Papers by Adewumi Adediran
Nigerian Journal of Paediatrics
Background: In the absence of acute phase reaction, ferritin concentration has been used as a sta... more Background: In the absence of acute phase reaction, ferritin concentration has been used as a standard measurement of iron stores. Low birth weight babies are at risk of developing iron lack because ferritin concentration at birth is influenced by duration of gestation, maternal iron status and conditions altering maternal–foetal iron exchange. Aim: The aim of this study was to determine the ferritin concentrations of low birth weight babies in comparison with that of normal birth weight babies. Materials and methods: Fortyfour normal birth weight (NBW) babies and 40 low birth weight (LBW) babies were recruited for the study. About 1.0ml of venous blood was drawn aseptically from each subject into a micro EDTA tube, centrifuged at 5000rpm for 5 minutes, the plasma separated into cryotubes and stored at-20oC until ready for quantitative determination of ferritin concentrations using direct immunoenzymatic colorimetric method. Data obtained was analysed statistically using the S...
Asian Food Science Journal
Background: Anaemia is a major public health concern worldwide, particularly in developing countr... more Background: Anaemia is a major public health concern worldwide, particularly in developing countries like Nigeria. In a previous study on determinants of prenatal anaemia, we found out that the majority of our respondents had dietary iron intake below the recommended value of 27mg∕day and all of them belonged to low socio-economic class. We opined that many of our respondents could have become pregnant with sub-optimal haemoglobin concentrations. Aim: This study was carried out to evaluate the prevalence of anaemia and the socio-economic determinants of anaemia in non-pregnant women of reproductive age in our community. Materials and Methods: The study which was descriptive and cross-sectional, involved two hundred consenting non-pregnant women of reproductive age in Ikenne Local Government Area of Ogun State, Nigeria. Interviewer-administered questionnaires were used to collect socio-demographic information and 24-hr dietary recall data which was used to determine the dietary diver...
The Pan African medical journal, Jul 19, 2012
Nigerian quarterly journal of hospital medicine, 2016
percentage of 60.7 % (162 of 267) tested positive to IgG anti-HBcore, while 39.3 % (105 of 267) t... more percentage of 60.7 % (162 of 267) tested positive to IgG anti-HBcore, while 39.3 % (105 of 267) tested negative.
Background: Infertility is a major problem in sickle cell disease patients, especially in males. ... more Background: Infertility is a major problem in sickle cell disease patients, especially in males. In addition to low serum testosterone, other abnormalities involving the accessory sex organs, such as the seminal vesicles and the prostate gland, as well as marked decrease in ejaculate volume may be observed in male HbSS patients. Hence, the need to study the role of sex hormones as a cause of infertility in male HbSS patients. Methods: An unmatched case-control study was performed using seventy-five consenting subjects from Lagos University Teaching Hospital. These included 47 patients with haemoglobin phenotype SS from the Sickle cell clinic and 28 volunteered medical students and members of staff with haemoglobin phenotype AA. Demographic data were obtained using a self-administered questionnaire. A total of 5 mls of blood was collected from each subject between 9.00 am & 11.am, and assayed for serum testosterone concentration. Results: The concentrations of serum testosterone in H...
Background: Hematological profile is considered one of the factors affecting pregnancy and its ou... more Background: Hematological profile is considered one of the factors affecting pregnancy and its outcome. Anemia is the most common hematological problem in pregnancy, followed by thrombocytopenia. Leukocytosis is almost always associated with pregnancy. The study reported here was designed to evaluate the overall mean values of seven major hematological parameters and their mean values at different trimesters of pregnancy. Subjects and methods: This examination was a cross-sectional study of 274 pregnant women who registered to attend the Lagos University Teaching Hospital or Lagos State University Teaching Hospital antenatal clinics between their first and third trimester. Blood (4.5 mL) was collected from each participant into a tube containing the anticoagulant ethylenediaminetetraacetic acid (EDTA). A full blood count was performed on each sample and the results were analyzed. Results: Overall, the values obtained were (mean ± standard deviation [SD]): hematocrit level, 30.16 % ±...
