Papers by AMANDA OKTAVIA RAMADANI
The aim of this study was to observe the characterization dosage form and release of diclofenac s... more The aim of this study was to observe the characterization dosage form and release of diclofenac sodi um with microemulsion w/o system from carbomer 940 gel base. Microemulsion contained ratio surfactant span80-tween80 and cosurfactant etanol 96% 6:1. Diclofenac s odium gel with emulsion was used as control. The evaluation included organol eptic, pH, spreadability, and also diclofenac sodium release test from gel base of each formula. Data from pH test, spreadability, and spread diameter of zero load, were evaluated based on independent sample t-test. The result showed that microemulsi on system in gel base (formula I) showed thicker consistency than emulsion in gel base (formula II). Microemulsion in base gel Carbomer 940 didn’t have effect on pH but it had effect on spreadability and spread diameter of zero load. Data analyze showed that pH of formula I was 6,00±0,02 and formula II was 5,97±0,03. Spreadability of formula I was 0,0120 ± 0,0020 and formula II was 0,0480 ± 0,0100. Spr...
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Papers by AMANDA OKTAVIA RAMADANI