Papers by Abdulrahman Aminu Musa
International Journal of Polymer Analysis and Characterization
Abstract In this investigation, a sample of epoxy resin was modified with different weight ratios... more Abstract In this investigation, a sample of epoxy resin was modified with different weight ratios (2, 5, 10, 15, and 20%) of a benzoxazine and thermally cured to form films; EB02, EB05, EB10, EB15, and EB20, respectively. The curing reaction of the benzoxazine molecules and epoxy prepolymer was monitored by the Fourier transform infrared (FTIR) spectroscopic analysis. The examination of anticorrosion performances of the individual films by the method of electrochemical impedance spectroscopy (EIS), was achieved by, respectively, coating the films on stainless steel (SS) substrates. The water absorption behavior of the individual films also was examined by water sorption (WS) analysis. The water intake of the tested modified-epoxy resin shows a linear dependence on the amount of polybenzoxazine in each of the samples. Better coating performances are seen, from the EIS results of modified epoxy films in comparison to the pure epoxy resin. However, the EB20 shows outstanding corrosion prevention property with excellent hydrophobicity.
Journal of Heterocyclic Chemistry
BADEGGI JOURNAL OF AGRICULTURAL RESEARCH AND ENVIRONMENT, 2021
Sweet potato is the second most important root crop after cassava in Nigeria. Due to decline in N... more Sweet potato is the second most important root crop after cassava in Nigeria. Due to decline in Nigeria‘s economy in recent years, the production of sweet potato has significantly increased from 2.4 million metric tonnes in 2000 to 4.1 million metric tons in 2017 to meet up with its demand for local consumption. However, the profitable production of the crop is being threatened by virus diseases such as Sweet potato feathery mottle virus (SPFMV), Sweet potato mild mottle virus (SPMMV), Sweet potato chlorotic stunt virus (SPCSV), Sweet potato leaf curl virus (SPLCV), and Cucumber mosaic virus (CMV). Useful information about these viruses is instrumental in the effective management of the crop in Nigeria. This paper reviewed the major viruses that affect sweet potato production in Nigeria.
Journal of Hematology, 2021
Background: Essential thrombocythemia (ET) is one of the "classic" Philadelphia chromosome negati... more Background: Essential thrombocythemia (ET) is one of the "classic" Philadelphia chromosome negative (Ph-) myeloproliferative neoplasms characterized by sustained thrombocytosis, increased megakaryopoiesis and high risk of vascular complications. ET is very rare in childhood. The annual incidence is approximately 1 per 10,000,000 in children less than 14 years, and about 60 times lower than adults. The genetic landscape and clonal features in childhood ET has not been well defined. There is no evidence-based guidance on the diagnosis of childhood ET. Methods: Medical records of 28 pediatric patients (age ≤ 14 years at diagnosis) with ET were reviewed and evaluated to characterize the different mutation profiles and to evaluate the treatment modalities used and the potential long-term outcome. Results: More than half of the patients were found to have positive history of parental consanguinity (57.1%) whereas positive family history was documented for more than a quarter of our patients (28.6%). Janus kinase 2 gene (JAK2) V617F mutation was positive in two of 26 patients (7.7%). Myeloproliferative leukemia virus oncogene (MPL) exon 10 and calreticulin (CALR) mutations were tested in eight patients, which were negative for all of them. Treatment included low-dose aspirin (LDA) in seven patients (50%), combination of LDA with hydroxyurea in three patients (21.4%), hydroxyurea in two patients (14.3%), combination of platelets apheresis with LDA and anagrelide in one patient each (7.1%). During the treatment, two patients experienced stroke (7.1%), one patient developed Budd-Chiari syndrome (3.6%) and one patient developed azoospermia (3.6%). Conclusions: The incidence of ET in children is extremely low in Saudi Arabia. Most of the children with ET were asymptomatic, and thrombocytosis was often discovered incidentally. JAK2 V617F mutation has no known impact on the prognosis or on the outcome of the disease in the pediatric age group that is in contrast to the adult ET. Children less than 1 year are at high risk for complications particularly during acute precipitating infectious episode. The potential complications and clinical course of pediatric ET are unpredictable.
RSC Advances, 2021
The inhibition performance of a novel benzenesulfonamide-based benzoxazine compound in the corros... more The inhibition performance of a novel benzenesulfonamide-based benzoxazine compound in the corrosion of X60 carbon steel an acidizing environment has been examined including some highly electronegative atoms.
