Papers by Krishnat Yadav
Diabetic nephropathy is one of the leading causes of end-
stage renal disease. End-stage renal di... more Diabetic nephropathy is one of the leading causes of end-
stage renal disease. End-stage renal disease is a worldwide
public health issue. Recent estimates by the National Institutes
of Health indicate that diabetes represents the single
largest cause of end-stage renal disease
[1]
. Renal involvement
in Type II Diabetes Mellitus (DM) was considered,
until a year ago, as a benign kidney condition, thought to
be causing loss of renal function similar to that seen in the
normal aging process. But today, it is known to have become
the single most common cause of end-stage renal
disease (ESRD) in the world. Type II DM patients on
maintenance dialysis use up a large percentage of monetary
reserves than those with non-diabetic ESRD. In addition,
Type II diabetic patients show poor results on dialysis and
have a higher mortality.
Clinical diagnosis and therapeutic management from an
earlier stage of diabetic nephropathy (DN) is of prime significance
in prevention of progression of DN to ESRD.
There are several biomarkers used to investigate & detect
kidney damage. Conventional biomarkers for kidney damage
include
glomerular
filtration rate (GFR), serum/plasma
creatinine, blood urea nitrogen (BUN), urinary microalbumin
excretion and several urinary findings such as
proteinuria and hematuria. However, these biomarkers are
non-specific and insensitive to early renal injury. Hence,
new specific markers are being developed
Introduction-Hodgkin's disease primarily involves lymphoreticular system with characteristic tumo... more Introduction-Hodgkin's disease primarily involves lymphoreticular system with characteristic tumor cells and infiltration of reactive lymphocytes, eosinophils and plasma cells. It is said that FNAC has greater diagnostic accuracy in Hodgkin's lymphoma than non Hodgkin's lymphoma.
The morbidity and mortality caused by the dilated cardiomyopathy arise from fatal complications l... more The morbidity and mortality caused by the dilated cardiomyopathy arise from fatal complications like ventricular tachy and bradyarrhythmias and congestive cardiac failure. A 36 year's old male residing at Navi Mumbai was admitted with the chief complaints of breathlessness on exertion since last 4 months, swelling over the body with distension of abdomen since last 3 months. There is no history of chest pain, syncope, and weight / appetite loss, Hypertension (HT), Ischemic Heart Disease (IHD), Valvular Heart Disease (VHD), Tuberculosis (TB) or any drugs in the past. On examination it was found that 2 D Echo-Dilated LA, LV, RA, RV; Mild MR,TR; LVEF <25%, normal blood reports, chest X-ray shows a marked cardiomegaly, ECG-Sinus tachycardia, LBBB, intra-ventricular conduction defects, poor progression of r waves. Other investigation shows TB PCR, Thyroid profile, Anemia profile, RFT and Urine (r/m) has not been detected any abnormality. USG (abdomen) detected minimal ascites with hepatomegaly. A liver enzyme, cardiac enzymes and serum potassium shows marginal elevation.
Aims and Objective-This study has been undertaken to evaluate the role of Fine Needle Aspiration ... more Aims and Objective-This study has been undertaken to evaluate the role of Fine Needle Aspiration Cytology (FNAC) in Human Immunodeficiency Virus (HIV) positive lymphadenopathy patients. Materials And Method-Forty HIV positive Patients with lymphadenopathy were subjected to FNAC over a period of eight months i.e. from January, 2011 to August, 2011 in pathology department in our tertiary care hospital. Aspiration was done as a routine procedure using 22 gauge needle with standard precautions after taking detailed clinical history and physical examination of the patients. Smears obtained were stained with May-Grunwald-Giemsa (MGG), Papanicolaou (PAP) and Hematoxylin & Eosin (H&E) stains. Special stain used was Ziehl-Neelsen (ZN) stain for Acid Fast Bacilli (AFB). Result-Age distribution was noted between 5 years to 67 years during the present study. The peak incidence was noted in fourth decade of life (32.5 %). In HIV positive patients, lymphadenopathy showed male predominance, with the male: female ratio of 3.44:1. Cervical lymph nodes were the most common site encountered (62.5 %) as an initial affected site. FNAC results were classified as an inadequate material, non-neoplastic lesions and neoplastic lesions. The most common etiology associated with HIV was Tuberculous lymphadenitis (40.54 %) followed by acute suppurative lymphadenitis (27.03 %). Conclusion-FNAC is simple and safe investigative procedure for diagnosis of lymphadenopathy in HIV positive patients. It obviates surgical excision and guides subsequent therapy and management. Many opportunistic infections can also be found out with the help of this procedure.
