Papers by Özlem Bostan Gayret
Journal of Pediatric Infectious Diseases
Objective Zinc and selenium levels are being investigated with increasing frequency in adult pati... more Objective Zinc and selenium levels are being investigated with increasing frequency in adult patients with coronavirus disease 2019 (COVID-19). However, levels of zinc and selenium in children with COVID-19 have not been adequately studied to date. Methods This prospective, observational study was conducted on 146 pediatric patients diagnosed with COVID-19 and 49 healthy controls between 2020 and 2021. Normal serum zinc reference values were 0.60 to 1.20 µg/mL for children 0 to 10 years old and 0.66 to 1.10 µg/mL for children ≥11 years old. The normal range for serum selenium concentration was considered between 70 and 150 µg/L. Deficiencies were defined for values below the reference range. Results Zinc and selenium levels were significantly lower in the COVID-19 (+) group compared with the controls (zinc: 0.7 ± 0.2 vs 0.9 ± 0.2 µg/mL, p < 0.001; selenium: 57.1 ± 9.1 vs 66.5 ± 11.4 µg/L, p < 0.01, respectively). Also, zinc and selenium levels were found to be statistically si...
İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi, 2016
SUMMARY Introduction: Henoch-Schonlein purpura (HSP) is an acute vasculitis that primarily affect... more SUMMARY Introduction: Henoch-Schonlein purpura (HSP) is an acute vasculitis that primarily affects children. Central nervous system (CNS) involvement and the appearance of neurological complications preceding the characteris- tic rash are rare. Posterior reversible encephalopathy sy- ndrome (PRES) and cerebral vasculitis are neurological complications of HSP. Case Presentation: We describe a case of 5-year-old girl who presented with seizures, loss of consciousness, and total loss of vision. Her HSP was atypical because the presenting symptoms were neurological complications rather than the characteristic rash, and her radiological features were compatible with PRES. She did not have re- nal impairment or hypertension. Her abnormal findings resolved following a standard course of corticosteroids. Conclusion: Our case is atypical because of the presence of CNS involvement before the characteristic rash with the absence of hypertension. The patient's HSP presented as a complicatio...
Bagcilar Medical Bulletin, 2018
Introduction: Extrapulmonary tuberculosis cases may display different clinical symptoms and this ... more Introduction: Extrapulmonary tuberculosis cases may display different clinical symptoms and this causes a delay in diagnosis. Nutritional deficiencies, migrations, and wars facilitate the development and the spreading speed of the disease. The aim of this article is to examine extrapulmonary tuberculosis patients with different clinical presentations. Method: In this study, 15 extrapulmoner tuberculosis cases who were hospitalized and treated in our pediatrics clinic in the last two years, has been evaluated retrospectively. Results: The average age of our group was 11.7 ± 4.5 and six of the assessed patients were Syrian origin. The shared complaints of five patients diagnosed with peritoneal tuberculosis were abdominal pain and bloating. Abdominal ultrasonography findings of the patients in concordance with diffuse ascites. Two of these patients, Mycobacterium tuberculosis had peritoneal effusion. All of the five patients diagnosed with lymph node tuberculosis had swelling on the neck, and all had pulmonary involvement. However, only one patient's lymph node biopsy was concordant with tuberculosis. One patient bone tuberculosis patient applied to our clinic with hip and back pain symptom. Pott's abscess was observed in the patient's thorax MRI and hip MRI was concordant with tuberculous arthritis. Our patient with renal tuberculosis was diagnosed during evaluation of sterile pyuria attacks and in her urine ARB (+) was detected and M. tuberculosis grew in urine culture. One patient with central nervous system involvement applied to our clinic with clouding of consciousness and headache. The cerebrospinal fluid (CSF) findings of the patient were concordant with tuberculosis and growth was observed in the CSF culture. One case with miliary tuberculosis had hypercalcemia and pulmonary involvement. The patient's M. tuberculosis DNA PCR test was positive in bronchoalveolar lavage fluid. Another patient with pericardial tuberculosis applied due to respiratory distress and had cardiomegaly and pericardial effusion. Nine of our patients also had a contact history, 12 had purified protein derivative of tuberculin (PPD) (+), and 11 had pulmonary involvement. Conclusion: Patients were admitted to our outpatient clinic with various clinical symptoms. After careful physical examinations were performed, detailed patient histories were taken and laboratory tests performed for differentials, patients were diagnosed with extrapulmonary tuberculosis. It was desired to emphasize that this disease may appear with different clinical presentations in endemic regions like our country.
