Symptoms of depression, anxiety, psychological discomfort, post-traumatic stress disorder and str... more Symptoms of depression, anxiety, psychological discomfort, post-traumatic stress disorder and stress were reported to be quite prevalent in the general population during the coronavirus disease-2019 (COVID-19) pandemic. 1 Female gender, being younger ≤40 years, chronic/psychiatric disorders, unemployment, student status, and frequent exposure to COVID-19-related social media/news are among the risk factors related to distress criteria in the general population during the COVID-19 outbreak. 1 Due to the frequent interaction with the health service, weakened immune status based on the cancer or its treatment, supportive medicines, and older age and comorbidities, cancer patients are one of the most vulnerable populations during the COVID-19 pandemic. 2 The studies on gynaecological cancer patients support distress effects from COVID-19. Because of the immunosuppression caused by chemotherapy, 73.2 percent of patients with gynaecological cancer believe that they are at increased risk of COVD-19 infection, although only 17.5 percent of patients are more dreaded of COVID-19 than their pre-existing cancer diagnosis. The majority of gynaecological cancer patients (71%) are afraid that if their treatment or oncological follow-up is delayed or cancelled, their disease may advance, and nearly half (53.1%) express fears of contracting COVID-19 from hospitals or clinics during oncological treatment or follow-up. 3 Despite the fact that the impact of the COVID-19 infection on gynaecological cancer patients receiving active therapy or being followed up has been
Background Primitive neuroectodermal tumors of uterus (PNET) are extremely rare in tumors of the ... more Background Primitive neuroectodermal tumors of uterus (PNET) are extremely rare in tumors of the female genital system and therefore there is no suYcient information about their diagnosis, treatment, and follow-up. Case The case is a 32-year-old, operated in emergency conditions due to intra-abdominal hemorrhage, and discusses our diagnosis and treatment approaches in the light of literature data. Conclusion To the best of our knowledge, this is Wrst report of uterine PNET that presented with intraabdominal hemorrhage due to uterine rupture. Despite advances in therapy, the prognosis is poor. The low number of these cases precludes accurate standardization of therapy.
Background/Aim: Preeclampsia (PE) complicates 2–8% of all pregnancies worldwide. Placental malper... more Background/Aim: Preeclampsia (PE) complicates 2–8% of all pregnancies worldwide. Placental malperfusion and dysfunction are observed in PE. The supply of glucose, the main energy substrate for the fetus and placenta, is regulated by placental expression and activity of specific glucose transporter proteins (GLUTs), primarily GLUT1. GLUT1 expression is affected by uteroplacental malperfusion and oxidative stress, which are important components of PE. Very few studies have investigated GLUT1 expression in preeclamptic placentas. In this study, we aimed to compare GLUT1 staining intensity in the terminal villi of the placenta in healthy subjects and patients with E-PE or L-PE and determine whether there was a relationship between GLUT1 staining intensity and IUGR. Methods: This case-control study was carried out in our hospital’s gynecology and obstetrics clinic, a tertiary center for perinatology cases. A total of 94 placentas, 47 of which were preeclamptic and 47 were from uneventful...
Öz The incidence of ectopic kidney is approximately 1:1,000 in newborns. Ectopic kidney has a pla... more Öz The incidence of ectopic kidney is approximately 1:1,000 in newborns. Ectopic kidney has a place outside of renal fossa and been found in the pelvis, abdomen, and thorax. We reported a case of a 51-year-old female who was referred to our hospital with the complaint of abnormal vaginal bleeding and pelvic pain. Adenocarcinoma of cervix was reported after biopsy, radical hysterectomy and bilateral salphingo-oopherectomy with pelvic and para-aortic lymph node dissection were performed. Unilateral, right renal ectopic kidney with vessels was observed during paraaortic lymphadenectomy in cervical cancer surgery. During gynecological oncologic surgery especially at the retroperitoneal stage congenital organ abnormalities must be kept in mind and surgery must be planned according to the abnormalities. Ektopik böbrek; yenidoğanda yaklaşık 1/1000 oranında görülen, renal fossa dışında pelvis, abdomen ve toraksta bulunan anormal yerleşimli böbreği tanımlar. Anormal uterin kanama ve pelvik ağrı şikayeti ile başvuran 51 yaşında kadın hastadan alınan serviks biyopsisi adenokarsinom olarak rapor edildi. Hasta onamı alınarak radikal histerektomi, bilateral salpingo-ooferektomi ve pelvik paraaortik lenf nodu diseksiyonu yapıldı. Cerrahinin paraaortik lenf nodu diseksiyonu aşamasında damarları ile birlikte unilateral renal ektopik böbrek tespit edildi. Onkolojik cerrahilerde özellikle de retroperitoneal bölge aşamasında komplikasyon oranlarını en düşük düzeylere indirmek için doğumsal organ yerleşim anomalileri akılda bulundurulmalı ve cerrahi planlaması yapılmalıdır.
