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{{Short description|Human leukocyte antigen serotype}}
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| align="center" colspan="2" | <div style="font-size:medium; line-height:120%;">major histocompatibility complex (human), class I, B55</div>
| align="center" colspan="2" | <div style="font-size:medium; line-height:120%;">major histocompatibility complex (human), class I, B55</div>
|-
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| bgcolor="#e7dcc3" | Alleles
| bgcolor="#e7dcc3" | Alleles
| bgcolor="#eeeeee" | B*5501, B*5502</br>
| bgcolor="#eeeeee" | B*5501, B*5502<br>
|-
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| colspan="2" bgcolor="#dddddd" | '''Structure''' (See [[HLA-B]])
| colspan="2" bgcolor="#dddddd" | '''Structure''' (See [[HLA-B]])
|-
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| bgcolor="#e7dcc3" | [[HUGO|Symbol(s)]]
| bgcolor="#e7dcc3" | [[Human Genome Organisation|Symbol(s)]]
| bgcolor="#eeeeee" | [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=4932 HLA-B]
| bgcolor="#eeeeee" | [https://web.archive.org/web/20070821210135/http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=4932 HLA-B]
|-
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| bgcolor="#e7dcc3" Rowspan = 2 | [[European Bioinformatics Institute|EBI-HLA]]
| bgcolor="#e7dcc3" Rowspan = 2 | [[European Bioinformatics Institute|EBI-HLA]]
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| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?B*550201 B*5502]
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?B*550201 B*5502]
|-
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| bgcolor="#e7dcc3" | [[Locus (genetics)|Locus]]
| bgcolor="#e7dcc3" | [[Locus (genetics)|Locus]]
| bgcolor="#eeeeee" | [[Chromosome 6 (human)|chr.6]] ''[http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6p21.31 6p21.31]''
| bgcolor="#eeeeee" | [[Chromosome 6 (human)|chr.6]] ''[https://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6p21.31 6p21.31]''
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'''HLA-B55''' (B55) is an [[Human leukocyte antigen|HLA]]-[[HLA-B|B]] [[serotype]]. B55 is a [[split antigen]] from the [[HLA-B22|B22]] [[broad antigen]], sister serotypes are [[HLA-B54|B54]] and [[HLA-B56|B56]]. The serotype identifies the more common HLA-B*55 gene products.<ref name="pmid15787720">{{cite journal | author = Marsh SG, Albert ED, Bodmer WF, ''et al.'' | title = Nomenclature for factors of the HLA system, 2004 | journal = Tissue Antigens | volume = 65 | issue = 4 | pages = 301–69 | year = 2005 | pmid = 15787720 | doi = 10.1111/j.1399-0039.2005.00379.x}}</ref> (For terminology help see: [[HLA-A#Historical Guide to Understanding Nomenclature|HLA-serotype tutorial]])
'''HLA-B55''' (B55) is an [[Human leukocyte antigen|HLA]]-[[HLA-B|B]] [[serotype]]. B55 is a [[split antigen]] from the [[HLA-B22|B22]] [[broad antigen]], sister serotypes are [[HLA-B54|B54]] and [[HLA-B56|B56]]. The serotype identifies the more common HLA-B*55 gene products.<ref name="pmid15787720">{{cite journal |pmc=2848993 |year=2010 |last1=Marsh |first1=S. G. |title=Nomenclature for factors of the HLA system, 2010 |journal=Tissue Antigens |volume=75 |issue=4 |pages=291–455 |last2=Albert |first2=E. D. |last3=Bodmer |first3=W. F. |last4=Bontrop |first4=R. E. |last5=Dupont |first5=B. |last6=Erlich |first6=H. A. |last7=Fernández-Viña |first7=M. |last8=Geraghty |first8=D. E. |last9=Holdsworth |first9=R. |last10=Hurley |first10=C. K. |last11=Lau |first11=M. |last12=Lee |first12=K. W. |last13=Mach |first13=B. |last14=Maiers |first14=M. |last15=Mayr |first15=W. R. |last16=Müller |first16=C. R. |last17=Parham |first17=P. |last18=Petersdorf |first18=E. W. |last19=Sasazuki |first19=T. |last20=Strominger |first20=J. L. |last21=Svejgaard |first21=A. |last22=Terasaki |first22=P. I. |last23=Tiercy |first23=J. M. |last24=Trowsdale |first24=J. |pmid=20356336 |doi=10.1111/j.1399-0039.2010.01466.x }}</ref> (For terminology help see: [[HLA-A#Historical Guide to Understanding Nomenclature|HLA-serotype tutorial]])