Iranian Journal of Pediatrics, 2017
Background: Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterised b... more Background: Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterised by recurrent fever, peritonitis, pleuritis, and arthritis. Three hundred and seventeen mutations and polymorphisms related to FMF have been identified to date. Objectives: The evaluation of the distribution of genetic mutations in children whose FMF study was conducted in Marmara region in Turkey and the relationship between clinical findings and the mutation was aimed in the study. Methods: The files of all patients whose pre-diagnosis of FMF and MEFV gene mutation analysis were made, were evaluated retrospectively. The results of the MEFV gene mutation analysis of the patients were screened retrospectively. Common MEFV gene mutation analyses were studied. The age, gender, presenting complaints, and histories of the patients were obtained from the files and records. Results: A total of 150 patients were included in the study. The mean age of the cases was 9.37 ± 4.43 years; 78 were female and 72 were male. Sixty-seven (44.7%) of the cases had abdominal pain, 30 (20%) had arthralgia, 25 (16.7%) had fever, 2 (1.3%) had chest pain, and 30 (20%) had other complaints. While the mutation with the highest frequency was R202Q (37.2%), it was observed that allele frequencies following this were E148Q (23.4%), M694V (21.9%), V726A (5.1%), and M680I (2.9%). Abdominal pain was detected as the most frequent presenting complaint. Conclusions: Although M694V gene mutation is the most frequently observed mutation in Turkey, we identified that the most frequent gene mutations were R202Q and E148Q in this study. This situation may be because most of our patients were from Anatolian regions where there are many ethnic groups. When the distribution of genotypes was examined by complaint, the most frequent complaint identified in all gene mutations was abdominal pain.
Iranian Red Crescent Medical Journal, 2016
Introduction: Homocystinuria is a hereditary disease caused by a defect in the enzymes involved i... more Introduction: Homocystinuria is a hereditary disease caused by a defect in the enzymes involved in metabolizing methionine. Homocystinuria can influence many systems and may be mistaken for other diseases, including Moyamoya disease. Here, we report the case of a 10-year-old male patient with a diagnosis of Moyamoya disease who had been monitored for that for an extended period. The patient's diagnosis was changed to homocystinuria as a result of lens subluxation and cataract findings. Case Presentation: A 10-year-old male patient presented with vomiting, headache, lethargy, muscular weakness, and eye redness. The patient was mentally retarded, his right pupil was hyperemic, and he had muscle weakness on his left side. In addition, his blood pressure was high. The patient's history included a diagnosis of Moyamoya. A neck and cranial computed tomography (CT) angiography showed no flow bilaterally past the bifurcation of the carotid artery. The patient's bilateral internal carotid arteries were determined to be occluded. It was considered that his eye findings could be compatible with a metabolic disease. On metabolic screening, the patient's homocysteine level was very high. In addition, a heterozygous A1298C mutation was identified in MTHFR. Therefore, the patient was started on a diet free from homocysteine and methionine. In addition, his treatment regimen included vitamins B12 and B6. With these treatments, the patient's complications regressed. Conclusions: In cases of unusual vascular lesions, metabolic diseases must be considered. In homocystinuria, early diagnosis and treatment are important. Blood homocysteine levels can be returned to normal, and some complications can be prevented.
Haseki Tıp Bülteni, 2016
Erken çocukluk döneminde tamamlayıcı beslenme önemlidir. Ailelerin bu konuda bilinçlendirilmesi g... more Erken çocukluk döneminde tamamlayıcı beslenme önemlidir. Ailelerin bu konuda bilinçlendirilmesi gerekmektedir. Bu çalışma, 6-24 ay arasında beslenmeyle ilgili anne ve babaların bilgi ve deneyimlerini değerlendirmek amacıyla düzenlendi.