Background/Aim: Menopausal transition (MT) is defined as the transition from reproductive to post... more Background/Aim: Menopausal transition (MT) is defined as the transition from reproductive to post-reproductive life. Oxytocin has beneficial effects on health problems, such as sexual activity disorder, vaginal atrophy, cardiovascular system diseases and acceleration in bone mass loss, which may develop due to changes in reproductive hormone levels during the MT period. During exercise, which can be used as adjuvant therapy for most of these health problems, a temporary increase in catecholamine levels is required for response to exercise-induced stress. However, the effects of exercise programs applied during the MT period on plasma dopamine (pDA) and plasma oxytocin (pOT) levels are unknown. The aim of this study was to investigate the effects of three different types of exercise on plasma dopamine (pDA) and plasma oxytocin (pOT) levels in sedentary women in the MT period. Methods: Twenty-six sedentary healthy participants in the MT period whose fitness levels in the standard maxi...
Clinical and Experimental Obstetrics & Gynecology
Background: Maresin-1 (MaR1) plays a major role in many inflammatory disorders. Polycystic ovary ... more Background: Maresin-1 (MaR1) plays a major role in many inflammatory disorders. Polycystic ovary syndrome (PCOS) aside from a hormonal disorder, an inflammation might also contribute to PCOS and its metabolic associations. Therefore, the purpose of this prospective study first time was to find out the blood, saliva and urine levels of MaR1 in PCOS patients and evaluate the correlations with other metabolic and hormonal parameters. Methods: Thirty PCOS patients and 30 matched healthy controls were enrolled to prospective case control study. Blood, urine and saliva samples were simultaneously collected from participants after overnight fasting. MaR1 levels in blood, urine and saliva samples were determined by enzyme-linked immunosorbent assay. Ferriman-Gallwey score, anthropometric, hormonal and some other metabolic parameters were also recorded. Regression analysis was preformed to find out the relationship between MaR1, C-reactive protein (CRP) and malondialdehyde (MDA), and hormonal and metabolic parameters. Results: Patients with PCOS compared with control women had higher MDA and CRP and decreased MaR1 levels. Blood, urine and saliva MDA and MaR1 levels were similar and indicated parallel decrease or increase in the PCOS and control groups. Furthermore, regression analysis indicated that blood CRP and MDA was positively associated with luteinizing hormone (LH) and fasting insulin (FI) in PCOS group (p < 0.05) while blood, urine and saliva MaR1 was negatively associated with CRP and MDA. Conclusions: Present results (MaR1, CRP and MDA together) in case of PCOS suggests that decreased MaR1 and elevated MDA and CRP levels in patients with PCOS and may be considered as a useful early biomarker (especially MaR1) in diagnosis of PCOS disease that has not been previously reported and regular monitoring of their levels could be helpful in clinical decisions.
Aim: : To measure obestatin levels in the blood and saliva samples of normal-weight patients with... more Aim: : To measure obestatin levels in the blood and saliva samples of normal-weight patients with polycystic ovary syndrome (PCOS) in comparison with normal-weight healthy controls, and to determine whether there were relationships between blood and/ or salivary obestatin levels and other measured parameters. Materials and Methods: Fifteen healthy women and 15 patients with PCOS, all of which had normal weight, were included in the study. Participants' age, height, weight, menstrual characteristics, hormone levels, body mass index, waist/hip ratio, and modified Ferriman-Gallwey (FG) scores were recorded. Obestatin levels were measured in both fasting blood and saliva samples. Homeostasis Model Assessment (HOMA-IR) was used to predict insulin resistance. Results: In the PCOS group, menstrual cycle duration and FG scores were significantly higher (P-value, <0.001, <0.001, respectively). The levels of luteinizing hormone, total testosterone and androstenedione were significantly higher in the PCOS group than in the control group (P-value, 0.001, 0.009, 0.004, respectively). In the PCOS group, blood obestatin level was 1265.2 ± 221.9 pg/ml, salivary obestatin level was 3095.33 ± 310.2 pg/ml; whereas the control group demonstrated lower levels of 939.66 ± 72.3 pg/ml and 2611.20 ± 217.1 pg/mL, respectively. However, no statistically significant difference was found between the PCOS and control groups when comparing obestatin levels in blood or saliva (P-value, 0.218, 0.369, respectively). No correlation was found between blood and salivary obestatin levels in either group. Finally, obestatin levels were not associated with any of the other measured parameters. Conclusion: Our results suggest that increased levels of obestatin, albeit in a small amount that would not be statistically significant in normal weight patients with PCOS, may have significant effects on weight control in these patients. In addition, our findings show that saliva sample can be used as an alternative to blood sample in the measurement of obestatin level in patients with PCOS.
