IP Archives of Cytology and Histopathology Research, 2018
Introduction: Being the most common benign tumor of the breast, fibroadenoma show considerable hi... more Introduction: Being the most common benign tumor of the breast, fibroadenoma show considerable histologic changes. It is important to highlight them as some of the changes are associated with increased risk of breast cancer. Aims and Objectives: To study the pattern and histologic changes in fibroadenoma breast. Materials and Methods: Retrospective analysis of histopathology of 55 cases of fibroadenoma breast diagnosed between Jan 2017 to Jun 2018. The pattern, epithelial and stromal changes were examined. Result: Commonest age group involved was in 3rd decade. Pericanalicular pattern was the predominant pattern. Apocrine and cystic change was the commonest change in epithelium. Two cases (3.6%) showed features of complex fibroadenoma. Three (5.5%) cases showed foci of tubular adenoma. Epithelial hyperplasia was seen in 5(9%) of cases of which 2 were mild, 2 were moderate and one was atypical hyperplasia. Inflammatory infiltrate in stroma was frequently observed. Conclusion: Fibroadenoma showed variety of histological changes of which complex fibroadenoma and epithelial hyperplasia are significantly important which requires appropriate management and follow up.
Aims: The clinical presentation and frequency of urogenital tumors varies in different regions of... more Aims: The clinical presentation and frequency of urogenital tumors varies in different regions of the world. This study was undertaken to analyze the frequency, clinical presentation, and the histopathological spectrum of the various male urogenital tumors diagnosed over a period of 3 years in a tertiary care institute. Materials and Methods: Three-year data were collected from the histopathology laboratory, which included all the cases of male urogenital tumors which were diagnosed histopathologically between November 2012 and October 2015. Results: A total of 10,297 surgical specimens of male patients were received in 3 years, of which 1749 were tumors of various organs in males. Of 1749 surgical specimens, 455 were genitourinary tumors. Frequency of urogenital tumors in males was 13.05%. Malignant tumors comprised the majority (99.53%). The age of the patients ranged from 19 to 98 years. The maximum number of patients was in the 5th–7th decade and the mean age of presentation was 64 years. Urinary bladder was the most common site for urogenital tumors (61.09%), with urothelial carcinoma being the most common histological type. Prostatic adenocarcinoma, renal cell carcinoma, and penile squamous cell carcinoma accounted for a significant number of cases. Testicular tumors were the least common and included predominantly mixed germ cell tumors. Conclusion: This study can be taken as a small step toward making the registry of patients with urogenital tumors providing valuable information regarding the frequency, clinical presentation, and histological spectrum. Large population-based studies for a longer duration of time across both males and females are needed in the ever-changing trends of urogenital tumors.
Tuberculous involvement of heart occurs in 1-2% cases and involvement of myocardium is rarer [1].... more Tuberculous involvement of heart occurs in 1-2% cases and involvement of myocardium is rarer [1]. Antemortem diagnosis is delayed due to its low incidence and late diagnosis. Most of the cases occur in young age in immunocompetent males [2]. We report a rare presentation of tuberculosis in a 5-y-old girl child, who presented with fever and anasarca for 2 mo, shortness of breath, abdominal distension and cough for 2 wk. The child was born at term, immunized for age and developmentally normal. She was febrile with pulse 140/ min, blood pressure 90/60 mmHg, respiratory rate 38/min and SPO 2 90%. Examination revealed generalised lymphadenopathy, bilateral basal crepts, muffled S1, S2, ascites and massive hepatomegaly. Chest radiograph showed enlarged cardiothoracic ratio with interstitial edema. Fine needle aspiration cytology (FNAC) of cervical lymph node showed necrosis and Zeihl Neelson stain was positive. A diagnosis of tuberculosis was given and child started on DOTS category I. Echocardiography showed dilated cardiomyopathy, moderate left ventricular dysfunction with ejection fraction 30%, mild pericardial effusion and Congestive heart failure-New York Heart Association Classification (CHF-NYHA) Grade III. Creatine kinase (CK-MB) was raised (49 IU), so a final diagnosis of cardiomyopathy with tubercular myocarditis was made. Child improved on anti-tubercular treatment (ATT) and decongestive measures. The incidence of tuberculosis is declining worldwide, however, it is still one of the most prevalent infectious etiologies. Tuberculosis usually spares the heart. The proposed
IP Archives of Cytology and Histopathology Research, 2018
Introduction: Being the most common benign tumor of the breast, fibroadenoma show considerable hi... more Introduction: Being the most common benign tumor of the breast, fibroadenoma show considerable histologic changes. It is important to highlight them as some of the changes are associated with increased risk of breast cancer. Aims and Objectives: To study the pattern and histologic changes in fibroadenoma breast. Materials and Methods: Retrospective analysis of histopathology of 55 cases of fibroadenoma breast diagnosed between Jan 2017 to Jun 2018. The pattern, epithelial and stromal changes were examined. Result: Commonest age group involved was in 3rd decade. Pericanalicular pattern was the predominant pattern. Apocrine and cystic change was the commonest change in epithelium. Two cases (3.6%) showed features of complex fibroadenoma. Three (5.5%) cases showed foci of tubular adenoma. Epithelial hyperplasia was seen in 5(9%) of cases of which 2 were mild, 2 were moderate and one was atypical hyperplasia. Inflammatory infiltrate in stroma was frequently observed. Conclusion: Fibroadenoma showed variety of histological changes of which complex fibroadenoma and epithelial hyperplasia are significantly important which requires appropriate management and follow up.
