File:MiRNA.svg

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**Overview of the miRNAs biogenesis**. In the canonical pathway in the nucleus, pri-miRNAs are cleaved into pre-miRNAs by Drosha. Pre-miRNAs are exported to the cytoplasm by exportin 5. In the cytoplasm, pre-miRNAs are cleaved into small dsRNAs by Dicer. Then, RISC mediates the recognition of the mRNA to be targeted. In the non-canonical pathway (Mirtron), Drosha cleavage is substituted with splicing. pri-miRNAs (pre-mRNAs) are processed to pre-miRNAs by the spliceosome machinery and debranching enzyme to generate double-stranded loop structures like the regular miRNAs. Subsequently, the RNA product of splicing adopts a pre-miRNA like form, and transferred to the cytoplasm by exportin 5 to continue with the canonical pathway. For more details please refer to the text.

Summary

Description

English: Diagram of microRNA. Based on [1], [2], [3], the wikipedia article, and various other sources.
The editable text is in this file, off beyond the page boundaries.

Date

23 December 2012, 20:43:59

Source

Own work

Author

Kelvinsong

Other versions

		transcription · transcription
	english		français

	bahasa Indonesia		русский

		micro rna · micro arn · микроРНК
	english

	français

	русский

		translation · traduction
	english		français

	bahasa Indonesia

		lac operon · opéron lactose
	english

	français

		transcription factors
	english

	français

	русский

tiếng Việt

		gene cloning
	english		français

		chloroplast dna
	english

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	Date/Time	Dimensions	User	Comment
current	10:23, 19 May 2019	2,181 × 1,226 (1,006 KB)	JoKalliauer	https://commons.wikimedia.org/wiki/Commons:Help_desk#Found_unsafe_CSS_in_the_style_element_of_uploaded_SVG_file Please delete src: url("data:font/woff;charset=utf-8;base64,data:application/x-font-ttf;base64
	02:06, 24 December 2012	2,181 × 1,226 (1.58 MB)	IsadoraofIbiza	remove confusing sentence
	02:01, 24 December 2012	2,181 × 1,226 (1.64 MB)	IsadoraofIbiza	moving text around
	01:49, 24 December 2012	2,181 × 1,226 (1.63 MB)	IsadoraofIbiza	adjusted number position
	01:46, 24 December 2012	2,181 × 1,226 (1.63 MB)	IsadoraofIbiza	User created page with UploadWizard