Bakirkoy Tip Dergisi / Medical Journal of Bakirkoy, 2021
Objective: This study aimed to analyze the effect of an absorbable hemostat produced from oxidize... more Objective: This study aimed to analyze the effect of an absorbable hemostat produced from oxidized regenerated cellulose (ORC) on pelvic adhesion formation in a rat model using an adhesion scoring system and immunohistochemical staining. Methods: This randomized, controlled experimental study included 20 female Wistar-Albino rats that were equally divided into the following groups: control and absorbable hemostat groups. The uterine horns of all the rats were exposed by laparotomy and using 10 W bipolar cautery. Five standard lesions were applied to the antimesenteric areas of each uterine horn. The experimental group received an absorbable hemostat to the traumatized uterine surfaces, whereas the control group did not. After a 28-day follow-up period, a relaparotomy was performed, and adhesions were evaluated based on an adhesion scoring system, and histological sections from areas with adhesion were obtained for immunohistochemical staining. Immunohistochemical staining included analysis of Ki-67 (proliferation index), CD-31 (neovascularization index), and Masson Trichrome [(MTC) fibrosis and collagen formation index]. Additionally, acute and chronic inflammation indices were determined via polymorphonuclear leukocytes (PMNL) and mononuclear leukocytes (MNL), respectively. Results: The intensity and scope of adhesion and overall adhesion ratings were substantially higher in the absorbable hemostat group than the control group (2.8±0.85 vs. 2.2±0.53, 0.92±0.26 vs. 0.61±0.25, and 3.72±0.96 vs. 2.81±0.75, respectively). Staining results for Ki-67, CD-31, MTC, PMNL, and MNL were also significantly higher in the absorbable hemostat group than in the control group (p<0.05 for all). Conclusion: The obtained results suggest that the use of ORC-based absorbable hemostats in pelvic surgery may increase adhesion formation on peritoneal surfaces by increasing inflammation, vascularity, and collagen formation.
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2009
Fe mo ral hi pop la zi de fe mur uzun lu ğu, 50 per sen ti lin al tın da dır ve izo le tip te ola... more Fe mo ral hi pop la zi de fe mur uzun lu ğu, 50 per sen ti lin al tın da dır ve izo le tip te ola bi le ce ği gi bi, fi bu lar ve/ve ya ul nar ano ma li ler le de bir lik te ola bilir. Na di ren fe mur ve ase ta bu lu mu da içe ren, pa tel la nın yok lu ğu ve ya hi pop la zi si gi bi alt eks tre mi te de fekt le riy le bir lik te gö rü le bi lir.1-3 Ay rı ca yüz, gas tro in tes ti nal sis tem, is ke let sis te mi, üro ge ni tal sis tem (hi pos pa di as, kü çük pe nis, vaji nal sep tum, çift ute rus, çift ser viks, ve zi ko-üre te ral ref lü, Unilateral Konjenital Kısa Femur
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2021
OBJECTIVE The aim of this retrospective case-control study was to analyze the effect of administe... more OBJECTIVE The aim of this retrospective case-control study was to analyze the effect of administering indomethacin after triggering final oocyte maturation in patients with poor ovarian response (POR) on the cycle cancellation rate due to premature ovulation (PO), the number of oocytes retrieved and the clinical outcomes of IVF cycles. STUDY DESIGN A total of 214 patients with POR, diagnosed according to the Bologna criteria, who underwent fresh IVF cycle via flexible gonadotrophin-releasing hormone antagonist (GnRH-ant) protocol were enrolled in the study. The control group consisted of 100 patients, whereas the indomethacin group included 114 patients who received 100 mg rectal indomethacin administered twice within the same day (twelve hours apart) -starting at twelve hours after triggering. Cycle cancelation rates (CCR), number of oocytes retrieved (nOR), implantation rates (IR), biochemical pregnancy (BP) and clinical pregnancy loss rates (CPL), ongoing pregnancy rates (OPR) and live birth rates (LBR) were compared between the indomethacin and control groups. RESULTS The CCR rate was significantly lower in the indomethacin group (1.8%) compared to the control group (1.8% vs %12%, p = 0.01). In the control group, those with cycle cancellation were older than those without cycle cancellation (mean age 42.2 ± 2.3 years vs. 39.36 ± 4.3 years, p = 0.001) and had lower anti-Müllerian hormone levels and lower antral follicle count (0.59 ± 0.2 ng/mL vs 0.79 ± 0.2 ng/mL, p = 0.001 and 4 ± 0.6 vs 5.7 ± 1.7, p = 0.001, respectively). In multivariable analysis, when the dependent variable in the logistic regression model was coded as the absence of cycle cancellation, it was observed that only indomethacin had a statistically significant effect on cycle cancellation (β = -1.931, standard error = 0.832, Exp(B) = 0.145, p = 0.020). nOR was higher in the indomethacin group than control group but the difference did not reach significance (p = 0.07). Moreover, the IR, OPR and LBR, BP and CPL values were similar in the indomethacin and control groups (p > 0.05). CONCLUSIONS Based on data from this study, it can be concluded that indomethacin reduces cycle cancelation due to PO in patients with POR -without compromising implantation and pregnancy rates. However, further randomized controlled trials with larger sample sizes are required to clarify the definitive effect of indomethacin in the treatment of patients with POR.
