SNF8

SNF8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ZME, 3CUQ
Identifiers
Aliases	SNF8, Dot3, EAP30, VPS22, ESCRT-II complex subunit, SNF8 subunit of ESCRT-II
External IDs	OMIM: 610904; MGI: 1343161; HomoloGene: 5239; GeneCards: SNF8; OMA:SNF8 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.32 Start 48,929,316 bp End 48,944,842 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 D|11 59.24 cM Start 95,925,711 bp End 95,938,256 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart mucosa of transverse colon gastric mucosa stromal cell of endometrium left coronary artery ganglionic eminence right auricle right adrenal gland popliteal artery tibial arteries Top expressed in embryo yolk sac morula dentate gyrus of hippocampal formation granule cell epiblast blastocyst right kidney superior frontal gyrus facial motor nucleus duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein N-terminus binding transcription factor binding protein C-terminus binding channel regulator activity protein binding Cellular component cytoplasm recycling endosome cytosol endosome membrane late endosome membrane transcription regulator complex plasma membrane nucleoplasm perinuclear region of cytoplasm endosome membrane extracellular exosome nucleus ESCRT II complex Biological process regulation of transcription, DNA-templated positive regulation of protein catabolic process multivesicular body sorting pathway regulation of transcription by RNA polymerase II multivesicular body assembly regulation of multivesicular body size involved in endosome transport transcription, DNA-templated endosomal transport regulation of protein complex stability positive regulation of gene expression early endosome to late endosome transport endocytic recycling regulation of protein catabolic process protein transport regulation of MAP kinase activity positive regulation of exosomal secretion protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway macroautophagy regulation of molecular function transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11267 27681 Ensembl ENSG00000159210 ENSMUSG00000006058 UniProt Q96H20 Q9CZ28 RefSeq (mRNA) NM_007241 NM_001317192 NM_001317193 NM_001317194 NM_033568 NM_001356362 RefSeq (protein) NP_001304121 NP_001304122 NP_001304123 NP_009172 NP_291046 NP_001343291 Location (UCSC) Chr 17: 48.93 – 48.94 Mb Chr 11: 95.93 – 95.94 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Vacuolar-sorting protein SNF8 is a protein that in humans is encoded by the SNF8 gene. It is a part of ESCRT-II complex.

Further reading

• Kamura T, Burian D, Khalili H, et al. (2001). "Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose". J. Biol. Chem. 276 (19): 16528–33. doi:10.1074/jbc.M010142200. PMID 11278625.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
• Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. Bibcode:2003PNAS..10012414M. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Bowers K, Piper SC, Edeling MA, et al. (2006). "Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII". J. Biol. Chem. 281 (8): 5094–105. doi:10.1074/jbc.M508632200. PMID 16371348.
• Langelier C, von Schwedler UK, Fisher RD, et al. (2006). "Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release". J. Virol. 80 (19): 9465–80. doi:10.1128/JVI.01049-06. PMC 1617254. PMID 16973552.