Aims: The clinical presentation and frequency of urogenital tumors varies in different regions of... more Aims: The clinical presentation and frequency of urogenital tumors varies in different regions of the world. This study was undertaken to analyze the frequency, clinical presentation, and the histopathological spectrum of the various male urogenital tumors diagnosed over a period of 3 years in a tertiary care institute. Materials and Methods: Three-year data were collected from the histopathology laboratory, which included all the cases of male urogenital tumors which were diagnosed histopathologically between November 2012 and October 2015. Results: A total of 10,297 surgical specimens of male patients were received in 3 years, of which 1749 were tumors of various organs in males. Of 1749 surgical specimens, 455 were genitourinary tumors. Frequency of urogenital tumors in males was 13.05%. Malignant tumors comprised the majority (99.53%). The age of the patients ranged from 19 to 98 years. The maximum number of patients was in the 5th–7th decade and the mean age of presentation was 64 years. Urinary bladder was the most common site for urogenital tumors (61.09%), with urothelial carcinoma being the most common histological type. Prostatic adenocarcinoma, renal cell carcinoma, and penile squamous cell carcinoma accounted for a significant number of cases. Testicular tumors were the least common and included predominantly mixed germ cell tumors. Conclusion: This study can be taken as a small step toward making the registry of patients with urogenital tumors providing valuable information regarding the frequency, clinical presentation, and histological spectrum. Large population-based studies for a longer duration of time across both males and females are needed in the ever-changing trends of urogenital tumors.
Tuberculous involvement of heart occurs in 1-2% cases and involvement of myocardium is rarer [1].... more Tuberculous involvement of heart occurs in 1-2% cases and involvement of myocardium is rarer [1]. Antemortem diagnosis is delayed due to its low incidence and late diagnosis. Most of the cases occur in young age in immunocompetent males [2]. We report a rare presentation of tuberculosis in a 5-y-old girl child, who presented with fever and anasarca for 2 mo, shortness of breath, abdominal distension and cough for 2 wk. The child was born at term, immunized for age and developmentally normal. She was febrile with pulse 140/ min, blood pressure 90/60 mmHg, respiratory rate 38/min and SPO 2 90%. Examination revealed generalised lymphadenopathy, bilateral basal crepts, muffled S1, S2, ascites and massive hepatomegaly. Chest radiograph showed enlarged cardiothoracic ratio with interstitial edema. Fine needle aspiration cytology (FNAC) of cervical lymph node showed necrosis and Zeihl Neelson stain was positive. A diagnosis of tuberculosis was given and child started on DOTS category I. Echocardiography showed dilated cardiomyopathy, moderate left ventricular dysfunction with ejection fraction 30%, mild pericardial effusion and Congestive heart failure-New York Heart Association Classification (CHF-NYHA) Grade III. Creatine kinase (CK-MB) was raised (49 IU), so a final diagnosis of cardiomyopathy with tubercular myocarditis was made. Child improved on anti-tubercular treatment (ATT) and decongestive measures. The incidence of tuberculosis is declining worldwide, however, it is still one of the most prevalent infectious etiologies. Tuberculosis usually spares the heart. The proposed
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