IntroductionThe aim of this prospective trial was to evaluate the ovarian reserve with anti-Mülle... more IntroductionThe aim of this prospective trial was to evaluate the ovarian reserve with anti-Müllerian hormone (AMH), which is the best predictor of ovarian reserve, and perform histological analysis after exposure to cisplatin with a GnRH agonist or antagonist.Material and methodsTwenty-four Wistar albino rats were randomly divided into three groups, each consisting of eight rats. In the GnRH agonist group (group 1), rats received a single dose of 50 mg/m2 cisplatin with 1 mg/kg triptorelin. In the GnRH antagonist group (group 2), rats received a single dose of 50 mg/m2 cisplatin with 1 mg/kg cetrorelix. In the control group (group 3), rats received 50 mg/m2 cisplatin. Ovarian reserve was assessed by AMH and histology.ResultsPrimary follicle counts were higher in group 2 (4.50 ±1.47 vs. 3.50 ±1.70 vs. 3.00 ±3.54) and secondary follicle counts were higher in group 1 (2.96 ±1.11 vs. 1.74 ±1.03 vs. 1.37 ±3.11). Numbers of tertiary follicles were higher both in groups 1 and 2 than the c...
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2009
on je ni tal kı sa fe mur, yak la şık ola rak 50.000 do ğum da bir gö rü lür. Da ha sık lık la sa... more on je ni tal kı sa fe mur, yak la şık ola rak 50.000 do ğum da bir gö rü lür. Da ha sık lık la sağ fe mur da or ta ya çı kar ve alt eks tre mi te le rin kon jeni tal asi met ri si ni içe ren fe mo ral hi pop la zi nin ve ya ap la zi nin bir şek li ola rak ta nım la nır. Fe mo ral hi pop la zi de fe mur uzun lu ğu, 50 per sen ti lin al tın da dır ve izole tip te ola bi le ce ği gi bi, fi bu lar ve/ve ya ul nar ano ma li ler le de bir lik te ola bilir. Na di ren fe mur ve ase ta bu lu mu da içe ren, pa tel la nın yok lu ğu ve ya hi pop la zi si gi bi alt eks tre mi te de fekt le riy le bir lik te gö rü le bi lir. 1-3 Ay rı ca yüz, gas tro in tes ti nal sis tem, is ke let sis te mi, üro ge ni tal sis tem (hi pos pa di as, kü çük pe nis, vaji nal sep tum, çift ute rus, çift ser viks, ve zi ko-üre te ral ref lü, Unilateral Konjenital Kısa Femur ÖZET Uni la te ral kon je ni tal kı sa fe mur, yak la şık ola rak 50.000 do ğum da bir or ta ya çı kan na dir bir is ke let bo zuk lu ğu dur. Da ha sık lık la sağ fe mur da or ta ya çı kar. Fa mil yal, ma ter nal ta li do mit kul lanı mı, vi ral en fek si yon, ir ra dyas yon, fo kal is ke mi, trav ma ve kim ya sal tok sin le re ma ruz kal ma gi bi çe şit li et iyo lo jik fak tör ler öne sü rül müş tür. Te mel prob lem, eks tre mi te ler ara sı uzun luk far kı dır. Biz 21. haf ta da pre na tal ta nı sı ko nu lan, di ğer yön ler den sağ lık lı, spo ra dik bir uni la te ral kon je ni tal kı sa fe mur olgusu sun duk. Ta nı, do ğum dan son ra te yit edil di. So nuç ola rak, pre na tal kı sa fe mur ta nı sı konu lan olgu la ra, uy gun za man da or to pe dik kon sül tas yon ya pı la bi lir. Böy le ce ge le cek te ki te da vi yöntem le ri için da ha iyi ka rar ve ril me si sağ la nır. Ul tra so nog ra fi nin kul la nı mı, is ke let bo zuk luk la rı nın da ha er ken pre na tal ta nı la rı nı sağ la ya bi lir. Anah tar Ke li me ler: Kon je ni tal; fe mur; ano ma li ler ABS TRACT Uni la te ral con ge ni tal short fe mur is a ra re ske le tal system ab nor ma lity se en in 1 of 50.000 births. It is mo re com monly se en on right fe mur. Ge ne tic pre dis po si ti on, ma ter nal tha li domi de use, vi ral in fec ti ons, ir ra di a ti on, fo cal isc he mi a, tra u ma, che mi cal to xins, are a few of sus pected eti o lo gic fac tors. Ma in prob lem is the dif fe ren ce bet we en the lenght of ex tre mi ti es. We he re in re port a spo ra dic uni la te ral short fe mur ca se, who has no ot her ano maly, di ag no sed at 21 we ek of preg nancy. Di ag no sis is ap pro ved with the short fe mur af ter birth. In conc lu si on, ort ho pe dic consul ta ti on may be gi ven at ap prop ri a te ti me to ca ses who ha ve pre na tal di ag no sis of short fe mur. Futu re tre at ment met hods may be cho sen bet ter when prac ti cal di ag no sis is pre sent use of ul tra so und may help early di ag no sis of ske le tal ab nor ma li ti es.
