Papers by Abdul Moeed khan
Medicine Science | International Medical Journal, 2017
Cellular & Molecular Biology Letters, 2017
Squamous cell carcinoma (SCC) is the most common cancer worldwide. The treatment of locally advan... more Squamous cell carcinoma (SCC) is the most common cancer worldwide. The treatment of locally advanced disease generally requires various combinations of radiotherapy, surgery, and systemic therapy. Despite aggressive multimodal treatment, most of the patients relapse. Identification of molecules that sustain cancer cell growth and survival has made molecular targeting a feasible therapeutic strategy. Survivin is a member of the Inhibitor of Apoptosis Protein (IAP) family, which is overexpressed in most of the malignancies including SCC and totally absent in most of the normal tissues. This feature makes survivin an ideal target for cancer therapy. It orchestrates several important mechanisms to support cancer cell survival including inhibition of apoptosis and regulation of cell division. Overexpression of survivin in tumors is also associated with poor prognosis, aggressive tumor behavior, resistance to therapy, and high tumor recurrence. Various strategies have been developed to target survivin expression in cancer cells, and their effects on apoptosis induction and tumor growth attenuation have been demonstrated. In this review, we discuss recent advances in therapeutic potential of survivin in cancer treatment.
Marine drugs, Jan 18, 2017
In continuation to our study of the chemical and biological potential of the secondary metabolite... more In continuation to our study of the chemical and biological potential of the secondary metabolites isolated from Omani seaweeds, we investigated a marine brown alga, Padina boergesenii. The phytochemical investigation resulted in the isolation of a new secondary metabolite, padinolic acid (1), along with some other semi-pure fractions and sub-fractions. The planar structure was confirmed through MS and NMR (1D and 2D) spectral data. The NOESY experiments coupled with the biogenetic consideration were helpful in assigning the stereochemistry in the molecule. Compound 1 was subjected to enzyme inhibition studies using urease, lipid peroxidase, and alpha-glucosidase enzymes. Compound 1 showed low to moderate α-glucosidase and urease enzyme inhibition, respectively, and moderate anti-lipid peroxidation activities. The current study indicates the potential of this seaweed and provides the basis for further investigation.
PLOS ONE, 2016
Accumulating evidence has recently supported the association of bacterial infection with the grow... more Accumulating evidence has recently supported the association of bacterial infection with the growth and development of cancers, particularly in organs that are constantly exposed to bacteria such as the lungs, colon, cervical cancer etc. Our in silico study on the proteome of Chlamydia pneumoniae suggests an unprecedented idea of the etiology of lung cancer and have revealed that the infection of C. pneumoniae is associated with lung cancer development and growth. It is reasonable to assume that C. pneumoniae transports its proteins within host-intracellular organelles during infection, where they may work with host-cell proteome. The current study was performed for the prediction of nuclear targeting protein of C. pneumoniae in the host cell using bioinformatics predictors including ExPASy pI/Mw tool, nuclear localization signal (NLS) mapper, balanced sub cellular localization predictor (BaCeILo), and Hum-mPLoc 2.0. We predicted 47/1112 nuclear-targeting proteins of C. pneumoniae connected with several possible alterations in host replication and transcription during intracellular infection. These nuclear-targeting proteins may direct to competitive interactions of host and C. pneumoniae proteins with the availability of same substrate and may be involved as etiological agents in the growth and development of lung cancer. These novel findings are expected to access in better understanding of lung cancer etiology and identifying molecular targets for therapy.
Genes & development, 2015
Glucose-rich diets shorten the life spans of various organisms. However, the metabolic processes ... more Glucose-rich diets shorten the life spans of various organisms. However, the metabolic processes involved in this phenomenon remain unknown. Here, we show that sterol regulatory element-binding protein (SREBP) and mediator-15 (MDT-15) prevent the life-shortening effects of a glucose-rich diet by regulating fat-converting processes in Caenorhabditis elegans. Up-regulation of the SREBP/MDT-15 transcription factor complex was necessary and sufficient for alleviating the life-shortening effect of a glucose-rich diet. Glucose feeding induced key enzymes that convert saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), which are regulated by SREBP and MDT-15. Furthermore, SREBP/MDT-15 reduced the levels of SFAs and moderated glucose toxicity on life span. Our study may help to develop strategies against elevated blood glucose and free fatty acids, which cause glucolipotoxicity in diabetic patients.
Jundishapur Journal of Microbiology, 2015
Pakistan Journal of Pharmaceutical Sciences
Infections associated with cancer are a major scourge and cause of substantial morbidity and mort... more Infections associated with cancer are a major scourge and cause of substantial morbidity and mortality in cancer patients. The aim of present study was to appraise the in vitro activity of anticancer agent vincristine and antifungal fluconazole alone and in combination against Candida spp. Results were interpreted in terms of fractional inhibitory concentration index (FICI). Antifungal activity of fluconazole showed marked synergism when used in combination with vincristine, with FICI ranging from 0.25-0.5 against different Candida spp. Although, the use of vincristine with fluconazole is always disputed due to its side effects including decreased peristalsis, but the present research can help to perform suitability analysis of fluconazole use in life threatening invasive candidiasis associated with cancer patients. In addition, the synergism in antifungal activity after using with vincristine also warrants further research in the direction of minimizing adverse reaction associated ...
Journal of Enzyme Inhibition and Medicinal Chemistry, 2010
of various fractions and compounds isolated for the first time from H. oblongifolium. Experimenta... more of various fractions and compounds isolated for the first time from H. oblongifolium. Experimental General Ultraviolet (UV) spectra were obtained on a Hitachi-U-3200 UV-visible spectrometer with CHCl 3 as solvent. Infrared (IR) spectra were recorded on a Vector 22 (Bruker) Fouriertransform infrared (FT-IR) spectrometer using CH 2 Cl 2 as solvent. 1H and 13 C nuclear magnetic resonance (NMR) spectra were recorded on a Bruker Avance AV-500 spectrometer. Chemical shifts () are expressed in ppm relative to tetramethylsilane (TMS) as internal standard and coupling constants are given in Hz. 1 H NMR spectra were referenced against the CHCl 3 + CH 3 OH signal at H 7.27, 4.9 and 13 C NMR spectra against the corresponding signal at C 77.04. Mass spectra (electron ionization (EI-) and high resolution (HR)-EI-MS) were measured in electron impact mode on Finnigan MAT-312 and MAT-95 XP spectrometers, and ions are denoted as m/z (%). Thin layer chromatography (TLC) was performed on pre-coated silica gel F-254 plates (E. Merck); the detection was done at 254 nm, by spraying with ceric sulfate reagent. Column silica gel (E. Merck, 70-230 mesh) and flash silica gel (E. Merck, 230-400 mesh) were used for column chroma
Uploads
Papers by Abdul Moeed khan