Blood, 2006
Background: T-cell acute lymphoblastic leukemia (T-ALL) constitutes 10% to 15 % of childhood ALL ... more Background: T-cell acute lymphoblastic leukemia (T-ALL) constitutes 10% to 15 % of childhood ALL cases in the Western literature. However, higher proportions, up to 40%, have been reported in certain developing countries. While the outcome of childhood T-ALL has improved dramatically over the last decades, by using intensive multi-agent chemotherapeutic regimens, about 30% to 40% of these patients still experience relapses. Patients and methods: Medical records of the 411 pediatric patients (0–13 years old) diagnosed with ALL and treated at our institution between January 1999 and December 2004 were retrospectively reviewed. Result: Fifty-three (12.9%) of the patients had T-ALL. 52 of these were treated according to a multi-drug chemotherapy protocol, based on a modification of the St. Jude Total XIII-B protocol, including high-dose methotrexate (HD-MTX), at 2gm/m2, and non-cross-resistant drug pair administered weekly during the continuation phase. The remaining one patient receive...
Blood, 2006
Unlike AML, children with Down syndrome and Acute Lymphoblastic Leukemia (DS-ALL) have been repor... more Unlike AML, children with Down syndrome and Acute Lymphoblastic Leukemia (DS-ALL) have been reported to achieve significantly lower rates of remission, with higher mortality and a poorer overall survival. To further study this, we conducted a retrospective review for all DS children who were diagnosed and treated for ALL at our institution from 1997 to 2006. 12 (1.8%) out of 645 children (age 0–14 years) diagnosed with ALL had DS. The median age at diagnosis was 55 months (range 23 – 108 months) and eight were male. The most frequent signs and symptoms were fever (n=11; 91.6%), bleeding tendency (n=8; 75%) and organomegaly (n=9; 83.3%). The median WBC count at diagnosis was 4.99×109/L (range 0.58–500×109/L). The median platelet count and hemoglobin were 255×109/L and 80.5g/L, respectively. None of the patients had CNS disease at diagnosis. Leukemia cell cytogenetics revealed only the additional chromosome 21 for all patients, except in one patient who had 48XY,+X,+21. All cases had ...
Blood, 2006
Biphenotypic acute leukemia (BAL) is now a well-defined entity. However, the outcome of this rare... more Biphenotypic acute leukemia (BAL) is now a well-defined entity. However, the outcome of this rare type of acute leukemia is variable and the treatment strategies are controversial. This is a retrospective review analyzing the clinical features and the outcome of BAL cases diagnosed and treated at our institution between January 1999 and December 2004. The diagnosis was based on morphological and cytochemical evaluation, supported with extensive immunophenotyping. The European Group for Immunophenotyping in Leukemia (EGIL) scoring system was utilized to diagnose the BAL. 17 patients (4.1% of 411 ALL patients) were classified as BAL. Of these 15 were B-lymphoid/myeloid and two were T/B-lymphoid. Median age at diagnosis was 7.23 years (range 1.3–14.4 years). Nine patients were male, four had WBC count >100 × 109/L, and 6 (35.3%) had CNS disease. Cytogenetic analysis was available in 14 cases of which three (21.4 %) had a normal karyotype. The most frequent abnormalities were MLL gen...
Polymer Bulletin, 2019
In this study, hydroxyl end functional group benzoxazine monomer (BZ-OH) was synthesized from eth... more In this study, hydroxyl end functional group benzoxazine monomer (BZ-OH) was synthesized from ethanolamine, bisphenol-A and paraformaldehyde. The monomer was analysed and confirmed by Fourier transform infrared, and (1H and 13C) nuclear magnetic resonance techniques, respectively. The benzoxazine (10% by weight) was incorporated into a (50:50) weight ratio of epoxy resin and its hardener. This mixture was first cured at room temperature for 24 h and then post-cured at temperatures; 90, 120, 150, 180, 200 and 220 °C, respectively. Thermal gravimetric analysis was employed to study the effect of the different curing temperatures on the thermal properties of the benzoxazine/epoxy mixture. The results showed an overall improvement in the thermal stability of the samples as the curing temperature is increased. However, the product cured at 220 °C depicted a better thermal behaviour, with a decomposition temperature in the range of 258–532 °C.
Blood, 2013
Post-transplant erythrocytosis is an ominous complication of kidney transplantation, occurring in... more Post-transplant erythrocytosis is an ominous complication of kidney transplantation, occurring in the first 8 to 24 months after surgery in 10% to 15% of transplant recipients; this is frequently associated with significant thromboembolic events and sometimes death. In patients undergoing allogeneic hematopoietic cell transplantation (HCT), erythrocytosis has not been previously well described. At our institution, we observed that some aplastic anemia (AA), and Fanconi anemia (FA) patients developed progressively increased hemoglobin (HB), hematocrit (HCT) and RBC readings on long term follow up. Thus, this study was conducted to assess the validity of this observation in AA/FA patients post HCT, and its impact on their health. Patients and Methods From January 1993 until December 2011, 144 pediatric patients underwent successful allogeneic HCT for AA or FA; median age at HCT 11.6 years (range, 6.6 -15). All patients included were alive at the time of the analysis, and had sustained...