Symptoms of depression, anxiety, psychological discomfort, post-traumatic stress disorder and str... more Symptoms of depression, anxiety, psychological discomfort, post-traumatic stress disorder and stress were reported to be quite prevalent in the general population during the coronavirus disease-2019 (COVID-19) pandemic. 1 Female gender, being younger ≤40 years, chronic/psychiatric disorders, unemployment, student status, and frequent exposure to COVID-19-related social media/news are among the risk factors related to distress criteria in the general population during the COVID-19 outbreak. 1 Due to the frequent interaction with the health service, weakened immune status based on the cancer or its treatment, supportive medicines, and older age and comorbidities, cancer patients are one of the most vulnerable populations during the COVID-19 pandemic. 2 The studies on gynaecological cancer patients support distress effects from COVID-19. Because of the immunosuppression caused by chemotherapy, 73.2 percent of patients with gynaecological cancer believe that they are at increased risk of COVD-19 infection, although only 17.5 percent of patients are more dreaded of COVID-19 than their pre-existing cancer diagnosis. The majority of gynaecological cancer patients (71%) are afraid that if their treatment or oncological follow-up is delayed or cancelled, their disease may advance, and nearly half (53.1%) express fears of contracting COVID-19 from hospitals or clinics during oncological treatment or follow-up. 3 Despite the fact that the impact of the COVID-19 infection on gynaecological cancer patients receiving active therapy or being followed up has been
Background Primitive neuroectodermal tumors of uterus (PNET) are extremely rare in tumors of the ... more Background Primitive neuroectodermal tumors of uterus (PNET) are extremely rare in tumors of the female genital system and therefore there is no suYcient information about their diagnosis, treatment, and follow-up. Case The case is a 32-year-old, operated in emergency conditions due to intra-abdominal hemorrhage, and discusses our diagnosis and treatment approaches in the light of literature data. Conclusion To the best of our knowledge, this is Wrst report of uterine PNET that presented with intraabdominal hemorrhage due to uterine rupture. Despite advances in therapy, the prognosis is poor. The low number of these cases precludes accurate standardization of therapy.
Background/Aim: Preeclampsia (PE) complicates 2–8% of all pregnancies worldwide. Placental malper... more Background/Aim: Preeclampsia (PE) complicates 2–8% of all pregnancies worldwide. Placental malperfusion and dysfunction are observed in PE. The supply of glucose, the main energy substrate for the fetus and placenta, is regulated by placental expression and activity of specific glucose transporter proteins (GLUTs), primarily GLUT1. GLUT1 expression is affected by uteroplacental malperfusion and oxidative stress, which are important components of PE. Very few studies have investigated GLUT1 expression in preeclamptic placentas. In this study, we aimed to compare GLUT1 staining intensity in the terminal villi of the placenta in healthy subjects and patients with E-PE or L-PE and determine whether there was a relationship between GLUT1 staining intensity and IUGR. Methods: This case-control study was carried out in our hospital’s gynecology and obstetrics clinic, a tertiary center for perinatology cases. A total of 94 placentas, 47 of which were preeclamptic and 47 were from uneventful...
Öz The incidence of ectopic kidney is approximately 1:1,000 in newborns. Ectopic kidney has a pla... more Öz The incidence of ectopic kidney is approximately 1:1,000 in newborns. Ectopic kidney has a place outside of renal fossa and been found in the pelvis, abdomen, and thorax. We reported a case of a 51-year-old female who was referred to our hospital with the complaint of abnormal vaginal bleeding and pelvic pain. Adenocarcinoma of cervix was reported after biopsy, radical hysterectomy and bilateral salphingo-oopherectomy with pelvic and para-aortic lymph node dissection were performed. Unilateral, right renal ectopic kidney with vessels was observed during paraaortic lymphadenectomy in cervical cancer surgery. During gynecological oncologic surgery especially at the retroperitoneal stage congenital organ abnormalities must be kept in mind and surgery must be planned according to the abnormalities. Ektopik böbrek; yenidoğanda yaklaşık 1/1000 oranında görülen, renal fossa dışında pelvis, abdomen ve toraksta bulunan anormal yerleşimli böbreği tanımlar. Anormal uterin kanama ve pelvik ağrı şikayeti ile başvuran 51 yaşında kadın hastadan alınan serviks biyopsisi adenokarsinom olarak rapor edildi. Hasta onamı alınarak radikal histerektomi, bilateral salpingo-ooferektomi ve pelvik paraaortik lenf nodu diseksiyonu yapıldı. Cerrahinin paraaortik lenf nodu diseksiyonu aşamasında damarları ile birlikte unilateral renal ektopik böbrek tespit edildi. Onkolojik cerrahilerde özellikle de retroperitoneal bölge aşamasında komplikasyon oranlarını en düşük düzeylere indirmek için doğumsal organ yerleşim anomalileri akılda bulundurulmalı ve cerrahi planlaması yapılmalıdır.
