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{{Infobox medical condition (new)
| name = Lipodystrophie
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'''Lipodystrophy''' syndromes are a group of genetic or acquired disorders in which the body is unable to produce and maintain healthy fat tissue.<ref>{{cite journal | vauthors = Phan J, Reue K | title = Lipin, a lipodystrophy and obesity gene | journal = Cell Metabolism | volume = 1 | issue = 1 | pages = 73–83 | date = January 2005 | pmid = 16054046 | doi = 10.1016/j.cmet.2004.12.002 | doi-access = free }}</ref><ref>{{Cite web |url=http://newsroom.ucla.edu/releases/UCLA-VA-Researchers-Discover-Fat-5841 |title=UCLA/VA Researchers discover fat gene |access-date=2017-06-15 |archive-url=https://web.archive.org/web/20181006000925/http://newsroom.ucla.edu/releases/UCLA-VA-Researchers-Discover-Fat-5841 |archive-date=2018-10-06 |url-status=dead }}</ref> The medical condition is characterized by abnormal or degenerative conditions of the body's [[adipose tissue]]. A more specific term, ''[[lipoatrophy]]'' ({{Lang|grc-latn|lipo}} is [[Greek language|Greek]] for 'fat', and {{Lang|grc-latn|dystrophy}} is Greek for 'abnormal or degenerative condition'), is used when describing the loss of fat from one area (usually the face). This condition is also characterized by a lack of circulating [[leptin]] which may lead to [[osteosclerosis]]. The absence of fat tissue is associated with [[insulin resistance]], [[hypertriglyceridemia]], [[Non-alcoholic fatty liver disease|non-alcoholic fatty liver disease (NAFLD)]] and [[metabolic syndrome]].<ref name=":0">{{cite journal | vauthors = Brown RJ, Araujo-Vilar D, Cheung PT, Dunger D, Garg A, Jack M, Mungai L, Oral EA, Patni N, Rother KI, von Schnurbein J, Sorkina E, Stanley T, Vigouroux C, Wabitsch M, Williams R, Yorifuji T | title = The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 101 | issue = 12 | pages = 4500–4511 | date = December 2016 | pmid = 27710244 | pmc = 5155679 | doi = 10.1210/jc.2016-2466 | url = }}</ref><ref name=":1">{{cite journal | vauthors = Ajluni N, Meral R, Neidert AH, Brady GF, Buras E, McKenna B, DiPaola F, Chenevert TL, Horowitz JF, Buggs-Saxton C, Rupani AR, Thomas PE, Tayeh MK, Innis JW, Omary MB, Conjeevaram H, Oral EA | title = Spectrum of disease associated with partial lipodystrophy: lessons from a trial cohort | journal = Clinical Endocrinology | volume = 86 | issue = 5 | pages = 698–707 | date = May 2017 | pmid = 28199729 | pmc = 5395301 | doi = 10.1111/cen.13311 }}</ref>
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== Types ==
Lipodystrophy can be divided into the following types:<ref name="Andrews">{{cite book |author1=James, William D. |author2=Berger, Timothy G. |title=Andrews' Diseases of the Skin: clinical Dermatology |publisher=Saunders Elsevier |year=2006 |isbn=978-0-7216-2921-6 |display-authors=etal}}</ref>{{rp|495–7}}
* Congenital lipodystrophy syndromes
** [[Congenital generalized lipodystrophy]] (Berardinelli-Seip syndrome)
** [[Familial partial lipodystrophy]]
** [[Marfanoid–progeroid–lipodystrophy syndrome]]
** [[CANDLE syndrome|Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature syndrome]]<ref>{{cite journal | vauthors = Torrelo A, Patel S, Colmenero I, Gurbindo D, Lendínez F, Hernández A, López-Robledillo JC, Dadban A, Requena L, Paller AS | title = Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome | journal = Journal of the American Academy of Dermatology | volume = 62 | issue = 3 | pages = 489–95 | date = March 2010 | pmid = 20159315 | doi = 10.1016/j.jaad.2009.04.046 }}</ref>
* Acquired lipodystrophy syndromes
** [[Acquired partial lipodystrophy]] (Barraquer-Simons syndrome)
** [[Acquired generalized lipodystrophy]]
** [[Centrifugal abdominal lipodystrophy]] (Lipodystrophia centrifugalis abdominalis infantilis)
** [[Lipoatrophia annularis]] (Ferreira-Marques lipoatrophia)
** [[Localized lipodystrophy]]
** [[HIV-associated lipodystrophy]]
== Epidemiology ==
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== See also ==
* [[Keppen–Lubinsky syndrome]]
* [[Lipoedema]]
* [[Cutis laxa]]
== References ==
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== External links ==
{{Medical resources
| DiseasesDB = 30066
| ICD11 = {{ICD11|EF01}}, {{ICD11|LD27.6}}
| ICD10 = {{ICD10|E|88|1|e|70}}
| ICD9 = {{ICD9|272.6}}
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| eMedicineSubj = med
| eMedicineTopic = 1307
| eMedicine_mult = {{eMedicine2|med|3523}}
| MeshID = D008060
}}
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