dypjhs.com by Krishnat Yadav
In health care clinical laboratories plays very important role in diagnosis and prognosis of the ... more In health care clinical laboratories plays very important role in diagnosis and prognosis of the disease. So clinical laboratories are rapidly transforming into an efficient and extremely automated fashion and its metamorphosis has been expensive. Due to cost factor, unbiased report, emergency services and shortage of skilled manpower, running such establishment is tedious task. Atomization of clinical laboratories minimizes certain workstations but quality delivery was lacunas before few decades. Quality control in clinical laboratories may be practiced prospectively and provide information about the acceptability of the most recent analytical run(s) or may be practiced retrospectively and provide information about past performance. The results of quality control evolved with the growing use of the multitest analyzer within the early 1970s. Laboratory managers gradually accomplished that the applying of ±2s qualitycontrol limits to multitest analyzer. As early as 1974, Haven expanded the allowable deviations of quality-control results by defining a run as out of control if either a single control observation exceeded the ±3s limits or 2 observations exceeded the ±2s limits. This approach was rationalized by Westgards investigations into the efficiency and appropriateness of various laboratory quality-control rules which describes of two control rules, one sensitive to systematic error and the other sensitive to random error. Point-ofcare (POC) analyzers are more precise and accurate but daily electronic quality control recommend. Laboratory professionals are reluctant to change systems if they are perceived to be working satisfactorily. The great emphasis on proficiency testing in CLIA 88 laboratory quality reports enhanced.
Aims and Objective-This study has been undertaken to evaluate the role of Fine Needle Aspiration ... more Aims and Objective-This study has been undertaken to evaluate the role of Fine Needle Aspiration Cytology (FNAC) in Human Immunodeficiency Virus (HIV) positive lymphadenopathy patients. Materials And Method-Forty HIV positive Patients with lymphadenopathy were subjected to FNAC over a period of eight months i.e. from January, 2011 to August, 2011 in pathology department in our tertiary care hospital. Aspiration was done as a routine procedure using 22 gauge needle with standard precautions after taking detailed clinical history and physical examination of the patients. Smears obtained were stained with May-Grunwald-Giemsa (MGG), Papanicolaou (PAP) and Hematoxylin & Eosin (H&E) stains. Special stain used was Ziehl-Neelsen (ZN) stain for Acid Fast Bacilli (AFB). Result-Age distribution was noted between 5 years to 67 years during the present study. The peak incidence was noted in fourth decade of life (32.5 %). In HIV positive patients, lymphadenopathy showed male predominance, with the male: female ratio of 3.44:1. Cervical lymph nodes were the most common site encountered (62.5 %) as an initial affected site. FNAC results were classified as an inadequate material, non-neoplastic lesions and neoplastic lesions. The most common etiology associated with HIV was Tuberculous lymphadenitis (40.54 %) followed by acute suppurative lymphadenitis (27.03 %). Conclusion-FNAC is simple and safe investigative procedure for diagnosis of lymphadenopathy in HIV positive patients. It obviates surgical excision and guides subsequent therapy and management. Many opportunistic infections can also be found out with the help of this procedure.