Background/Aim: Menopausal transition (MT) is defined as the transition from reproductive to post... more Background/Aim: Menopausal transition (MT) is defined as the transition from reproductive to post-reproductive life. Oxytocin has beneficial effects on health problems, such as sexual activity disorder, vaginal atrophy, cardiovascular system diseases and acceleration in bone mass loss, which may develop due to changes in reproductive hormone levels during the MT period. During exercise, which can be used as adjuvant therapy for most of these health problems, a temporary increase in catecholamine levels is required for response to exercise-induced stress. However, the effects of exercise programs applied during the MT period on plasma dopamine (pDA) and plasma oxytocin (pOT) levels are unknown. The aim of this study was to investigate the effects of three different types of exercise on plasma dopamine (pDA) and plasma oxytocin (pOT) levels in sedentary women in the MT period. Methods: Twenty-six sedentary healthy participants in the MT period whose fitness levels in the standard maxi...
Clinical and Experimental Obstetrics & Gynecology
Background: Maresin-1 (MaR1) plays a major role in many inflammatory disorders. Polycystic ovary ... more Background: Maresin-1 (MaR1) plays a major role in many inflammatory disorders. Polycystic ovary syndrome (PCOS) aside from a hormonal disorder, an inflammation might also contribute to PCOS and its metabolic associations. Therefore, the purpose of this prospective study first time was to find out the blood, saliva and urine levels of MaR1 in PCOS patients and evaluate the correlations with other metabolic and hormonal parameters. Methods: Thirty PCOS patients and 30 matched healthy controls were enrolled to prospective case control study. Blood, urine and saliva samples were simultaneously collected from participants after overnight fasting. MaR1 levels in blood, urine and saliva samples were determined by enzyme-linked immunosorbent assay. Ferriman-Gallwey score, anthropometric, hormonal and some other metabolic parameters were also recorded. Regression analysis was preformed to find out the relationship between MaR1, C-reactive protein (CRP) and malondialdehyde (MDA), and hormonal and metabolic parameters. Results: Patients with PCOS compared with control women had higher MDA and CRP and decreased MaR1 levels. Blood, urine and saliva MDA and MaR1 levels were similar and indicated parallel decrease or increase in the PCOS and control groups. Furthermore, regression analysis indicated that blood CRP and MDA was positively associated with luteinizing hormone (LH) and fasting insulin (FI) in PCOS group (p < 0.05) while blood, urine and saliva MaR1 was negatively associated with CRP and MDA. Conclusions: Present results (MaR1, CRP and MDA together) in case of PCOS suggests that decreased MaR1 and elevated MDA and CRP levels in patients with PCOS and may be considered as a useful early biomarker (especially MaR1) in diagnosis of PCOS disease that has not been previously reported and regular monitoring of their levels could be helpful in clinical decisions.
Aim: : To measure obestatin levels in the blood and saliva samples of normal-weight patients with... more Aim: : To measure obestatin levels in the blood and saliva samples of normal-weight patients with polycystic ovary syndrome (PCOS) in comparison with normal-weight healthy controls, and to determine whether there were relationships between blood and/ or salivary obestatin levels and other measured parameters. Materials and Methods: Fifteen healthy women and 15 patients with PCOS, all of which had normal weight, were included in the study. Participants' age, height, weight, menstrual characteristics, hormone levels, body mass index, waist/hip ratio, and modified Ferriman-Gallwey (FG) scores were recorded. Obestatin levels were measured in both fasting blood and saliva samples. Homeostasis Model Assessment (HOMA-IR) was used to predict insulin resistance. Results: In the PCOS group, menstrual cycle duration and FG scores were significantly higher (P-value, <0.001, <0.001, respectively). The levels of luteinizing hormone, total testosterone and androstenedione were significantly higher in the PCOS group than in the control group (P-value, 0.001, 0.009, 0.004, respectively). In the PCOS group, blood obestatin level was 1265.2 ± 221.9 pg/ml, salivary obestatin level was 3095.33 ± 310.2 pg/ml; whereas the control group demonstrated lower levels of 939.66 ± 72.3 pg/ml and 2611.20 ± 217.1 pg/mL, respectively. However, no statistically significant difference was found between the PCOS and control groups when comparing obestatin levels in blood or saliva (P-value, 0.218, 0.369, respectively). No correlation was found between blood and salivary obestatin levels in either group. Finally, obestatin levels were not associated with any of the other measured parameters. Conclusion: Our results suggest that increased levels of obestatin, albeit in a small amount that would not be statistically significant in normal weight patients with PCOS, may have significant effects on weight control in these patients. In addition, our findings show that saliva sample can be used as an alternative to blood sample in the measurement of obestatin level in patients with PCOS.