==Serotype==
==Serotype==
B*55:03 is one of the four B alleles that reacts with neither Bw4 nor Bw6. The others are [[HLA-B18|B*18:06]], [[HLA-B46|B*46:01]], and [[HLA-B73|B*73:01]].<ref>{{cite journal |last1=Voorter |first1=CE |last2=van der Vlies |first2=S |last3=Kik |first3=M |last4=van den Berg-Loonen |first4=EM |title=Unexpected Bw4 and Bw6 reactivity patterns in new alleles. |journal=Tissue Antigens |date=October 2000 |volume=56 |issue=4 |pages=363–70 |pmid=11098937 |doi=10.1034/j.1399-0039.2000.560409.x }}</ref>

{| border="0" cellspacing="0" cellpadding="0" style="text-align:center; background:#ffffff; margin-right: 1em; border:2px #e0e0ff solid;"
{| border="0" cellspacing="0" cellpadding="0" style="text-align:center; background:#ffffff; margin-right: 1em; border:2px #e0e0ff solid;"
|+ B55 and B22 serotype recognition of some HLA B*55 allele-group gene products<ref>[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]</ref>
|+ B55 and B22 serotype recognition of some HLA B*55 allele-group gene products<ref>[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]</ref>
|- style="background:#f0f0ff"
|- style="background:#f0f0ff"
| style="width:60px" | B*55 || style="width:60px" | '''B55'''
| style="width:60px" | B*55 || style="width:60px" | '''B55'''
| style="width:60px" | B22 || style="width:60px" | Sample
| style="width:60px" | B22 || style="width:60px" | Sample
|- style="background:#f0f0ff"
|- style="background:#f0f0ff"
| allele || % || % || size (N)
| allele || % || % || size (N)
|-
|-
| style = "background:#e8e8f8" | 5501 || 92 || 5 || 453
| style = "background:#e8e8f8" | 5501 || 92 || 5 || 453
|-
|-
| style = "background:#e8e8f8" | 5502 || 84 || 2 || 309
| style = "background:#e8e8f8" | 5502 || 84 || 2 || 309
|}
|}


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|+ '''HLA B*5501 frequencies'''
|+ '''HLA B*5501 frequencies'''
|- style="background:#efe5ef"
|- style="background:#efe5ef"
| || || freq
| || || freq
|- style="background:#eee5ef"
|- style="background:#eee5ef"
| ref. || align="left" |Population || style="width:50px" | (%)
| ref. || align="left" |Population || style="width:50px" | (%)
|-
|-
| <ref name = "pmid12753660">{{cite journal | author = Middleton D, Menchaca L, Rood H, Komerofsky R | title = New allele frequency database: http://www.allelefrequencies.net | journal = Tissue Antigens | volume = 61 | issue = 5 | pages = 403–7 | year = 2003 | pmid = 12753660 | doi =10.1034/j.1399-0039.2003.00062.x }}</ref> || align="left"|India New Delhi||3.8
| <ref name = "pmid12753660">{{cite journal |vauthors=Middleton D, Menchaca L, Rood H, Komerofsky R | title = New allele frequency database | journal = Tissue Antigens | volume = 61 | issue = 5 | pages = 403–7 | year = 2003 | pmid = 12753660 | doi =10.1034/j.1399-0039.2003.00062.x | doi-access = free }}</ref> || align="left"|India New Delhi||3.8
|-
|-
| <ref name = "pmid12753660"/> || align="left"|Singapore Chinese Han||3.5
| <ref name = "pmid12753660"/> || align="left"|Singapore Chinese Han||3.5
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| <ref name = "pmid12753660"/> || align="left"|Spain Eastern Andalusia Gipsy||3.5
| <ref name = "pmid12753660"/> || align="left"|Spain Eastern Andalusia Gipsy||3.5
|-
|-
| <ref name = "pmid12753660"/> || align="left"|Georgia Tibilisi Kurds||3.4
| <ref name = "pmid12753660"/> || align="left"|Georgia Tbilisi Kurds||3.4
|-
|-
| <ref name = "pmid12753660"/> || align="left"|India North Delhi||3.3
| <ref name = "pmid12753660"/> || align="left"|India North Delhi||3.3
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| <ref name = "pmid12753660"/> || align="left"|India North Hindus||2.9
| <ref name = "pmid12753660"/> || align="left"|India North Hindus||2.9
|-
|-
| <ref name = "pmid12753660"/> || align="left"|Georgia Tibilisi Georgians||2.8
| <ref name = "pmid12753660"/> || align="left"|Georgia Tbilisi Georgians||2.8
|-
|-
| <ref name = "pmid12753660"/> || align="left"|Russia Tuva (2)||2.8
| <ref name = "pmid12753660"/> || align="left"|Russia Tuva (2)||2.8
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|}
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{{clear left}}
==References==
==References==
{{reflist}}
{{reflist}}
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{{HLA-B serotypes}}
{{HLA-B serotypes}}


