Papers by Ahmet KARABULUT
Ege Tıp Dergisi, 2021
Schwannomas are peripheral nerve sheath tumors usually detected in adults which are extremely rar... more Schwannomas are peripheral nerve sheath tumors usually detected in adults which are extremely rare in pediatric population and when present they are commonly associated with Neurofibromatosis type 2. While frequently observed in the head, neck, and extremities, they could be detected anywhere in the body including abdominal cavity. The most common site for intraabdominal schwannomas is stomach and pelvic schwannomas are extremely rare. The imaging characteristics are quite diverse, and they could seldom be pure cystic. Herein, we describe a case in the pediatric age group diagnosed with pelvic cystic schwannoma.
Os trigonum ilk kez 1804 yilinda Rosenmuller tarafindan tanimlanmistir. Os trigonum talus’un post... more Os trigonum ilk kez 1804 yilinda Rosenmuller tarafindan tanimlanmistir. Os trigonum talus’un posterolateral tarafinda yer alan aksesuar bir kemiktir. Genellikle 8-13 yaslarinda talus’un yaninda ayri bir ossifikasyon merkezi olarak gelisim gosterir ve 12 ay icinde kaynasmasi beklenir. Kaynasma gerceklesmez ise ayri bir kemik olarak gelisir ve os trigonum adini alir. Os trigonum ayagin asiri plantar fleksiyonu sonucu talus ve calcaneus arasinda sikisarak ayak arka kisminda agriya neden olur ve boylece asemptomatik olan durumun semptom gostermesine os trigonum sendromu denilmektedir. Hastanemizin acil travma birimine futbol oynarken ayak bileginde burkulma sonucu sag ayaginda agri ve sislik sikayeti ile basvuran 15 yasinda erkek hastada Direkt Grafi (DG) ve Manyetik Rezonans Goruntuleme (MRG) yontemleri yardimi ile os trigonum tespit edilmistir.
Bu araştırmada, 2019 Türkçe Dersi Öğretim Programı'ndaki kazanımların Webb'in bilgi derinliği sev... more Bu araştırmada, 2019 Türkçe Dersi Öğretim Programı'ndaki kazanımların Webb'in bilgi derinliği seviyeleri açısından değerlendirilmesi amaçlanmıştır. Çalışma nitel araştırma yöntemine göre gerçekleştirilmiş ve bu kapsamda doküman incelemesi yöntemi kullanılmıştır. Araştırmanın veri toplama aracını, (çalışma materyali) 2019 yılında yayımlanan Türkçe Dersi Öğretim Programı oluşturmaktadır. Elde edilen veriler, betimsel analiz yolu ile analiz edilmiştir. Araştırma sürecinde Webb'in bilgi derinliği ile ilgili literatür taraması yapılarak tematik çerçeve oluşturulmuş ve 2019 Türkçe Dersi Öğretim Programı'nda yer alan 5, 6, 7 ve 8. sınıfa ait kazanımlar liste halinde çıkarılmıştır. Her bir kazanım Webb'in Bilgi Derinliği Seviyelerine uygun oldukları bir veya birden fazla seviye ile kodlanmıştır. Webb'in Bilgi Derinliği Seviyelerinde sınıf bazında en fazla bilgi seviyesinin seviye 2'de toplandığı, bu bilgi seviyesini seviye 3 ve seviye 1'in takip ettiği görülmektedir. En üst basamak olan seviye 4'ün ise kazanımlarda çok az yer kapladığı, 5. ve 6. sınıf ile 7. ve 8. sınıfın bilgi derinliği seviyelere göre yüzdelik ortalamalarının birbirlerine yakın oldukları görülmektedir. Türkçe Dersi Öğretim Programında yer alan ortaokul seviyesi kazanımlarının yarısına yakınının 2. seviyede, %25´e yakınının 3. seviyede, kazanımların %20´ ye yakınının 3. Seviyede ve son olarak da %5 civarlarında 4. Seviyede dağılım gösterdiğine ulaşılmıştır. Elde edilen bulgular, kazanımların genellikle 2. Seviye yani yetenekler ve kavramlar kısmında yığılma gösterdiğini, stratejik düşünmeye yönelik kazanımların % 20, geniş düşünmeye dönük kazanımların ise sadece % 5 seviyesinde dağılım göstermesi, programın üst düzey düşünme becerilerine çok fazla yer ayırmadığını göstermektedir.