Iranian Red Crescent Medical Journal, 2019
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease with a specific immune ... more Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease with a specific immune and inflammatory mechanism. This study investigates inflammatory biomarkers and their correlation with disease severity. Objectives: The aim of this study is to determine the relationship between platelet parameters [(mean platelet volume (MPV), platelet distribution width (PDW)], the neutrophil-lymphocyte ratio (NLR), the platelet-lymphocyte ratio (PLR), and AD severity in children. Methods: In this retrospective study, we reviewed patients diagnosed with AD and a healthy control group at the department of pediatrics at Health Sciences in a university-affiliated hospital in Istanbul, Turkey, between January 2015 and December 2016. The study included 79 children with AD and 75 healthy controls. AD severity was graded using the Scoring Atopic Dermatitis (SCORAD) index. Complete blood count was measured, and NLR and PLR were calculated. NLR, PLR, MPV, PDW were compared between AD patients and healthy controls, and the correlations between these indexes and clinical characteristics were analyzed. Results: No significant difference was observed between patients and controls for MPV, NLR, and PLR (P = 0.708, P = 0.340, P = 0.179, respectively). In the AD group, PDW was lower than controls (17.39 ± 1.45, 18.04 ± 1.65, P = 0.006). In the severe AD group, MPV was higher (7.62 ± 1.81, 6.64 ± 1.16, P = 0.035) and PDW was lower than in the mild AD group (16.52 ± 1.49, 17.93 ± 1.44, P = 0.0001). Conclusions: Mean MPV and PDW levels are correlated with atopic dermatitis severity in children.
The Journal of Child, 2018
Çocukluk çağı astım tedavisinde lökotrien antagonisti ile inhale kortikosteroidler kullanılmaktad... more Çocukluk çağı astım tedavisinde lökotrien antagonisti ile inhale kortikosteroidler kullanılmaktadır. Çalışma, astım tanısı almış çocuklarda lökotrien reseptör antagonisti ile inhale kortikosteroid tedavisinin etkinliğini karşılaştırmak için yapılmıştır. Gereç ve Yöntem: Çalışmaya 6-14 yaş grubunda astım tanısı alan 62 hasta dâhil edildi. Hastalar ardışık iki gruba ayrılarak birinci gruba montelukast gece yatmadan önce 5 mg, ikinci gruba inhale kortikosteroid (budesonide) 400 mcg/gün 2 doza bölünerek verildi. Hastalar 6 ay süreyle takip edildi. Değerlendirmede FEV1'deki değişiklikler birincil hedef alındı. Ayrıca tedavi öncesi ve sonrası günlük kısa etkili β2 agonist kullanımı, gece uyanma, acile başvuru, okula devamsızlık değerleri ile karşılaştırıldı. Bulgular: Tedavi sonrasında, tedavi öncesine göre her iki grupta; FEV1 ortalamasında, kısa etkili β2 agonist kullanımı, gece uyanma, acile başvuru ve okula devamsızlık açısından ileri düzeyde düzelme görüldü (p=0,001). Ancak, iki grup arasında istatistiki fark saptanmadı. Sonuç: Astımlı çocuklarda tek başına monlelukast tedavisi; kolay uygulanabilir, güvenilir ve inhale kortikosteroidler kadar etkili bir seçenek olarak saptanmıştır.
