The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart.[5]
Paoletti A, Moudjou M, Paintrand M, et al. (1997). "Most of centrin in animal cells is not centrosome-associated and centrosomal centrin is confined to the distal lumen of centrioles". J. Cell Sci. 109 (13): 3089–102. doi:10.1242/jcs.109.13.3089. PMID9004043.
LeDizet M, Beck JC, Finkbeiner WE (1999). "Differential regulation of centrin genes during ciliogenesis in human tracheal epithelial cells". Am. J. Physiol. 275 (6 Pt 1): L1145–56. doi:10.1152/ajplung.1998.275.6.L1145. PMID9843852.
Laoukili J, Perret E, Middendorp S, et al. (2000). "Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro". J. Cell Sci. 113 (8): 1355–64. doi:10.1242/jcs.113.8.1355. PMID10725219.
Cox JA, Tirone F, Durussel I, et al. (2005). "Calcium and magnesium binding to human centrin 3 and interaction with target peptides". Biochemistry. 44 (3): 840–50. doi:10.1021/bi048294e. PMID15654740.
Poole E, Strappe P, Mok HP, et al. (2005). "HIV-1 Gag-RNA interaction occurs at a perinuclear/centrosomal site; analysis by confocal microscopy and FRET". Traffic. 6 (9): 741–55. doi:10.1111/j.1600-0854.2005.00312.x. PMID16101678. S2CID36574274.
