Major prion protein: Difference between revisions

'''''PRNP''''' ('''prion protein''') is the human [[gene]] encoding for the major [[prion]] protein '''PrP''' (protease-resistant-prion protein, Pr for '''pr'''ion, and P for '''p'''rotein), also known as '''CD230''' ([[cluster of differentiation]] 230).<ref name = "pmid3755672">{{cite journal | vauthors = Kretzschmar HA, Stowring LE, Westaway D, Stubblebine WH, Prusiner SB, Dearmond SJ | title = Molecular cloning of a human prion protein cDNA | journal = DNA | volume = 5 | issue = 4 | pages = 315–24 | date = August 1986 | pmid = 3755672 | doi = 10.1089/dna.1986.5.315}}</ref><ref name = "pmid3094007">{{cite journal | vauthors = Sparkes RS, Simon M, Cohn VH, Fournier RE, Lem J, Klisak I, Heinzmann C, Blatt C, Lucero M, Mohandas T | title = Assignment of the human and mouse prion protein genes to homologous chromosomes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 83 | issue = 19 | pages = 7358–62 | date = October 1986 | pmid = 3094007 | pmc = 386716 | doi = 10.1073/pnas.83.19.7358 | bibcode = 1986PNAS...83.7358S | doi-access = free }}</ref><ref name = "pmid3014653">{{cite journal | vauthors = Liao YC, Lebo RV, Clawson GA, Smuckler EA | title = Human prion protein cDNA: molecular cloning, chromosomal mapping, and biological implications | journal = Science | volume = 233 | issue = 4761 | pages = 364–7 | date = July 1986 | pmid = 3014653 | doi = 10.1126/science.3014653 | bibcode = 1986Sci...233..364L }}</ref><ref name = "pmid2877664">{{cite journal | vauthors = Robakis NK, Devine-Gage EA, Jenkins EC, Kascsak RJ, Brown WT, Krawczun MS, Silverman WP | title = Localization of a human gene homologous to the PrP gene on the p arm of chromosome 20 and detection of PrP-related antigens in normal human brain | journal = Biochem. Biophys. Res. Commun. | volume = 140 | issue = 2 | pages = 758–65 | date = October 1986 | pmid = 2877664 | doi = 10.1016/0006-291X(86)90796-5 }}</ref> Expression of the protein is most predominant in the [[nervous system]] but occurs in many other tissues throughout the body.<ref name = "pmid11357156">{{cite journal | vauthors = Prusiner SB | title = Shattuck lecture--neurodegenerative diseases and prions | journal = N Engl J Med | volume = 344 | issue = 20 | pages = 1516–26 | year = 2001 | pmid = 11357156 | doi = 10.1056/NEJM200105173442006}}</ref><ref name = "pmid15494743">{{cite journal | vauthors = Weissmann C | title = The state of the prion | journal = Nat Rev Microbiol | volume = 2 | issue = 11 | pages = 861–71 | year = 2004 | pmid = 15494743 | doi = 10.1038/nrmicro1025| s2cid = 20992257 }}</ref><ref name = "review2">{{cite journal | vauthors = Zomosa-Signoret V, Arnaud JD, Fontes P, Alvarez-Martinez MT, Liautard JP | title = Physiological role of the cellular prion protein | journal = Vet. Res. | volume = 39 | issue = 4 | pages = 9 | year = 2008 | pmid = 18073096 | doi = 10.1051/vetres:2007048| url = https://hal.archives-ouvertes.fr/hal-00902908/file/hal-00902908.pdf | doi-access = free }}</ref>