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Elastic fiber

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Elastic fibers (or yellow fibers) are an essential component of the extracellular matrix composed of bundles of proteins (elastin) which are produced by a number of different cell types including fibroblasts, endothelial, smooth muscle, and airway epithelial cells.[1] These fibers are able to stretch many times their length, and snap back to their original length when relaxed without loss of energy. Elastic fibers include elastin, elaunin and oxytalan.

Elastic fiber
Subcutaneous tissue from a young rabbit. Highly magnified. (Elastic fibers labeled at right)
Identifiers
FMA63868
Anatomical terminology

Elastic fibers are formed via elastogenesis,[2][3] a highly complex process involving several key proteins including fibulin-4, fibulin-5, latent transforming growth factor β binding protein 4, and microfibril associated protein 4.[4][5][6][7] In this process tropoelastin, the soluble monomeric precursor to elastic fibers is produced by elastogenic cells and chaperoned to the cell surface. Following excretion from the cell, tropoelastin self associates into ~200 nm particles by coacervation, an entropically driven process involving interactions between tropoelastin's hydrophobic domains, which is mediated by glycosaminoglycans, heparan, and other molecules.[8][9][10] These particles then fuse to give rise to 1-2 micron spherules which continue to grow as they move down from the cells surface before being deposited onto fibrillin microfibrillar scaffolds.[1]

Following deposition onto microfibrils tropoelastin is insolubilized via extensive crosslinking by members of the lysyl oxidase and lysyl oxidase like family of copper-dependent amine oxidases into amorphous elastin, a highly resilient, insoluble polymer that is metabolically stable over a human lifespan.[1] These two families of enzymes react with the many lysine residues present in tropoelastin to form reactive aldehydes and allysine via oxidative deamination.[11]

These reactive aldehydes and allysines can react with other lysine and allysine residues to form desmosine, isodesmosine, and a number of other polyfunctional crosslinks that join surrounding molecules of tropoelastin into an extensively crosslinked elastin matrix. This process creates a diverse array of intramolecular and intermolecular crosslinks[12] These unique crosslinks are responsible for elastin's durability and persistence. Maintenance of crosslinked elastin is carried out by a number of proteins including lysyl oxidase-like 1 protein.[13]

Mature elastic fibers consist of an amorphous elastin core surrounded by a glycosaminoglycans, heparan sulphate,[14] and number of other proteins such as microfibrillar-associated glycoproteins, fibrillin, fibullin, and the elastin receptor.

Distribution

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Thick elastic fibers from the visceral pleura (outer lining) of the human lung

Elastic fibers are found in the skin, lungs, arteries, veins, connective tissue proper, elastic cartilage, periodontal ligament, fetal tissue and other tissues which must undergo mechanical stretching.[1] In the lung there are thick and thin elastic fibers.[3]

Elastic fibers are absent from scarring, keloids and dermatofibromas and they are decreased greatly, or are absent in anetodermas.[15]

Histology

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Elastic fibers stain well with aldehyde fuchsin, orcein,[16] and Weigert's elastic stain in histological sections.

The permanganate-bisulfite-toluidine blue reaction is a highly selective and sensitive method for demonstrating elastic fibers under polarizing optics. The induced birefringence demonstrates the highly ordered molecular structure of the elastin molecules in the elastic fiber. This is not readily apparent under normal optics.

Defects and disease

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There is evidence to believe that certain defects of any components of the elastic matrix may impair and alter the structural appearance of elastic and collagen fibers.

Cutis laxa and Williams syndrome have elastic matrix defects that have been directly associated with alterations in the elastin gene.

Alpha-1 antitrypsin deficiency is a genetic disorder where elastin is excessively degraded by elastase, a degrading protein released by neutrophils during the inflammatory response. This leads most often to emphysema and liver disease in affected individuals.

Buschke–Ollendorff syndrome, Menkes disease, pseudoxanthoma elasticum, and Marfan's syndrome have been associated with defects in copper metabolism and lysyl oxidase or defects in the microfibril (defects in fibrillin, or fibullin for example).

Hurler disease, a lysosomal storage disease, is associated with an altered elastic matrix.

Hypertension and some congenital heart defects are associated with alterations in the great arteries, arteries, and arterioles with alterations in the elastic matrix.

Elastosis

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Elastosis is the buildup of elastic fibers in tissues, and is a form of degenerative disease.[17] There are a multitude of causes, but the most commons cause is actinic elastosis of the skin, also known as solar elastosis, which is caused by prolonged and excessive sun exposure, a process known as photoaging. Uncommon causes of skin elastosis include elastosis perforans serpiginosa, perforating calcific elastosis and linear focal elastosis.[17]

Skin elastosis causes
Condition Distinctive features Histopathology
Actinic elastosis
(most common, also called solar elastosis) 		Elastin replacing collagen fibers of the papillary dermis and reticular dermis  
Elastosis perforans serpiginosa Degenerated elastic fibers and transepidermal perforating canals (arrow in image points at one of them)[18]  
Perforating calcific elastosis Clumping of short elastic fibers in the dermis.[18]  
Linear focal elastosis Accumulation of fragmented elastotic material within the papillary dermis and transcutaneous elimination of elastotic fibers.[18]  