Type II diabetic mellitus (DM) is a chronic
metabolic disease that impairs normal insulin produc... more Type II diabetic mellitus (DM) is a chronic
metabolic disease that impairs normal insulin production
and glucose transport to the liver and muscles. In the India,
about 1-5% population suffer from diabetes or related
complication. So there is need to cure this disease. DM
chronic auditory complications may include spiral ganglia
atrophy, degeneration of the vestibulocochlear nerve myelin
sheath, reduction of the number of spiral lamina nerve
fibers, and thickening of the capillary walls of the stria
vascularis and small arteries. Aim and objectiv e: This
study aims to know the incidence of common parameters,
blood sugar levels, levels of lipids and the hearing thresholds
of individuals. Materials and Methods: It is a cross
sectional research study featuring hearing impairment in
transport workers diagnosed as type II diabetic. All individuals
were
interviewed
by
various
sets
of
questions
related
to listening ability of subjects and underwent a physical
examination, blood investigations, glucose and lipids
(Cholesterol, Triglyceride, HDL, LDL & VLDL) were
measured and Ear examination performed for presence of
wax. Results: There are positive findings in common parameters,
clinical parameters and common questionary
related to hearing impairment. Conclusion: Statistically
significant differences were seen in common, blood sugar
levels, lipid levels ans clinical and adaptive (acquired) parameter
findings of diabetic subjects when compared to
nondiabetic subjects. The findings and results gathered in
this study point to the existence of a relationship between
diabetic, lipid levels and hearing loss in heavy vehicle
transport subjects.
Key words: Hyperglycemia, hyperlipidemia, hearing impairment.
medical case report, bioinfo.com by Krishnat Yadav
Introduction: Acute renal failure (ARF) is seen mostly in Plasmodium falciparum infection, but P.... more Introduction: Acute renal failure (ARF) is seen mostly in Plasmodium falciparum infection, but P. vivax and P. malariae can cause renal impairment rarely. Malarial ARF is commonly found in adults and older children with falciparum malaria. Material & Methods: Ninety five patients from Pad. Dr. D Y Patil Hospital and Research Centre, Navi Mumbai, were included in this study during July-Aug 2010. Out of 95 patients 38 patients are control, 10 patients infected by P. falciparum, 36 patients infected by P. vivax and 11 are mix infection of P. falciparum & P. vivax. All patients' diagnosis is confirmed by clinical examination as well as peripheral blood smear. Results: Renal involvement present as electrolyte abnormality as Hyponatraemia, Oliguria, Uraecemia and jaundice. Acute Renal Failure (ARF) occurs as a complication of P. falciparum malarial infection in less than 1% of cases, but the mortality reported up to 40%. Malarial ARF is diagnosed when serum creatinine level greater than 3 mg/dL and/or urinary output is less than 400 ml in 24 hours. The serum concentrations of Creatinine, urea, proteins ( Total proteins & albumin), Bilirubin (conjugated and total bilirubin) in malaria patients were significantly higher (p<0.05) than those of malaria free individuals. We conclude that renal dysfunction, acute renal failure and liver dysfunction are clinical features of malaria Conclusion: In spite of several researches and ultramodern techniques, mechanism of malarial ARF and its effective management has remained unclear. In many cases reversal of renal dysfunction takes place may be due to biotransformation of antigen and response of immune system. In addition, the literature is almost silent on the mechanism of recent increase in incidence of ARF and multiple complications specifically around coastal regions in India.
