Papers by Abdullah özdemir
PubMed, Feb 1, 2023
Objective: Burns are a global medical and economic problem. In addition to high costs, the length... more Objective: Burns are a global medical and economic problem. In addition to high costs, the lengthy therapeutic process and the emotional trauma experienced by patients and their families indirectly worsen the socioeconomic damage caused. Kidney failure observed after burns is highly correlated with mortality. Materials and methods: Twenty-eight male Sprague-Dawley rats (age four months, weight 250-350 g) were included in the study. They were randomly assigned into four groups consisting of seven rats each with similar mean weights. Group 1 (n=7) represented the healthy control group (C), Group 2 (n=7) the Sham+dexmedetomidine (DEX) 100 mcg/kg (three doses) (S+DEX100) group, Group 3 (n=7) the 30% Burn (B), and Group 4 (n=7) the 30% Burn+DEX 100 mcg/kg/day group (B+DEX100) (three doses). Thiobarbituric acid reactive substances (TBARS), total thiol (TT), interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) values in kidney tissues were investigated biochemically, and histopathological analyses were also performed. Nuclear factor κB (NF-κB)/p65 was measured using immunohistochemistry, and the TUNEL assay was applied to indicate apoptotic tubular epithelial cells. Results: TBARS, IL-1, and TNF-α in kidney tissues decreased in the B+DEX100 group compared to the 30% burn group, while total thiol values increased. Histopathologically, atypical glomeruli, particularly necrotic tubules, and inflammation in peritubular areas decreased in the B+DEX100 group compared to the 30% burn group. In addition, apoptotic tubular epithelial cells exhibiting TUNEL positivity and tubular epithelial cells exhibiting NF-кβ/p65 positivity also decreased in the B+DEX100 group compared to the 30% burn group. Conclusions: Dexmedetomidine reduced apoptotic activity in rats and exhibited anti-inflammatory antioxidant effects in the burn model in this study.
BioMed Research International, 2014
We reviewed our experience to compare the effectiveness of epidural analgesia and total intraveno... more We reviewed our experience to compare the effectiveness of epidural analgesia and total intravenous analgesia on postoperative pain control in patients undergoing endovascular abdominal aortic aneurysm repair. Records of 32 patients during a 2-year period were retrospectively investigated. TIVA group (= 18) received total intravenous anesthesia, and EA group (= 14) received epidural anesthesia and sedation. Pain assessment was performed on all patients on a daily basis during rest and activity on postoperative days until discharge from ward using the numeric rating scale. Data for demographic variables, required anesthetic level, perioperative hemodynamic variables, postoperative pain, and morbidities were recorded. There were no relevant differences concerning hospital stay (TIVA group: 14.1 ± 7.0, EA group: 13.5 ± 7.1), perioperative blood pressure variability (TIVA group: 15.6 ± 18.1, EA group: 14.8 ± 11.5), and perioperative hemodynamic complication rate (TIVA group: 17%, EA group: 14%). Postoperative pain scores differed significantly (TIVA group: 5.4 ± 0.9, EA group: 1.8 ± 0.8, < 0.001). Epidural anesthesia and postoperative epidural analgesia better reduce postoperative pain better compared with general anesthesia and systemic analgesia, with similar effects on hemodynamic status.
Journal of Chemical Neuroanatomy
Phoenix Medical Journal
Amaç: Pandemi döneminde COVID-19 yoğun bakım ünitesinde çalışan hemşirelerde koronofobi sıklığını... more Amaç: Pandemi döneminde COVID-19 yoğun bakım ünitesinde çalışan hemşirelerde koronofobi sıklığını ve ilişkili risk faktörlerini saptamak. Gereç ve Yöntem: Etik kurul onamını (no: 2021/147) takiben, Nisan 2021-Ocak 2022 tarihleri arasında yoğun bakım ünitelerinde hemşire statüsünde çalışan sağlık çalışanlarına gönüllülük esasına göre anket uygulandı. Demografik veriler ve Koronavirüs-19 Fobisi Ölçeğinin Türkçe’ye adapte edilmiş soruları soruldu. Eksik yanıt veya yanıt yanında yorum içeren anketler analiz edilmedi. Bulgular: Toplam 102 katılımcının verileri değerlendirildi. Ortalama Koronavirüs-19 Fobisi skoru orta düzeyde (50,1±10,7) idi. Alt boyut puanları şu şekilde saptandı: psikolojik skor hafif yüksek (18,1±4,1), somatik skor hafif düşük (10,1±3,2), sosyal skor orta düzseyde (13,7±3,4), ekonomik skor hafif düşük (8,2±2,7) Alt skorların birbirleriyle korele olduğu, en kuvvetli korelasyonun somatik ve ekonomi boyutlar arasında olduğu bulundu. Total ve alt skorların cinsiyetler ara...
