This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Abstract Radiological characterization of radionuclides contained in the phosphate rocks, phospho... more Abstract Radiological characterization of radionuclides contained in the phosphate rocks, phosphogypsum, phosphoric acid, and phosphates fertilizers (DAP, NPS, NPK, TSP, and TAP) in Morocco have been performed to provide a database for the assessment of the environmental and the radiological impacts. The measurements of the activity concentration were carried out using both alpha and gamma spectrometry. Additionally, the radiological parameters such as the gamma radiation hazard index, the internal and external hazard index as well as the outdoor and indoor absorbed gamma dose rates. The corresponding annual effective dose rates and the total excess lifetime cancer risk (ELCR) were also estimated to discuss the radiological hazard. The primary results showed that the activity concentrations of 238U, 234U, and 235U were 174.58–2604.14, 143.03–2765.34 and 8.35–131.64 Bq kg−1, respectively. The 230Th, 232Th and 234Th concentrations found were 239.29–1656.36, 0.68–17.71 and 133.54–2194.27 Bq kg−1, respectively. The specific activities of 226Ra and 40K ranged from
la réactivité de la 3-éthoxycarbonylméthyléne-2-oxo-1-[3(5)-phénylpyrazol-5(3)-5-1,2,3,4-tétrahyd... more la réactivité de la 3-éthoxycarbonylméthyléne-2-oxo-1-[3(5)-phénylpyrazol-5(3)-5-1,2,3,4-tétrahydroquinoxaline a été examinée. Une réaction ultérieure avec l'acétyléne dicarboxylate d'éthyle conduit aux dérivés de l'aconitate-quinoxaline 6 et 7. La sulfuration du composé 4 donne le thioamide correspondant. La bromation conduit aux composés tribromés et monobromés 9 et 10.
La réactivité de la 3-éthoxycarbonylméthyléne-2-oxo-1-[3(5)-phénylpyrazol-5(3)-5- 1,2,3,4-tétrahy... more La réactivité de la 3-éthoxycarbonylméthyléne-2-oxo-1-[3(5)-phénylpyrazol-5(3)-5- 1,2,3,4-tétrahydroquinoxaline a été examinée. Une réaction ultérieure avec l'acétyléne dicarboxylate d'éthyle conduit aux dérivés de l'aconitate-quinoxaline 6 et 7. La sulfuration du composé 4 donne le thioamide correspondant. La bromation conduit aux composés tribromés et monobromés 9 et 10.
Hydrazine and phenylhydrazine induced ring opening of méthyl isodehydroacetate respectively on C ... more Hydrazine and phenylhydrazine induced ring opening of méthyl isodehydroacetate respectively on C 6 and C 2 positions to afford 4-[1-[3-methyl-5-oxopyrazol-4-yl]ethyl-3methyl]pyrazolin-5-one and bipyrazolone. Almost pyrimido[1,2-a]benzimidazole has been prepared by a sequence involving 2-amino benzimidazole. Keywords : methylisodehydroacetate / bipyrazolone / pyrimido[1,2-a]benzimidazole Résumé : L'action de l'hydrazine et de la phénylhydrazine sur l'isodéhydroacétate de méthyle conduit respectivement après ouverture du cycle pyranique sur les positions C 6 et C 2 , au 4-[1-[3-methyl-5oxopyrazol-4-yl]ethyl-3-methyl]pyrazolin-5-one et à la bipyrazolone. Alors que la pyrimido[1,2a]benzimidazole est obtenue lorsque le 2-amino benzimidazole est utilisé comme agent binucléophile.
An earlier study reports the synthesis of oxindole derivatives bearing an oxazolidin-2-one sub-un... more An earlier study reports the synthesis of oxindole derivatives bearing an oxazolidin-2-one sub-unit. The title Sciff base (Scheme I) is the starting reactant for the synthesis of other heterocyclic systems (Alsubari et al., 2009). We have supporting information sup-5
Carbamates insecticides are used increasingly in agriculture as a replacement for environmentally... more Carbamates insecticides are used increasingly in agriculture as a replacement for environmentally more persistent organochlorine insecticides for the control of insect pests. It was the most used pesticides in Loukkous-Morocco. Conventional methods employed to detect/analyze carbamates residues are time consuming and require sophisticated equipment only available in well-equipped laboratories. In addition, the conventional methods usually require a lot of complex pre-treatment of samples. Therefore, convenient and rapid pesticide detection system is urgently needed. In this order, we aimed to develop a rapid ELISA (enzyme-linked immuno-Sorbent Assay) for detection of some carbamates such as carbendazim [methyl 2-benzimidazole carbamate] and carbofuran [2,3-dihydro-2,2-dimethyl-7-benzofuranylmethyl carbamate]. To develop an immunoassay for carbendazim and carbofuran we have synthesized molecules with acid function (haptens with 4 and 5 carbons) that are coupled with BSA protein and injected to the rabbits, collected antibodies are used for the achievements of the immunoanalytical assay.