International Journal of Education and Literacy Studies, 2020
This study aims to examine Turkish exam papers of the students, who study in the secondary school... more This study aims to examine Turkish exam papers of the students, who study in the secondary school of 5th, 6th, 7th and 8th classes. The exam papers have been examined from various aspects, including the number and type of questions, the language expression and distribution of the questions, the cognitive level (according to the Bloom’s taxonomy), the type of texts used, and the visuals use. The samples of the study were selected using convenience sampling method from 17 secondary schools located in the center of Ağrı Province in Turkey and the exam papers prepared by 36 Turkish teachers who worked at these schools. The tests which were examined included 2633 questions in 161 exam papers. We also developed “the Exam Paper Examination Form” for collecting more data which we analyzed and interpreted by using the document analysis model. According to the results obtained, it has been found that the teachers mostly prefer to use the multiple-choice question type in the Turkish exam paper...
European Urology Supplements, 2011
Materials & Methods: EFS was performed on phenylephrine (PhE) pre-contracted penile corpus cavern... more Materials & Methods: EFS was performed on phenylephrine (PhE) pre-contracted penile corpus cavernosum smooth muscle from male New Zealand White rabbits. The intrinsic nerves were field-stimulated electrically (voltage, 30 V; pulse duration, 1 ms; trains of pulses, 10 seconds; train interval, 3-5 min; frequency, 0.5-32 Hz). We also investigated the penile tracing elicited by EFS (voltage, 30 V; pulse duration, 1 ms; frequency, 8 Hz) on guanethidine (Guan), tetrodotoxin (TTX), Nω nitro-L-arginine-methyl ester (L-NAME), atropine or eserine pre-incubated tissues. results: We obtained consilient results from both models. Phase I was abolished by L-NAME. Phase II was significantly decreased by eserine and Guan but increased by L-NAME. Phase III was abolished by atropine but enhanced by eserine and Guan. TTX diminished all the three phases. Conclusions: The results indicated that EFS stimulated adrenergic, cholinergic, and NANC neuroeffector systems simultaneously. Phase I was related to the NO pathway. Phase II was multiply affected by self-recovery property, adrenergic nerve and cholinergic nerve. Phase III was related to cholinergic nerve.
British Journal of Urology, 1996
To investigate the effects of pentoxifylline on penile blood flow and potency in patients with er... more To investigate the effects of pentoxifylline on penile blood flow and potency in patients with erectile dysfunction due to borderline arterial insufficiency. Following a routine diagnostic evaluation, 36 patients with borderline arterial disease diagnosed using penile duplex ultrasonography were included in the study. Of these patients, 20 (mean age 54 years, range 40-66) received 1.2 g of pentoxifylline daily, divided into three doses orally, for 2 months and 16 (mean age 54 years, range 34-65) received a placebo. Peak systolic velocities (PSVs) before and after the treatment were compared with those in patients receiving a placebo. The clinical improvement in erectile function was also evaluated. Twelve of 20 patients receiving pentoxifylline had an increase in PSV at the end of the treatment period. The mean change in PSV achieved by pentoxifylline treatment (6.25 cm/s) was significantly higher than that achieved by the placebo (0.38 cm/s). Seven patients had a positive response (successful coitus achieved after treatment with pentoxifylline). No serious side-effects occurred. Pentoxifylline was well tolerated and could increase penile arterial inflow, shown objectively as an increase in PSV on penile duplex ultrasonography. These findings should encourage further studies of the efficacy of pentoxifylline in the treatment of impotence.
European Urology Supplements, 2010
(70%) and by ureteral tube graft in 1 patient. Total primary success rate was 69.3% (52 of 75 pat... more (70%) and by ureteral tube graft in 1 patient. Total primary success rate was 69.3% (52 of 75 patients). Recurrent stricture developed in 23 patients. Seven and 11 patients were successfully treated by secondary end-to-end anastomosis and direct vision internal urethrotomies, respectively. Overall success rate was 93.3% (70 of 75 patients). Five treatment failures are still following up and when needed direct vision urethrotomy is performed. No penil curvature, penile shortening or urethral diverticula were occurred. conclusions: Open urethral reconstruction techniques are effective for primary and secondary surgical interventions in pediatric and adolescent patients with post-traumatic urethral strictures in experienced centers and provide excellent long-term results with minimal morbidity.