Annals of Medical Research, 2019
Aim: Colistin’s parenteral use was limited due to nephrotoxicity related to decreased renal per... more Aim: Colistin’s parenteral use was limited due to nephrotoxicity related to decreased renal perfusion, nephrotoxins and ischemia-reperfusion injury. Colistin became popular again because of multiple drug resistance (1, ). This study aimed to retrospectively evaluate the characteristics of intensive care patient groups with and without colistin-induced acute kidney injury. Material and Methods: Following approval of local ethics committee, information of the patients, who were treated in the anesthesia and surgical intensive care units between 01/01/2016 and 30/06/2017, were analyzed retrospectively. Results: Twenty patients (59%) developed acute kidney injury during colistin treatment. No statistically significant difference was observed between the groups with and without acute kidney injury in terms of age, gender and duration of stay in the intensive care unit, however, patients with acute kidney injury were found to be older and stayed in the intensive care unit for a longer p...
Biomarkers, 2021
Abstract Background Secondary injury is a potentially modifiable factor of outcome in traumatic b... more Abstract Background Secondary injury is a potentially modifiable factor of outcome in traumatic brain injury. This study aimed to investigate thymoquinone's effects on trauma-induced neuronal damage. Methods Eighteen adult female Sprague–Dawley rats were assigned into three groups following ketamine and xylazine anaesthesia (n = 6): Control, Trauma, Trauma + Thymoquinone. First dose of thymoquinone was administered three hours after the trauma. Results The trauma group showed significant oedema, vascular congestion, and ischaemia. Also, caspase-3 activity and malondialdehyde content of brain tissue was significantly increased, and Na,K-ATPase activity and glutathione levels were significantly reduced. Thymoquinone significantly reduced oedema, vascular congestion, ischaemia, and caspase-3 activity compared with the trauma group. While Na,K-ATPase activity and glutathione levels was similar to the Control group, malondialdehyde content was similar to the trauma group. Conclusions This study showed that low dose thymoquinone exhibited a neuroprotective effect following severe traumatic brain injury, if administered within three hours of injury. Similar levels of glutathione and malondialdehyde suggest no antioxidant effect. Significant reduction in oedema and ischaemia in the neuron cells and partially preserved activity of Na,K-ATPase suggest that thymoquinone protects mitochondrial functions and energy levels of the neuronal cells following severe traumatic brain injury.
Secondary traumatic brain injury is a potentially modifiable and important determinator of the ou... more Secondary traumatic brain injury is a potentially modifiable and important determinator of the outcome. Sedation and analgesia are common components of the therapy. However current drug therapies have disadvantages like respiratory depression. The objective of this study was to investigate the effect of dexmedetomidine (Dex), a sedative drug with little to no depressive effect on respiratory centers, on secondary injury in rat brain tissue. Eighteen rats were randomized into three groups: Trauma group received anesthesia, followed by head trauma with Mild Traumatic Brain Injury Apparatus, the Trauma+Dex group received additional treatment of 100µg/kg intraperitoneal dexmedetomidine daily for three days, The Control group received anesthesia only. Malondialdehyde (MDA), glutathione (GSH), Na+, K+-ATPase, or sodium/potassium (Na/K-ATPase), and cysteine-aspartic proteases, cysteine aspartates-3 (caspase-3) levels were measured. MDA levels were highest in the Trauma group (p = 0.002 vs ...
Turkish Journal of Intensive Care, 2020
Immune plasma therapy (IPT) is an established therapy that involves transfer of passive immunity.... more Immune plasma therapy (IPT) is an established therapy that involves transfer of passive immunity. Given the lack of vaccine and specific therapy for Coronavirus diseases-2019 (COVID-19), IPT has been successfully used in intensive care units (ICUs). This study aimed to investigate the effect of IPT and adjuvant therapies on the morbidity and mortality of patients with COVID-19. Materials and Methods: Data of patients who were treated in ICUs during the COVID-19 pandemic were retrospectively reviewed. Patient characteristics, dose and duration of adjuvant therapies specific for COVID-19 (IPT, vitamin C, methylprednisolone, n-acetyl cysteine), vital signs, hemodynamic and respiratory function, COVID-19 infection parameters, and outcomes such as morbidities and mortality were recorded. Results: Data of five patients with COVID-19 who underwent IPT were analyzed. Three patients without comorbidities recovered and were sent home. One patient with a history of uncontrolled diabetes mellitus died on day 32 of admission in the ICU. Yet another patient with a history of hypertension was tracheotomized and discharged to a palliative care center with a home ventilator because of chronic respiratory insufficiency. Conclusion: These results suggest that IPT may have positive effects on COVID-19 infection. However, given the limited number of cases treated in several discrete centers, there is a need for meta-analysis or a randomized clinical trial.