The Turkish Journal of Pediatrics, 2020
Background and objectives. One way to measure arterial stiffness is the ambulatory arterial stiff... more Background and objectives. One way to measure arterial stiffness is the ambulatory arterial stiffness index (AASI), which is the relationship between diastolic and systolic ambulatory blood pressure (BP) over 24-hours. Methods. We studied the difference in AASI between obese and lean children. AASI was calculated from 24hour ambulatory blood pressure monitoring in 53 obese children (33 girls) and compared with age-matched 42 healthy subjects (20 girls). Hypertension was defined according to the criteria of the American Heart Association. To evaluate inflammation, the blood level of high-sensitive C-reactive protein was measured. Results. The mean age was 10.6 ± 2.83 years in obese children and 11.3 ± 3.17 years in healthy subjects. Hypertension was determined in three (5.6%) obese children. The median heart rate-SDS, pulse pressure and blood pressure values did not differ between the two groups. The mean AASI was significantly higher in obese children compared to healthy subjects (0.42 ± 0.15 vs. 0.29 ± 0.18, p <0.001). AASI significantly correlated with nighttime SBP-SDS, nighttime SBP-load, systolic and diastolic nocturnal dipping, with no independent predictor. Conclusion. This study confirms that AASI is increased in obese children. AASI calculation is a useful, costeffective, and an easy method to evaluate arterial stiffness. Early detection of increased arterial stiffness can help clinicians come up with preventive measures in the management of patients.
Purpose: Febrile seizures (FS) are the most commonly seen seizure type in children and its etiolo... more Purpose: Febrile seizures (FS) are the most commonly seen seizure type in children and its etiology is not fully understood. It is seen in 2-4% of all children. The most common factors contributing the etiopathogenesis of FS are fever, genetic predisposition and age. Other triggering factors include deficiency of iron, zinc and immunoglobulins as well as cytokine and interferon mechanisms. Methods: This prospective and sectional study includes children between the ages 5 months to 5 years, who came to the outpatient pediatric clinic of Health Sciences University Bagcilar Research and Education Hospital between August 2020 and May 2021. The patient group includes 53 patients who came to the emergency service with febrile seizures and came for a follow-up within the following month and the control group includes 53 healthy children who came for a routine checkup with no prior history of seizures or other illnesses. Results: The age of first time FS ranged from 7 months to 60 months wi...
Medical Bulletin of Haseki
Passive smoking is an important public health issue due to the clinical problems it causes. In th... more Passive smoking is an important public health issue due to the clinical problems it causes. In this study, we determined the effect of passive smoking on respiratory tract infections using a survey method, family history, and urine cotinine/creatinine ratio. Methods: Seventy-two children who came to the Pediatric Outpatient Clinic at Istanbul Bagcilar Training and Research Hospital for a checkup with no current health problems between November 2020 and March 2021 were included in this prospective cross-sectional study. The study group included 36 children with at least one active smoker in the house, and the control group included 36 children with no active smokers in the house. With the survey, sociodemographic variables about the family and child as well as the frequency of lower or upper respiratory tract infection history were questioned. Cotinine and creatinine levels were measured using the urine samples of the patients included in the study. Results: The frequency of respiratory tract infections in the last two years was increased in the group with an active smoker in the household. The frequency of bronchopneumonia in the case group was 44.4%, whereas it was 5.6% in the control group. The sinus infection was seen in 22.2% of those in the case group, while there were no sinus infections reported in the control group. Bronchopneumonia and sinus infections were statistically significant in the case group (p<0.01 and p<0.01 respectively). The median cotinine levels in the active smokers in the house group were 20.94 ng/mL (0-491) and 16.62 ng/mL (0-121) in the nonsmoker group. 55.6% of children with a history of cigarette smoke exposure and a urine cotinine level higher than 10 ng/mL were considered passive smokers (the normal range is 0-10 ng/mL). Conclusion: Frequent respiratory tract infections and hospitalization may be prevented by informing families about the risks of exposure to cigarette smoke as well as raising awareness of the harms of cigarette smoke.
Bagcilar Medical Bulletin
Evaluation of clinical features and results in multisystem inflammatory syndrome in children (MIS... more Evaluation of clinical features and results in multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease-2019.
Bagcilar Medical Bulletin, 2021
In this study, we aimed to evaluate the relationship among neutrophil-lymphocyte ratio (NLR), C-r... more In this study, we aimed to evaluate the relationship among neutrophil-lymphocyte ratio (NLR), C-reactive protein (CRP) and disease severity in 0-2-year-old children diagnosed and hospitalized with bronchiolitis. Method: This retrospective cross-sectional study includes 158 patients aged 0-2 years, who were hospitalized for bronchiolitis between 01.12.2018 and 04.01.
