Epilepsi gebelik sırasında da görülebilen, kronik bir hastalıktır. Epileptik nöbet geçirmenin cid... more Epilepsi gebelik sırasında da görülebilen, kronik bir hastalıktır. Epileptik nöbet geçirmenin ciddi maternal ve fetal riskleri vardır, bu nedenle gebelikte tedaviye devam etmek gerekir. Konjenital malformasyon (KM) oranları özellikle birinci kuşak antiepileptik kullanımı ile artmaktadır. Levetirasetam (LEV) ise ikinci kuşak antiepileptik olup, teratojenik yan etkileri daha azdır. LEV kullanan gebede KM ile ilgili yayınlar olmasına rağmen, bu ilaca özgü herhangi bir malformasyon bildirilmemiştir. Biz, gebeliği boyunca LEV kullanan ve fetüste sol el yokluğu (acheiria) izlenen bir vakayı bildirmekteyiz.
Indian Journal of Radiology and Imaging, Oct 1, 2021
Background Extrapulmonary tuberculosis (TB) is associated with major diagnostic difficulties as i... more Background Extrapulmonary tuberculosis (TB) is associated with major diagnostic difficulties as it has many atypical symptoms and its imaging findings are similar to those of many other diseases. Case Report We present the case of a 50-year-old woman with a complex cystic mass in her pelvis and a 2-month history of pain. Thoracoabdominal computed tomography (CT) revealed the following: (1) multiple supraclavicular, axillary, mediastinal, and abdominal pathologic lymph nodes with central hypoattenuation; (2) sternal and dorsal vertebral bone destruction with a soft tissue mass; and (3) multiple hypoattenuating masses in the liver. 18 F-fludeoxyglucose positron emission tomography/ computed tomography (18 F-FDG PET/CT) revealed pathologic uptake in the defined areas, which were similar to metastases. Chest X-ray was normal. Diffuse metastatic disease was suspected clinically, but careful analysis of the imaging findings and the final pathologic results revealed multisystemic extrapulmonary TB. Clinical and radiological recovery was significant after anti-TB treatment at the 6-month follow-up. Conclusion Extrapulmonary TB without pulmonary involvement is associated with major diagnostic difficulties, especially with PET-CT. However, recognition and understanding of the CT or MR imaging spectrum can aid in the correct diagnosis and management of the disease.
International journal of gynaecology and obstetrics, Jun 30, 2023
ObjectiveTo evaluate the symptoms of Long COVID (LC), frequency of symptoms, and possible risk fa... more ObjectiveTo evaluate the symptoms of Long COVID (LC), frequency of symptoms, and possible risk factors in women diagnosed with coronavirus disease 2019 (COVID‐19) during pregnancy.MethodsWe conducted a single‐center, cross‐sectional, retrospective study in 99 pregnant women who were polymerase chain reaction‐positive (PCR+) for COVID‐19 between March 1, 2020 and April 30, 2022. The control group consisted of 99 women who gave birth between these dates and did not have COVID‐19. We evaluated the clinical manifestations, symptom prevalence, and symptom characteristics of acute COVID‐19 and the LC in the PCR+ group as well as questioned the control group for LC symptoms.ResultsOf the women in the PCR+ group, 74 (74.7%) had at least one LC symptom, and the most common symptoms were fatigue (54; 72.9%), myalgia/arthralgia (49; 66.2%), and anosmia/ageusia (31; 41.9%). The rate of LC symptoms in the control group was 14 (14.1%). The prevalence of LC symptoms was higher in severely/critically symptomatic patients (23; 100%) in the acute period of disease than in asymptomatic/mildly symptomatic (51; 67.1%) (P = 0.005). Hospitalization during acute infection (adjusted odds ratio [aOR] = 13.30), having one or more symptoms (aOR = 4.75), and having symptoms such as cough (aOR = 6.27) and myalgia/arthralgia (aOR = 12.93) increased the likelihood of LC.ConclusionMany women experienced LC after suffering acute COVID‐19 in pregnancy, but LC prevalence was similar to the general population. LC correlates with severity, type, and number of symptoms of acute COVID‐19.