See also

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References

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  1. ^ a b c d Vindin H, Mithieux SM, Weiss AS (November 2019). "Elastin architecture". Matrix Biology. 84: 4–16. doi:10.1016/j.matbio.2019.07.005. PMID 31301399. S2CID 196458819.
  2. ^ Mithieux SM, Weiss AS (2005). "Elastin". Advances in Protein Chemistry. 70. Elsevier: 437–61. doi:10.1016/s0065-3233(05)70013-9. ISBN 978-0-12-034270-9. PMID 15837523.
  3. ^ a b Thunnissen E, Motoi N, Minami Y, Matsubara D, Timens W, Nakatani Y, Ishikawa Y, Baez-Navarro X, Radonic T, Blaauwgeers H, Borczuk AC, Noguchi M (August 2021). "Elastin in pulmonary pathology: relevance in tumours with a lepidic or papillary appearance. A comprehensive understanding from a morphological viewpoint". Histopathology. 80 (3): 457–467. doi:10.1111/his.14537. PMC 9293161. PMID 34355407.
  4. ^ Robertson IB, Horiguchi M, Zilberberg L, Dabovic B, Hadjiolova K, Rifkin DB (September 2015). "Latent TGF-β-binding proteins". Matrix Biology. 47: 44–53. doi:10.1016/j.matbio.2015.05.005. PMC 4844006. PMID 25960419.
  5. ^ Pilecki B, Holm AT, Schlosser A, Moeller JB, Wohl AP, Zuk AV, et al. (January 2016). "Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation". The Journal of Biological Chemistry. 291 (3): 1103–14. doi:10.1074/jbc.M115.681775. PMC 4714194. PMID 26601954.
  6. ^ Dabovic B, Chen Y, Choi J, Vassallo M, Dietz HC, Ramirez F, et al. (April 2009). "Dual functions for LTBP in lung development: LTBP-4 independently modulates elastogenesis and TGF-beta activity". Journal of Cellular Physiology. 219 (1): 14–22. doi:10.1002/jcp.21643. PMC 2719250. PMID 19016471.
  7. ^ Nakamura T, Lozano PR, Ikeda Y, Iwanaga Y, Hinek A, Minamisawa S, et al. (January 2002). "Fibulin-5/DANCE is essential for elastogenesis in vivo". Nature. 415 (6868): 171–5. doi:10.1038/415171a. PMID 11805835. S2CID 4343659.
  8. ^ Yeo GC, Keeley FW, Weiss AS (September 2011). "Coacervation of tropoelastin". Advances in Colloid and Interface Science. 167 (1–2): 94–103. doi:10.1016/j.cis.2010.10.003. PMID 21081222.
  9. ^ Wu WJ, Vrhovski B, Weiss AS (July 1999). "Glycosaminoglycans mediate the coacervation of human tropoelastin through dominant charge interactions involving lysine side chains". The Journal of Biological Chemistry. 274 (31): 21719–24. doi:10.1074/jbc.274.31.21719. PMID 10419484.
  10. ^ Tu Y, Weiss AS (July 2008). "Glycosaminoglycan-mediated coacervation of tropoelastin abolishes the critical concentration, accelerates coacervate formation, and facilitates spherule fusion: implications for tropoelastin microassembly". Biomacromolecules. 9 (7): 1739–44. doi:10.1021/bm7013153. PMID 18547105.
  11. ^ Lucero HA, Kagan HM (October 2006). "Lysyl oxidase: an oxidative enzyme and effector of cell function". Cellular and Molecular Life Sciences. 63 (19–20): 2304–16. doi:10.1007/s00018-006-6149-9. PMC 11136443. PMID 16909208. S2CID 31863161.
  12. ^ Schräder CU, Heinz A, Majovsky P, Karaman Mayack B, Brinckmann J, Sippl W, Schmelzer CE (September 2018). "Elastin is heterogeneously cross-linked". The Journal of Biological Chemistry. 293 (39): 15107–15119. doi:10.1074/jbc.RA118.004322. PMC 6166741. PMID 30108173.
  13. ^ Liu X, Zhao Y, Gao J, Pawlyk B, Starcher B, Spencer JA, et al. (February 2004). "Elastic fiber homeostasis requires lysyl oxidase-like 1 protein". Nature Genetics. 36 (2): 178–82. doi:10.1038/ng1297. PMID 14745449.
  14. ^ Gheduzzi D, Guerra D, Bochicchio B, Pepe A, Tamburro AM, Quaglino D, et al. (February 2005). "Heparan sulphate interacts with tropoelastin, with some tropoelastin peptides and is present in human dermis elastic fibers". Matrix Biology. 24 (1): 15–25. doi:10.1016/j.matbio.2004.12.001. PMID 15748998.
  15. ^ Ackerman AB, Böer A, Bennin B, Gottlieb GJ (January 2005). Histologic Diagnosis of Inflammatory Skin Diseases An Algorithmic Method Based on Pattern Analysis: Embryologic, Histologic, and Anatomic Aspects: Elastic Fibers (Third ed.). Ardor Scribendi. p. 522. ISBN 9781893357259. Archived from the original on June 20, 2018. Retrieved December 28, 2016. Elastic fibers are absent from scarring processes such as scars, keloids, and dermatofibromas
  16. ^ "Connective Tissue". Archived from the original on November 7, 2008.
  17. ^ a b Wright B. "Elastosis". DermNet NZ.
  18. ^ a b c Hosen MJ, Lamoen A, De Paepe A, Vanakker OM (2012). "Histopathology of pseudoxanthoma elasticum and related disorders: histological hallmarks and diagnostic clues". Scientifica. 2012: 598262. doi:10.6064/2012/598262. PMC 3820553. PMID 24278718.
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