is related to the production of free radicals by neutrophils, malondialdehyde (MDA) is an indicator of lipid peroxidation that is a general mechanism of tissue damage by free radicals. This study is aimed at determining and comparing the ADA activity and MDA level in nasal polyps and normal mucosa. STUDY DESIGN AND SETTING: Twenty-three patients with nasal polyps and a control group consisting of 14 patients with septal deviation and lower turbinate hypertrophy were included in the study. Tissue MDA level was measured by the method of Okawa with modification and tissue ADA activity by the method of Giusti. RESULTS: In patients with nasal polyp, mean tissue MDA level and ADA activity were 2.43 ± 0.38 nmol/mg protein (Pr) and 0.235 ± 0.055 U/mg Pr, respectively, which were signific...
The aim of this study was to investigate the effects of noise on hearing, lipid peroxidation and ... more The aim of this study was to investigate the effects of noise on hearing, lipid peroxidation and antioxidant enzymes in textile workers. Thirty textile workers exposed to high noise 105 dB (A) in a textile factory, and 30 healthy male volunteers in our hospital as a control group were included in the study. In both groups, following audiometric tests, blood samples were obtained. In these blood samples, Malonydialdehyte (MDA), Superoxide dismutase (SOD) and Catalase (CAT) levels were investigated. Statistical analysis was performed by using SPSS version 11.0 (SPSS Inc., Chicago 1L) software program. Mean pure tone audiometric thresholds in workers were significantly higher than in control subjects at frequencies 2,000, 4,000 and 6,000 Hz (p<0.05). Hearing losses were more evident at high frequencies (4-6 kHz) than at low frequencies in worker group. (p<0.05). It was observed that textile workers with longer employment duration had poorer hearing threshoulds and the hearing loss had started on those who had worked for 5-8 yr. While MDA levels were significantly higher in workers than controls (p<0.001), CAT activity was significantly lower (p<0.005). Also, SOD activity was lower in workers but difference was not statistically significant. We observed a significant change in hearing threshold of the textile workers compared with that of the control group. Increase in MDA level and decreases in CAT and SOD activities in textile workers, support the opinion that the noise causes the oxidative stress. The fact that noise both causes hearing loss and increases oxidative stress suggests that there may be a relationship between the oxidative stress and hearing loss. But, further studies are needed in order to verify this opinion.
Objectives Puberphonia or mutational falsetto (MF) is seen more in males, and hormonal changes ar... more Objectives Puberphonia or mutational falsetto (MF) is seen more in males, and hormonal changes are considered to be among the aetiological causes. Therefore, the aim of this study was to investigate the molecules [G protein-coupled oestrogen receptor 1 (GPER-1), aromatase, 17-beta-hydroxysteroid dehydrogenase (17β-HSD), cyclic adenosine monophosphate (cAMP) levels] related to receptors and pathways in patients with MF. Methods The study included 30 MF patients and a control group of 30 healthy individuals. Voice recordings were made of the MF patients and acoustic analyses were applied. The serum GPER-1, aromatase, 17β-HSD, cAMP levels and TSH, estradiol, prolactin, progesterone, and testosterone levels were evaluated in venous blood samples. Results In the MF patients, the GPER-1 level determined of mean 3.68 (1.95-4.26) pg/ml, 17 beta dehydrogenase of 5.25 (2.73-6.77) ng/ml, and cAMP of 24.62 (11.62-30.35) ng/ml were statistically signficantly higher than those of the control group (p = 0.008, p = 0.002, p = 0.003, respectively). The aromatase level in the MF patients was found to be 3.48 (2.01-4.91) and the difference between the two groups was not statistically significant (p = 0.067). Conclusion The GPER-1, 17β-HSD, and cAMP levels were found to be higher in the MF patients than in the control group, suggesting that they could be of importance in the diagnosis and treatment of MF. Keywords Mutational falsetto • GPER-1 (G protein-coupled estrogen receptor) • Aromatase • 17 beta hydroxysteroid dehydrogenase (17β-HSD) • Gyclic adenosine monophosphate (cAMP) • Voice analysis
Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat, 2004
Maraş powder (MP) is a kind of smokeless tobacco prepared by a mixture of ash and the powder obta... more Maraş powder (MP) is a kind of smokeless tobacco prepared by a mixture of ash and the powder obtained from the leaves of a tobacco plant called "deli tütün" in the region. In this study, we investigated the physical changes occurring in the oral cavity of MP users. A total of 92 subjects (5 females, 87 males; mean age 46.6+/-14.3 years; range 21 to 88) who had been using MP were included in the study. Subjects with a history of MP usage of less than one year duration and those who smoked cigarettes were excluded from the study. Of the patients, 86 applied the MP between the lower labial mucosa and gingiva. All the patients had dental discoloration in varying degrees. There were total dental prosthesis in 12 subjects, partial dental prosthesis in two, absence of incisors in four, and dental decay of varying degrees in 30 cases. Forty-six cases had mild, 15 cases had marked, and 12 cases had severe gingival recession. In 22 cases, there were lesions in the labial mucosa wher...
Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat, 2005
Pilomatrixomas are benign neoplasms of the hair follicle, presenting as a mass in the head and ne... more Pilomatrixomas are benign neoplasms of the hair follicle, presenting as a mass in the head and neck region. Those arising from the parotid region may pose a diagnostic challenge. We present six patients (age range 6 to 68 years) with pilomatrixoma in the head and neck region. The lesions were located in the preauricular region in two cases, and in the periorbital region, the forehead, the neck, and in the dorsum of the nose in the other patients, respectively. The main complaint was a hard, slow-growing mass in all the cases. All the patients were treated surgically. Histopathologic diagnosis was pilomatrixoma. No recurrences or surgery-associated complications were observed in the follow-up period.
The aim of the present study is to investigate the effect of N-acetylcysteine (NAC) given 30 minu... more The aim of the present study is to investigate the effect of N-acetylcysteine (NAC) given 30 minutes before carboplatin administration on carboplatininduced ototoxicity and nitric oxide (NO) levels in a rat model. Study Design: Animal study. Methods: Eighteen Sprague-Dawley rats were divided into three groups that each contained six animals. Intraperitoneal injection of physiologic saline was performed in group 1 twice with an interval of 30 minutes. Group 2 was treated with a single bolus administration of carboplatin at a dose of 256 mg/kg 30 minutes after the intraperitoneal injection of physiologic saline. Group 3 was treated with a single bolus administration of carboplatin at a dose of 256 mg/kg 30 minutes after the intraperitoneal injection of NAC at a dose of 400 mg/kg. Pretreatment and posttreatment distortion product otoacoustic emissions (DPOAE) were performed in rats from all groups. Then, the animals were sacrificed on the fourth day, and cochlear tissue NO and glutathione peroxidase (GSH-Px) levels were measured. Results: The comparison of pre-and posttreatment DPOAE responses did not demonstrate any significant changes for groups 1 and 3. Results of group 2 showed a decrease of the DPOAE amplitude. Cochlear NO levels were significantly higher in rats treated with carboplatin than in controls and in those treated with carboplatin plus NAC (P Ͻ .05). Cochlear GSH-Px levels were higher in rats treated with carboplatin plus NAC than in those treated with carboplatin, but the difference did not reach statistical significance (P ϭ .079). Conclusions: The present study showed that carboplatin at higher doses induced hearing loss and increased NO levels in the cochlea of rats. NAC appears to have a protective effect against carboplatin-induced ototoxicity, which may be related to its inhibitory effect on NO production.
