INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, May 1, 2022
Tuberculosis has been one of the major public health concerns since many years now. Around 15-20%... more Tuberculosis has been one of the major public health concerns since many years now. Around 15-20% of TB cases are found to be extrapulmonary1. Diagnosis is challenging due to its pauci bacillary nature2. The objective of this study is to determine the pattern and sites of extra pulmonary tuberculosis in patients presenting to our tertiary hospital. Materials and Methods- This is a hospital based retrospective observational study. A total of 73 patients were included in the study. Study period was 1 year (Jan 2019 – Jan 2020). Data regarding the various samples, sites and various tests done – AFB, CBNAAT were collected. Both microbiologically or clinically diagnosed extrapulmonary tuberculosis were included. Records were obtained from the medical records maintained in the DOTS centre of our hospital. Results-Majority of the patients belonged to the age group of 21-40 years (42.5%) with male (61.6%) predominance. Most common extrapulmonary site was pleura (27.8%) and least common was endometrium (1.4%). 71.2% of the cases were clinically diagnosed and 28.8% were microbiologically conrmed. CBNAAT detected TB bacilli in 23.3% of the cases. Conclusion- In our study the most common site of extrapulmonary tuberculosis was pleura presenting as pleural effusion and in majority of them TB bacilli could not be detected.
International Journal of Research in Medical Sciences
Background: This study was conducted to evaluate the clinical, pathological and radiological prof... more Background: This study was conducted to evaluate the clinical, pathological and radiological profile of suspected lung malignancy and its correlation with bronchoscopic findings.Methods: A hospital based prospective study was conducted in the department of pulmonary medicine on 74 patients who were suspected with lung malignancy, clinically or radiologically. Following a detailed clinical examination, chest x-ray and CECT thorax, patients were included in the study and were subjected to bronchoscopy. Based on the bronchoscopic findings BAL, TBNA, forceps biopsy and TBLB were performed.Results: Out of 74 patients, most of them belonged to the age group of 51-65 years. Majority were males. Cough was the most common symptom. 51 patients had weight loss and 48 had associated reduced appetite. 50 (67.6%) were smokers. Out of them 43 (86%) were beedi smokers. In CT thorax, most common presentation was mass lesion followed by consolidation, nodules and interstial thickening. Right side was...
Tuberculosis has been one of the major public health concerns since many years now. Around 15-20%... more Tuberculosis has been one of the major public health concerns since many years now. Around 15-20% of TB cases are found to be extrapulmonary1. Diagnosis is challenging due to its pauci bacillary nature2. The objective of this study is to determine the pattern and sites of extra pulmonary tuberculosis in patients presenting to our tertiary hospital. Materials and Methods- This is a hospital based retrospective observational study. A total of 73 patients were included in the study. Study period was 1 year (Jan 2019 – Jan 2020). Data regarding the various samples, sites and various tests done – AFB, CBNAAT were collected. Both microbiologically or clinically diagnosed extrapulmonary tuberculosis were included. Records were obtained from the medical records maintained in the DOTS centre of our hospital. Results-Majority of the patients belonged to the age group of 21-40 years (42.5%) with male (61.6%) predominance. Most common extrapulmonary site was pleura (27.8%) and least common was ...
