Glycosylphosphatidylinositol anchor attachment 1 protein is a protein that in humans is encoded by the GPAA1gene.[5][6]
Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hiroi Y, Komuro I, Matsushita I, Aburatani H, Hosoda T, Nakahori Y, et al. (December 1998). "Assignment of the human GPAA1 gene, which encodes a product required for the attachment of glycosylphosphatidylinositols to proteins, at 8q24". Genomics. 54 (2): 354–5. doi:10.1006/geno.1998.5490. PMID9828142.
Hiroi Y, Komuro I, Chen R, Hosoda T, Mizuno T, Kudoh S, et al. (January 1998). "Molecular cloning of human homolog of yeast GAA1 which is required for attachment of glycosylphosphatidylinositols to proteins". FEBS Letters. 421 (3): 252–8. doi:10.1016/S0014-5793(97)01576-7. PMID9468317. S2CID30327972.
Inoue N, Ohishi K, Endo Y, Fujita T, Takeda J, Kinoshita T (1999). "Human and mouse GPAA1 (Glycosylphosphatidylinositol anchor attachment 1) genes: genomic structures, chromosome loci and the presence of a minor class intron". Cytogenetics and Cell Genetics. 84 (3–4): 199–205. doi:10.1159/000015258. PMID10393431. S2CID23878595.