Seroprevalence of human T lymphotropic virus antibodies among healthy blood donors at a tertiary ... more Seroprevalence of human T lymphotropic virus antibodies among healthy blood donors at a tertiary centre in Lagos, Nigeria
amongst normal pregnant women in Nigeria
The Nigerian medical practitioner, 2016
With improvement in the management of cancer patients, viral infections have become important com... more With improvement in the management of cancer patients, viral infections have become important complications affecting morbidity and mortality. This study aimed to determine the prevalence of Human Cytomegalovirus (HCMV) infection in patients with haematological malignancies, with or without past history of blood transfusion in Lagos State University Teaching Hospital, Ikeja (LASUTH). A cross-sectional, case control study was carried out among healthy blood donors attending the blood donor clinic and patients with confirmed haematological malignancies. A total of 5 ml blood sample was collected from each consenting participant and the serum was assayed for CMV IgG and CMV IgM using an enzyme-linked immunosorbent assay (ELISA)-based kit. A total of 148 participants were recruited into the study consisting of 72 patients with haematologic malignancy and 76 healthy blood donors. The seroprevalence of anti-CMV IgG was similar in both groups (98.6% and 94.7% respectively) while there was ...
American journal of blood research, 2021
BACKGROUND Anaemia is common worldwide and pregnant women are one of the most vulnerable group. A... more BACKGROUND Anaemia is common worldwide and pregnant women are one of the most vulnerable group. Although, anaemia in the general population including pregnant women is multi-factorial in aetiology, the most frequent cause in pregnancy worldwide is iron deficiency. In Nigeria, an estimated prevalence of anaemia among pregnant women ranges from 35-75%. Anaemia in pregnancy (AIP) is associated with significant perinatal and maternal morbidity and mortality including premature birth and low birth weight. AIM The aim of this study was to determine the prevalence, demographic and socio-economic determinants of anaemia in pregnancy in a rural community of South-West Nigeria. MATERIALS AND METHODS One-hundred and fifty consenting pregnant women aged 18-42 years in the three trimesters were recruited from four primary health centres of Ikene Local Government of Ogun State of Nigeria after ethical approval was obtained from the Ethics Unit of the Medical officer of Health of the Local Governm...
The Nigerian postgraduate medical journal, 2011
AIMS AND OBJECTIVES The study aimed at reviewing the utilisation of blood / blood products and ha... more AIMS AND OBJECTIVES The study aimed at reviewing the utilisation of blood / blood products and haematological profile changes, with a view to developing a hospital transfusion guideline in open heart surgery in Nigeria. MATERIALS AND METHODS The surgeries were performed at the intensive care unit theatre of Lagos State University Teaching Hospital. Eligibility for surgery was determined by the Cardiologist and the cardiovascular Surgeon based on clinical presentation, electro- and echocardiography assessments among other tests. Fourteen open-heart surgeries were conducted. Blood products demand for different procedures and several peri-operative laboratory parameters such as full blood count, and coagulation profile were determined. RESULTS The greatest demand for blood products was found in valvular surgery and atrial septal defect (ASD) where a mean of four units of red cell concentrate, fresh frozen plasma and cryoprecipitate were transfused. Other surgeries such as, patent ductu...
Nigerian Postgraduate Medical Journal, 2019
Background: The presence of human leukocyte antigen (HLA) B*57:01 allele predicts hypersensitivit... more Background: The presence of human leukocyte antigen (HLA) B*57:01 allele predicts hypersensitivity reaction (HSR) to abacavir (ABC), a nucleoside reverse-transcriptase inhibitor used for human immunodeficiency virus (HIV) treatment. However, the prevalence of this allele amongst Nigerians with HIV is yet to be established. We aimed to determine the prevalence of HLA-B*57:01 allele amongst Nigerians with HIV infection. Methods: We conducted a multicentre cross-sectional epidemiologic survey. Between April 2016 and April 2017, patients were enrolled across five HIV treatment facilities in Nigeria. Participants' demographic information and their history of ABC exposure were obtained, and venous blood was obtained for HLA typing. Results: One thousand five hundred and four (1504) adults were enrolled, with a mean age of 44.6 ± 10.7 years, 1078 (71.7%) were female. 1463 (97.3%) were on antiretroviral therapy. ABC use was reported by 12 (0.8%) participants and none reported HSR. Of 1500 blood samples that were processed, 1458 (97.2%) were successfully typed. Of these, 132 (9.1%) were HLA-B*57 positive using non-specific low-resolution HLA-B*5701 primer mix. On further analysis, none of the 132 samples (0%) had the HLA-B*5701 allele. Conclusion: HLA-B*5701allele is rare amongst Nigerians.
