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File:MiRNA-biogenesis.jpg

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Overview of the miRNAs biogenesis. In the canonical pathway in the nucleus, pri-miRNAs are cleaved into pre-miRNAs by Drosha. Pre-miRNAs are exported to the cytoplasm by exportin 5. In the cytoplasm, pre-miRNAs are cleaved into small dsRNAs by Dicer. Then, RISC mediates the recognition of the mRNA to be targeted. In the non-canonical pathway (Mirtron), Drosha cleavage is substituted with splicing. pri-miRNAs (pre-mRNAs) are processed to pre-miRNAs by the spliceosome machinery and debranching enzyme to generate double-stranded loop structures like the regular miRNAs. Subsequently, the RNA product of splicing adopts a pre-miRNA like form, and transferred to the cytoplasm by exportin 5 to continue with the canonical pathway. For more details please refer to the text.

Summary

Description
English: Overview of microRNA processing in animals, from transcription to the formation of the effector complex. There are two pathways, one for microRNAs from independent genes and one for intronic microRNAs.

Enzymes in the picture:
Drosha, Pasha (pri-miRNA → pre-miRNA)
Spliceosome (pre-mRNA → intron lariat)
Debranching enzyme (intron lariat → RNA that can fold into pre-miRNA)
RAN-GTP, Exportin-5 (export from nucleus)
Dicer (pre-miRNA → miRNA)

Abbrevations:
pri-miRNA = primary microRNA transcript
pre-mRNA = precursor messenger RNA
pre-miRNA = precursor microRNA
miRNA = microRNA
miRNA* = antisense microRNA
miRNP = microRNA ribonucleoprotein
עברית: תהליכים בסינתזה של MicroRNA
Date
Source

Own work (Original text: I created this work entirely by myself.)

References:

  • Esquela-Kerscher A, Slack FJ (2006) Oncomirs — microRNAs with a role in cancer. Nat Rev Cancer 6: 259–69. PubMed
  • Okamura K, Hagen JW, Duan H, Tyler DM, Lai EC (2007) The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell 130: 89–100. PubMed
Author Narayanese (talk)
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Original upload log

The original description page was here. All following user names refer to en.wikipedia.
  • 2009-04-13 18:00 Narayanese 1520×1610× (356456 bytes) removed PolII from picture
  • 2009-04-13 17:33 Narayanese 1520×1610× (379131 bytes) {{Information |Description = microRNA biosynthesis |Source = I created this work entirely by myself. |Date = 13 April 2009 |Author = ~~~ |other_versions = }}


The original description page was here. All following user names refer to he.wikipedia.
  • 2009-12-03 08:34 Adiel lo 1520×1610× (356456 bytes) ==תקציר== {{מידע| |תיאור=תהליכים בסינתזה של [[MicroRNA]] |מקור=ויקיפדיה אנגלית [http://en.wikipedia.org/wiki/File:MiRNA-biogenesis.jpg[ |תאריך יצירה= |יוצר=http://en.wikipedia.org/wiki/User:Nar

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current08:23, 28 June 2012Thumbnail for version as of 08:23, 28 June 20121,520 × 1,610 (348 KB)OgreBot(BOT): Reverting to most recent version before archival
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