Acta Crystallographica Section E-structure Reports Online, Mar 23, 2001
The structure of the title compound, C 11 H 12 N 2 S, established by an X-ray crystallographic st... more The structure of the title compound, C 11 H 12 N 2 S, established by an X-ray crystallographic study, shows that the molecule is composed of three cycles: bicyclic benzimidazole and the thiazepine ring which is bent. Comment Thiazepinobenzimidazole derivatives constitute an interesting series of heterocyclic compounds, particularly for their biological activities (
International Journal of Environmental Analytical Chemistry, Aug 11, 2019
ABSTRACT A competitive enzyme-linked immunosorbent assay (ELISA) test using polyclonal rabbit ant... more ABSTRACT A competitive enzyme-linked immunosorbent assay (ELISA) test using polyclonal rabbit antibodies for detection of Chlorpyrifos-ethyl (CPE) and its two major metabolites of degradation [3,5,6-Trichlororpyridin-2-ol (TCP) and O,O’-diethylthiophosphoric acid (DETP)], has been developed. We have first synthetized haptens of these three molecules, with 4 and 5 carbons spacer arms having carboxyl function at their ends. Haptens with 5 carbons’ spacer arm have been coupled to Bovine Serum Albumin (BSA) then injected to rabbits for polyclonal antibodies production. Haptens with 4 carbons spacer arm have been coupled to Human Albumin (HAS) to be in well plates coating to perform the ELISA tests. After adjusting the ELISA parameters, we have plotted the B/B0 (%) values against the logarithm of analyst concentrations. The IC50 values and detection limits were obtained through fitting the curves. The IC50 value of CPE and TCP were 651 and 5.61 ppb, with detection limits about 2.3410−2 and 2.18 10−3 ppb, respectively. We report for the first time, ELISA system developed for DETP with IC50 of 76.5 and a detection limit of 8.81 10−3 ppb. To evaluate the potential interferences that may be encountered in environmental water samples, pH, ionic strength, humic acid and some heavy metals were tested upon IC50 of the developed ELISA systems. In addition, several pesticides as well as CPE metabolites were tested for cross reactivity study. In all cases, the interference of the CPE assay was negligible. TCP assay represented a high cross reactivity to CPE but no interference with the others compounds. For DETP, no cross reactivity with the TCP was detected, but it was higher with CPE and the others pesticides. The developed ELISA systems have been compared with HPLC technique. Both techniques gave values of the same order of CPE and TCP prepared concentrations with a better sensitivity for ELISA system.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
As part of the synthesis of the benzimidazole derivative heterocyclique system, we are interested... more As part of the synthesis of the benzimidazole derivative heterocyclique system, we are interested in studying the condensation of the o-phenylenediamines with amino-acids such as aspartic acid, serine and histidine. The interest that these present is based mainly on their pharmacological properties. They have, in fact anti-inflammatory, antidepressive, antibacterial and antihistamine properties. On the other hand, it should be noted that 5,6-dimethyl-1-(alpha-D-ribofuranosyl) benzimidazole constitutes part of vitamin B12. Taken together, these results led us to pursue our research in this domain while focusing on new methods of benzimidazolic derivative synthesis. It should be said that the obtaining of these compounds depends on the quantity of the amino-acid. All synthesized products have been characterized by infrared, nuclear magnetic resonance and mass spectrometry.