Morbid obesity is becoming a worldwide health concern. Anesthesiologists face increasing numbers ... more Morbid obesity is becoming a worldwide health concern. Anesthesiologists face increasing numbers of obese patients requiring elective and emergency surgeries. Morbid obesity is associated with cardiovascular, pulmonary, degenerative joint disorders, and clinical syndromes such as obstructive sleep apnea syndrome. Hypoxic events are common in anesthetised morbidly obese patients due to atelectasis. This paper discusses spinal surgery with spinal anesthesia in a morbidly obese patient. The spinal block ended before the surgery was completed and the surgeon injected local anesthetic intradurally through the surgical incision and the operation ended without any complications. The patient was discharged the next day. We conclude that in selected cases when general anesthesia increases the risk, regional anesthesia may decrease perioperative complications and hospital stay. Key words: Morbid Obesity; Spinal Surgery; Spinal Anesthesia.
Amaç: Zehirlenme, madde maruziyeti sonucu organizmada istenmeyen yan etkilerin gözlenmesidir. Bu ... more Amaç: Zehirlenme, madde maruziyeti sonucu organizmada istenmeyen yan etkilerin gözlenmesidir. Bu çalışmamızda yoğun bakım ihtiyacı olan intoksikasyon vakalarının demografik özelliklerini, etiyoloji ve prognozlarını retrospektif olarak değerlendirilmeyi amaçladık. Gereç ve Yöntemler: Hastanemiz Cerrahi Yoğun Bakım Ünitesinde Ocak 2012 - Ocak 2014 tarihleri arasında akut ilaç zehirlenmesi tanısı ile yatırılan 23 olgu geriye dönük olarak incelenmiştir. Bulgular: Toplam 23 hastanın (12 kadın %52,2) verileri incelendi. Yaş ortalaması kadınlarda 26±10 yıl, erkeklerde 37±18,7 yıl idi. Akut zehirlenme sebebi 20 hastada (%87) intihar amaçlı ilaç alımı, 2 hastada (%9) arı sokması, 1 hastada (% 3) alkol alımıydı. Yoğun bakımda bir yılda takip ettiğimiz vakaların %7,9\'u intoksikasyon olguları idi. 5 hastada (%22) solunum yetmezliğine sekonder mekanik ventilatör ihtiyacı oldu ve ortalama 9,6 gün mekanik ventilatöre bağlı kaldıkları belirlendi. Yoğun bakım yatış süresi ortalama 4,6 gündü. Sonuç: Akut intoksikasyon nedeniyle yoğun bakım ihtiyacı görülen hastaların çoğunluğunun, suisid amaçlı ilaç alan bayan hastalar olduğunu ve çok kısa süreli takip gerektirdiklerini saptadık. Akut intoksikasyon hastalarının retrospektif incelenmesinin, bu hastaların takip kalitesi ve yoğun bakım ünitelerindeki klinik işleyişin iyileştirilmesi açısından periyodik olarak tekrarlanmasının faydalı olacağı kanaatindeyizAim: Intoxication is the development of unwanted effects due to exposure to an agent. We retrospectively investigated intoxication cases requiring intensive care treatment, and aim to present demographics, etiologies and prognoses. Material and Methods: We retrospectively investigated records of 23 patients, who were diagnosed with acute drug intoxication and treated in surgical intensive care unit during January 2013 and January 2014. Results: Data from a total of 23 patients (12 female, 52,5%) were analysed. The mean age of the patients was 26±10 years in women and 37±19 years in men. The reason of acute intoxication was suicide attempt with drugs in twenty patients (87%), bee bites in 2 patients (9%), and alcohol intoxication in one patient (3%). Five patients required mechanical ventilation secondary to respiratory insufficiency for an average of 9.6 days. The overall average duration of intensive care stay was 4.6 days. Conclusion: We conclude that majority of patients requiring intensive care treatment due to acute intoxication were female patients who attempted suicide and these patients required a very short duration of follow-up. We are in the opinion that follow-up quality of these patients and clinical management of intensive care units may benefit from periodical retrospective analysis of acute intoxication case
Turkish Journal of Intensive Care, 2021
Objective: Laboratory parameters may predict the severity and mortality of coronavirus disease 20... more Objective: Laboratory parameters may predict the severity and mortality of coronavirus disease 2019 (COVID-19). We investigated the relationship of laboratory findings obtained at admission and 72nd hour and mortality and morbidity of patients with pneumonia who were treated in two intensive care units. Materials and Methods: Chart data of 75 patients (March-May 2020) were retrospectively analysed. Patient characteristics and laboratory parameters were compared according to the presence of COVID-19 and mortality. Patients with COVID-19 were compared according to mortality and gender. Results: The mean patient age was 74.7 ± 11.3 years. COVID-19 positivity was not associated with marked differences in laboratory values. Lung disease, bedridden status, worse renal function scores, and high C-reactive protein level was more often observed in non-survivors (p < 0.05). A decline in D-dimer level was more apparent in survivors; the increase in ferritin and neutrophillymphocyte ratio was more apparent in non-survivors (not significant). Among patients with COVID-19, women had higher mean platelet volume than men (p = 0.033). The rise in ferritin level was more pronounced in men, whereas the rise in neutrophil-lymphocyte ratio and platelet-lymphocyte ratio was higher in women. Conclusion: In this geriatric cohort, chronic lung disease and bedridden status were the main determinants of mortality. Moreover, different patterns of inflammatory markers may help predict the severity of COVID-19.