European Urology Supplements, 2009
European Urology Supplements, 2009
European Urology Supplements, 2009
European Urology Supplements, 2007
Introduction & Objectives: The functional results following two different reflux prevention techn... more Introduction & Objectives: The functional results following two different reflux prevention techniques in orthotopic ileal bladder substitution were compared in a prospective controlled randomized trial.
European Urology Supplements, 2010
the results of the surgery. 9 patients engaged in sexual intercourse regularly. All patients have... more the results of the surgery. 9 patients engaged in sexual intercourse regularly. All patients have maintained their penile length. conclusions: Prolonged ischemic priapism results in cavernosal fibrosis and a subsequent loss of penile length. The immediate insertion of a penile prosthesis in this situation is simple and maintains penile length. The complication rate is low and the subsequent outcome excellent.
Urology, 2000
We present a patient with symptoms of frequency, a mild decrease in urinary stream, and urinary r... more We present a patient with symptoms of frequency, a mild decrease in urinary stream, and urinary retention due to a huge hydatid cyst located in the retrovesical region. Chest radiography and abdominal computed tomography did not reveal any other site of hydatid disease involvement. Since the cyst was in intimate contact with the seminal vesicles and the vasa deferentia, part of the hydatid sac wall adherent to these structures was left behind during the surgical excision. The patient was free of voiding symptoms, and no other episode of urinary retention had occurred at 6 months of follow-up. Pelvic computed tomography did not reveal recurrence of hydatid disease at 6 months postoperatively.
Toxicology in Vitro, 2000
ÐSalicylates are among the oldest and most widely used drugs and are known to lead to foetal deat... more ÐSalicylates are among the oldest and most widely used drugs and are known to lead to foetal death, growth retardation and congenital abnormalities in experimental animals. In this study, the eects of acetyl salicylic acid (ASA), salicylic acid (SAL) and sodium salicylate (NaSAL) on early organogenesis and the interaction of these molecules with free radicals has been investigated. Postimplantation rat embryos were cultured in vitro from day 9.5 of gestation for 48 hr. ASA, SAL and NaSAL were added to whole rat serum at concentrations between 0.1 and 0.6 mg/ml. Also, the lowest eective concentration of ASA for all parameters (0.3 mg/ml) and the same concentration of NaSAL and SAL was added to the culture media in the presence of superoxide dismutase (SOD) (30 U/ml) or glutathione (0.5 "mol/ml). The growth and development of embryos was compared and each embryo was evaluated for the presence of any malformations. When compared to growth of control embryos, the salicylates decreased all growth and developmental parameters in a concentration-responsive manner. There was also a concentration-related increase in overall dysmorphology, including the incidence of haematoma in the yolk sac and neural system, open neural tube, abnormal tail torsion and the absence of fore limb bud. When SOD was added in the presence of ASA, growth and developmental parameters were improved and there was a signi®cant decrease in the incidence of malformations. Addition of SOD also decreased the incidence of malformations in the presence of SAL, but did not eect the growth and developmental parameters of SAL and NaSAL. There was no signi®cant difference between the embryos grown in the presence of these three molecules on the addition of glutathione. The eects of salicylates might involve free oxygen radicals by the non-enzymatic production of the highly teratogenic metabolites 2,3-and 2,5-dihydroxybenzoic acid. An enhanced production of these metabolites in embryonic tissues may be directly related to the increased risk of congenital malformations.
The EMBO Journal, 2007
Protection from NO gas, a toxic byproduct of anaerobic respiration in Pseudomonas aeruginosa, is ... more Protection from NO gas, a toxic byproduct of anaerobic respiration in Pseudomonas aeruginosa, is mediated by nitric oxide (NO) reductase (NOR), the norCB gene product. Nevertheless, a norCB mutant that accumulated B13.6 lM NO paradoxically survived anaerobic growth. Transcription of genes encoding nitrate and nitrite reductases, the enzymes responsible for NO production, was reduced 450and 2.5-fold in the norCB mutant. This was due, in part, to a predicted compromise of the [4Fe-4S] 2 þ cluster in the anaerobic regulator ANR by physiological NO levels, resulting in an inability to bind to its cognate promoter DNA sequences. Remarkably, two O 2-dependent dioxygenases, homogentisate-1,2-dioxygenase (HmgA) and 4-hydroxyphenylpyruvate dioxygenase (Hpd), were derepressed in the norCB mutant. Electron paramagnetic resonance studies showed that HmgA and Hpd bound NO avidly, and helped protect the norCB mutant in anaerobic biofilms. These data suggest that protection of a P. aeruginosa norCB mutant against anaerobic NO toxicity occurs by both control of NO supply and reassignment of metabolic enzymes to the task of NO sequestration.