Progress in Nutrition, 2018
Background: Iron Deficiency Anemia (IDA) is the most common anemia in all age groups. The coexist... more Background: Iron Deficiency Anemia (IDA) is the most common anemia in all age groups. The coexistence of iron deficiency anemia and zinc (Zn) deficiency is quite common, for most of the etiologic factors are common. The purpose of this study is to determine the prevalence of zinc deficiency in children with iron deficiency and/or iron deficiency anemia. Method: One hundred and sixty child patients within 6month-5 year age range diagnosed with iron deficiency and/or iron deficiency anemia and 91 children with no iron deficiency and/or iron deficiency anemia diagnosis were included in the study. The relationships between serum zinc levels and other biochemical and hematological parameters were examined. Results: It was observed that the study and control groups had similar demographic characteristics, and there was no statistically significant difference between two groups in terms of average age (months), distribution of age groups, and gender groups. Statistically significant differ...
Journal of Dr Behcet Uz Children s Hospital, 2018
Amaç: Atopik dermatit çocukluk çağının en sık görülen kronik, kaşıntılı inflamatuvar cilt hastalı... more Amaç: Atopik dermatit çocukluk çağının en sık görülen kronik, kaşıntılı inflamatuvar cilt hastalığıdır. Son yıllarda hastalığın patogenezinde immünmodülatör etkileri ile D vitamininin rolü tartışılmaktadır. Çalışmamızda, D vitamini eksikliği ile atopik dermatit hastalık varlığı ve hastalığın şiddeti ile arasındaki ilişkinin araştırılması planlanmıştır. Yöntem: Bağcılar Eğitim ve Araştırma Hastanesi Çocuk Alerji Polikliniğinde atopik dermatit tanısı alan 5 yaş altı 62 hasta çalışmaya alındı. Kontrol grubunu hastanemiz çocuk sağlığı polikliniğine başvuran aynı yaş grubunda sağlıklı 30 çocuk oluşturdu. Atopik dermatitli olguların hastalık ile ilgili eozinofil, total IgE, spesifik IgE düzeyleri hasta dosyalarından kaydedildi. Hastalık şiddeti SCORAD indeksi kullanılarak değerlendirildi. SCORAD indeks puanı <25 olanlar hafif, 25-50 olanlar orta, >50 olanlar ağır hastalık grubunu oluşturdu. 25(OH)D düzeyi ≥30 ng/ml yeterli, 21-29 ng/ ml yetersiz, ≤20 ng/ml eksiklik olarak kabul edildi. İstatistiksel analizde p<0,05 değeri anlamlı kabul edildi. Bulgular: Atopik dermatitli olgular ile kontrol grubu arasında yaş, cinsiyet dağılımı açısından anlamlı fark saptanmadı. Olguların %22,6'sında (n=14) D vitamini eksikliği saptanırken, sağlıklı çocukların %3'ünde (n=10) D vitamini eksikliği vardı. SCORAD indeksi hafif olanların 25 (OH) D vitamini ortalaması 39,47±18,49, orta olanların 25 (OH) D vitamini ortalaması 25,07±13,74 olup, her iki grup arasında fark saptanmadı (p=0,059). Sonuç: Çalışmamızda D vitamini düzeyi ile atopik dermatit varlığı ve şiddeti arasında ilişki bulunmamıştır.
