Papers by Abdelbaset Elasbali
Infectious Agents and Cancer, 2012
Journal of Biomolecular Structure & Dynamics, Sep 12, 2022
Current Medical Imaging Reviews, Oct 1, 2022
Background: Diagnostic radiology has been linked to several health consequences. Thus, the presen... more Background: Diagnostic radiology has been linked to several health consequences. Thus, the present study aimed to assess the practice, knowledge, and awareness of the diverse effects of diagnostic radiology among radiology staff and students in Saudi Arabia. Methodology: In this study, 107 participants were recruited from August to December 2020. The study included 56 radiology personnel (staff from Hail City Hospitals) and 51 radiology medical students (students from the University of Ha’il). Results: To the question, “Have you ever been informed of radiation and its effects?” about 6/107 (5.6 %) answered “No,” among which 5/6 (83.3 %) were the staff. In response to the question, “In your opinion, how hazardous is radiation to your body?” about 8/104 (7.7 %) indicated it as nonhazardous (3 were staff and 5 were students). To the question, “Do you believe that radiation in medical sites is harmful?” about 20/104 (19.2 %) answered, “No” (8 were staff and 12 were students). Conclusion: There is a lack of awareness, knowledge, and practice towards ionizing radiation protection measures among radiology medical students and radiology department staff in Northern Saudi Arabia. The paper notifies the health system advisors to include stressing guidelines regarding radiation hazards. More actions are deemed necessary for the safety of patients and radiation workers.
International Journal of Medical Research and Health Sciences, 2019
Background: Thyroid disorders represent a major problem in Saudi Arabia, particularly in the nort... more Background: Thyroid disorders represent a major problem in Saudi Arabia, particularly in the northern part of the country. The objective of the current study was to investigate the immunohistochemical expression of CK19, CD56, and Gal-3 in a series of Saudi patients with thyroid carcinoma in Northern Saudi Arabia (Hail) region. Methodology: This is a retrospective study, investigated 50 formalin-fixed paraffin wax tissue blocks with a confirmed diagnosis of thyroid carcinoma from Northern Saudi Arabia. Immunohistochemistry demonstration was for CK19, CD56, and Gal-3 markers applying Avidin-Biotin method. Results: Out of the 50 patients, 45(90%) were females and 5(10%) were males, aged 13-70 years old with a mean age of 43 years. CK19 was positively expressed in 74% of the thyroid carcinoma. Positive CD56 expression was demonstrated in 45.7%, 58.3%, and 100% of the papillary, follicular and undifferentiated thyroid carcinomas, correspondingly. Positive Galectin-3 expression was demonstrated in 71.4%, 58.3%, and 100% of the papillary, follicular and undifferentiated thyroid carcinomas, correspondingly. Conclusion: Papillary thyroid carcinoma is the most common thyroid cancer in Northern Saudi Arabia. Females represent more than 90% of the cases of the thyroid carcinoma in Northern Saudi Arabia. CK19, CD56, and Gal-3 are useful for the assessment of thyroid carcinoma.
Toxicology and Environmental Health Sciences, Mar 1, 2020
Objective Doxorubicin (DOX) is a widely used antineoplastic drug with several toxic effects. We i... more Objective Doxorubicin (DOX) is a widely used antineoplastic drug with several toxic effects. We investigated the protective effect of co-administration of baicalein (BL; a flavonoid) and losartan (LT; angiotensin receptor blocker) on DOX-induced hepatotoxicity. Methods Male Wistar albino rats were divided into these seven groups (n = 6): (1) Control group; (2) DOX group; (3) DOX + LT group (LT, 7 mg/kg/day orally); (4) DOX + BL low-dose group (BL, 5 mg/kg/day orally); (5) DOX + BL highdose group (BL, 10 mg/kg/day orally); (6) DOX + LT + BL(5) low-dose group; and (7) DOX + LT + BL(10) high-dose group. After 2 weeks of LT and BL treatment, a dose of DOX (15 mg/kg, intraperitoneal) was administered to the rats in groups 2 to 6 and continued for seven more days. Results The use of serum levels of liver enzymes, tumor necrosis factor-α, interleukin (IL)-6, and IL1β and estimated the activity of thiobarbituric acid-reactivesubstances, glutathione, superoxide dismutase, catalase, and glutathione peroxidase in liver homogenates. In addition, we measured the activity of caspase-3, nitric oxide, inducible nitric oxide synthase, endothelial nitric oxide synthase, and nuclear factor kappa-B (NF-κB) p65 in hepatic cells and subjected the liver sections to histological examination. While the DOX-induced increase in serum liver enzymes, pro-inflammatory cytokines, and biomarkers was alleviated by BL and/or LT treatment, the BL + LT groups showed the most potent protective effects. Conclusions Our study demonstrates remarkable anti-oxidative and anti-inflammatory effects of BL and LT in rodents challenged with DOX. Concurrent administration of BL and LT showed a marked synergistic effect in restoration of histological features and alleviation of hepatic oxidative injury via inhibition of reactive oxygen species and anti-inflammatory mechanisms.