OBJECTIVES: Although there are many reports on adenosine deaminase (ADA) activities in different ... more OBJECTIVES: Although there are many reports on adenosine deaminase (ADA) activities in different tissues, no information is available about the enzyme activity in nasal mucosa and polyp tissues. Whereas ADA is related to the production of free radicals by neutrophils, malondialdehyde (MDA) is an indicator of lipid peroxidation that is a general mechanism of tissue damage by free radicals. This study is aimed at determining and comparing the ADA activity and MDA level in nasal polyps and normal mucosa. STUDY DESIGN AND SETTING: Twenty-three patients with nasal polyps and a control group consisting of 14 patients with septal deviation and lower turbinate hypertrophy were included in the study. Tissue MDA level was measured by the method of Okawa with modification and tissue ADA activity by the method of Giusti. RESULTS: In patients with nasal polyp, mean tissue MDA level and ADA activity were 2.43 ± 0.38 nmol/mg protein (Pr) and 0.235 ± 0.055 U/mg Pr, respectively, which were signific...
The aim of this study was to investigate the effects of noise on hearing, lipid peroxidation and ... more The aim of this study was to investigate the effects of noise on hearing, lipid peroxidation and antioxidant enzymes in textile workers. Thirty textile workers exposed to high noise 105 dB (A) in a textile factory, and 30 healthy male volunteers in our hospital as a control group were included in the study. In both groups, following audiometric tests, blood samples were obtained. In these blood samples, Malonydialdehyte (MDA), Superoxide dismutase (SOD) and Catalase (CAT) levels were investigated. Statistical analysis was performed by using SPSS version 11.0 (SPSS Inc., Chicago 1L) software program. Mean pure tone audiometric thresholds in workers were significantly higher than in control subjects at frequencies 2,000, 4,000 and 6,000 Hz (p<0.05). Hearing losses were more evident at high frequencies (4-6 kHz) than at low frequencies in worker group. (p<0.05). It was observed that textile workers with longer employment duration had poorer hearing threshoulds and the hearing loss had started on those who had worked for 5-8 yr. While MDA levels were significantly higher in workers than controls (p<0.001), CAT activity was significantly lower (p<0.005). Also, SOD activity was lower in workers but difference was not statistically significant. We observed a significant change in hearing threshold of the textile workers compared with that of the control group. Increase in MDA level and decreases in CAT and SOD activities in textile workers, support the opinion that the noise causes the oxidative stress. The fact that noise both causes hearing loss and increases oxidative stress suggests that there may be a relationship between the oxidative stress and hearing loss. But, further studies are needed in order to verify this opinion.
Objectives Puberphonia or mutational falsetto (MF) is seen more in males, and hormonal changes ar... more Objectives Puberphonia or mutational falsetto (MF) is seen more in males, and hormonal changes are considered to be among the aetiological causes. Therefore, the aim of this study was to investigate the molecules [G protein-coupled oestrogen receptor 1 (GPER-1), aromatase, 17-beta-hydroxysteroid dehydrogenase (17β-HSD), cyclic adenosine monophosphate (cAMP) levels] related to receptors and pathways in patients with MF. Methods The study included 30 MF patients and a control group of 30 healthy individuals. Voice recordings were made of the MF patients and acoustic analyses were applied. The serum GPER-1, aromatase, 17β-HSD, cAMP levels and TSH, estradiol, prolactin, progesterone, and testosterone levels were evaluated in venous blood samples. Results In the MF patients, the GPER-1 level determined of mean 3.68 (1.95-4.26) pg/ml, 17 beta dehydrogenase of 5.25 (2.73-6.77) ng/ml, and cAMP of 24.62 (11.62-30.35) ng/ml were statistically signficantly higher than those of the control group (p = 0.008, p = 0.002, p = 0.003, respectively). The aromatase level in the MF patients was found to be 3.48 (2.01-4.91) and the difference between the two groups was not statistically significant (p = 0.067). Conclusion The GPER-1, 17β-HSD, and cAMP levels were found to be higher in the MF patients than in the control group, suggesting that they could be of importance in the diagnosis and treatment of MF. Keywords Mutational falsetto • GPER-1 (G protein-coupled estrogen receptor) • Aromatase • 17 beta hydroxysteroid dehydrogenase (17β-HSD) • Gyclic adenosine monophosphate (cAMP) • Voice analysis
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