No significant differences were noted between the groups in terms of E, A, and E/A ratio z-scores... more No significant differences were noted between the groups in terms of E, A, and E/A ratio z-scores (p > 0.05). The ICT and IRT z-scores were found to be significantly higher in the study group compared with those in the control group (p = 0.001 and p = 0.034). Mod-MPI z-score was also found significantly higher in the study group than in the control group (p = 0.034). There was no significant difference between the groups in terms of ET (p > 0.05). The signs of systolic, diastolic, and global cardiac dysfunction were demonstrated in fetuses of pregnant women with chronic smoking. It, therefore, merits consideration that the fetal heart is also exposed to the detrimental effects of smoking.
Maternal smoking during pregnancy remains a major public health issue and is associated with adve... more Maternal smoking during pregnancy remains a major public health issue and is associated with adverse perinatal outcomes. This study aimed to evaluate fetal cardiac functions in chronic maternal smoking during pregnancy and to compare them with non-smoker pregnant women. Forty-two smoker pregnant women between 24 and 34 weeks of gestation and gestational age-matched 44 non-smoker pregnant women were enrolled in this cross-sectional study. Fetal cardiac functions were measured using conventional Doppler echocardiography. The peak velocities of the mitral valve during early diastole (E) and atrial contraction (A) were measured, and the E/A ratio was calculated. The following time periods were also calculated; isovolumetric contraction time (ICT), isovolumetric relaxation time (IRT), and ejection time (ET). Then, the fetal left ventricle modified myocardial performance index (Mod-MPI) was calculated. No significant differences were noted between the groups in terms of E, A, and E/A rati...
Background Extrapulmonary tuberculosis (TB) is associated with major diagnostic difficulties as i... more Background Extrapulmonary tuberculosis (TB) is associated with major diagnostic difficulties as it has many atypical symptoms and its imaging findings are similar to those of many other diseases. Case Report We present the case of a 50-year-old woman with a complex cystic mass in her pelvis and a 2-month history of pain. Thoracoabdominal computed tomography (CT) revealed the following: (1) multiple supraclavicular, axillary, mediastinal, and abdominal pathologic lymph nodes with central hypoattenuation; (2) sternal and dorsal vertebral bone destruction with a soft tissue mass; and (3) multiple hypoattenuating masses in the liver. 18F-fludeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) revealed pathologic uptake in the defined areas, which were similar to metastases. Chest X-ray was normal. Diffuse metastatic disease was suspected clinically, but careful analysis of the imaging findings and the final pathologic results revealed multisystemic extrapulmona...
International Journal of Gynecology & Obstetrics
ObjectiveTo evaluate the symptoms of Long COVID (LC), frequency of symptoms, and possible risk fa... more ObjectiveTo evaluate the symptoms of Long COVID (LC), frequency of symptoms, and possible risk factors in women diagnosed with coronavirus disease 2019 (COVID‐19) during pregnancy.MethodsWe conducted a single‐center, cross‐sectional, retrospective study in 99 pregnant women who were polymerase chain reaction‐positive (PCR+) for COVID‐19 between March 1, 2020 and April 30, 2022. The control group consisted of 99 women who gave birth between these dates and did not have COVID‐19. We evaluated the clinical manifestations, symptom prevalence, and symptom characteristics of acute COVID‐19 and the LC in the PCR+ group as well as questioned the control group for LC symptoms.ResultsOf the women in the PCR+ group, 74 (74.7%) had at least one LC symptom, and the most common symptoms were fatigue (54; 72.9%), myalgia/arthralgia (49; 66.2%), and anosmia/ageusia (31; 41.9%). The rate of LC symptoms in the control group was 14 (14.1%). The prevalence of LC symptoms was higher in severely/critical...