Annals of Tropical Pathology, 2018
Background: The choice of high-performance liquid chromatography (HPLC) to measure HbF and HbA2in... more Background: The choice of high-performance liquid chromatography (HPLC) to measure HbF and HbA2in sickle cell disease patients is regarded as a method of choice by many researchers. This study was aimed at using HPLC in determining the mean and gender-specific reference values of HbF and HbA2in sickle cell anemia (SCA) population and bringing to fore all associated implications. Materials and Methods: This was a cross-sectional, retrospective, descriptive study involving SCA patients. All case notes containing HPLC hemoglobin quantification reports were reviewed to extract the percentages of HbA2, HbF, and HbS of patients. The demographic data of individual patients were also obtained from the records. Data were analyzed with IBM SPSS Statistics for Windows, Version 20.0 Armonk, New York, USA. Results: A total of 100 participants' records were reviewed consisting of 40 (40%) males and 60 (60%) females. The overall mean age (±standard deviation [SD]) of participants was 25.89 years ±9.34. The overall mean HbF and HbA2were 6.94% ±5.05 and 3.75% ±0.74, respectively. Thirty percent had HbF <3%, whereas 34% of them had elevated HbA2level >4%. The mean (±SD) HbF and HbA2for both males and females were 6.97% ±5.45 and 3.68% ±0.58, 6.92% ±4.87, and 3.80% ±0.83, respectively. Conclusions: Thirty percent of the study participants had HbF <3%, whereas 34% of them had elevated HbA2level >4% and could indeed be carrying beta thalassemia trait with the sickle cell gene.
Annals of Tropical Pathology, 2018
Sickle cell anemia (SCA) patients have a point mutation in the 6th codon of the hemoglobin gene i... more Sickle cell anemia (SCA) patients have a point mutation in the 6th codon of the hemoglobin gene in which adenine is replaced by thymine resulting in replacement of glutamic acid with valine on the 6th amino acid in the β globin chain of the hemoglobin. Despite identical basic genetic mutation in all SCA patients, significant variation in clinical severity occurs. Clinical severity of SCA varies from mild to very severe types requiring more intensive medical interventions such as use of hydroxyurea (HU) and stem cell transplantation. Use of HU has improved clinical outcome in SCA and is recommended for moderate-to-severe varieties of SCA. This review brings to the fore mode of action, indications, commencement of therapy, monitoring, toxicity, and discontinuation of HU in selected SCA patients.
Journal of Tropical Medicine, 2016
Background. This study sought to identify the pattern of electrocardiographic changes in steady s... more Background. This study sought to identify the pattern of electrocardiographic changes in steady state adult sickle cell anaemia.Methods.A case-control, cross-sectional study was conducted amongst sickle cell patients attending the sickle cell clinic of Lagos State University Teaching Hospital, Ikeja, and HbAA controls. All consenting participants had haemoglobin electrophoresis done and were subjected to electrocardiography (ECG). The descriptive data were given as means ± standard deviation (SD). The differences were considered to be statistically significant when thepvalue obtained was <0.05.Results.A total of ninety-three sickle cell anaemia (SCA) patients and ninety haemoglobin AA (controls) were enrolled. There was no significant difference in the age of the participants with SCA and that of the controls but the body mass index was significantly higher in controls (p=0.0001). Overall, 73.1% (68 of 93) had abnormal ECG while only 2 of 90 (2.2%) of controls had abnormal ECG. T...
