Papers by Anders Backlund
Journal of biomolecular screening, Aug 1, 2002
Pharmaceutics
Alpinia galanga Willd., greater galangal, has been used for thousands of years as a spice as well... more Alpinia galanga Willd., greater galangal, has been used for thousands of years as a spice as well as in traditional medicine. Its central nervous system (CNS) stimulant activity and neuroprotective effects have been proved both in animal models and human trials. However, the compounds responsible for these effects have not been identified yet. Therefore, the main constituents (p-OH-benzaldehyde (1), trans-p-coumaryl-alcohol (2), p-coumaryl-aldehyde (4), galanganol A (5), galanganol B (6), trans-p-acetoxycinnamyl alcohol (7), 1′S-1′-acetoxychavicol acetate (ACA, 9), and 1′S-1′-acetoxyeugenol acetate (AEA, 10)) were isolated to investigate their aqueous stability and passive diffusion across the gastro-intestinal tract (GIT) membrane and the blood–brain barrier (BBB) by the parallel artificial membrane permeability assay (PAMPA). Our positive results for compounds 1, 2, 4, 7, 9, and 10 suggest good permeability, thus potential contribution to the effects of greater galangal in the CNS...
Flowering Plants. Eudicots, 2016
Flowering Plants. Eudicots, 2016
Planta Medica, Aug 24, 2006
Planta Medica, 2016
Screening of compounds of Evernia prunastri (L.) for their antiproliferative activity in glioblas... more Screening of compounds of Evernia prunastri (L.) for their antiproliferative activity in glioblastoma cells
ChemGPS-NP-based analysis for a series of briarane-type diterpenoids active in an inhibition assa... more ChemGPS-NP-based analysis for a series of briarane-type diterpenoids active in an inhibition assay of COX-2, as well as previously studied 2,592 COX-2 (light green) inhibitors from the ChEMBL database.
The cyclotides are a family of naturally occurring peptides characterized by cyclic cystine knot ... more The cyclotides are a family of naturally occurring peptides characterized by cyclic cystine knot (CCK) structural motif, which comprises a cyclic head-to-tail backbone featuring six conserved cysteine residues that form three disulfide bonds. This unique structural motif makes cyclotides exceptionally resistant to chemical, thermal and enzymatic degradation. They also exhibit a wide range of biological activities including insecticidal, cytotoxic, anti-HIV and antimicrobial effects.The cyclotides found in plants exhibit considerable sequence and structural diversity, which can be linked to their evolutionary history and that of their host plants. To clarify the evolutionary link between sequence diversity and the distribution of individual cyclotides across the genus Viola, selected known cyclotides were classified using signature sequences within their precursor proteins. By mapping the classified sequences onto the phylogenetic system of Viola, we traced the flow of cyclotide gene...
Sesquiterpene lactones (STLs) present one of the largest groups of plant specialized metabolites ... more Sesquiterpene lactones (STLs) present one of the largest groups of plant specialized metabolites with a wide range of biological activities. They are a valuable source for new plant derived drugs a ...
ChemGPS-NP study on antileukemic triterpenoids from widely-used medicinal mushrooms in Asia
Separation and identification on stereoisomers of manoalide derivatives and their configuration-d... more Separation and identification on stereoisomers of manoalide derivatives and their configuration-depending antileukemic effects in vitro and in vivo
Zeitschrift für Phytotherapie, 2016
Planta Medica, 2016
Predicting the mechanism of action of antituberculosis agents using chemical global positioning s... more Predicting the mechanism of action of antituberculosis agents using chemical global positioning system - natural product
Kew Bulletin, 2000
A phylogenetic analysis of 589 plastid rbcl. gene sequences representing nearly all eudicot famil... more A phylogenetic analysis of 589 plastid rbcl. gene sequences representing nearly all eudicot families (a total of 308 families; seven photosynthetic and four parasitic families are missing) was performed, and bootstrap re-sampling was used to assess support for clades. Based on these data, the ordinal classification of eudicots is revised following the previous classification of angiosperms by the Angiosperm Phylogeny Group (APG) , Putative additional orders are discussed (e.g. Dilleniales, Escalloniales, VitaiRs) , and several additional families are assigned to orders for future updates of the APG classification. The use of rbcl. alone in such a large matrix was found to be practical in discovering and providing bootstrap support for most orders, Combination of these data with other matrices for the rest of the angiosperms should provide the framework for a complete phylogeny to be used in macroevolutionary studies, !:-':TRODL'CTlON The angiosperms are the first division of organisms to have been reclassified largely on the basis of molecular data analysed phylogenetically (APG 1998). Several largescale molecular phylogenies have been produced for the angiosperms, based on both plastid rbcL (Chase et al. 1993, 1999, in press) and atpB (Savolainen et al. in press) genes, and on 18S rDNA from the nuclear genome (Soltis et al. 1997a; Soltis & Soltis 1998a). At higher taxonomic levels, these genes have also been combined in pairs (
Files underlying the phylogenetic trees shown in Additional File 2
Planta Medica, 2008
Natural compounds are evolutionary selected and pre-validated by Nature, displaying a unique dive... more Natural compounds are evolutionary selected and pre-validated by Nature, displaying a unique diversity of chemical properties and corresponding biological activities. Of utmost importance for a rational discovery and exploration of new biologically active compounds are two aspects: one the identification and charting of the biologically relevant chemical space, the other a similar charting of the corresponding evolutionary space. he first key to this is the coverage of the natural products' chemical space. For this purpose we introduced ChemGPS-NP, with the aim to provide a tool for more efficient and stringent compound comparison, to identify parts of chemical space related to particular biological activities, and to track changes in chemical properties due to e.g. evolutionary traits and modifications in biosynthesis. Physical-chemical properties not directly discernible from structural data can be compared, making selection more rational when screening natural compounds and analogues. The second key would consequently be to explore evolutionary space by elucidating and utilising robust phylogenies for the organisms under study. From this basis reflecting the evolutionary history and hence biosynthesis development, further conclusions can be drawn. Based these initial attempts, the intersection of chemical and evolutionary space have been explored. With regard to e.g. compound classes such as iridoids, betalains, and sesquiterpene lactones, evolutionary patterns of changes in physical-chemical properties are observed and compared. For eight major classes of plant defence peptides analyses of structure base alignments provide arguments for rational classification. In addition, evolution of the enzyme Rubisco, have been explored with reference to major structural features.
Abstract: In many countries today, the number of students selecting chemistry for higher studies ... more Abstract: In many countries today, the number of students selecting chemistry for higher studies is decreasing. At the same time, interest in the environmental aspects of chemistry, green chemistry, and sustainable use of natural products is increasing among the young gen-eration of students. By modernizing and renewing a venerable proven science, pharmacog-nosy would have a strategic position to connect biology and chemistry. This multidisciplinary subject is important for discovery of novel and unique molecules with drug potential, and for revealing unknown targets, by studying evolutionary structure–activity optimization in na-ture. In this paper, the overall aim and strategies of our research are presented and exempli-fied by three different research projects. Natural products are involved in scientific issues important for a sustainable society, and a multidisciplinary subject such as pharmacognosy can, therefore, be useful in increas-ing future interest in both chemistry and b...
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Papers by Anders Backlund