AIM In this study, we aimed to investigate the soluble endoglin (sEng) levels in the pregnant wom... more AIM In this study, we aimed to investigate the soluble endoglin (sEng) levels in the pregnant women with fetal growth restriction (FGR) and to examine the possible relation of the sEng levels with the time remaining to delivery and maternal and fetal complications. METHODS A total of 42 pregnant women diagnosed with FGR were retrospectively reviewed. Using the maternal blood samples it is at the collected 24-37 gestational weeks, the sEng levels were measured. Fetal biometry measurements, umbilical artery, uterine artery, middle cerebral artery Doppler indices were documented. RESULTS Of all patients, 17 (40%) were diagnosed with early-onset FGR, while 25 (60%) were diagnosed with late-onset FGR. Abnormal Doppler findings were present in 25 (60%) patients. Of 42 newborns, 18 (42%) were hospitalized in the neonatal unit. The mean sEng level calculated by taking the average of the first and second blood samples was 63.24±49.83 ng/mL. There was no statistically significant difference i...
Bu arastirmanin amaci; ustbilissel okudugunu anlama farkindaligi, okudugunu anlama ve okuma tutu... more Bu arastirmanin amaci; ustbilissel okudugunu anlama farkindaligi, okudugunu anlama ve okuma tutumlarinin cinsiyet, okul oncesi egitim alma, kitap okumayi sevme, anne-baba ogrenim durumu degiskenlerine gore incelenmesidir. Iliskisel tarama modeli kullanilan arastirma Tekirdag Ili Saray Ilcesi’nde ogrenim goren 313 besinci sinif ogrencisi ile gerceklesmistir. Ogrencilerin ustbilissel okudugunu anlama farkindaliklari Gelen’in 2003 yilinda gelistirdigi “Ustbilissel Okudugunu Anlama Farkindaligi Olcegi”; Turkce dersine iliskin okudugunu anlama duzeyleri Demirel tarafindan 1995 yilinda hazirlanan “Balon” metni, okuma tutumlari ise McKenna ve Kear tarafindan 1990 yilinda gelistirilen “Okuma Tutum Olcegi” ile olculmustur. Arastirma sonucunda, ustbilissel okudugunu anlama farkindaligi, okudugunu anlama ve okuma tutumu puanlari, kiz ogrencilerin erkeklere, okul oncesi egitim alan ogrencilerin almayanlara, kitap okumayi sevdigini soyleyen ogrencilerin sevmeyenlere gore daha yuksek...
Epilepsi gebelik sırasında da görülebilen, kronik bir hastalıktır. Epileptik nöbet geçirmenin cid... more Epilepsi gebelik sırasında da görülebilen, kronik bir hastalıktır. Epileptik nöbet geçirmenin ciddi maternal ve fetal riskleri vardır, bu nedenle gebelikte tedaviye devam etmek gerekir. Konjenital malformasyon (KM) oranları özellikle birinci kuşak antiepileptik kullanımı ile artmaktadır. Levetirasetam (LEV) ise ikinci kuşak antiepileptik olup, teratojenik yan etkileri daha azdır. LEV kullanan gebede KM ile ilgili yayınlar olmasına rağmen, bu ilaca özgü herhangi bir malformasyon bildirilmemiştir. Biz, gebeliği boyunca LEV kullanan ve fetüste sol el yokluğu (acheiria) izlenen bir vakayı bildirmekteyiz.
Indian Journal of Radiology and Imaging, Oct 1, 2021
Background Extrapulmonary tuberculosis (TB) is associated with major diagnostic difficulties as i... more Background Extrapulmonary tuberculosis (TB) is associated with major diagnostic difficulties as it has many atypical symptoms and its imaging findings are similar to those of many other diseases. Case Report We present the case of a 50-year-old woman with a complex cystic mass in her pelvis and a 2-month history of pain. Thoracoabdominal computed tomography (CT) revealed the following: (1) multiple supraclavicular, axillary, mediastinal, and abdominal pathologic lymph nodes with central hypoattenuation; (2) sternal and dorsal vertebral bone destruction with a soft tissue mass; and (3) multiple hypoattenuating masses in the liver. 18 F-fludeoxyglucose positron emission tomography/ computed tomography (18 F-FDG PET/CT) revealed pathologic uptake in the defined areas, which were similar to metastases. Chest X-ray was normal. Diffuse metastatic disease was suspected clinically, but careful analysis of the imaging findings and the final pathologic results revealed multisystemic extrapulmonary TB. Clinical and radiological recovery was significant after anti-TB treatment at the 6-month follow-up. Conclusion Extrapulmonary TB without pulmonary involvement is associated with major diagnostic difficulties, especially with PET-CT. However, recognition and understanding of the CT or MR imaging spectrum can aid in the correct diagnosis and management of the disease.