Allergologia et Immunopathologia, 2020
Background: Various inflammatory biomarkers have been used in asthma cases for evaluating inflamm... more Background: Various inflammatory biomarkers have been used in asthma cases for evaluating inflammation, however it has been determined that the majority of these biomarkers are insufficient for putting forth the course and severity of the disease. Osteoprotegerin is a glycoprotein mediator in the lung and macrophages. As far as we know, there are no studies about the role played by osteoprotegerin in child patients with asthma. Objective: It was planned to examine the relationship between osteoprotegerin levels in childhood asthma and respiratory functions and airway inflammation and to assess its use as a biomarker. Methods: The study included patients aged 6-16 years who were diagnosed with asthma at the pediatric allergy outpatient clinic of Bagcilar Training and Research Hospital in Turkey. The correlation analyses for the osteoprotegerin levels of asthma patients and their respiratory functions were examined. Results: The age average of asthma cases was 10.61 ± 3.04 years and 51.2 % were female. No statistically significant difference was observed between the osteoprotegerin levels of the groups (p > 0.05). A negative and statistically significant correlation was observed between the FEV1 and FVC values and osteoprotegerin levels (p = 0.015, p = 0.003). Conclusions: This was the first study to examine the relationship between osteoprotegerin levels and airway inflammation in children with asthma. We believe that there is a need for wider scale studies in which clinical symptoms and more parameters are evaluated for defining the
Bagcilar Medical Bulletin, 2020
Nowadays, there are compelling data on the increase in traditional and complementary medicine pra... more Nowadays, there are compelling data on the increase in traditional and complementary medicine practices in adults. Although the use of complementary medicine practices in children is frequently observed, studies on children are more limited in this subject. Studies on children mostly include those with chronic diseases. Our study aimed to evaluate the use of traditional and complementary medicine therapies in children without chronic diseases and parents' knowledge. Method: The study was conducted at Bağcılar Training and Research Hospital Pediatric Clinic between 1 December 2018 and 28 February 2019. In the study, 200 patients in the 0-15 age group without any known chronic diseases were included. A questionnaire form was applied to either mothers or fathers of the patients, and the practices they performed in traditional medicine, their knowledge, and experience, and their socioeconomic-cultural status were questioned. Results: In our study, which evaluated the use of traditional and complementary medicine methods in children without chronic diseases, 95.5% of the children had a history of the use of at least one complementary medicine method. The use of herbal tea was the most preferred complementary medicine method (68.8%). Other methods were the use of immune boosters, prayers, massage, nutrition-diet, acupuncture, and music. More than half of the patients (56%) had heard or learned about complementary medicine methods from their family elders. The rate of those who had learned about them from the media was determined to be 14%, and the rate of those who had learned from Amaç: Günümüzde, yetişkinlerde geleneksel ve tamamlayıcı tıp uygulamalarının artması ile ilgili ilgi çekici veriler mevcuttur. Bu konuda çocuklarda yapılan çalışmalar daha sınırlı olmakla birlikte, tamamlayıcı tıp uygulamalarının çocuklarda kullanımı sıklıkla görülmektedir. Çocuklardaki çalışmalar daha çok kronik hastalığı olanları kapsamaktadır. Çalışmamızda kronik hastalığı olmayan çocuklarda geleneksel ve tamamlayıcı tıp tedavilerinin kullanımı ve ebeveyn bilgilerinin değerlendirilmesi amaçlanmıştır.
Bagcilar Medical Bulletin, 2019
Childhood obesity is one of the most important children's health problems that is gradually incre... more Childhood obesity is one of the most important children's health problems that is gradually increasing all over the world. Dyslipidemia which coexists with obesity is a risk factor for atherosclerotic diseases in adulthood. In this study, the usability of the neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) in predicting dyslipidemia, a serious complication of obesity, in children were investigated. Method: Two hundred and seven cases aged between 11-17 years who were diagnosed with obesity at the Pediatrics Clinic of our hospital and 50 cases with no disorders whose complete blood count was performed for routine purposes were retrospectively investigated. The genders, ages, and