Blood, 2011
1136 Introduction: Glanzmann thrombasthenia (GT) is a rare autosomal recessive inherited bleeding... more 1136 Introduction: Glanzmann thrombasthenia (GT) is a rare autosomal recessive inherited bleeding disorder characterized by an impaired platelet aggregation and variable bleeding tendency. Inherited genetic mutations in integrin alpha IIb and beta3 (ITGA2B, ITGB3) result in a heterogeneity of the thrombasthenia phenotypes. It is phenotypically expressed in homozygotes or compound heterozygotes, given that 50% of normal aIIbb3 is sufficient to guarantee unimpaired platelet function that result in asymptomatic carriers. Defects in ITGB3 result in failure of binding of B3 and alpha IIb. These defects had been reported in Arabs (Iraqi Jews). We are reporting some results of Saudi GT genotype project. Materials & Methods: In this study, we analyzed the entire coding region ITGB3 gene using polymerase chain reaction (PCR) and direct sequencing with primers specifically designed to amplify the coding region of exon 1–15 and exon /Intron boundaries in a cohort of 51 GT patients diagnosed an...
Blood, 2005
Acute myelocytic leukemia (AML) in Down Syndrome (DS) children is characterized by a young age of... more Acute myelocytic leukemia (AML) in Down Syndrome (DS) children is characterized by a young age of onset…
Blood, 2014
BACKGROUND The rare coagulation disorders are heritable abnormalities of hemostasis that may pres... more BACKGROUND The rare coagulation disorders are heritable abnormalities of hemostasis that may present significant difficulties in diagnosis and management to hemophilia center clinicians. The common feature shared by these disorders is that their overall population frequency is low (with the exception of factor XI deficiency). Consequently, diagnosis and monitoring of affected individuals may require specialist phenotypic and molecular investigations that are not widely available. There may be considerable inter-individual variation in bleeding phenotype amongst affected individuals resulting at least in part from the molecular heterogeneity of the rare coagulation disorders. The bleeding risks in affected individuals may therefore be difficult to assess. Coagulation factor support may require the prescription of unlicensed treatment products that are not readily available. Although the rare coagulation disorders are uncommon, most hemophilia centers will have a handful of individual...
Biology of Blood and Marrow Transplantation, 2016
Biology of Blood and Marrow Transplantation, 2014
Hematopoietic cell transplantation (HCT) can cure bone marrow failure in patients with Fanconi An... more Hematopoietic cell transplantation (HCT) can cure bone marrow failure in patients with Fanconi Anemia (FA), and it is generally accepted that these patients should receive low-intensity conditioning because of the underlying DNA repair defect in their cells. Outcomes for recipients of matched related HCT have generally been favorable, but only a few studies have scrutinized the factors that may affect the eventual outcome of these patients. This retrospective analysis of 94 pediatric patients with FA who underwent related HCT at King Faisal Specialist Hospital & Research Center was carried out to attempt to identify factors that may affect outcome. Results showed overall survival (OS) probabilities of 92.5%, 89%, and 86% at 1, 5, and 10 years, respectively. In univariate analysis, use of higher dose cyclophosphamide (CY) (60 mg/kg) conditioning was associated with a better 10-year OS than lower dose CY (20 mg/kg) conditioning (91% versus 82%, respectively; P ¼ .035), and use of radiation-containing regimens was associated with a significantly lower 10-year OS than nonradiation regimens (76% versus 91%, respectively; P ¼ .005). Of the 4 regimens used in this study, the fludarabine-based regimen was associated with the highest survival (95.2%; P ¼ .034). The use of the higher dose CY (60 mg/kg) was associated with a significantly increased incidence of hemorrhagic cystitis (HC) (20% versus 5.6% respectively; P ¼ .049). Three patients (3%) developed squamous cell carcinoma (2 oropharyngeal and 1 genitourinary), at 9.4, 5.4, and 13.3 years after HCT; 2 of them had radiationcontaining conditioning. In conclusion, our data suggest that although using a higher dose CY (60 mg/kg) conditioning regimen may be associated with better survival, it is also associated with a significantly increased risk of HC. The addition of fludarabine to the low-dose CY (20 mg/kg) is associated with the best survival. On the other hand, radiation-containing regimens are associated with significantly lower survival.