Turkish Journal of Anesthesia and Reanimation, 2018
Controlled hypotension is commonly induced during functional endoscopic sinus surgery to limit mu... more Controlled hypotension is commonly induced during functional endoscopic sinus surgery to limit mucosal bleeding. This may be detrimental to elderly patients and patients with arterial stenosis. The aim of this pilot study was to determine if a normotensive anaesthetic technique with sufficient analgesia and without profound vasodilation may reduce intraoperative bleeding and incidence of adverse haemodynamic effects associated with vasodilation and variable rate continuous infusions. Methods: In this double-blind randomised controlled trial in a tertiary care centre, a total of 88 patients were randomised to receive intravenously either 0.1 mg kg −1 metoprolol and 1 mg kg −1 tramadol following anaesthesia induction (MT group) or a bolus dose of 0.5 µg kg −1 remifentanil following anaesthesia induction, followed by 0.25-0.5 µg kg −1 min −1 remifentanil infusion (R group). The primary outcome was quality of surgical field and incidence of adverse haemodynamic effects. The secondary outcomes were time to achieve intraoperative bleeding score <3, bleeding rate and changes in cerebral regional oximetry. Results: A total of 105 patients were recruited, in which 88 were randomised. The median intraoperative bleeding score was similar (1, interquartile range: 1-1, p=0.69). The mean bleeding rate was lower in the MT group, although the difference was not significant (p=0.052, 95% CI 0 to 8.8). Hypotension, bradycardia and cerebral desaturation in the MT group were not observed compared to hypotension in 3 (7%), bradycardia in 18 (41%) and cerebral desaturation in 2 (5%) patients in the R group (p=0.241, p<0.001, p=0.474, respectively). Conclusion: Providing sufficient analgesia and eliminating stress response can provide stable heart rate and good surgical field with no need for additional hypotension. This normotensive technique may be useful in patients with stenotic arteries or ischaemic organ diseases.
Journal of Emergency Medicine Case Reports, 2018
Infantile hemangioma is the most common vascular tumor in children. Although they usually regress... more Infantile hemangioma is the most common vascular tumor in children. Although they usually regress without treatment, complications develop in approximately 10% of cases, and surgical intervention is required (2). Depending on the size and neighboring organs of the hemangioma, life-threatening obstructions or organ failures may occur. Hemangiomas most commonly appear in the head and neck region and cause airway stenosis (3).
Türk Yoğun Bakım Derneği Dergisi, 2015
Journal of Cardio-Vascular-Thoracic Anaesthesia and Intensive Care Society, 2014
Akut respiratuar yetmezlik, etiyolojisinde çok sayıda faktörün yer aldığı, her yaş grubunda morta... more Akut respiratuar yetmezlik, etiyolojisinde çok sayıda faktörün yer aldığı, her yaş grubunda mortalitesi yüksek ciddi bir tablodur. Ekstrakorporeal membranöz oksijenatörlerin gelişmesiyle, oksijenasyonun bir membran aracılığı ile sağlanması ve akciğer koruyucu ventilasyon uygulanması şeklinde tedavi yaygınlaşmaktadır. Yüksekten düşmeye bağlı ağır torakal hasar nedeniyle opere edilen bir hastamızda gelişen akut respiratuar yetmezlik tablosunun tedavisini sunduk. Hipoksi nedeniyle dokuz gün boyunca veno-venöz EKMO uygulanan hastanın oksijenasyonu düzeldi. Bir aylık iyileşme sürecini takiben trakeotomize hâlde servise taburcu edildi.
Abant Medical Journal, 2015
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Papers by Abdullah özdemir