Papers by Larry Ereshefsky
Dicp-The annals of pharmacotherapy, Jul 1, 1979
Objectives After reading this article, the learner should be able to: 1. identify the typical tar... more Objectives After reading this article, the learner should be able to: 1. identify the typical target symptoms of mania and depression; 2. identify appropriate indications for lithium therapy; 3. identify the proposed pharmacology of the lithium ion; 4. apply the pharmacokinetics of lithium to clinical practice cases; 5. recognize the usually accepted dose ranges for lithium maintenance and acute therapy.
Alzheimers & Dementia, Jul 1, 2016
Dicp-The annals of pharmacotherapy, Jul 1, 1981
CRC Press eBooks, Mar 19, 2003
PubMed, Sep 1, 1993
Neuroleptic malignant syndrome is thought to be a result of dopamine receptor blockade in the str... more Neuroleptic malignant syndrome is thought to be a result of dopamine receptor blockade in the striatum. Clozapine has only weak affinity for dopamine type 1 and 2 receptors, and therefore it was thought this drug would not precipitate the syndrome. However, six cases of the syndrome have been reported in patients receiving clozapine monotherapy. A review of the pathoetiology of symptoms occurring in the syndrome is included.
Value in Health, Oct 1, 2017
methodology, findings from the studies were found to be highly variable -total costs ranged betwe... more methodology, findings from the studies were found to be highly variable -total costs ranged between USD 3,000 to 12,000, while proportion of indirect costs varied between 32 and 82% across these studies. Based on collected information, direct costs attributed to medical care contributed to only 20% while informal care provided by family and direct costs of social care (provided by community care professionals, and in residential home settings) contributed 40% each of the total cost of dementia in China. ConClusions: Costs data for Dementia in China is limited and further efforts are required to generate this data to support health policy and research as changing demographics, urban/rural shift and increased diagnosis rates are expected to lead to an epidemic of AD dementia in China in the near future.
Value in Health, May 1, 2015
displaying seven treatment attributes: medication, therapy, school involvement, caregiver behavio... more displaying seven treatment attributes: medication, therapy, school involvement, caregiver behavior training, physician management, provider communication and out-of-pocket costs. Every attribute was operationalized into 3 possible levels. Within each task, caregivers selected one best and one worst attribute. A scaleadjusted latent-class (SALC) analysis was conducted to account for variability in the consistency of responses. RESULTS: Our study population of 164 caregivers were on average 42 years old (SD 8.7), predominantly female (95%), white (65%), married (61%), college-educated (73%), and 20% had a child who was diagnosed with ADHD for ≤ 1year. Based on the aggregate results, using medication everyday was the most preferred treatment attribute (coefficient= 2.41, p< 0.001). Three latent classes (i.e. segments) that best described the data were identified, and the scale factor included in the model was significant (p< 0.001). The 3 segments comprised 28%, 27%, and 45% of our study population. Segment 1 has the strongest preference for 'medication' (coefficients= 3.69 -4.34, all p< 0.001) while Segment 2 displayed the least preference for medication (coefficients= -1.49 --3.36, all p< 0.001). Segment 3 was most costavoidant (coefficients= -2.13 --6.11, all p< 0.001) but had the strongest preference for 'school involvement' (coefficients= 0.63 -2.58, all p< 0.05). CONCLUSIONS: This study demonstrated variation in caregivers' priorities for ADHD treatment attributes. A better understanding of preferences for evidence-based treatment options can enhance patient-centered care. By utilizing SALC, our study reduces the likelihood of misclassification error.
The Journal of Clinical Pharmacology, Nov 1, 2003
The objective of this study was to investigate pharmacokinetic and pharmacodynamic interactions b... more The objective of this study was to investigate pharmacokinetic and pharmacodynamic interactions between midazolam and fluoxetine, fluvoxamine, nefazodone, and ketoconazole. Forty healthy subjects were randomized to receive one of the four study drugs for 12 days in a parallel study design: fluoxetine 60 mg per day for 5 days, followed by 20 mg per day for 7 days; fluvoxamine titrated
Alzheimer's & Dementia, 2021
BackgroundAthira Pharma, Inc. is developing a new class of blood‐brain barrier (BBB)‐penetrant sm... more BackgroundAthira Pharma, Inc. is developing a new class of blood‐brain barrier (BBB)‐penetrant small molecule drugs aimed at activating the neurotrophic system HGF/MET to promote multiple neurorestorative processes, with the potential to ultimately improve brain function. ATH‐1017 is the lead clinical candidate for the treatment of Alzheimer’s disease (AD). Electroencephalogram (EEG) plays a growing role in facilitating dose exploration of investigational agents like ATH‐1017 by demonstrating brain penetration and target engagement, helping to accelerate CNS drug development.MethodThe translational measure quantitative electroencephalogram (qEEG) was assessed in preclinical animal models and in human volunteers, including healthy young, healthy elderly, and AD subjects as part of a randomized, double‐blind Phase 1a/b trial assessing the safety and pharmacodynamics of ATH‐1017.ResultAs measured by qEEG, ATH‐1017 induced a fast onset and sustained gamma power induction across a range ...
Annals of Pharmacotherapy, 1982
Psychopharmacology Bulletin, 1983
Alzheimer's & Dementia, 2021
IntroductionApathy is common in neurocognitive disorders (NCD) but NCD‐specific diagnostic criter... more IntroductionApathy is common in neurocognitive disorders (NCD) but NCD‐specific diagnostic criteria are needed.MethodsThe International Society for CNS Clinical Trials Methodology Apathy Work Group convened an expert group and sought input from academia, health‐care, industry, and regulatory bodies. A modified Delphi methodology was followed, and included an extensive literature review, two surveys, and two meetings at international conferences, culminating in a consensus meeting in 2019.ResultsThe final criteria reached consensus with more than 80% agreement on all parts and included: limited to people with NCD; symptoms persistent or frequently recurrent over at least 4 weeks, a change from the patient's usual behavior, and including one of the following: diminished initiative, diminished interest, or diminished emotional expression/responsiveness; causing significant functional impairment and not exclusively explained by other etiologies.DiscussionThese criteria provide a fra...
The Journal of Prevention of Alzheimer's Disease, 2020
Dementia is characterized by a significant decline in one of several cognitive domains such as me... more Dementia is characterized by a significant decline in one of several cognitive domains such as memory, language and executive function, affecting independence and representing a significant deterioration from a previous level of functioning (1). Alzheimer’s Disease (AD) represents the most common form of dementia and contributes up to 70% of the almost 50 million dementia cases worldwide, a number that is projected to double in 20 years (2).
Applied Therapeutics, 1992
The Journal of clinical psychiatry, 1986
The evolution of the federal government's role in the regulation and evaluation of generic ps... more The evolution of the federal government's role in the regulation and evaluation of generic psychotropic medications is described. To place many of the methodologic bioequivalence issues for antipsychotic agents into perspective, the pharmacokinetics of these drugs are reviewed. Appropriate methodologies for studying the pharmacokinetics and pharmacodynamics of psychotropic drugs are in early developmental stages. Many of the issues relating to bioequivalence of generic products will not be resolved until a better understanding of these factors is developed.
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Papers by Larry Ereshefsky