[EN] Preformed chiral bis(oxazoline)copper complex having a 4-aminobutyl linker in the meso carbo... more [EN] Preformed chiral bis(oxazoline)copper complex having a 4-aminobutyl linker in the meso carbon has been covalently attached to single wall carbon nanotubes (1 µm average length) through the carboxylic acid groups and the resulting material used as recoverable catalyst for the hydroxyalkylation of 1,3-dimethoxybenzene by ethyl trifluoropyruvate obtaining ee up to 97 %.Moussaif, A.; Martín González, R.; Ramli, Y.; Zniber, R.; Achour, R.; El Ghoul, M.; Alvaro Rodríguez, MM.... (2011). CHIRAL BIS(OXAZOLINE)COPPER(II) COVALENTLY ANCHORED TO SINGLE WALL CARBON NANOTUBE AS RECOVERABLE CATALYST FOR ENANTIOSELECTIVE FRIEDEL-CRAFTS HYDROXYALKYLATION. Revue Roumaine de Chimie. 56(6):675-680. http://hdl.handle.net/10251/90965S67568056
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Abstract Radiological characterization of radionuclides contained in the phosphate rocks, phospho... more Abstract Radiological characterization of radionuclides contained in the phosphate rocks, phosphogypsum, phosphoric acid, and phosphates fertilizers (DAP, NPS, NPK, TSP, and TAP) in Morocco have been performed to provide a database for the assessment of the environmental and the radiological impacts. The measurements of the activity concentration were carried out using both alpha and gamma spectrometry. Additionally, the radiological parameters such as the gamma radiation hazard index, the internal and external hazard index as well as the outdoor and indoor absorbed gamma dose rates. The corresponding annual effective dose rates and the total excess lifetime cancer risk (ELCR) were also estimated to discuss the radiological hazard. The primary results showed that the activity concentrations of 238U, 234U, and 235U were 174.58–2604.14, 143.03–2765.34 and 8.35–131.64 Bq kg−1, respectively. The 230Th, 232Th and 234Th concentrations found were 239.29–1656.36, 0.68–17.71 and 133.54–2194.27 Bq kg−1, respectively. The specific activities of 226Ra and 40K ranged from
la réactivité de la 3-éthoxycarbonylméthyléne-2-oxo-1-[3(5)-phénylpyrazol-5(3)-5-1,2,3,4-tétrahyd... more la réactivité de la 3-éthoxycarbonylméthyléne-2-oxo-1-[3(5)-phénylpyrazol-5(3)-5-1,2,3,4-tétrahydroquinoxaline a été examinée. Une réaction ultérieure avec l'acétyléne dicarboxylate d'éthyle conduit aux dérivés de l'aconitate-quinoxaline 6 et 7. La sulfuration du composé 4 donne le thioamide correspondant. La bromation conduit aux composés tribromés et monobromés 9 et 10.
La réactivité de la 3-éthoxycarbonylméthyléne-2-oxo-1-[3(5)-phénylpyrazol-5(3)-5- 1,2,3,4-tétrahy... more La réactivité de la 3-éthoxycarbonylméthyléne-2-oxo-1-[3(5)-phénylpyrazol-5(3)-5- 1,2,3,4-tétrahydroquinoxaline a été examinée. Une réaction ultérieure avec l'acétyléne dicarboxylate d'éthyle conduit aux dérivés de l'aconitate-quinoxaline 6 et 7. La sulfuration du composé 4 donne le thioamide correspondant. La bromation conduit aux composés tribromés et monobromés 9 et 10.
Hydrazine and phenylhydrazine induced ring opening of méthyl isodehydroacetate respectively on C ... more Hydrazine and phenylhydrazine induced ring opening of méthyl isodehydroacetate respectively on C 6 and C 2 positions to afford 4-[1-[3-methyl-5-oxopyrazol-4-yl]ethyl-3methyl]pyrazolin-5-one and bipyrazolone. Almost pyrimido[1,2-a]benzimidazole has been prepared by a sequence involving 2-amino benzimidazole. Keywords : methylisodehydroacetate / bipyrazolone / pyrimido[1,2-a]benzimidazole Résumé : L'action de l'hydrazine et de la phénylhydrazine sur l'isodéhydroacétate de méthyle conduit respectivement après ouverture du cycle pyranique sur les positions C 6 et C 2 , au 4-[1-[3-methyl-5oxopyrazol-4-yl]ethyl-3-methyl]pyrazolin-5-one et à la bipyrazolone. Alors que la pyrimido[1,2a]benzimidazole est obtenue lorsque le 2-amino benzimidazole est utilisé comme agent binucléophile.
An earlier study reports the synthesis of oxindole derivatives bearing an oxazolidin-2-one sub-un... more An earlier study reports the synthesis of oxindole derivatives bearing an oxazolidin-2-one sub-unit. The title Sciff base (Scheme I) is the starting reactant for the synthesis of other heterocyclic systems (Alsubari et al., 2009). We have supporting information sup-5
Carbamates insecticides are used increasingly in agriculture as a replacement for environmentally... more Carbamates insecticides are used increasingly in agriculture as a replacement for environmentally more persistent organochlorine insecticides for the control of insect pests. It was the most used pesticides in Loukkous-Morocco. Conventional methods employed to detect/analyze carbamates residues are time consuming and require sophisticated equipment only available in well-equipped laboratories. In addition, the conventional methods usually require a lot of complex pre-treatment of samples. Therefore, convenient and rapid pesticide detection system is urgently needed. In this order, we aimed to develop a rapid ELISA (enzyme-linked immuno-Sorbent Assay) for detection of some carbamates such as carbendazim [methyl 2-benzimidazole carbamate] and carbofuran [2,3-dihydro-2,2-dimethyl-7-benzofuranylmethyl carbamate]. To develop an immunoassay for carbendazim and carbofuran we have synthesized molecules with acid function (haptens with 4 and 5 carbons) that are coupled with BSA protein and injected to the rabbits, collected antibodies are used for the achievements of the immunoanalytical assay.