Journal of Industrial Microbiology & Biotechnology, 2006
The aim of this work was to study the effects of applying a strain of Propionibacterium acidiprop... more The aim of this work was to study the effects of applying a strain of Propionibacterium acidipropionici, with or without Lactobacillus plantarum, on the fermentation and aerobic stability characteristics of low dry matter (DM) corn (Zea mays L.) and sorghum (Sorghum bicolor L.) silages. Corn at the dent stage and sorghum at the flowering stage were harvested. Treatments comprised control (no additives), P. acidipropionici, L. plantarum and a combination of P. acidipropionici and L. plantarum. Fresh forages were sampled prior to ensiling. Bacterial inoculants were applied to the fresh forage at 1.0 x 10(6) colony-forming units per gram. After treatment, the chopped fresh materials were ensiled in 1.5-l anaerobic glass jars equipped with a lid that enabled gas release only. Three jars per treatment were sampled on days 2, 4, 8, 16 and 60 after ensiling, for chemical and microbiological analysis. At the end of the ensiling period, 60 days, the silages were subjected to an aerobic stability test. The L. plantarum inoculated silages had significantly higher levels of lactic acid than the controls, P. acidipropionici and combination of P. acidipropionici and L. plantarum inoculated silages (P<0.05). The P. acidipropionici did not increase propionic and acetic acid levels of the silages. After the aerobic exposure test, the L. plantarum and combination of P. acidipropionici and L. plantarum had produced more CO2 than the controls and the silages inoculated with P. acidipropionici (P<0.05). All silages had high levels of CO2 and high numbers of yeasts and molds in the experiment. Therefore, all silages were deteriorated under aerobic conditions. The P. acidipropionici and combination of P. acidipropionici and L. plantarum were not able to improve the aerobic stability of fast-fermenting silages, because they could not work well in this acidic environment. The results showed that P. acidipropionici and combination of P. acidipropionici and L. plantarum did not improve the aerobic stability of low DM corn and sorghum silages, which are prone to aerobic deterioration.
Journal of Clinical Investigation, 2006
Mucoid, mucA mutant Pseudomonas aeruginosa cause chronic lung infections in cystic fibrosis (CF) ... more Mucoid, mucA mutant Pseudomonas aeruginosa cause chronic lung infections in cystic fibrosis (CF) patients and are refractory to phagocytosis and antibiotics. Here we show that mucoid bacteria perish during anaerobic exposure to 15 mM nitrite (NO 2-) at pH 6.5, which mimics CF airway mucus. Killing required a pH lower than 7, implicating formation of nitrous acid (HNO 2) and NO, that adds NO equivalents to cellular molecules. Eighty-seven percent of CF isolates possessed mucA mutations and were killed by HNO 2 (3-log reduction in 4 days). Furthermore, antibiotic-resistant strains determined were also equally sensitive to HNO 2. More importantly, HNO 2 killed mucoid bacteria (a) in anaerobic biofilms; (b) in vitro in ultrasupernatants of airway secretions derived from explanted CF patient lungs; and (c) in mouse lungs in vivo in a pH-dependent fashion, with no organisms remaining after daily exposure to HNO 2 for 16 days. HNO 2 at these levels of acidity and NO 2also had no adverse effects on cultured human airway epithelia in vitro. In summary, selective killing by HNO 2 may provide novel insights into the important clinical goal of eradicating mucoid P. aeruginosa from the CF airways.
Journal of Applied Microbiology, 2006
Aerobic deterioration of sensitive silages is still a big problem in the ensiling process. Spoila... more Aerobic deterioration of sensitive silages is still a big problem in the ensiling process. Spoilage microorganisms in aerobically deteriorated silages include lactate-assimilating yeasts and moulds (Pahlow 1991). Whole-crop cereal silages, such as wheat, sorghum and maize are susceptible to aerobic deterioration. Susceptibility to spoilage is a very important factor determining silage quality and digestibility (Ashbell et al. 2002). Therefore, it is very important to find suitable additives that inhibit fungi and protect the silage upon aerobic exposure. Bacterial inoculants are one of the most common additives used in the ensiling process. These products,
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Papers by Ahmet KARABULUT