Leukemia & Lymphoma, 2012
Results of second-line therapy for childhood acute lymphoblastic leukemia (ALL) remain suboptimal... more Results of second-line therapy for childhood acute lymphoblastic leukemia (ALL) remain suboptimal, particularly for high-risk groups identified using timing and site of relapse. We report results of prospectively collected data for pediatric patients with ALL who received risk adjusted second-line therapy. The 59 patients who failed first-line ALL therapy included 36 (61%) with bone marrow (BM), 13 (22.1%) with isolated extramedullary (EM) and 10 (16.9%) with BM + EM relapse. Some 51.8% patients were reinduced with high dose cytosine arabinoside (HDAraC)-based and 48.2% with standard four-drug regimens. In all, 38/56 (67.9%) achieved a complete remission (CR) with second-line therapy; the overall CR rate was 78.6% and was not associated with CR1 duration (p =0.8). Three-year overall survival (OS) was 45.3%, and was 61.4% for those achieving a CR. No risk group benefited from HSCT over chemotherapy. Patients with isolated EM relapse beyond 18 months of CR1 and BM relapse beyond 12 months off-therapy had an excellent outcome (OS 91.7%), identifying a particularly good-risk cohort. Patients not in this category continue with poor outcome even following hematopoietic stem cell transplant.
Cancer, 2003
BACKGROUND. The goals of the current study were to examine the incidence and severity of toxicity... more BACKGROUND. The goals of the current study were to examine the incidence and severity of toxicity resulting from dexamethasone and prednisone during induction therapy for children with precursor B-cell acute lymphoblastic leukemia (ALL) and to determine whether the addition of daunomycin affected toxicity. METHODS. Medical records of patients with precursor B-cell ALL from January 1996 through June 2000 were reviewed retrospectively for toxicity during the 4-week induction phase and the 2 weeks after the induction phase. RESULTS. One hundred seventy-six patients age Ͻ 14 years were diagnosed with precursor B-cell ALL from January 1996 through June 2000. Of the 156 evaluable patients, 106 were treated with prednisone and 50 with dexamethasone. Fifty-two patients received steroids, L-asparaginase, and vincristine, whereas 104 high-risk patients received daunomycin in addition to these 3 agents. The incidence of gastritis was significantly higher among patients receiving dexamethasone (P ϭ 0.01); incidence rates of hyperglycemia, hypertension, and myopathy were similar for all treatment groups. Dexamethasone led to more weight gain than did prednisone (ϩ11.9% vs. ϩ5.4%; P ϭ 0.002). Serious infections were observed in 27 (25.5%) and 18 (36%) patients receiving prednisone and dexamethasone, respectively (P Յ 0.2). Five patients, four of whom received prednisone and one of whom received dexamethasone, died of infection. The addition of daunomycin to treatment regimens increased overall toxicity (P Ͻ 0.01). When daunomycin was included in treatment regimens, toxicity was greater among patients receiving dexamethasone; in contrast, when daunomycin was not included, toxicity was equal for both treatment groups. Regardless of daunomycin use, there was no difference in the incidence of serious infection between the two groups. ALL treatment was not compromised by steroid-related toxicity in either group. CONCLUSIONS. The addition of daunomycin led to a much larger increase in dexamethasone-related toxicity compared with the increase in prednisone-related toxicity. Although the use of daunomycin enhanced dexamethasone-related toxicity, this enhancement did not result in a higher mortality rate or the alteration of planned ALL therapy.
Asian Cardiovascular and Thoracic Annals, 2012
Current dosing guidelines for unfractionated heparin therapy in pediatric patients are based on r... more Current dosing guidelines for unfractionated heparin therapy in pediatric patients are based on recommendations of only one study that evaluated a weight-based dosing nomogram. To test the hypothesis that adhering to a strict weight-based nomogram yields better therapeutic results in pediatric patients, we prospectively monitored 25 consecutive pediatric patients who received unfractionated heparin based on the nomogram, and compared them to control patients whose treatment did not follow the standard nomogram. The mean time needed to achieve the target activated partial thromboplastin time was significantly shorter in the study group than the control group (18.32 ± 9.98 vs. 43.8 ± 30 h). A higher proportion of the study group reached the target activated partial thromboplastin time at 12, 24, and 36 h, compared to controls: 44% vs. 6%, 72% vs. 28%, 100% vs. 58%, respectively. Within the study group, patients under 1 year of age needed more time to achieve the target activated parti...
Annals of Saudi Medicine, 2008
C hildhood acute lymphoblastic leukemia (ALL) has served as a model for cancer treatment for over... more C hildhood acute lymphoblastic leukemia (ALL) has served as a model for cancer treatment for over five decades. With more precise diagnost t tic criteria and risk stratification, more effective therapy administered in controlled clinical trials, and better supportive care, the outlook for children with ALL has
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Papers by Abdulrahman Aminu Musa