Bakirkoy Tip Dergisi / Medical Journal of Bakirkoy, 2021
Objective: This study aimed to analyze the effect of an absorbable hemostat produced from oxidize... more Objective: This study aimed to analyze the effect of an absorbable hemostat produced from oxidized regenerated cellulose (ORC) on pelvic adhesion formation in a rat model using an adhesion scoring system and immunohistochemical staining. Methods: This randomized, controlled experimental study included 20 female Wistar-Albino rats that were equally divided into the following groups: control and absorbable hemostat groups. The uterine horns of all the rats were exposed by laparotomy and using 10 W bipolar cautery. Five standard lesions were applied to the antimesenteric areas of each uterine horn. The experimental group received an absorbable hemostat to the traumatized uterine surfaces, whereas the control group did not. After a 28-day follow-up period, a relaparotomy was performed, and adhesions were evaluated based on an adhesion scoring system, and histological sections from areas with adhesion were obtained for immunohistochemical staining. Immunohistochemical staining included analysis of Ki-67 (proliferation index), CD-31 (neovascularization index), and Masson Trichrome [(MTC) fibrosis and collagen formation index]. Additionally, acute and chronic inflammation indices were determined via polymorphonuclear leukocytes (PMNL) and mononuclear leukocytes (MNL), respectively. Results: The intensity and scope of adhesion and overall adhesion ratings were substantially higher in the absorbable hemostat group than the control group (2.8±0.85 vs. 2.2±0.53, 0.92±0.26 vs. 0.61±0.25, and 3.72±0.96 vs. 2.81±0.75, respectively). Staining results for Ki-67, CD-31, MTC, PMNL, and MNL were also significantly higher in the absorbable hemostat group than in the control group (p<0.05 for all). Conclusion: The obtained results suggest that the use of ORC-based absorbable hemostats in pelvic surgery may increase adhesion formation on peritoneal surfaces by increasing inflammation, vascularity, and collagen formation.
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2009
Fe mo ral hi pop la zi de fe mur uzun lu ğu, 50 per sen ti lin al tın da dır ve izo le tip te ola... more Fe mo ral hi pop la zi de fe mur uzun lu ğu, 50 per sen ti lin al tın da dır ve izo le tip te ola bi le ce ği gi bi, fi bu lar ve/ve ya ul nar ano ma li ler le de bir lik te ola bilir. Na di ren fe mur ve ase ta bu lu mu da içe ren, pa tel la nın yok lu ğu ve ya hi pop la zi si gi bi alt eks tre mi te de fekt le riy le bir lik te gö rü le bi lir.1-3 Ay rı ca yüz, gas tro in tes ti nal sis tem, is ke let sis te mi, üro ge ni tal sis tem (hi pos pa di as, kü çük pe nis, vaji nal sep tum, çift ute rus, çift ser viks, ve zi ko-üre te ral ref lü, Unilateral Konjenital Kısa Femur
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2021
OBJECTIVE The aim of this retrospective case-control study was to analyze the effect of administe... more OBJECTIVE The aim of this retrospective case-control study was to analyze the effect of administering indomethacin after triggering final oocyte maturation in patients with poor ovarian response (POR) on the cycle cancellation rate due to premature ovulation (PO), the number of oocytes retrieved and the clinical outcomes of IVF cycles. STUDY DESIGN A total of 214 patients with POR, diagnosed according to the Bologna criteria, who underwent fresh IVF cycle via flexible gonadotrophin-releasing hormone antagonist (GnRH-ant) protocol were enrolled in the study. The control group consisted of 100 patients, whereas the indomethacin group included 114 patients who received 100 mg rectal indomethacin administered twice within the same day (twelve hours apart) -starting at twelve hours after triggering. Cycle cancelation rates (CCR), number of oocytes retrieved (nOR), implantation rates (IR), biochemical pregnancy (BP) and clinical pregnancy loss rates (CPL), ongoing pregnancy rates (OPR) and live birth rates (LBR) were compared between the indomethacin and control groups. RESULTS The CCR rate was significantly lower in the indomethacin group (1.8%) compared to the control group (1.8% vs %12%, p = 0.01). In the control group, those with cycle cancellation were older than those without cycle cancellation (mean age 42.2 ± 2.3 years vs. 39.36 ± 4.3 years, p = 0.001) and had lower anti-Müllerian hormone levels and lower antral follicle count (0.59 ± 0.2 ng/mL vs 0.79 ± 0.2 ng/mL, p = 0.001 and 4 ± 0.6 vs 5.7 ± 1.7, p = 0.001, respectively). In multivariable analysis, when the dependent variable in the logistic regression model was coded as the absence of cycle cancellation, it was observed that only indomethacin had a statistically significant effect on cycle cancellation (β = -1.931, standard error = 0.832, Exp(B) = 0.145, p = 0.020). nOR was higher in the indomethacin group than control group but the difference did not reach significance (p = 0.07). Moreover, the IR, OPR and LBR, BP and CPL values were similar in the indomethacin and control groups (p > 0.05). CONCLUSIONS Based on data from this study, it can be concluded that indomethacin reduces cycle cancelation due to PO in patients with POR -without compromising implantation and pregnancy rates. However, further randomized controlled trials with larger sample sizes are required to clarify the definitive effect of indomethacin in the treatment of patients with POR.
