IRF7

Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors.

IRF7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2O61
Identifiers
Aliases	IRF7, IRF-7H, IRF7A, IRF7B, IRF7C, IRF7H, IMD39, interferon regulatory factor 7, IRF-7
External IDs	OMIM: 605047; MGI: 1859212; HomoloGene: 128624; GeneCards: IRF7; OMA:IRF7 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.5 Start 612,553 bp End 615,983 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F5 Start 140,842,619 bp End 140,846,394 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood right lobe of liver spleen monocyte mucosa of transverse colon apex of heart lymph node bone marrow bone marrow cells Top expressed in granulocyte gastrula blood mucous cell of stomach ileum jejunum duodenum large intestine colon thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity protein binding RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding Cellular component nucleoplasm endosome membrane nucleus cytoplasm cytosol Biological process positive regulation of type I interferon-mediated signaling pathway regulation of transcription, DNA-templated positive regulation of interferon-alpha production MDA-5 signaling pathway interferon-gamma-mediated signaling pathway immune system process regulation of adaptive immune response response to virus negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription, DNA-templated regulation of type I interferon production cellular response to DNA damage stimulus TRIF-dependent toll-like receptor signaling pathway positive regulation of transcription, DNA-templated negative regulation of macrophage apoptotic process type I interferon signaling pathway immunoglobulin mediated immune response establishment of viral latency regulation of immune response viral process regulation of monocyte differentiation positive regulation of transcription by RNA polymerase II positive regulation of interferon-beta production interferon-beta production regulation of MyD88-independent toll-like receptor signaling pathway positive regulation of type I interferon production innate immune response regulation of MyD88-dependent toll-like receptor signaling pathway interferon-alpha production defense response to virus regulation of gene expression Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3665 54123 Ensembl ENSG00000276561 ENSG00000185507 ENSMUSG00000025498 UniProt Q92985 P70434 RefSeq (mRNA) NM_001572 NM_004029 NM_004030 NM_004031 NM_001252600 NM_001252601 NM_016850 RefSeq (protein) NP_001563 NP_004020 NP_004022 NP_001239529 NP_001239530 NP_058546 Location (UCSC) Chr 11: 0.61 – 0.62 Mb Chr 7: 140.84 – 140.85 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.

The IRF7 pathway was shown to be silenced in some metastatic breast cancer cell lines, which may help the cells avoid the host immune response. Restoring IRF7 to these cell lines reduced metastases and increased host survival time in animal models.

The IRF7 gene and product were shown to be defective in a patient with severe susceptibility to H1N1 influenza, while susceptibility to other viral diseases such as CMV, RSV, and parainfluenza was unaffected.

Interactions

IRF7 has been shown to interact with IRF3. Also, IRF7 has been shown to interact with Aryl Hydrocarbon Receptor Interacting Protein (AIP), which is a negative regulator for the antiviral pathway.

See also

• Interferon regulatory factors

Further reading

• Ning S, Pagano JS, Barber GN (September 2011). "IRF7: activation, regulation, modification and function". Genes and Immunity. 12 (6): 399–414. doi:10.1038/gene.2011.21. PMC 4437765. PMID 21490621.
• Pitha PM, Au WC, Lowther W, Juang YT, Schafer SL, Burysek L, Hiscott J, Moore PA (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth". Biochimie. 80 (8–9): 651–8. doi:10.1016/S0300-9084(99)80018-2. PMID 9865487.
• Zhang L, Pagano JS (January 2002). "Structure and function of IRF-7". Journal of Interferon & Cytokine Research. 22 (1): 95–101. doi:10.1089/107999002753452700. PMID 11846980.
• Zhang L, Pagano JS (October 1997). "IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency". Molecular and Cellular Biology. 17 (10): 5748–57. doi:10.1128/MCB.17.10.5748. PMC 232423. PMID 9315633.
• Wathelet MG, Lin CH, Parekh BS, Ronco LV, Howley PM, Maniatis T (March 1998). "Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo". Molecular Cell. 1 (4): 507–18. doi:10.1016/S1097-2765(00)80051-9. PMID 9660935.
• Au WC, Moore PA, LaFleur DW, Tombal B, Pitha PM (October 1998). "Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes". The Journal of Biological Chemistry. 273 (44): 29210–7. doi:10.1074/jbc.273.44.29210. PMID 9786932.
• Lu R, Au WC, Yeow WS, Hageman N, Pitha PM (October 2000). "Regulation of the promoter activity of interferon regulatory factor-7 gene. Activation by interferon and silencing by hypermethylation". The Journal of Biological Chemistry. 275 (41): 31805–12. doi:10.1074/jbc.M005288200. PMID 10924517.
• Paris MJ, Williams BR (October 2000). "Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5". Genomics. 69 (2): 196–202. doi:10.1006/geno.2000.6339. PMID 11031102.
• Marié I, Smith E, Prakash A, Levy DE (December 2000). "Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain". Molecular and Cellular Biology. 20 (23): 8803–14. doi:10.1128/MCB.20.23.8803-8814.2000. PMC 86519. PMID 11073981.
• Smith EJ, Marié I, Prakash A, García-Sastre A, Levy DE (March 2001). "IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein". The Journal of Biological Chemistry. 276 (12): 8951–7. doi:10.1074/jbc.M008717200. PMID 11124948.
• Au WC, Yeow WS, Pitha PM (February 2001). "Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3". Virology. 280 (2): 273–82. doi:10.1006/viro.2000.0782. PMID 11162841.
• Lu R, Moore PA, Pitha PM (May 2002). "Stimulation of IRF-7 gene expression by tumor necrosis factor alpha: requirement for NFkappa B transcription factor and gene accessibility". The Journal of Biological Chemistry. 277 (19): 16592–8. doi:10.1074/jbc.M111440200. PMID 11877397.
• Morin P, Bragança J, Bandu MT, Lin R, Hiscott J, Doly J, Civas A (March 2002). "Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription". Journal of Molecular Biology. 316 (5): 1009–22. doi:10.1006/jmbi.2001.5401. PMID 11884139.
• Caillaud A, Prakash A, Smith E, Masumi A, Hovanessian AG, Levy DE, Marié I (December 2002). "Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding". The Journal of Biological Chemistry. 277 (51): 49417–21. doi:10.1074/jbc.M207484200. PMID 12374802.
• Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (February 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nature Medicine. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
• Yang H, Lin CH, Ma G, Baffi MO, Wathelet MG (May 2003). "Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators". The Journal of Biological Chemistry. 278 (18): 15495–504. doi:10.1074/jbc.M212940200. PMID 12604599.
• Ning S, Hahn AM, Huye LE, Pagano JS (September 2003). "Interferon regulatory factor 7 regulates expression of Epstein-Barr virus latent membrane protein 1: a regulatory circuit". Journal of Virology. 77 (17): 9359–68. doi:10.1128/JVI.77.17.9359-9368.2003. PMC 187426. PMID 12915551.
• Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT (October 2003). "LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF". The Journal of Experimental Medicine. 198 (7): 1043–55. doi:10.1084/jem.20031023. PMC 2194210. PMID 14517278.
• Lin R, Noyce RS, Collins SE, Everett RD, Mossman KL (February 2004). "The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genes". Journal of Virology. 78 (4): 1675–84. doi:10.1128/JVI.78.4.1675-1684.2004. PMC 369457. PMID 14747533.

External links

• Media related to Interferon regulatory factor-7 at Wikimedia Commons
• IRF7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.