Papers by Mindaugas Žukauskas
Bioorganic Chemistry, 2021
Synthesis of β-amino acid derivatives containing hydrazone and azole moieties is described. For t... more Synthesis of β-amino acid derivatives containing hydrazone and azole moieties is described. For this purpose, the appropriate hydrazide was treated with aromatic aldehydes, ketones and phenyl iso(thio)cyanates to obtain the desired outcome. The synthesized target compounds were evaluated for their anticancer properties. The assay displayed 3,3'-((2,6-diethylphenyl)azanediyl)bis(N'-(benzylidene)propanehydrazide) to possess the convincing anticancer effect against triple-negative breast cancer cells in vitro. To further study the anticancer properties of compounds containing a hydrazone moiety in breast cancer, series of previously and newly prepared dihydrazones were investigated. It was determined that derivatives with the bis(N'-(4-bromobenzylidene) fragment in the structure are exclusively cytotoxic to cancer cells. The most active compounds against both cell lines were those containing electron withdrawing 4-BrPh or 4-ClPh moieties, together with either chlorine, bromine or iodine groups in para position of phenyl ring. Selected two representative compounds showed migrastatic activity in MDA-MB-231 cell line, where both of them reduced the growth of breast cancer and glioblastoma cell 3D cultures and inhibited cell colony formation. 2009 Elsevier Ltd. All rights reserved.
Mokslas - Lietuvos ateitis, 2019
Conflict resolution and leadership is growing research topic in academic literature. The demand o... more Conflict resolution and leadership is growing research topic in academic literature. The demand of leaders of organizations to manage conflicts requires further analysis of this topic. It is necessary for better understanding of conflict resolution relationship with leadership. Bibliometrical analysis reveals this relationship. The study analyses 526 references collected from the Web of Science database and uses the VOSviewer program to graphically map the material. The bibliometric analysis involves co-occurrence of keywords, co-citation and co-authorship. The results identify the leading trends and development status in terms of impact, main journals, authors, papers, topics and countries. The analysis and graphical presentations are relevant for researchers and practitioners for better understanding of the state of the art of concflict resolution and leadership.
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Papers by Mindaugas Žukauskas