bioinfo.com by Krishnat Yadav
In Indian population highest numbers of patients are suffering from Coronary heart disease (CHD).... more In Indian population highest numbers of patients are suffering from Coronary heart disease (CHD). It is projected to be 40 million Indians may suffer due to Coronary heart disease by the year 2020 [1]. Present study revealed that conventional markers for CHD are in-sufficient to predict the risk. The measurement of hs-CRP level & clinical indication may predict as a diagnostic marker for early detection of Coronary heart disease. The present study was carried at Padamashree Dr D Y Patil Hospital & Research Centre, Navi Mumbai. Fasting blood samples were collected from male and female patients attending Cardiology & Diabetic Clinics. The study designed between the different groups as diabetic, diabetic with hypertension and Myocardial Infraction & normal healthy individuals between the ages 25-60 years. It was concluded that hs-CRP level was increased significantly in diabetic, diabetic with hypertension and MI, though their lipid levels were within normal range. Key words-hs-CRP-lipid profile-diabetic mellitus diabetic mellitus with hypertension-myocardial infraction International Journal of Molecular Biology
Diabetes is a disease characterized by chronic hyperglycemia and several musculoskeletal disorder... more Diabetes is a disease characterized by chronic hyperglycemia and several musculoskeletal disorders associates with patients of diabetic mellitus. Some are because of the disease process, others have a higher incidence in those with diabetes, and yet others are likely associated with common etiologies. The objective of the present study is to document the association of cutaneous manifestations and diabetes. Total 90 type I & II diabetic patients were studied for abnormal glucose metabolism and cutaneous manifestations with respect to infections, neuropathy, nephropathy and retinopathy. Out of 90, four percent were type I and Ninety-six percent of patients were type II diabetes. 63 patients were present cutaneous manifestations out of these 49 females (77.78%) and 14 males (22.22%). Infections and other ddermatopathy (76%) were the commonest manifestations. Diabetic retinopathy (13%) and nephropathy (11%) Hypertension (49.20%), Neuropathy (4.76%) and Coronary Disease (12.69 %) were reported. Cutaneous manifestations are quite common in type II diabetes mellitus and patients presents with multiple cutaneous manifestations, should be evaluated for systemic complications.
The morbidity and mortality caused by the dilated cardiomyopathy arise from fatal complications l... more The morbidity and mortality caused by the dilated cardiomyopathy arise from fatal complications like ventricular tachy and bradyarrhythmias and congestive cardiac failure. A 36 year's old male residing at Navi Mumbai was admitted with the chief complaints of breathlessness on exertion since last 4 months, swelling over the body with distension of abdomen since last 3 months. There is no history of chest pain, syncope, and weight / appetite loss, Hypertension (HT), Ischemic Heart Disease (IHD), Valvular Heart Disease (VHD), Tuberculosis (TB) or any drugs in the past. On examination it was found that 2 D Echo-Dilated LA, LV, RA, RV; Mild MR,TR; LVEF <25%, normal blood reports, chest X-ray shows a marked cardiomegaly, ECG-Sinus tachycardia, LBBB, intra-ventricular conduction defects, poor progression of r waves. Other investigation shows TB PCR, Thyroid profile, Anemia profile, RFT and Urine (r/m) has not been detected any abnormality. USG (abdomen) detected minimal ascites with hepatomegaly. A liver enzyme, cardiac enzymes and serum potassium shows marginal elevation.
jarbs.com by Krishnat Yadav
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Papers by Krishnat Yadav
stage renal disease. End-stage renal disease is a worldwide
public health issue. Recent estimates by the National Institutes
of Health indicate that diabetes represents the single
largest cause of end-stage renal disease
[1]
. Renal involvement
in Type II Diabetes Mellitus (DM) was considered,
until a year ago, as a benign kidney condition, thought to
be causing loss of renal function similar to that seen in the
normal aging process. But today, it is known to have become
the single most common cause of end-stage renal
disease (ESRD) in the world. Type II DM patients on
maintenance dialysis use up a large percentage of monetary
reserves than those with non-diabetic ESRD. In addition,
Type II diabetic patients show poor results on dialysis and
have a higher mortality.
Clinical diagnosis and therapeutic management from an
earlier stage of diabetic nephropathy (DN) is of prime significance
in prevention of progression of DN to ESRD.