Journal of Medical Science And clinical Research, 2017
Background: During recent years, disease caused by human immunodeficiency virus (HIV) and tubercu... more Background: During recent years, disease caused by human immunodeficiency virus (HIV) and tuberculosis (TB) have been the two leading infectious diseases associated with mortality worldwide. The delays in diagnosis and initiation of anti-tubercular treatment often lead to increased transmission of TB in the community and spread to extrapulmonary sites within the patient. Our study aimed at to assess the role of CBNAAT in early diagnosis of TB in HIV patients and detection of M. tuberculosis in sputum by CBNAAT compared to conventional sputum microscopy in pulmonary TB Methods: The study screened 211 patients with clinical symptoms suggestive of pulmonary tuberculosis. 30 subjects were found to be seropositive for HIV. Out of 30 HIV-TB patients, 20 were male. Direct microscopic sputum examination was done using Light Emitting Diode based Fluorescent Microscopy (LED-FM) method. All patients also submitted sputum sample for GeneXpert MTB/Rif test, a cartridge based nucleic acid amplification test (CBNAAT), analysed using G X4 system. Results: LED-Fluorescent Microscopy sputum examination was positive for acid fast bacilli in 8/30 HIV seropositive patients and 131/181 subjects who were seronegative for HIV. The data suggested patients who were HIV positive were less likely to have sputum smear positive results. CBNAAT detected M. tuberculosis in 17/30 HIV-seropositive patients and in 133/181 HIV-seronegative subjects. 56.7% of the patients who were positive for HIV were also positive for MTB and two of them had rifampicin resistance detected by CBNAAT. Conclusions: CBNAAT significantly increased the conclusive diagnosis of tuberculosis in patients co-infected with HIV, and additionally detected rifampicin resistance, thus providing huge leap in management of tuberculosis in HIV setting.
International Journal of Research in Medical Sciences, 2017
Background: Tuberculosis (TB) remains a major health concern worldwide. Extra pulmonary tuberculo... more Background: Tuberculosis (TB) remains a major health concern worldwide. Extra pulmonary tuberculosis (EPTB) in India accounts up to 20% of all tuberculosis cases. EPTB often remains undetected and untreated due to variable clinical presentation and lack of diagnostic means. Early detection of TB and drug resistance is important in the management of TB. The aim of present study was to assess the role of cartridge based nucleic acid amplification test in rapid diagnosis of tubercular pleural effusion.Methods: The study screened 211 symptomatic patients. The patients with clinical and radiological presentations suggestive of pleural effusion were analyzed using light’s criteria to make a diagnosis of tubercular pleural effusion; these patients submitted pleural fluid sample for smear microscopy after concentration for presence of acid fast bacilli under light emitting diode based fluorescent microscopy (LED-FM), and for cartridge based nucleic acid amplification test (CBNAAT) using GX4...
Background: During recent years, disease caused by human immunodeficiency virus (HIV) and tubercu... more Background: During recent years, disease caused by human immunodeficiency virus (HIV) and tuberculosis (TB) have been the two leading infectious diseases associated with mortality worldwide. The delays in diagnosis and initiation of anti-tubercular treatment often lead to increased transmission of TB in the community and spread to extrapulmonary sites within the patient. Our study aimed at to assess the role of CBNAAT in early diagnosis of TB in HIV patients and detection of M. tuberculosis in sputum by CBNAAT compared to conventional sputum microscopy in pulmonary TB Methods: The study screened 211 patients with clinical symptoms suggestive of pulmonary tuberculosis. 30 subjects were found to be seropositive for HIV. Out of 30 HIV-TB patients, 20 were male. Direct microscopic sputum examination was done using Light Emitting Diode based Fluorescent Microscopy (LED-FM) method. All patients also submitted sputum sample for GeneXpert MTB/Rif test, a cartridge based nucleic acid amplification test (CBNAAT), analysed using G X4 system. Results: LED-Fluorescent Microscopy sputum examination was positive for acid fast bacilli in 8/30 HIV seropositive patients and 131/181 subjects who were seronegative for HIV. The data suggested patients who were HIV positive were less likely to have sputum smear positive results. CBNAAT detected M. tuberculosis in 17/30 HIV-seropositive patients and in 133/181 HIV-seronegative subjects. 56.7% of the patients who were positive for HIV were also positive for MTB and two of them had rifampicin resistance detected by CBNAAT. Conclusions: CBNAAT significantly increased the conclusive diagnosis of tuberculosis in patients co-infected with HIV, and additionally detected rifampicin resistance, thus providing huge leap in management of tuberculosis in HIV setting.