Bone Marrow Research, 2016
Background. Sickle cell anaemia (SCA) is an inherited condition whose clinical manifestations ari... more Background. Sickle cell anaemia (SCA) is an inherited condition whose clinical manifestations arise from the tendency of haemoglobin to polymerize and deform red blood cells into characteristic sickle shape. Allogeneic bone marrow transplantation offers a cure. The aim of this study was to determine the level of awareness, knowledge, and acceptance of this beneficial procedure in Nigeria. Materials and Methods. This multicentre cross-sectional study was conducted in 7 tertiary hospitals in Nigeria in 2015. Approval was obtained from each institution’s research and ethics committee. A pretested structured questionnaire was administered to respondents aged 18 years and above and to the parents or guardians of those below 18 years of age. Results. There were 265 respondents comprising 120 males and 145 females. One hundred and seventy-one (64.5%) respondents were aware of BMT for the treatment of SCA. About 67.8% (116 of 171) of those who were aware believed SCA can be cured with BMT (...
Interdisciplinary Perspectives on Infectious Diseases, 2016
Background. Anaemia is a common complication of human immunodeficiency virus (HIV) infection. The... more Background. Anaemia is a common complication of human immunodeficiency virus (HIV) infection. The aim of this study was to investigate the impact of HIV infection and zidovudine on red blood cells (RBC) parameters and urine methylmalonic acid (UMMA) levels in patients with HIV infection.Material and Methods. A cross-sectional study involving 114 subjects, 94 of which are HIV-infected nonanaemic and 20 HIV negative subjects (Cg) as control. Full blood count parameters and urine methylmalonic acid (UMMA) level of each subject were determined. Associations were determined by Chi-square test and logistic regression statistics where appropriate.Results. Subjects on zidovudine-based ART had mean MCV (93 fL) higher than that of control group (82.9 fL) and ART-naïve (85.9 fL) subjects and the highest mean RDW. Mean UMMA level, which reflects vitamin B12 level status, was high in all HIV-infected groups but was significantly higher in ART-naïve subjects than in ART-experienced subjects.Concl...
Nigerian medical journal : journal of the Nigeria Medical Association
Sickle cell anaemia (SCA) remains associated with high risks of morbidity and early death. Childr... more Sickle cell anaemia (SCA) remains associated with high risks of morbidity and early death. Children with SCA are at high risk for ischaemic stroke and transient ischaemic attacks, secondary to intracranial arteriopathy involving carotid and cerebral arteries. Allogeneic haematopoietic stem cell transplantation (HSCT) is the only curative treatment for SCA. We report our experience with transplantation in a group of patients with the Black African variant of SCA. This study included 31 consecutive SCA patients who underwent bone marrow transplantation from human leukocyte antigen (HLA)-identical sibling donors between 2010 and 2014 following a myeloablative-conditioning regimen. The median patient age was 10 years (range 2-17 years). Before transplantation, 14 patients had recurrent, painful, vaso-occlusive crisis; ten patients had recurrent painful crisis in association with acute chest syndrome; three patients experienced ischaemic stroke and recurrent vaso-occlusive crisis; two pa...
Nutrition and Metabolic Insights, 2015
BackgroundMetabolic syndrome (MetS), a clinical condition characterized by insulin resistance, gl... more BackgroundMetabolic syndrome (MetS), a clinical condition characterized by insulin resistance, glucose intolerance, dyslipidemia, hypertension, and obesity, has been linked with raised levels of serum ferritin (Sfr) concentrations.ObjectivesThis study was carried out to compare hemoglobin (Hb) and Sfr concentrations in patients with MetS, regular donors and first-time donors.Materials and MethodsA total of 102 subjects who were between 18 and 60 years were enrolled for the study. They were divided into three groups. The first group ( n = 20) was made up of 5 males and 15 females, all who met the criteria that define MetS. The second group ( n = 52; M = 34, F = 18) were regular donors, while the last group ( n = 30; M = 16, F = 14) were first-time donors or those who had not donated before. Following an overnight fast, 20 mL of venous blood was drawn from each subject. About 5 mL of this was put into sodium ethylenediaminetetraacetate (EDTA) specimen bottles for the full blood count ...
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Papers by Adewumi Adediran