There are several biomarkers used to investigate & detect
kidney damage. Conventional biomarkers for kidney damage
include
glomerular
filtration rate (GFR), serum/plasma
creatinine, blood urea nitrogen (BUN), urinary microalbumin
excretion and several urinary findings such as
proteinuria and hematuria. However, these biomarkers are
non-specific and insensitive to early renal injury. Hence,
new specific markers are being developed
dypjhs.com by Krishnat Yadav
metabolic disease that impairs normal insulin production
and glucose transport to the liver and muscles. In the India,
about 1-5% population suffer from diabetes or related
complication. So there is need to cure this disease. DM
chronic auditory complications may include spiral ganglia
atrophy, degeneration of the vestibulocochlear nerve myelin
sheath, reduction of the number of spiral lamina nerve
fibers, and thickening of the capillary walls of the stria
vascularis and small arteries. Aim and objectiv e: This
study aims to know the incidence of common parameters,
blood sugar levels, levels of lipids and the hearing thresholds
of individuals. Materials and Methods: It is a cross
sectional research study featuring hearing impairment in
transport workers diagnosed as type II diabetic. All individuals
were
interviewed
by
various
sets
of
questions
related
to listening ability of subjects and underwent a physical
examination, blood investigations, glucose and lipids
(Cholesterol, Triglyceride, HDL, LDL & VLDL) were
measured and Ear examination performed for presence of
wax. Results: There are positive findings in common parameters,
clinical parameters and common questionary
related to hearing impairment. Conclusion: Statistically
significant differences were seen in common, blood sugar
levels, lipid levels ans clinical and adaptive (acquired) parameter
findings of diabetic subjects when compared to
nondiabetic subjects. The findings and results gathered in
this study point to the existence of a relationship between
diabetic, lipid levels and hearing loss in heavy vehicle
transport subjects.
Key words: Hyperglycemia, hyperlipidemia, hearing impairment.
medical case report, bioinfo.com by Krishnat Yadav
bioinfo.com by Krishnat Yadav
jarbs.com by Krishnat Yadav
stage renal disease. End-stage renal disease is a worldwide
public health issue. Recent estimates by the National Institutes
of Health indicate that diabetes represents the single
largest cause of end-stage renal disease
[1]
. Renal involvement
in Type II Diabetes Mellitus (DM) was considered,
until a year ago, as a benign kidney condition, thought to
be causing loss of renal function similar to that seen in the
normal aging process. But today, it is known to have become
the single most common cause of end-stage renal
disease (ESRD) in the world. Type II DM patients on
maintenance dialysis use up a large percentage of monetary
reserves than those with non-diabetic ESRD. In addition,
Type II diabetic patients show poor results on dialysis and
have a higher mortality.
Clinical diagnosis and therapeutic management from an
earlier stage of diabetic nephropathy (DN) is of prime significance
in prevention of progression of DN to ESRD.
There are several biomarkers used to investigate & detect
kidney damage. Conventional biomarkers for kidney damage
include
glomerular
filtration rate (GFR), serum/plasma
creatinine, blood urea nitrogen (BUN), urinary microalbumin
excretion and several urinary findings such as
proteinuria and hematuria. However, these biomarkers are
non-specific and insensitive to early renal injury. Hence,
new specific markers are being developed
metabolic disease that impairs normal insulin production
and glucose transport to the liver and muscles. In the India,
about 1-5% population suffer from diabetes or related
complication. So there is need to cure this disease. DM
chronic auditory complications may include spiral ganglia
atrophy, degeneration of the vestibulocochlear nerve myelin
sheath, reduction of the number of spiral lamina nerve
fibers, and thickening of the capillary walls of the stria
vascularis and small arteries. Aim and objectiv e: This
study aims to know the incidence of common parameters,
blood sugar levels, levels of lipids and the hearing thresholds
of individuals. Materials and Methods: It is a cross
sectional research study featuring hearing impairment in
transport workers diagnosed as type II diabetic. All individuals
were
interviewed
by
various
sets
of
questions
related
to listening ability of subjects and underwent a physical
examination, blood investigations, glucose and lipids
(Cholesterol, Triglyceride, HDL, LDL & VLDL) were
measured and Ear examination performed for presence of
wax. Results: There are positive findings in common parameters,
clinical parameters and common questionary
related to hearing impairment. Conclusion: Statistically
significant differences were seen in common, blood sugar
levels, lipid levels ans clinical and adaptive (acquired) parameter
findings of diabetic subjects when compared to
nondiabetic subjects. The findings and results gathered in
this study point to the existence of a relationship between
diabetic, lipid levels and hearing loss in heavy vehicle
transport subjects.
Key words: Hyperglycemia, hyperlipidemia, hearing impairment.