BioMed Research International, Sep 20, 2022
Effluents discharged by poultry meat industries are heavily polluted with raw materials, such as ... more Effluents discharged by poultry meat industries are heavily polluted with raw materials, such as fat, blood residues, and proteins. Thus, untreated effluents directly discharged into the environment may constitute a public health threat. This study aims to evaluate the bacterial diversity of three water qualities: industrial poultry wastewater (PWW), tap water (TW), and PWW diluted with TW (50 : 50) (V/V) (TWPWW) by the combination of culture-independent and culture-dependent approaches. The total bacterial DNA was extracted using phenol/chloroform method. The hypervariable 16S rRNA region V3-V5 was amplified by PCR using universal primers. The amplicons were separated by vertical electrophoresis on a polyacrylamide gel of increasing denaturing gradient according to their richness in GC bases. Selected bands were reamplified and sequenced. Pure isolated bacteria from nutrient agar medium were characterized according to their morphological and biochemical characteristics. Genomic DNA from pure strains was extracted by boiling method, and a molecular amplification of the 16S-23S ITS region of the 16S rRNA gene was performed using the universal primers. Selected isolates were identified by sequencing. Results showed a high bacterial load and diversity in PWW in comparison with TW and TWPWW. A collection of 44 strains was obtained, and 25 of them were identified by sequencing. Proteobacteria represented 76% of isolated bacteria Gamma-Proteobacteria was the predominate isolate (68%). Other isolates were Firmicutes (8%), Bacteroidetes (12%), and Actinobacteria (8%). These isolates belong to different genera, namely,
Open Journal of Obstetrics and Gynecology, 2019
Background: Continued exposure to sex hormones such as estrogen is a critical risk for subsequent... more Background: Continued exposure to sex hormones such as estrogen is a critical risk for subsequent breast cancer. Thus the present study aimed to assess the levels of knowledge towards hormonal related breast cancer risk factors in Qurayyat, Northern Saudi Arabia. Methodology: This descriptive study included 737 Saudi volunteers living in the city of Qurayyat, Northern Saudi Arabia. For females, only those agreeing to participate in the breast self-examination workshop were included, and non-respondents were included in the questionnaire. Results: For the question apropos "Inheritance as a risk factor for BC," 405/607 (66.7%) females signposted certainly "Yes," as well as, 70/130 (54%) males signposted certainly "Yes." The odds ratio (OR) and 95% confidence interval (95% CI) were not statistically significant, but the level of knowledge was relatively higher among females OR (95% CI) = 1.4321 (0.9597 to 2.1370), P = 0.0786. "Are early puberty and late menopause risk factors for breast cancer?" No statistical significant differences were eminent between males and females, OR (95% CI) = 0.8878 (0.5932 to 1.3287), P = 0.5629. Conclusion: Saudi women are enthusiastically willing to raise their knowledge and awareness of breast cancer prevention and control. Although women have greater knowledge about breast cancer risk factors compared to men, still some gaps need to be filled.
International Journal of Biological Macromolecules, Jul 1, 2022
PubMed, Jun 1, 2023
Objective: The goal of this study was to look at the patterns of thyroid tumors and how thyroid c... more Objective: The goal of this study was to look at the patterns of thyroid tumors and how thyroid cancer markers showed up in immunohistochemistry in Northern Saudi Arabia. Patients and methods: This study investigated retrospectively 190 patients who attended with thyroid complaints. About 140 thyroid biopsies were diagnosed in the Department of Pathology at King Salman Hospital, Ha'il, from November 2019 to November 2020. Results: Out of the 190 patients who attended with thyroid complaints, 140/190 (73.7%) were detected with thyroid lesions (58 malignant and 82 benign). Benign lesions included goiter 49/82 (60%), follicular adenoma 17/82 (21%), Hashimoto's thyroiditis 13/82 (16%), and toxic goiter 3/82 (3%). 5/6 (83.3%) of males with benign lesions had goiters. CK19 was positive in 68.5% of the cases; 71.8% were papillary, 66.7% were follicular, and 100% were undifferentiated carcinomas. Out of the 26/54 (48%) CD56-positive cases, 18/39 (46%) were papillary, 7/12 (58.3%) were follicular, and 3/3 (100%) were undifferentiated carcinomas. Out of the 35/54 (64.8%) Galectin-3-positive cases, 69.2% were papillary, 7/12 (58.3%) were follicular, and 3/3 (100%) were undifferentiated carcinomas. Conclusions: Thyroid cancer is prevalent in northern Saudi Arabia, with the predominant type being papillary thyroid carcinoma. Most patients are female and younger. The combined use of CK19, CD56, and Galectin-3 tumor markers assists in the accurate differential diagnosis of thyroid neoplasms.