{{DEFAULTSORT:Hla-B55}}
[[Category:HLA-B alleles|5]]
[[Category:HLA-B alleles|5]]

Latest revision as of 14:45, 26 June 2024

major histocompatibility complex (human), class I, B55
Alleles B*5501, B*5502
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*5501
B*5502
Locus chr.6 6p21.31

HLA-B55 (B55) is an HLA-B serotype. B55 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B56. The serotype identifies the more common HLA-B*55 gene products.[1] (For terminology help see: HLA-serotype tutorial)

Serotype

[edit]

B*55:03 is one of the four B alleles that reacts with neither Bw4 nor Bw6. The others are B*18:06, B*46:01, and B*73:01.[2]

B55 and B22 serotype recognition of some HLA B*55 allele-group gene products[3]
B*55 B55 B22 Sample
allele % % size (N)
5501 92 5 453
5502 84 2 309

Allele distribution

[edit]
HLA B*5501 frequencies
freq
ref. Population (%)
[4] India New Delhi 3.8
[4] Singapore Chinese Han 3.5
[4] Spain Eastern Andalusia Gipsy 3.5
[4] Georgia Tbilisi Kurds 3.4
[4] India North Delhi 3.3
[4] France South East 3.1
[4] Israel Arab Druse 3.0
[4] India North Hindus 2.9
[4] Georgia Tbilisi Georgians 2.8
[4] Russia Tuva (2) 2.8
[4] Georgia Svaneti Svans 2.5
[4] Iran Baloch 2.5
[4] Singapore Thai 2.5
[4] Sudanese 2.5
[4] Mexico Mestizos 2.4
[4] Spain Eastern Andalusia 2.4
[4] Ireland South 2.0
[4] Azores Central Islands 1.8
[4] Bulgaria 1.8
[4] Israel Ashkenazi and Non Ashkenazi Jews 1.8
[4] Oman 1.7
[4] Tunisia Tunis 1.7
[4] India Andhra Pradesh Golla 1.4
[4] China Tibet 1.3
[4] Uganda Kampala 1.2
[4] Finland 1.1
[4] Portugal North 1.1
[4] Portugal Centre 1.0
[4] Singapore Riau Malay 1.0
[4] B*5502
[4] Taiwan Taroko 14.5
[4] American Samoa 12.0
[4] China Guangxi Maonan 6.0
[4] Japan Ainu Hokkaido 5.0
[4] China Tibet Autonomous Region Tibetans 4.7
[4] Singapore Chinese 3.0
[4] China Beijing Shijiazhuang Tianjian Han 2.9
[4] China North Han 2.9
[4] South Korea (3) 2.7
[4] Hong Kong Chinese 2.2
[4] Japan (5) 2.2
[4] Taiwan Ami 2.0
[4] Thailand (3) 2.0
[4] New Caledonia 1.0
[4] Philippines Ivatan 1.0

References

[edit]
  1. ^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. ^ Voorter, CE; van der Vlies, S; Kik, M; van den Berg-Loonen, EM (October 2000). "Unexpected Bw4 and Bw6 reactivity patterns in new alleles". Tissue Antigens. 56 (4): 363–70. doi:10.1034/j.1399-0039.2000.560409.x. PMID 11098937.
  3. ^ derived from IMGT/HLA
  4. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
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