examination findings of the cases were recorded. In obese children, leukocyte, hemoglobin, platelet, mean platelet volume, neutrophil and lymphocyte levels were evaluated in the complete blood count performed at the first admission. The NLR and the PLR were calculated. Preprandial blood glucose and preprandial insulin, serum aminotransferase values, and the lipid profile were recorded. Results: While dyslipidemia was determined in 99 (47.82%) of 207 cases who were diagnosed with obesity, it was not determined in 108 (52.18%) cases. The systolic blood pressure, diastolic blood pressure, and preprandial insulin level were higher in cases with dyslipidemia than the group without dyslipidemia. The PLR average of the dyslipidemic group was 112.75±39.11, the PLR average of the non-dyslipidemic group was 104.78±31.38, and the PLR average of the control group was 110.20±39.35, and there was no statistically significant difference between the PLR averages of the groups (p=0.353). The NLR average was 1.52±0.69 in Amaç: Çocukluk çağı obezitesi tüm dünyada giderek artan en önemli çocuk sağlığı sorunlarından biridir. Obezite ile birlikte olan dislipidemi, erişkin dönemde aterosklerotik hastalıklar için bir risk faktörüdür. Bu çalışmada çocuklarda, obezitenin ciddi bir komplikasyonu olan dislipidemiyi öngörmede nötrofil-lenfosit oranı (NLO) ve platelet-lenfosit oranının (PLO) kullanılabilirliğini araştırdık. Yöntem: Hastanemiz Çocuk Sağlığı ve Hastalıkları Kliniği'nde obezite tanısı alan 11-17 yaş arası 207 olgu ve herhangi bir rahatsızlığı olmayıp rutin amaçlı tam kan tahlili yapılan 50 olgu retrospektif olarak incelendi. Olguların cinsiyetleri, yaşları, muayene bulguları kaydedildi. Obez çocuklarda ilk başvuruda alınan tam kan sayımında lökosit, hemoglobin, trombosit, ortalama trombosit hacmi, nötrofil ve lenfosit düzeyleri değerlendirildi. NLO ve PLO hesaplandı. Açlık kan şekeri ve açlık insülin, serum aminotransferaz değerleri ve lipid profili kaydedildi. Bulgular: Obezite tanısı alan 207 olgunun 99'unda (%47,82) dislipidemi saptanırken, 108 olguda (%52, 18) dislipidemi saptanmadı. Dislipidemi saptanan olguların sistolik kan basıncı, diastolik kan basıncı ve açlık insülin düzeyi dislipidemi olmayan gruptan daha yüksekti. Dislipidemik grubun PLO ortalaması 112,75±39, 11, dispidemik olmayan grubun PLO ortalaması 104,78±31,38, kontrol grubunun PLO ortalaması 110,20±39,35 olup grupların PLO ortalamaları arasında istatistiksel olarak anlamlı farklılık gözlenmemiştir (p=0,353). NLO ortalaması dislipidemik grupta 1,52±0,69, dislipidemik olmayan grupta 1,66±0,81, kontrol grubunda 1,72±1,26 idi. Her üç grubun NLO ortalaması arasında istatistiksel olarak anlamlı farklılık gözlenmemiştir (p=0,295).
The Journal of Pediatric Research, 2019
Acute viral respiratory tract infection is the leading cause of hospitalization for infants and y... more Acute viral respiratory tract infection is the leading cause of hospitalization for infants and young children in developed countries and is a major cause of death in developing countries. The aim of this study was to identify the viruses in children hospitalized for lower respiratory tract infections during winter period and to evaluate the relationship between the clinical features of the patients and the severity of the disease. Materials and Methods: The nasopharyngeal aspirates of 200 patients aged 0-24 months hospitalized with a diagnosis of lower respiratory tract infection were analyzed using the real-time polymerase chain reaction method. We looked for associations between viral agent, duration of hospitalization and respiratory distress scale. Results: The viral factor was identified in 150 (75%) patients. Rhinovirus was the most frequent viral agent followed by respiratory syncytial virus and adenovirus; (52.67%), (16.0%) and (8.67%) respectively. The average length of hospitalization for respiratory syncytial virus (p=0.001), adenovirus (p=0.009), influenza A virüs (p=0.007), and bocavirus (p=0.009) infections were significantly longer. Adenovirus (p=0.029), respiratory syncytial virus (p=0.001) and bocavirus (p= 0.009) were significantly associated with length of hospitalization. No significant correlation was identified between the viruses and respiratory distress scores (p>0.05). Conclusion: We conclude that in hospitalized children with lower respiratory tract infection, rhinovirus was the most frequently observed viral etiological agent. Longer length of hospitalization was needed in RSV, adenovirus and bocavirus in infants with lower respiratory tract infections. Infants with respiratory infections should be monitored due to the risk of developing severe complications during disease progression.
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Papers by Özlem Bostan Gayret