IntroductionThe aim of this prospective trial was to evaluate the ovarian reserve with anti-Mülle... more IntroductionThe aim of this prospective trial was to evaluate the ovarian reserve with anti-Müllerian hormone (AMH), which is the best predictor of ovarian reserve, and perform histological analysis after exposure to cisplatin with a GnRH agonist or antagonist.Material and methodsTwenty-four Wistar albino rats were randomly divided into three groups, each consisting of eight rats. In the GnRH agonist group (group 1), rats received a single dose of 50 mg/m2 cisplatin with 1 mg/kg triptorelin. In the GnRH antagonist group (group 2), rats received a single dose of 50 mg/m2 cisplatin with 1 mg/kg cetrorelix. In the control group (group 3), rats received 50 mg/m2 cisplatin. Ovarian reserve was assessed by AMH and histology.ResultsPrimary follicle counts were higher in group 2 (4.50 ±1.47 vs. 3.50 ±1.70 vs. 3.00 ±3.54) and secondary follicle counts were higher in group 1 (2.96 ±1.11 vs. 1.74 ±1.03 vs. 1.37 ±3.11). Numbers of tertiary follicles were higher both in groups 1 and 2 than the c...
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2009
on je ni tal kı sa fe mur, yak la şık ola rak 50.000 do ğum da bir gö rü lür. Da ha sık lık la sa... more on je ni tal kı sa fe mur, yak la şık ola rak 50.000 do ğum da bir gö rü lür. Da ha sık lık la sağ fe mur da or ta ya çı kar ve alt eks tre mi te le rin kon jeni tal asi met ri si ni içe ren fe mo ral hi pop la zi nin ve ya ap la zi nin bir şek li ola rak ta nım la nır. Fe mo ral hi pop la zi de fe mur uzun lu ğu, 50 per sen ti lin al tın da dır ve izole tip te ola bi le ce ği gi bi, fi bu lar ve/ve ya ul nar ano ma li ler le de bir lik te ola bilir. Na di ren fe mur ve ase ta bu lu mu da içe ren, pa tel la nın yok lu ğu ve ya hi pop la zi si gi bi alt eks tre mi te de fekt le riy le bir lik te gö rü le bi lir. 1-3 Ay rı ca yüz, gas tro in tes ti nal sis tem, is ke let sis te mi, üro ge ni tal sis tem (hi pos pa di as, kü çük pe nis, vaji nal sep tum, çift ute rus, çift ser viks, ve zi ko-üre te ral ref lü, Unilateral Konjenital Kısa Femur ÖZET Uni la te ral kon je ni tal kı sa fe mur, yak la şık ola rak 50.000 do ğum da bir or ta ya çı kan na dir bir is ke let bo zuk lu ğu dur. Da ha sık lık la sağ fe mur da or ta ya çı kar. Fa mil yal, ma ter nal ta li do mit kul lanı mı, vi ral en fek si yon, ir ra dyas yon, fo kal is ke mi, trav ma ve kim ya sal tok sin le re ma ruz kal ma gi bi çe şit li et iyo lo jik fak tör ler öne sü rül müş tür. Te mel prob lem, eks tre mi te ler ara sı uzun luk far kı dır. Biz 21. haf ta da pre na tal ta nı sı ko nu lan, di ğer yön ler den sağ lık lı, spo ra dik bir uni la te ral kon je ni tal kı sa fe mur olgusu sun duk. Ta nı, do ğum dan son ra te yit edil di. So nuç ola rak, pre na tal kı sa fe mur ta nı sı konu lan olgu la ra, uy gun za man da or to pe dik kon sül tas yon ya pı la bi lir. Böy le ce ge le cek te ki te da vi yöntem le ri için da ha iyi ka rar ve ril me si sağ la nır. Ul tra so nog ra fi nin kul la nı mı, is ke let bo zuk luk la rı nın da ha er ken pre na tal ta nı la rı nı sağ la ya bi lir. Anah tar Ke li me ler: Kon je ni tal; fe mur; ano ma li ler ABS TRACT Uni la te ral con ge ni tal short fe mur is a ra re ske le tal system ab nor ma lity se en in 1 of 50.000 births. It is mo re com monly se en on right fe mur. Ge ne tic pre dis po si ti on, ma ter nal tha li domi de use, vi ral in fec ti ons, ir ra di a ti on, fo cal isc he mi a, tra u ma, che mi cal to xins, are a few of sus pected eti o lo gic fac tors. Ma in prob lem is the dif fe ren ce bet we en the lenght of ex tre mi ti es. We he re in re port a spo ra dic uni la te ral short fe mur ca se, who has no ot her ano maly, di ag no sed at 21 we ek of preg nancy. Di ag no sis is ap pro ved with the short fe mur af ter birth. In conc lu si on, ort ho pe dic consul ta ti on may be gi ven at ap prop ri a te ti me to ca ses who ha ve pre na tal di ag no sis of short fe mur. Futu re tre at ment met hods may be cho sen bet ter when prac ti cal di ag no sis is pre sent use of ul tra so und may help early di ag no sis of ske le tal ab nor ma li ti es.
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