Acta Crystallographica Section E-structure Reports Online, Mar 23, 2001
The structure of the title compound, C 11 H 12 N 2 S, established by an X-ray crystallographic st... more The structure of the title compound, C 11 H 12 N 2 S, established by an X-ray crystallographic study, shows that the molecule is composed of three cycles: bicyclic benzimidazole and the thiazepine ring which is bent. Comment Thiazepinobenzimidazole derivatives constitute an interesting series of heterocyclic compounds, particularly for their biological activities (
International Journal of Environmental Analytical Chemistry, Aug 11, 2019
ABSTRACT A competitive enzyme-linked immunosorbent assay (ELISA) test using polyclonal rabbit ant... more ABSTRACT A competitive enzyme-linked immunosorbent assay (ELISA) test using polyclonal rabbit antibodies for detection of Chlorpyrifos-ethyl (CPE) and its two major metabolites of degradation [3,5,6-Trichlororpyridin-2-ol (TCP) and O,O’-diethylthiophosphoric acid (DETP)], has been developed. We have first synthetized haptens of these three molecules, with 4 and 5 carbons spacer arms having carboxyl function at their ends. Haptens with 5 carbons’ spacer arm have been coupled to Bovine Serum Albumin (BSA) then injected to rabbits for polyclonal antibodies production. Haptens with 4 carbons spacer arm have been coupled to Human Albumin (HAS) to be in well plates coating to perform the ELISA tests. After adjusting the ELISA parameters, we have plotted the B/B0 (%) values against the logarithm of analyst concentrations. The IC50 values and detection limits were obtained through fitting the curves. The IC50 value of CPE and TCP were 651 and 5.61 ppb, with detection limits about 2.3410−2 and 2.18 10−3 ppb, respectively. We report for the first time, ELISA system developed for DETP with IC50 of 76.5 and a detection limit of 8.81 10−3 ppb. To evaluate the potential interferences that may be encountered in environmental water samples, pH, ionic strength, humic acid and some heavy metals were tested upon IC50 of the developed ELISA systems. In addition, several pesticides as well as CPE metabolites were tested for cross reactivity study. In all cases, the interference of the CPE assay was negligible. TCP assay represented a high cross reactivity to CPE but no interference with the others compounds. For DETP, no cross reactivity with the TCP was detected, but it was higher with CPE and the others pesticides. The developed ELISA systems have been compared with HPLC technique. Both techniques gave values of the same order of CPE and TCP prepared concentrations with a better sensitivity for ELISA system.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
As part of the synthesis of the benzimidazole derivative heterocyclique system, we are interested... more As part of the synthesis of the benzimidazole derivative heterocyclique system, we are interested in studying the condensation of the o-phenylenediamines with amino-acids such as aspartic acid, serine and histidine. The interest that these present is based mainly on their pharmacological properties. They have, in fact anti-inflammatory, antidepressive, antibacterial and antihistamine properties. On the other hand, it should be noted that 5,6-dimethyl-1-(alpha-D-ribofuranosyl) benzimidazole constitutes part of vitamin B12. Taken together, these results led us to pursue our research in this domain while focusing on new methods of benzimidazolic derivative synthesis. It should be said that the obtaining of these compounds depends on the quantity of the amino-acid. All synthesized products have been characterized by infrared, nuclear magnetic resonance and mass spectrometry.
[EN] Preformed chiral bis(oxazoline)copper complex having a 4-aminobutyl linker in the meso carbo... more [EN] Preformed chiral bis(oxazoline)copper complex having a 4-aminobutyl linker in the meso carbon has been covalently attached to single wall carbon nanotubes (1 µm average length) through the carboxylic acid groups and the resulting material used as recoverable catalyst for the hydroxyalkylation of 1,3-dimethoxybenzene by ethyl trifluoropyruvate obtaining ee up to 97 %.Moussaif, A.; Martín González, R.; Ramli, Y.; Zniber, R.; Achour, R.; El Ghoul, M.; Alvaro Rodríguez, MM.... (2011). CHIRAL BIS(OXAZOLINE)COPPER(II) COVALENTLY ANCHORED TO SINGLE WALL CARBON NANOTUBE AS RECOVERABLE CATALYST FOR ENANTIOSELECTIVE FRIEDEL-CRAFTS HYDROXYALKYLATION. Revue Roumaine de Chimie. 56(6):675-680. http://hdl.handle.net/10251/90965S67568056
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