Talk:Calcitonin
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Question
editWhile not versed in pharmacology, I do understand a fair amount of physiology. I had remove parathyroid tissue to correct an imbalance of calcium (Dr's diagnosis) and have been told it wasn't the correct tissue that was removed. Can anyone explain this?—Preceding unsigned comment added by 207.81.87.73 (talk • contribs) Patandmike
- What was the imbalance you had? -- Boris 10:45, 28 January 2007 (UTC)
WikiProject class rating
editThis article was automatically assessed because at least one WikiProject had rated the article as stub, and the rating on other projects was brought up to Stub class. BetacommandBot 07:52, 10 November 2007 (UTC)
Effects of Calcitonin in Counteracting PTH
editThe article states, "It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH)," and, "In many ways, calcitonin has the counter effects of parathyroid hormone (PTH)."
The article on PTH has pretty good explanations of the processes by which PTH affects serum calcium. This article on calitonin suggests that calcitonin opposes the effects of PTH. Does this happen by blocking PTH receptors, or by some other process(es)?
An explanation similar in detail to the parathyroid hormone article, with reference(s) to online medical research or review articles, would be greatly appreciated.
Leeirons (talk) 16:56, 11 December 2007 (UTC)
A related question... the article states that calcitonin is involved in "Vitamin D regulation." Is this by way of the effect on PTH (in transient: calcitonin increases → bone calcium loss decreases → serum calcium decreases → PTH increases → vitmain D 1,25 increases), or does calcitonin have its own, more direct effect on vitamin D?
Calcitonin effects on Calcium reabsorption by the kidney tubules
editThat's what the article says:
Inhibits Ca2+ and phosphate reabsorption by the kidney tubules[7]
Though the very references number 7 ( http://www.ncbi.nlm.nih.gov/pubmed/9058369 ) says: "It is concluded that in man calcitonin like PTH is a renal Ca- and Mg-conserving hormone."
So according to PubMed's most recent researchs even though calcitonin's action is to reduce calcemia, it's effect on the kidney tubules is to actually enhance Ca2+ reabsorption.
--Nimorn (talk) 22:01, 22 January 2009 (UTC)
Recent research may show that Ca2+ is reabsorbed in the kidney, but it is by no means an established fact and should not be included as factual in the article. Established textbooks such as Rhoades and Bell: Medical Physiology and BRS Physiology, which was already cited, say that Ca2+ is not reabsorbed in the kidney. The article cited is useful but by no means evidence of a complete contradiction of knowledge which has already been established. I've never changed a wikipedia article so I'll leave that to more experienced users, but it should be made clear in the article that although recent research may be in contradiction, when a med student takes their board exam, the kidney will DECREASE reabsorption of Ca2+ in response to calcitonin.
"In the kidneys, CT decreases the tubular reabsorption of calcium and phosphate. This leads to an increase in urinary excretion of both calcium and phosphate and, ultimately, to decreased levels of both ions in the plasma." from Rhoades and Bell Medical Physiology 2009
--72.88.239.221 (talk) 05:18, 31 March 2011 (UTC)
- Must agree with the above. Numerous current medical texts (Martini and Nath: Anatomy and physiology 2009; Rhoades and Bell: Medical Physiology 2009) maintain the traditional view that Calcitonin effects an increase in renal Ca++ excretion. It should be noted that both the Rhoades text, as well as Marieb/Hoehn (Human Anatomy and Physiology 2010) stress that the influence of Calcitonin on Ca++ homeostasis appears to be minor, especially with regard to renal reabsorption. Wiki article should be revised to reflect scientific consensus and current medical practice, rather than outdated fringe research. — Preceding unsigned comment added by 68.57.177.106 (talk) 15:54, 10 July 2011 (UTC)
Printing problem
editSorry if this isn't the place for formatting issues. This page is horribly broken in print at the moment. Something in the image/chemical data box in the right column blows up two pages of printing. I'd fix it if I knew anything about Wikipedia printing formats. It appears fine for display, just broken in print. Unitsquarehead (talk) 23:19, 25 May 2011 (UTC)
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