International Journal of Medical Research and Health Sciences, 2018
Oral cancer is one of the most common cancers worldwide. In recent years, there is a remarkable i... more Oral cancer is one of the most common cancers worldwide. In recent years, there is a remarkable increase in the incidence of oral cancer in Saudi Arabia, particularly among relatively younger people. The increase in the incidence of oral cancer has been linked to several etiological factors, which greatly differs from geographical region to another. Therefore, the aim of the present review was to discuss the most important risk factors associated with oral cancer in light of the available literature from Saudi Arabia. Etiological factors discussed in this review of literature include genetic factors, tobacco use, alcohol consumption, infections, dietary factors, oral hygiene, etc. These etiological factors were discussed in view of the available literature (in the Medline and another electronic database) in general and literature pertains to Saudi Arabia in particular. This review can make important information available for health policymakers to implement better strategies for oral cancer prevention, early detection, and overall control. The review also helps in identifying the gaps between researchers to complete the whole image of oral cancer in Saudi Arabia with subsequent precise oral cancer control.
DOAJ (DOAJ: Directory of Open Access Journals), May 1, 2022
Clinical Medicine and Diagnostics, 2019
Background: Breast self-examination (BSE) is one of the accepted and cost-effective breast cancer... more Background: Breast self-examination (BSE) is one of the accepted and cost-effective breast cancer screening methods, which can effectively contribute to the prevention and early detection efforts. The present study aimed to assess the level of knowledge of BSE's trainees about features for early detection of the breast lumps in Qurayyat, Northern Saudi Arabia. Methodology: This is a descriptive study that included 626 Saudi women volunteers living in the city of Alquriat, Northern Saudi Arabia. Participants were randomly selected by simple random method regardless of age, gender, education level or occupation. For BSE, only those agreeing to participate in the breast self-examination workshop were included. Results: Inquiries regarding features of breast lesions covered; Do you know the signs that you can consider during doing BSE”, 64.7% stated “Yes” and the remaining 35.3% stated “No”; “Can you identify a present breast lump”, 95.4% stated “Yes” and the remaining 4.6% stated “No”; “Can you distinguish the differences in the appearance of the two breasts” 87.5% stated “Yes” and the remaining 12.5% stated “No”. Conclusion: There is a relatively higher level of knowledge of breast signs that can be measured in the course of BSE. Accidental detection of 5.3% of breast lesions in this randomize sample, necessitate the importance of a primary screening program, as well as, implementation of BSE training programs in Northern Saudi Arabia.
Journal of Biomolecular Structure and Dynamics
Journal of Biomolecular Structure and Dynamics
Journal of Biomolecular Structure and Dynamics
Journal of Biomolecular Structure and Dynamics
International Journal of Molecular Sciences
Metabolic reprogramming is a key attribute of cancer progression. An altered expression of pyruva... more Metabolic reprogramming is a key attribute of cancer progression. An altered expression of pyruvate kinase M2 (PKM2), a phosphotyrosine-binding protein is observed in many human cancers. PKM2 plays a vital role in metabolic reprogramming, transcription and cell cycle progression and thus is deliberated as an attractive target in anticancer drug development. The expression of PKM2 is essential for aerobic glycolysis and cell proliferation, especially in cancer cells, facilitating selective targeting of PKM2 in cell metabolism for cancer therapeutics. We have screened a virtual library of phytochemicals from the IMPPAT (Indian Medicinal Plants, Phytochemistry and Therapeutics) database of Indian medicinal plants to identify potential activators of PKM2. The initial screening was carried out for the physicochemical properties of the compounds, and then structure-based molecular docking was performed to select compounds based on their binding affinity towards PKM2. Subsequently, the ADM...
Evidence-based Complementary and Alternative Medicine, Oct 17, 2022
Objective. is study aimed to associate the expression of P53, BCL2, PTEN, and HER2/neu tumor mark... more Objective. is study aimed to associate the expression of P53, BCL2, PTEN, and HER2/neu tumor markers in speci c breast cancer lesions. Methods. is study analyzed the immunohistochemical expression of P53, BCL2, PTEN, and HER2/neu tumor markers for 306 patients who presented with lesions. Tissue blocks and patients' identi cation data were retrieved from the department of pathology, AL Madinah Almonwarah hospital, Al Madinah, UAE. Results. Of the 306 patients, 104 had benign lesions and 202 had malignancy (including 194 females and 6 males). Most females were presented with invasive ductal carcinoma (IDC), followed by in ltrating ductal carcinoma, and invasive lobular carcinoma (ILC), representing 70%, 23.2%, and 3.7%, respectively. Positive P53, BCL2, PTEN, and HER2 were identi ed in 20.8%, 11.9%, 91%, and 18.3%, respectively. Conclusion: e expression of P53, BCL2, PTEN, and HER2/neu tumor markers among Saudi patients with breast cancer is relatively similar in many parts of the world.
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Papers by Abdelbaset Elasbali