in 1882, as well as the availability of effective treatment and the use of a live attenuated vacc... more in 1882, as well as the availability of effective treatment and the use of a live attenuated vaccine, TB remains one of the deadliest communicable diseases. According to WHO estimates 1.5 million of TB
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, May 1, 2022
Tuberculosis has been one of the major public health concerns since many years now. Around 15-20%... more Tuberculosis has been one of the major public health concerns since many years now. Around 15-20% of TB cases are found to be extrapulmonary1. Diagnosis is challenging due to its pauci bacillary nature2. The objective of this study is to determine the pattern and sites of extra pulmonary tuberculosis in patients presenting to our tertiary hospital. Materials and Methods- This is a hospital based retrospective observational study. A total of 73 patients were included in the study. Study period was 1 year (Jan 2019 – Jan 2020). Data regarding the various samples, sites and various tests done – AFB, CBNAAT were collected. Both microbiologically or clinically diagnosed extrapulmonary tuberculosis were included. Records were obtained from the medical records maintained in the DOTS centre of our hospital. Results-Majority of the patients belonged to the age group of 21-40 years (42.5%) with male (61.6%) predominance. Most common extrapulmonary site was pleura (27.8%) and least common was endometrium (1.4%). 71.2% of the cases were clinically diagnosed and 28.8% were microbiologically conrmed. CBNAAT detected TB bacilli in 23.3% of the cases. Conclusion- In our study the most common site of extrapulmonary tuberculosis was pleura presenting as pleural effusion and in majority of them TB bacilli could not be detected.
International Journal of Research in Medical Sciences
Background: This study was conducted to evaluate the clinical, pathological and radiological prof... more Background: This study was conducted to evaluate the clinical, pathological and radiological profile of suspected lung malignancy and its correlation with bronchoscopic findings.Methods: A hospital based prospective study was conducted in the department of pulmonary medicine on 74 patients who were suspected with lung malignancy, clinically or radiologically. Following a detailed clinical examination, chest x-ray and CECT thorax, patients were included in the study and were subjected to bronchoscopy. Based on the bronchoscopic findings BAL, TBNA, forceps biopsy and TBLB were performed.Results: Out of 74 patients, most of them belonged to the age group of 51-65 years. Majority were males. Cough was the most common symptom. 51 patients had weight loss and 48 had associated reduced appetite. 50 (67.6%) were smokers. Out of them 43 (86%) were beedi smokers. In CT thorax, most common presentation was mass lesion followed by consolidation, nodules and interstial thickening. Right side was...
Tuberculosis has been one of the major public health concerns since many years now. Around 15-20%... more Tuberculosis has been one of the major public health concerns since many years now. Around 15-20% of TB cases are found to be extrapulmonary1. Diagnosis is challenging due to its pauci bacillary nature2. The objective of this study is to determine the pattern and sites of extra pulmonary tuberculosis in patients presenting to our tertiary hospital. Materials and Methods- This is a hospital based retrospective observational study. A total of 73 patients were included in the study. Study period was 1 year (Jan 2019 – Jan 2020). Data regarding the various samples, sites and various tests done – AFB, CBNAAT were collected. Both microbiologically or clinically diagnosed extrapulmonary tuberculosis were included. Records were obtained from the medical records maintained in the DOTS centre of our hospital. Results-Majority of the patients belonged to the age group of 21-40 years (42.5%) with male (61.6%) predominance. Most common extrapulmonary site was pleura (27.8%) and least common was ...