International journal of gynaecology and obstetrics, Jun 30, 2023
ObjectiveTo evaluate the symptoms of Long COVID (LC), frequency of symptoms, and possible risk fa... more ObjectiveTo evaluate the symptoms of Long COVID (LC), frequency of symptoms, and possible risk factors in women diagnosed with coronavirus disease 2019 (COVID‐19) during pregnancy.MethodsWe conducted a single‐center, cross‐sectional, retrospective study in 99 pregnant women who were polymerase chain reaction‐positive (PCR+) for COVID‐19 between March 1, 2020 and April 30, 2022. The control group consisted of 99 women who gave birth between these dates and did not have COVID‐19. We evaluated the clinical manifestations, symptom prevalence, and symptom characteristics of acute COVID‐19 and the LC in the PCR+ group as well as questioned the control group for LC symptoms.ResultsOf the women in the PCR+ group, 74 (74.7%) had at least one LC symptom, and the most common symptoms were fatigue (54; 72.9%), myalgia/arthralgia (49; 66.2%), and anosmia/ageusia (31; 41.9%). The rate of LC symptoms in the control group was 14 (14.1%). The prevalence of LC symptoms was higher in severely/critically symptomatic patients (23; 100%) in the acute period of disease than in asymptomatic/mildly symptomatic (51; 67.1%) (P = 0.005). Hospitalization during acute infection (adjusted odds ratio [aOR] = 13.30), having one or more symptoms (aOR = 4.75), and having symptoms such as cough (aOR = 6.27) and myalgia/arthralgia (aOR = 12.93) increased the likelihood of LC.ConclusionMany women experienced LC after suffering acute COVID‐19 in pregnancy, but LC prevalence was similar to the general population. LC correlates with severity, type, and number of symptoms of acute COVID‐19.
No significant differences were noted between the groups in terms of E, A, and E/A ratio z-scores... more No significant differences were noted between the groups in terms of E, A, and E/A ratio z-scores (p > 0.05). The ICT and IRT z-scores were found to be significantly higher in the study group compared with those in the control group (p = 0.001 and p = 0.034). Mod-MPI z-score was also found significantly higher in the study group than in the control group (p = 0.034). There was no significant difference between the groups in terms of ET (p > 0.05). The signs of systolic, diastolic, and global cardiac dysfunction were demonstrated in fetuses of pregnant women with chronic smoking. It, therefore, merits consideration that the fetal heart is also exposed to the detrimental effects of smoking.
Maternal smoking during pregnancy remains a major public health issue and is associated with adve... more Maternal smoking during pregnancy remains a major public health issue and is associated with adverse perinatal outcomes. This study aimed to evaluate fetal cardiac functions in chronic maternal smoking during pregnancy and to compare them with non-smoker pregnant women. Forty-two smoker pregnant women between 24 and 34 weeks of gestation and gestational age-matched 44 non-smoker pregnant women were enrolled in this cross-sectional study. Fetal cardiac functions were measured using conventional Doppler echocardiography. The peak velocities of the mitral valve during early diastole (E) and atrial contraction (A) were measured, and the E/A ratio was calculated. The following time periods were also calculated; isovolumetric contraction time (ICT), isovolumetric relaxation time (IRT), and ejection time (ET). Then, the fetal left ventricle modified myocardial performance index (Mod-MPI) was calculated. No significant differences were noted between the groups in terms of E, A, and E/A rati...
Background Extrapulmonary tuberculosis (TB) is associated with major diagnostic difficulties as i... more Background Extrapulmonary tuberculosis (TB) is associated with major diagnostic difficulties as it has many atypical symptoms and its imaging findings are similar to those of many other diseases. Case Report We present the case of a 50-year-old woman with a complex cystic mass in her pelvis and a 2-month history of pain. Thoracoabdominal computed tomography (CT) revealed the following: (1) multiple supraclavicular, axillary, mediastinal, and abdominal pathologic lymph nodes with central hypoattenuation; (2) sternal and dorsal vertebral bone destruction with a soft tissue mass; and (3) multiple hypoattenuating masses in the liver. 18F-fludeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) revealed pathologic uptake in the defined areas, which were similar to metastases. Chest X-ray was normal. Diffuse metastatic disease was suspected clinically, but careful analysis of the imaging findings and the final pathologic results revealed multisystemic extrapulmona...