Journal of Medical Science And clinical Research, 2017
Background: During recent years, disease caused by human immunodeficiency virus (HIV) and tubercu... more Background: During recent years, disease caused by human immunodeficiency virus (HIV) and tuberculosis (TB) have been the two leading infectious diseases associated with mortality worldwide. The delays in diagnosis and initiation of anti-tubercular treatment often lead to increased transmission of TB in the community and spread to extrapulmonary sites within the patient. Our study aimed at to assess the role of CBNAAT in early diagnosis of TB in HIV patients and detection of M. tuberculosis in sputum by CBNAAT compared to conventional sputum microscopy in pulmonary TB Methods: The study screened 211 patients with clinical symptoms suggestive of pulmonary tuberculosis. 30 subjects were found to be seropositive for HIV. Out of 30 HIV-TB patients, 20 were male. Direct microscopic sputum examination was done using Light Emitting Diode based Fluorescent Microscopy (LED-FM) method. All patients also submitted sputum sample for GeneXpert MTB/Rif test, a cartridge based nucleic acid amplification test (CBNAAT), analysed using G X4 system. Results: LED-Fluorescent Microscopy sputum examination was positive for acid fast bacilli in 8/30 HIV seropositive patients and 131/181 subjects who were seronegative for HIV. The data suggested patients who were HIV positive were less likely to have sputum smear positive results. CBNAAT detected M. tuberculosis in 17/30 HIV-seropositive patients and in 133/181 HIV-seronegative subjects. 56.7% of the patients who were positive for HIV were also positive for MTB and two of them had rifampicin resistance detected by CBNAAT. Conclusions: CBNAAT significantly increased the conclusive diagnosis of tuberculosis in patients co-infected with HIV, and additionally detected rifampicin resistance, thus providing huge leap in management of tuberculosis in HIV setting.
International Journal of Research in Medical Sciences, 2017
Background: Tuberculosis (TB) remains a major health concern worldwide. Extra pulmonary tuberculo... more Background: Tuberculosis (TB) remains a major health concern worldwide. Extra pulmonary tuberculosis (EPTB) in India accounts up to 20% of all tuberculosis cases. EPTB often remains undetected and untreated due to variable clinical presentation and lack of diagnostic means. Early detection of TB and drug resistance is important in the management of TB. The aim of present study was to assess the role of cartridge based nucleic acid amplification test in rapid diagnosis of tubercular pleural effusion.Methods: The study screened 211 symptomatic patients. The patients with clinical and radiological presentations suggestive of pleural effusion were analyzed using light’s criteria to make a diagnosis of tubercular pleural effusion; these patients submitted pleural fluid sample for smear microscopy after concentration for presence of acid fast bacilli under light emitting diode based fluorescent microscopy (LED-FM), and for cartridge based nucleic acid amplification test (CBNAAT) using GX4...
Background: During recent years, disease caused by human immunodeficiency virus (HIV) and tubercu... more Background: During recent years, disease caused by human immunodeficiency virus (HIV) and tuberculosis (TB) have been the two leading infectious diseases associated with mortality worldwide. The delays in diagnosis and initiation of anti-tubercular treatment often lead to increased transmission of TB in the community and spread to extrapulmonary sites within the patient. Our study aimed at to assess the role of CBNAAT in early diagnosis of TB in HIV patients and detection of M. tuberculosis in sputum by CBNAAT compared to conventional sputum microscopy in pulmonary TB Methods: The study screened 211 patients with clinical symptoms suggestive of pulmonary tuberculosis. 30 subjects were found to be seropositive for HIV. Out of 30 HIV-TB patients, 20 were male. Direct microscopic sputum examination was done using Light Emitting Diode based Fluorescent Microscopy (LED-FM) method. All patients also submitted sputum sample for GeneXpert MTB/Rif test, a cartridge based nucleic acid amplification test (CBNAAT), analysed using G X4 system. Results: LED-Fluorescent Microscopy sputum examination was positive for acid fast bacilli in 8/30 HIV seropositive patients and 131/181 subjects who were seronegative for HIV. The data suggested patients who were HIV positive were less likely to have sputum smear positive results. CBNAAT detected M. tuberculosis in 17/30 HIV-seropositive patients and in 133/181 HIV-seronegative subjects. 56.7% of the patients who were positive for HIV were also positive for MTB and two of them had rifampicin resistance detected by CBNAAT. Conclusions: CBNAAT significantly increased the conclusive diagnosis of tuberculosis in patients co-infected with HIV, and additionally detected rifampicin resistance, thus providing huge leap in management of tuberculosis in HIV setting.
in 1882, as well as the availability of effective treatment and the use of a live attenuated vacc... more in 1882, as well as the availability of effective treatment and the use of a live attenuated vaccine, TB remains one of the deadliest communicable diseases. According to WHO estimates 1.5 million of TB
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