International Journal of Gynecology & Obstetrics
ObjectiveTo evaluate the symptoms of Long COVID (LC), frequency of symptoms, and possible risk fa... more ObjectiveTo evaluate the symptoms of Long COVID (LC), frequency of symptoms, and possible risk factors in women diagnosed with coronavirus disease 2019 (COVID‐19) during pregnancy.MethodsWe conducted a single‐center, cross‐sectional, retrospective study in 99 pregnant women who were polymerase chain reaction‐positive (PCR+) for COVID‐19 between March 1, 2020 and April 30, 2022. The control group consisted of 99 women who gave birth between these dates and did not have COVID‐19. We evaluated the clinical manifestations, symptom prevalence, and symptom characteristics of acute COVID‐19 and the LC in the PCR+ group as well as questioned the control group for LC symptoms.ResultsOf the women in the PCR+ group, 74 (74.7%) had at least one LC symptom, and the most common symptoms were fatigue (54; 72.9%), myalgia/arthralgia (49; 66.2%), and anosmia/ageusia (31; 41.9%). The rate of LC symptoms in the control group was 14 (14.1%). The prevalence of LC symptoms was higher in severely/critical...
AIM In this study, we aimed to investigate the soluble endoglin (sEng) levels in the pregnant wom... more AIM In this study, we aimed to investigate the soluble endoglin (sEng) levels in the pregnant women with fetal growth restriction (FGR) and to examine the possible relation of the sEng levels with the time remaining to delivery and maternal and fetal complications. METHODS A total of 42 pregnant women diagnosed with FGR were retrospectively reviewed. Using the maternal blood samples it is at the collected 24-37 gestational weeks, the sEng levels were measured. Fetal biometry measurements, umbilical artery, uterine artery, middle cerebral artery Doppler indices were documented. RESULTS Of all patients, 17 (40%) were diagnosed with early-onset FGR, while 25 (60%) were diagnosed with late-onset FGR. Abnormal Doppler findings were present in 25 (60%) patients. Of 42 newborns, 18 (42%) were hospitalized in the neonatal unit. The mean sEng level calculated by taking the average of the first and second blood samples was 63.24±49.83 ng/mL. There was no statistically significant difference i...
Bu arastirmanin amaci; ustbilissel okudugunu anlama farkindaligi, okudugunu anlama ve okuma tutu... more Bu arastirmanin amaci; ustbilissel okudugunu anlama farkindaligi, okudugunu anlama ve okuma tutumlarinin cinsiyet, okul oncesi egitim alma, kitap okumayi sevme, anne-baba ogrenim durumu degiskenlerine gore incelenmesidir. Iliskisel tarama modeli kullanilan arastirma Tekirdag Ili Saray Ilcesi’nde ogrenim goren 313 besinci sinif ogrencisi ile gerceklesmistir. Ogrencilerin ustbilissel okudugunu anlama farkindaliklari Gelen’in 2003 yilinda gelistirdigi “Ustbilissel Okudugunu Anlama Farkindaligi Olcegi”; Turkce dersine iliskin okudugunu anlama duzeyleri Demirel tarafindan 1995 yilinda hazirlanan “Balon” metni, okuma tutumlari ise McKenna ve Kear tarafindan 1990 yilinda gelistirilen “Okuma Tutum Olcegi” ile olculmustur. Arastirma sonucunda, ustbilissel okudugunu anlama farkindaligi, okudugunu anlama ve okuma tutumu puanlari, kiz ogrencilerin erkeklere, okul oncesi egitim alan ogrencilerin almayanlara, kitap okumayi sevdigini soyleyen ogrencilerin sevmeyenlere gore daha yuksek...
Uploads
Papers by Hülya Kandemir